Orphan drugs in development for Huntington’s disease: Challenges and progress

Orphan Drugs: Research and Reviews

Volumn 5, Issue , 2015, Pages 1-9

  Burgunder, Jean Marc ^a,b,c,d  

^a UNIVERSITY OF BERN   (Switzerland)

^b SICHUAN UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Disease modifying therapy; Huntington s disease; Symptomatic treatment

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BIOLOGICAL MARKER; COPPER; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DOPAMINE 2 RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KYNURENINE MONOOXYGENASE; LAQUINIMOD; MESSENGER RNA; ORPHAN DRUG; OXYGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR ALPHA; POLYGLUTAMINE; PRIDOPIDINE; SELISISTAT; SMALL INTERFERING RNA; TETRABENAZINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER; ZINC FINGER PROTEIN;

CAG REPEAT; CELL FUNCTION; CORPUS STRIATUM; EXCITOTOXICITY; GENE MUTATION; GENE THERAPY; GENETIC TRANSCRIPTION; GLIA CELL; HUMAN; HUNTINGTON CHOREA; IMMUNE RESPONSE; INTRACELLULAR SIGNALING; LIVER FAILURE; MITOCHONDRION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PHENOTYPE; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RNA TRANSLATION;

EID: 84936754470     PISSN: None     EISSN: 22306161     Source Type: Journal    
DOI: 10.2147/ODRR.S49198     Document Type: Review

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