Echinacoside induces apoptosis in human SW480 colorectal cancer cells by induction of oxidative DNA damages

International Journal of Molecular Sciences

Volumn 16, Issue 7, 2015, Pages 14655-14668

  Dong, Liwei ^a   Yu, Debin ^a   Wu, Nuoting ^a   Wang, Hongge ^a   Niu, Jiajing ^a   Wang, Ye ^a   Zou, Zhihua ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

8 oxoG; Apoptosis; Cell cycle arrest; DNA damage; Echinacoside

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOCHROME C; ECHINACOSIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; GLYCOSIDE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY ASSAY; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION ASSAY; DNA STRAND BREAKAGE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; UPREGULATION; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; COLORECTAL TUMOR; DRUG EFFECTS; METABOLISM; OXIDATIVE STRESS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DNA DAMAGE; GLYCOSIDES; HUMANS; OXIDATIVE STRESS;

EID: 84936884066     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160714655     Document Type: Article

References (34)

1. Jiang, Y., Tu, P.F. Analysis of chemical constituents in Cistanche species. J. Chromatogr. A 2009, 1216, 1970-1979.
2. Wang, T., Zhang, X., Xie, W. Cistanche deserticola Y.C. Ma, "desert ginseng", A review. Am. J. Chin. Med. 2012, 40, 1123-1141.
3. Freeman, C., Spelman, K. A critical evaluation of drug interactions with Echinacea spp. Mol. Nutr. Food Res. 2008, 52, 789-798.
4. Hudson, J.B. Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. J. Biomed. Biotechnol. 2012, 2012, 769-896.
5. Zhang, D., Li, H., Wang, J.B. Echinacoside inhibits amyloid fibrillization of HEWL and protects against AP-induced neurotoxicity. Int. J. Biol. Macromol. 2015, 72, 243-253.
6. Wu, Y., Li, L., Wen, T., Li, Y.Q. Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats. Toxicology 2007, 232, 50-56.
7. Li, X., Gou, C., Yang, H., Qiu, J., Gu, T., Wen, T. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand. J. Gastroenterol. 2014, 49, 993-1000.
8. Xie, H., Zhu, H., Cheng, C., Liang, Y., Wang, Z. Echinacoside retards cellular senescence of human fibroblastic cells MRC-5. Pharmazie 2009, 64, 752-754.
9. Wang, S., Zheng, G., Tian, S., Zhang, Y., Shen, L., Pak, Y., Shen, Y., Qian, J. Echinacoside improves hematopoietic function in 5-FU-induced myelosuppression mice. Life Sci. 2015, 123, 86-92.
10. Jia, Y., Guan, Q., Guo, Y., Du, C. Echinacoside stimulates cell proliferation and prevents cell apoptosis in intestinal epithelial MODE-K cells by up-regulation of transforming growth factor-ßl expression. J. Pharmacol. Sci. 2012, 115, 99-108.
11. Morikawa, T., Ninomiya, K., Imamura, M., Akaki, J., Fujikura, S., Pan, Y., Yuan, D., Yoshikawa, M., Jia, X., Li, Z., et al. Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice. J. Nat. Med. 2014, 68, 561-566.
12. Yang, X., Li, F., Yang, Y., Shen, J., Zou, R., Zhu, P., Zhang, C., Yang, Z., Li, P. Efficacy and safety of echinacoside in a rat osteopenia model. Evid. Based Complement. Altern. Med. 2013, 2013, 926-928.
13. Kuang, R., Sun, Y., Zheng, X. Suppression of nitric oxide implicated in the protective effect of echinacoside on H2O2-induced PC12 cell injury. Nat. Prod. Commun. 2010, 5, 571-574.
14. Xiong, Q., Kadota, S., Tani, T., Namba, T. Antioxidative effects of phenylethanoids from Cistanche deserticola. Biol. Pharm. Bull. 1996, 19, 1580-1585.
15. Zhang, Y., Du, Y., Le, W., Wang, K., Kieffer, N., Zhang, J. Redox control of the survival of healthy and diseased cells. Antioxid. Redox Signal. 2011, 15, 2867-2908.
16. Russo, M.T., Blasi, M.F., Chiera, F., Fortini, P., Degan, P., Macpherson, P., Furuichi, M., Nakabeppu, Y., Karran, P., Aquilina, G., et al. The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. Mol. Cell. Biol. 2004, 24, 465-474.
17. Ventura, I., Russo, M.T., de Luca, G., Bignami, M. Oxidized purine nucleotides, genome instability and neurodegeneration. Mutat. Res. 2010, 703, 59-65.
18. Rajendran, P., Nandakumar, N., Rengarajan, T., Palaniswami, R., Gnanadhas, E.N., Lakshminarasaiah, U., Gopas, J., Nishigaki, I. Antioxidants and human diseases. Clin. Chim. Acta 2014, 436, 332-347.
19. Rai, P., Onder, T.T., Young, J.J., McFaline, J.L., Pang, B., Dedon, P.C., Weinberg, R.A. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc. Natl. Acad. Sci. USA 2009, 106, 169-174.
20. DeNicola, G.M., Karreth, F.A., Humpton, T.J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K.H., Yeo, C.J., Calhoun, E.S., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011, 475, 106-109.
21. Santos, M.A., Faryabi, R.B., Ergen, A.V., Day, A.M., Malhowski, A., Canela, A., Onozawa, M., Lee, J.E., Callen, E., Gutierrez-Martinez, P., et al. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature 2014, 514, 107-111.
22. Sayin, V.L., Ibrahim, M.X., Larsson, E., Nilsson, J.A., Lindahl, P., Bergo, M.O. Antioxidants accelerate lung cancer progression in mice. Sci. Transl. Med. 2014, 6, 221-215.
23. Harris, I.S., Treloar, A.E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K.C., Yung, K.Y., Brenner, D., Knobbe-Thomsen, C.B., Cox, M.A., et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell 2015, 27, 211-222.
24. Wong, H.S., Ko, K.M. Herba Cistanches stimulates cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration in H9c2 cardiomyocytes. Pharm. Biol. 2013, 51, 64-73.
25. Struthers, L., Patel, R., Clark, J., Thomas, S. Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues. Anal. Biochem. 1998, 255, 20-31.
26. Bridge, G., Rashid, S., Martin, S.A. DNA mismatch repair and oxidative DNA damage, Implications for cancer biology and treatment. Cancers 2014, 6, 1597-1614.
27. Caldecott, K.W. Single-strand break repair and genetic disease. Nat. Rev. Genet. 2008, 9, 619-631.
28. Ward, I.M., Minn, K., van Deursen, J., Chen, J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell. Biol. 2003, 23, 2556-2563.
29. Nakabeppu, Y. Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells. Int. J. Mol. Sci. 2014, 15, 12543-12557.
30. Colussi, D., Brandi, G., Bazzoli, F., Ricciardiello, L. Molecular pathways involved in colorectal cancer, Implications for disease behavior and prevention. Int. J. Mol. Sci. 2013, 14, 16365-16385.
31. Satelli, A., Mitra, A., Brownlee, Z., Xia, X., Bellister, S., Overman, M.J., Kopetz, S., Ellis, L.M., Meng, Q.H., Li, S. Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression. Clin. Cancer Res. 2015, 21, 899-906.
32. Liao, X., Lochhead, P., Nishihara, R., Morikawa, T., Kuchiba, A., Yamauchi, M., Imamura, Y., Qian, Z.R., Baba, Y., Shima, K., et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N. Engl. J. Med. 2012, 367, 1596-1606.
33. Domingo, E., Church, D.N., Sieber, O., Ramamoorthy, R., Yanagisawa, Y., Johnstone, E., Davidson, B., Kerr, D.J., Tomlinson, I.P., Midgley, R. Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. J. Clin. Oncol. 2013, 31, 4297-4305.
34. Ahmed, D., Eide, P.W., Eilertsen, I.A., Danielsen, S.A., Eknaes, M., Hektoen, M., Lind, G.E., Lothe, R.A. Epigenetic and genetic features of 24 colon cancer cell lines. Oncogenesis 2013, 2, doi:10.1038/oncsis.2013.35.