Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages 8415-8420

  Issa, Peter Charbel ^a,b   Barnard, Alun R ^a   Herrmann, Philipp ^b   Washington, Ilyas ^c   MacLaren, Robert E ^a,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BONN   (Germany)

^c New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^d MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

A2E; Age related macular degeneration; ALK 001; Bisretinoid; C20 D3 vitamin A

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A4; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; BETA ACTIN; C20 D3 VITAMIN A; CARBON; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; LIPOFUSCIN; MESSENGER RNA; PROPERDIN; RETINOL; UNCLASSIFIED DRUG; ABCA4 PROTEIN, MOUSE; DEUTERIUM; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOFLUORESCENCE; CONTROLLED STUDY; DIMERIZATION; DISEASE COURSE; DNA TRANSCRIPTION; ELECTRORETINOGRAPHY; EXON; FEMALE; GENETIC ASSOCIATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; RETINOPATHY; STARGARDT DISEASE; TRANSCRIPTION REGULATION; TRANSMISSION ELECTRON MICROSCOPY; 129 MOUSE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MACULAR DEGENERATION; METABOLISM; PATHOPHYSIOLOGY; PIGMENT EPITHELIUM; RETINA; TREATMENT OUTCOME; ULTRASTRUCTURE;

MURINAE; MUS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DEUTERIUM; DIMERIZATION; ELECTRORETINOGRAPHY; LIPOFUSCIN; MACULAR DEGENERATION; MICE, 129 STRAIN; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; PHENOTYPE; RETINA; RETINAL PIGMENT EPITHELIUM; TREATMENT OUTCOME; VITAMIN A; VITAMINS;

EID: 84936797991     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506960112     Document Type: Article

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