메뉴 건너뛰기




Volumn 43, Issue 9, 2015, Pages 4505-4516

AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; PROTEIN KINASE B; THREONINE;

EID: 84936792293     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv176     Document Type: Article
Times cited : (35)

References (43)
  • 2
    • 84867183192 scopus 로고    scopus 로고
    • Histone phosphorylation: A chromatin modification involved in diverse nuclear events
    • Rossetto, D., Avvakumov, N. and Cote, J. (2012) Histone phosphorylation: A chromatin modification involved in diverse nuclear events. Epigenetics, 7, 1098-1108.
    • (2012) Epigenetics , vol.7 , pp. 1098-1108
    • Rossetto, D.1    Avvakumov, N.2    Cote, J.3
  • 3
    • 28444456705 scopus 로고    scopus 로고
    • The histone code at DNA breaks: A guide to repair? Nat
    • Van Attikum, H. and Gasser, S.M. (2005) The histone code at DNA breaks: A guide to repair? Nat. Rev. Mol. Cell Biol., 6, 757-765.
    • (2005) Rev. Mol. Cell Biol. , vol.6 , pp. 757-765
    • Van Attikum, H.1    Gasser, S.M.2
  • 4
    • 0034700511 scopus 로고    scopus 로고
    • A role for Saccharomyces cerevisiae histone H2A in DNA repair
    • Downs, J.A., Lowndes, N.F. and Jackson, S.P. (2000) A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature, 408, 1001-1004.
    • (2000) Nature , vol.408 , pp. 1001-1004
    • Downs, J.A.1    Lowndes, N.F.2    Jackson, S.P.3
  • 6
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki, M., Clapperton, J.A., Mohammad, D., Yaffe, M.B., Smerdon, S.J. and Jackson, S.P. (2005) MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell, 123, 1213-1226.
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 8
    • 24344481673 scopus 로고    scopus 로고
    • Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4
    • Utley, R.T., Lacoste, N., Jobin-Robitaille, O., Allard, S. and Cote, J. (2005) Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4. Mol. Cell. Biol., 25, 8179-8190.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 8179-8190
    • Utley, R.T.1    Lacoste, N.2    Jobin-Robitaille, O.3    Allard, S.4    Cote, J.5
  • 9
    • 3042685445 scopus 로고    scopus 로고
    • Phosphorylation of histone H2B at DNA double-strand breaks
    • Fernandez-Capetillo, O., Allis, C.D. and Nussenzweig, A. (2004) Phosphorylation of histone H2B at DNA double-strand breaks. J. Exp. Med., 199, 1671-1677.
    • (2004) J. Exp. Med. , vol.199 , pp. 1671-1677
    • Fernandez-Capetillo, O.1    Allis, C.D.2    Nussenzweig, A.3
  • 10
    • 73349092441 scopus 로고    scopus 로고
    • Histones: Annotating chromatin
    • Campos, E.I. and Reinberg, D. (2009) Histones: Annotating chromatin. Annu. Rev. Genet., 43, 559-599.
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 559-599
    • Campos, E.I.1    Reinberg, D.2
  • 11
    • 79955475464 scopus 로고    scopus 로고
    • Unravelling the means to an end: RNA polymerase II transcription termination
    • Kuehner, J.N., Pearson, E.L. and Moore, C. (2011) Unravelling the means to an end: RNA polymerase II transcription termination. Nat. Rev. Mol. Cell Biol., 12, 283-294.
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 283-294
    • Kuehner, J.N.1    Pearson, E.L.2    Moore, C.3
  • 12
    • 33745178478 scopus 로고    scopus 로고
    • Terminating the transcript: Breaking up is hard to do
    • Rosonina, E., Kaneko, S. and Manley, J.L. (2006) Terminating the transcript: Breaking up is hard to do. Genes Dev., 20, 1050-1056.
    • (2006) Genes Dev. , vol.20 , pp. 1050-1056
    • Rosonina, E.1    Kaneko, S.2    Manley, J.L.3
  • 13
    • 0023478621 scopus 로고
    • A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene
    • Logan, J., Falck-Pedersen, E., Darnell, J.E. Jr and Shenk, T. (1987) A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proc. Natl. Acad. Sci. U.S.A., 84, 8306-8310.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 8306-8310
    • Logan, J.1    Falck-Pedersen, E.2    Darnell, J.E.3    Shenk, T.4
  • 14
    • 0023990221 scopus 로고
    • A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II
    • Connelly, S. and Manley, J.L. (1988) A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II. Genes Dev., 2, 440-452.
    • (1988) Genes Dev. , vol.2 , pp. 440-452
    • Connelly, S.1    Manley, J.L.2
  • 15
    • 66149187105 scopus 로고    scopus 로고
    • Transcription termination by nuclear RNA polymerases
    • Richard, P. and Manley, J.L. (2009) Transcription termination by nuclear RNA polymerases. Genes Dev., 23, 1247-1269.
    • (2009) Genes Dev. , vol.23 , pp. 1247-1269
    • Richard, P.1    Manley, J.L.2
  • 17
    • 62849120533 scopus 로고    scopus 로고
    • C-terminal binding protein maintains mitochondrial activities
    • Kim, J.H. and Youn, H.D. (2009) C-terminal binding protein maintains mitochondrial activities. Cell Death Differ., 16, 584-592.
    • (2009) Cell Death Differ. , vol.16 , pp. 584-592
    • Kim, J.H.1    Youn, H.D.2
  • 18
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
    • Langmead, B., Trapnell, C., Pop, M. and Salzberg, S.L. (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol., 10, R25.
    • (2009) Genome Biol. , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 20
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y.C., Laslo, P., Cheng, J.X., Murre, C., Singh, H. and Glass, C.K. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell, 38, 576-589.
    • (2010) Mol. Cell , vol.38 , pp. 576-589
    • Heinz, S.1    Benner, C.2    Spann, N.3    Bertolino, E.4    Lin, Y.C.5    Laslo, P.6    Cheng, J.X.7    Murre, C.8    Singh, H.9    Glass, C.K.10
  • 22
    • 84899493057 scopus 로고    scopus 로고
    • Ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases
    • Shen, L., Shao, N., Liu, X. and Nestler, E. (2014) ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC Genomics, 15, 284.
    • (2014) BMC Genomics , vol.15 , pp. 284
    • Shen, L.1    Shao, N.2    Liu, X.3    Nestler, E.4
  • 23
    • 38649118240 scopus 로고    scopus 로고
    • Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
    • Shimada, M., Niida, H., Zineldeen, D.H., Tagami, H., Tanaka, M., Saito, H. and Nakanishi, M. (2008) Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell, 132, 221-232.
    • (2008) Cell , vol.132 , pp. 221-232
    • Shimada, M.1    Niida, H.2    Zineldeen, D.H.3    Tagami, H.4    Tanaka, M.5    Saito, H.6    Nakanishi, M.7
  • 24
    • 2542440487 scopus 로고    scopus 로고
    • Phosphorylation of histone H2A inhibits transcription on chromatin templates
    • Zhang, Y., Griffin, K., Mondal, N. and Parvin, J.D. (2004) Phosphorylation of histone H2A inhibits transcription on chromatin templates. J. Biol. Chem., 279, 21866-21872.
    • (2004) J. Biol. Chem. , vol.279 , pp. 21866-21872
    • Zhang, Y.1    Griffin, K.2    Mondal, N.3    Parvin, J.D.4
  • 26
    • 0344844473 scopus 로고    scopus 로고
    • Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response
    • Tan, J. and Hallahan, D.E. (2003) Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response. Cancer Res., 63, 7663-7667.
    • (2003) Cancer Res. , vol.63 , pp. 7663-7667
    • Tan, J.1    Hallahan, D.E.2
  • 27
    • 0347747970 scopus 로고    scopus 로고
    • A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells
    • Kau, T.R., Schroeder, F., Ramaswamy, S., Wojciechowski, C.L., Zhao, J.J., Roberts, T.M., Clardy, J., Sellers, W.R. and Silver, P.A. (2003) A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell, 4, 463-476.
    • (2003) Cancer Cell , vol.4 , pp. 463-476
    • Kau, T.R.1    Schroeder, F.2    Ramaswamy, S.3    Wojciechowski, C.L.4    Zhao, J.J.5    Roberts, T.M.6    Clardy, J.7    Sellers, W.R.8    Silver, P.A.9
  • 29
    • 84855170184 scopus 로고    scopus 로고
    • Nucleosome surface containing nucleosomal DNA entry/exit site regulates H3-K36me3 via association with RNA polymerase II and Set2
    • Endo, H., Nakabayashi, Y., Kawashima, S., Enomoto, T., Seki, M. and Horikoshi, M. (2012) Nucleosome surface containing nucleosomal DNA entry/exit site regulates H3-K36me3 via association with RNA polymerase II and Set2. Genes Cells, 17, 65-81.
    • (2012) Genes Cells , vol.17 , pp. 65-81
    • Endo, H.1    Nakabayashi, Y.2    Kawashima, S.3    Enomoto, T.4    Seki, M.5    Horikoshi, M.6
  • 32
    • 84901752073 scopus 로고    scopus 로고
    • DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression
    • Jang, S.M., Azebi, S., Soubigou, G. and Muchardt, C. (2014) DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression. EMBO Rep., 15, 686-694.
    • (2014) EMBO Rep. , vol.15 , pp. 686-694
    • Jang, S.M.1    Azebi, S.2    Soubigou, G.3    Muchardt, C.4
  • 33
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • Brazil, D.P. and Hemmings, B.A. (2001) Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem. Sci., 26, 657-664.
    • (2001) Trends Biochem. Sci. , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 34
    • 33645844251 scopus 로고    scopus 로고
    • The role of Rat1 in coupling mRNA 3-end processing to transcription termination: Implications for a unified allosteric-torpedo model
    • Luo, W., Johnson, A.W. and Bentley, D.L. (2006) The role of Rat1 in coupling mRNA 3-end processing to transcription termination: Implications for a unified allosteric-torpedo model. Genes Dev., 20, 954-965.
    • (2006) Genes Dev. , vol.20 , pp. 954-965
    • Luo, W.1    Johnson, A.W.2    Bentley, D.L.3
  • 35
    • 84868252050 scopus 로고    scopus 로고
    • Genome-wide technology for determining RNA stability in mammalian cells: Historical perspective and recent advantages based on modified nucleotide labeling
    • Tani, H. and Akimitsu, N. (2012) Genome-wide technology for determining RNA stability in mammalian cells: Historical perspective and recent advantages based on modified nucleotide labeling. RNA Biol., 9, 1233-1238.
    • (2012) RNA Biol. , vol.9 , pp. 1233-1238
    • Tani, H.1    Akimitsu, N.2
  • 36
    • 84857047339 scopus 로고    scopus 로고
    • PhosphoSitePlus: A comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse
    • Hornbeck, P.V., Kornhauser, J.M., Tkachev, S., Zhang, B., Skrzypek, E., Murray, B., Latham, V. and Sullivan, M. (2012) PhosphoSitePlus: A comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res., 40, D261-D270.
    • (2012) Nucleic Acids Res. , vol.40 , pp. D261-D270
    • Hornbeck, P.V.1    Kornhauser, J.M.2    Tkachev, S.3    Zhang, B.4    Skrzypek, E.5    Murray, B.6    Latham, V.7    Sullivan, M.8
  • 39
    • 0035694785 scopus 로고    scopus 로고
    • Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction
    • Thomson, S., Clayton, A.L. and Mahadevan, L.C. (2001) Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction. Mol. Cell, 8, 1231-1241.
    • (2001) Mol. Cell , vol.8 , pp. 1231-1241
    • Thomson, S.1    Clayton, A.L.2    Mahadevan, L.C.3
  • 40
    • 69249208791 scopus 로고    scopus 로고
    • The Akt kinases: Isoform specificity in metabolism and cancer
    • Gonzalez, E. and McGraw, T.E. (2009) The Akt kinases: Isoform specificity in metabolism and cancer. Cell Cycle, 8, 2502-2508.
    • (2009) Cell Cycle , vol.8 , pp. 2502-2508
    • Gonzalez, E.1    McGraw, T.E.2
  • 41
    • 24744452428 scopus 로고    scopus 로고
    • Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines
    • Kim, I.A., Bae, S.S., Fernandes, A., Wu, J., Muschel, R.J., McKenna, W.G., Birnbaum, M.J. and Bernhard, E.J. (2005) Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res., 65, 7902-7910.
    • (2005) Cancer Res. , vol.65 , pp. 7902-7910
    • Kim, I.A.1    Bae, S.S.2    Fernandes, A.3    Wu, J.4    Muschel, R.J.5    McKenna, W.G.6    Birnbaum, M.J.7    Bernhard, E.J.8
  • 42
    • 42949165854 scopus 로고    scopus 로고
    • PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
    • Bozulic, L., Surucu, B., Hynx, D. and Hemmings, B.A. (2008) PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol. Cell, 30, 203-213.
    • (2008) Mol. Cell , vol.30 , pp. 203-213
    • Bozulic, L.1    Surucu, B.2    Hynx, D.3    Hemmings, B.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.