Stability of peptide drugs in the colon

European Journal of Pharmaceutical Sciences

Volumn 78, Issue , 2015, Pages 31-36

  Wang, Jie ^a   Yadav, Vipul ^a   Smart, Alice L ^a   Tajiri, Shinichiro ^a,b   Basit, Abdul W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Biopharmaceuticals; Colonic delivery; Colonic metabolism; Large intestine; Microbiota; Oral delivery of peptides and proteins

Indexed keywords

ARGIPRESSIN; BUSERELIN; CALCITONIN; CYCLOSPORIN A; DESLORELIN; DESMOPRESSIN; GLUCAGON; GONADORELIN DERIVATIVE; GOSERELIN; HISTRELIN; INSULIN; LEUPRORELIN; NAFARELIN; OCTREOTIDE; OXYTOCIN; PEPTIDE DERIVATIVE; SECRETIN; SOMATOSTATIN; OCTANOL; PEPTIDE; PEPTIDE HYDROLASE; WATER;

ARTICLE; COLON; CONFORMATIONAL TRANSITION; DRUG STABILITY; ENZYME SPECIFICITY; FECES MICROFLORA; HUMAN; HYDROLYSIS; LIPOPHILICITY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SURFACE AREA; BACTERIUM; CHEMISTRY; FECES; INTESTINE FLORA; METABOLISM; MICROBIOLOGY;

1-OCTANOL; BACTERIA; COLON; FECES; GASTROINTESTINAL MICROBIOME; HUMANS; PEPTIDE HYDROLASES; PEPTIDES; WATER;

EID: 84936756721     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.06.018     Document Type: Article

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