Toward oral delivery of biopharmaceuticals: An assessment of the gastrointestinal stability of 17 peptide drugs

Molecular Pharmaceutics

Volumn 12, Issue 3, 2015, Pages 966-973

  Wang, Jie ^a   Yadav, Vipul ^a   Smart, Alice L ^a   Tajiri, Shinichiro ^a,b   Basit, Abdul W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Biopharmaceuticals; gastrointestinal fluids; metabolism; oral delivery; peptides and proteins

Indexed keywords

ARGIPRESSIN; BUSERELIN; CALCITONIN; CYCLOSPORIN A; DESLORELIN; DESMOPRESSIN; GLUCAGON; GONADORELIN DERIVATIVE; GOSERELIN; HISTRELIN; LEUPRORELIN; NAFARELIN; OCTREOTIDE; OXYTOCIN; PEPTIDE DERIVATIVE; RECOMBINANT HUMAN INSULIN; SECRETIN; SOMATOSTATIN; PEPTIDE; PEPTIDE HYDROLASE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG METABOLISM; DRUG STABILITY; EXPERIMENTAL PIG; GASTROINTESTINAL TRACT; HUMAN; INTESTINE FLUID; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; STOMACH JUICE; ANIMAL; BODY FLUID; CHEMISTRY; IN VITRO STUDY; METABOLISM; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PIG; SMALL INTESTINE;

ADMINISTRATION, ORAL; ANIMALS; BIOPHARMACEUTICS; BODY FLUIDS; DRUG STABILITY; GASTRIC JUICE; GASTROINTESTINAL TRACT; HUMANS; IN VITRO TECHNIQUES; INTESTINE, SMALL; PEPTIDE HYDROLASES; PEPTIDES; PROTEOLYSIS; SUS SCROFA;

EID: 84924111992     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500809f     Document Type: Article

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