Global identification and quantitative analysis of chemical constituents in traditional Chinese medicinal formula Qi-Fu-Yin by ultra-high performance liquid chromatography coupled with mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 114, Issue , 2015, Pages 376-389

  Li, Meng Ning ^a   Dong, Xin ^a   Gao, Wen ^a   Liu, Xin Guang ^a   Wang, Rui ^a   Li, Ping ^a   Yang, Hua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ginsenoside; Global identification; HPLC MS; Qi Fu Yin; Quantitative analysis

Indexed keywords

ALKALOID; CAFFEIC ACID; CHIKUSETSU SAPONIN; CHINESE DRUG; CHLOROGENIC ACID; FERULIC ACID; FLAVANOID; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 3; GLYCOSIDE; GLYCYRRHIZIC ACID; HERBACEOUS AGENT; IONONE DERIVATIVE; IRIDOID; LIQUIRITIGENIN; LIQUIRITIN; OLIGOSACCHARIDE; PHENOL DERIVATIVE; PHTHALIDE DERIVATIVE; QI FU YIN; SAPONIN; SESQUITERPENE LACTONE; TRITERPENE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHONE DERIVATIVE; BENZOFURAN DERIVATIVE; ESTER; FLAVONOID; GINSENOSIDE; LACTONE; PHTHALIDE; QI-FU-YIN;

ACCURACY; ANALYTICAL EQUIPMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHINESE MEDICINE; ELECTROSPRAY MASS SPECTROMETRY; HERBAL MEDICINE; MASS SPECTROMETER; MASS SPECTROMETRY; NEUROPROTECTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY; TRADITIONAL MEDICINE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CALIBRATION; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; LIMIT OF DETECTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; REFERENCE VALUE; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; TEMPERATURE;

ALKALOIDS; BENZOFURANS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; DRUGS, CHINESE HERBAL; ESTERS; FLAVONOIDS; GINSENOSIDES; GLYCOSIDES; LACTONES; LIMIT OF DETECTION; MAGNETIC RESONANCE SPECTROSCOPY; MEDICINE, CHINESE TRADITIONAL; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SAPONINS; TANDEM MASS SPECTROMETRY; TEMPERATURE; TRITERPENES;

EID: 84936749629     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.05.030     Document Type: Article

References (36)

1. Xing G.H., Lin C.R., Hu N., Niu Y.C., Sun Y.R. Effect of Qifuyin on ability of learning and memory and expression of somatostatin in hippocampus on model rats of Alzheimer's Disease induced by β-amyloid (1-42). Chin. J. Inform. Tradit. Chin. Med. 2010, 17:34-36.
2. Kim H.J., Kim P., Shin C.Y. A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system. J. Ginseng Res. 2013, 37:8-29.
3. Kim J., Kim S.H., Lee D.S., Lee D.J., Kim S.H., Chung S., Yang H.O. Effects of fermented ginseng on memory impairment and beta-amyloid reduction in Alzheimer's disease experimental models. J. Ginseng Res. 2013, 37:100-107.
4. Zhang X.L., Zhang A.H., Jiang B., Bao Y.M., Wang J.Y., An L.J. Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa. Phytomedicine 2008, 15:484-490.
5. Huang S.H., Li C.M., Chiang B.H. Protective effects of Angelica sinensis extract on amyloid β-peptide-induced neurotoxicity. Phytomedicine 2008, 15:710-721.
6. Lin Z.H., Xiao Z.B., Zhu D.N., Yan Y.Q., Yu B.Y., Wang Q.J. Aqueous extracts of FBD, a Chinese herb formula composed of Poria cocos, Atractylodes macrocephala, and Angelica sinensis reverse scopolamine induced memory deficit in ICR mice. Pharm. Biol. 2009, 47:396-401.
7. Ahn J.Y., Kim S., Jung T.Y., Ha S.E. Effect of Licorice (Glycyrrhiza uralensis Fisch) on amyloid-beta-induced neurotoxicity in PC12Cells. Food Sci. Biotechnol. 2010, 19:1391-1395.
8. Liu Z., Zhao X., Liu B., Liu A.J., Li H., Mao X., Wu B., Bi K.S., Jia Y. Jujuboside A, a neuroprotective agent from semen Ziziphi Spinosae ameliorates behavioral disorders of the dementia mouse model induced by A beta (1-42). Eur. J. Pharmacol. 2014, 738:206-213.
9. Naito R., Tohda C. Characterization of anti-neurodegenerative effects of Polygala tenuifolia in abeta (25-35)-treated cortical neurons. Biol. Pharm. Bull. 2006, 29:1892-1896.
10. Zhang H.M., Li S.L., Zhang H., Wang Y., Zhao Z.L., Chen S.L., Xu H.X. Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach. J. Pharm. Biomed. Anal. 2012, 62:258-273.
11. Sun B.S., Xu M.Y., Li Z., Yang Y.B., Sung C.K. UPLC-Q-TOF-MS/MS analysis for steaming times-dependent profiling of steamed Panax quinquefolius and its ginsenosides transformations induced by repetitious steaming. J. Ginseng Res. 2012, 36:277-290.
12. Zhou S.S., Xu J.D., Zhu H., Shen H., Xu J., Mao Q., Li S.L., Yan R. Simultaneous determination of original, degraded ginsenosides and aglycones by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for quantitative evaluation of Du-Shen-Tang, the decoction of ginseng. Molecules 2014, 19:4083-4104.
13. Wang H.Y., Hua H.Y., Liu X.Y., Liu J.H., Yu B.Y. In vitro biotransformation of red ginseng extract by human intestinal microflora: metabolites identification and metabolic profile elucidation using LC-Q-TOF/MS. J. Pharm. Biomed. Anal. 2014, 98:296-306.
14. Xu J.D., Mao Q., Shen H., Zhu L.Y., Li S.L., Yan R. Ultra-high performance liquid chromatography coupled with photo-diode array and quadrupole/time-of-flight mass spectrometry based chemical profiling approach to evaluate the influence of preparation methods on the holistic quality of Qiong-Yu-Gao, a traditional complex herbal medicine. J. Chromatogr. A 2013, 1304:154-168.
15. Li S.L., Song J.Z., Qiao C.F., Zhou Y., Qian K.D., Lee K.H., Xu H.X. A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis. J. Pharm. Biomed. Anal. 2010, 51:812-823.
16. Qi L.W., Wen X.D., Cao J., Li C.Y., Li P., Yi L., Wang Y.X., Cheng X.L., Ge X.X. Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2008, 22:2493-2509.
17. Wang Y.L., Liang Y.Z., Chen B.M. High-performance liquid chromatography with atmospheric pressure chemical ionization and electrospray ionization mass spectrometry for analysis of Angelica sinensis. Phytochem. Anal. 2007, 18:265-274.
18. Yang F., Xiao Y.S., Zhang F.F., Xue X.Y., Xu Q., Liang X.M. High performance liquid chromatography-mass spectrometry analysis of Radix Angelica Sinensis. Acta. Pharmacol. Sin. 2006, 41:1078-1083.
19. Shan G.S., Zhang L.X., Zhao Q.M., Xiao H.B., Zhuo R.J., Xu G., Jiang H., You X.M., Jia T.Z. Metabolomic study of raw and processed Atractylodes macrocephala Koidz by LC-MS. J. Pharm. Biomed. Anal. 2014, 98:74-84.
20. Cui X.B., Shan C.X., Wen H.M., Li W., Wu H. UFLC/Q-TOF-MS based analysis on material base of atractylodis macrocephalae rhizoma stir-fried with wheat bran. Chin. J. Chin. Mater. Med. 2013, 38:1929-1933.
21. Huang T.M., Chen N.Z., Wang D.L., Lai Y.H. Infrared-assisted extraction coupled with high performance liquid chromatography (HPLC) for determination of liquiritin and glycyrrhizic acid in licorice root. Anal. Methods 2014, 6:5986-5991.
22. Yan Y., Chai C.Z., Wang D.W., Yue X.Y., Zhu D.N., Yu B.Y. HPLC-DAD-Q-TOF-MS/MS analysis and HPLC quantitation of chemical constituents in traditional Chinese medicinal formula Ge-Gen Decoction. J. Pharm. Biomed. Anal. 2011, 54:535-544.
23. Zheng Y.F., Qi L.W., Zhou J.L., Li P. Structural characterization and identification of oleananetype triterpene saponins in Glycyrrhiza uralensis Fischer by rapid-resolution liquid chromatography coupled with time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24:3261-3270.
24. Li Y.J., Chen J., Li Y., Li Q., Zheng Y.F., Fu Y., Li P. Screening and characterization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J. Chromatogr. A 2011, 1218:8181-8191.
25. Montoro P., Maldini M., Russo M., Postorino S., Piacente S., Pizza C. Metabolic profiling of roots of liquorice (Glycyrrhiza glabra) from different geographical areas by ESI/MS/MS and determination of major metabolites by LC-ESI/MS and LC-ESI/MS/MS. J. Pharm. Biomed. Anal. 2011, 54:535-544.
26. Yang B., Dong W., Zhang A.H., Sun H., Wu F.F., Wang P., Wang X.J. Ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry for rapid analysis of constituents of Suanzaoren decoction. J. Sep. Sci. 2011, 34:3208-3215.
27. Liu J.J., Chen B., Yao S.Z. Simultaneous analysis and identification of main bioactive constituents in extract of Zizyphus jujube var. sapinosa (Zizyphi spinosi semen) by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. Talanta 2007, 71:668-675.
28. Zarga M.A., Sabri S., Aboudi A.A., Ajaz M.S., Sultana N., Ranman A.U. New cyclopeptide alkaloids from Zizyphus lotus. J. Nat. Prod. 1995, 58:504-511.
29. Ling Y., Li Z.X., Chen M.C., Sun Z.L., Fan M.S., Huang C.G. Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J. Pharm. Biomed. Anal. 2013, 85:1-13.
30. Liu J.Y., Yang X.D.J.M., He M., Xia Xu L.Z., Yang S.L. Structure analysis of triterpene saponins in Polygala tenuifolia by electrospray ionization ion trap multiple-stage mass spectrometry. J. Mass Spectrom. 2007, 42:861-873.
31. Li J., Dong X.B., Jiang Y., Gao Q.T., Jiang Z.Y., Cheung A.W.H., Duan R., Dong T.T.X., Tu P.F., Tsim K.W.K. Simultaneous determination of phenols in Radix Polygalae by high performance liquid chromatography: quality assurance of herbs from different regions and seasons. J. Sep. Sci. 2007, 30:2583-2589.
32. Yan J.J., Jung J.S., Kim T.K., Hansan M.A., Hong C.W., Nam J.S., Song D.K. Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer Disease. Biol. Pharm. Bull. 2013, 140-143. 36.
33. Hu Y., Liu M.Y., Liu P., Dong X.Z., Boran A.D.W. Neuroprotective effects of 3,6'-disinapoyl sucrose through increased BDNF levels and CREB phosphorylation via the CaMKII and ERK1/2 pathway. J. Mol. Neurosci. 2014, 53:600-607.
34. Dong X.Z., Huang C.L., Yu B.Y., Hu Y., Mu L.H., Liu P. Effect of tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells. Phytomedicine 2014, 21:1178-1188.
35. Song X.Y., Hu J.F., Chu S.F., Zhang Z., Xu S., Yuan Y.H., Han N., Liu Y., Niu F., He X. Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3 beta signaling pathway and the A beta formation prevention in rats. Eur. J. Pharmacol. 2013, 710:29-38.
36. Song J.H., Lee J.W., Shim B., Lee C.Y., Choi S., Kang C., Sohn N.W., Shin J.W. Glycyrrhizin alleviates neuroinflammation and memory deficit induced by systemic lipopolysaccharide treatment in mice. Molecules 2013, 18:15788-15803.