Metabolomic study of raw and processed Atractylodes macrocephala Koidz by LC-MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 98, Issue , 2014, Pages 74-84

  Shan, Guo Shun ^a   Zhang, Liang Xiao ^b   Zhao, Qi Miao ^a   Xiao, Hong Bin ^c   Zhuo, Rong Jie ^c   Xu, Gang ^a   Jiang, Hong ^d   You, Xian Min ^a,b   Jia, Tian Zhu ^a  

^a LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^d Liaoning Institute of Light Industry   (China)

Author keywords

Atractylodes macrocephala Koidz; Chemical markers; Multivariate statistical analysis; Processing mechanism; Ultra performance liquid chromatography tandem time of flight mass spectrometry

Indexed keywords

1 ACETYL 3 ALPHA METHYLBUTYRYL ATRACTYTYLENTRIOL; 1 ACETYL 3 SENECIOYL ATRACTYLENTRIOL; 1 ALPHA METHYLBUTYRL ATRACTYTYLENTRIOL; 1 ISOVALERYL ATRACTTYLENTRIOL; 3 BETA ACETOXYATRACTYLONE; 5,7 FLAVONONE; 7 HYDROXY EUDESM 4(15),11(13) DIEN 2 ACID; 8 BETA METHOXY ATRACTYLENOLIDE I; ATRACTYLENOLACTAM; ATRACTYLENOLIDE; ATRACTYLENOLIDE VI; ATRACTYLODES MACROCEPHALA EXTRACT; ATRACTYLOSIDE A; ATRACTYLOSIDE B; BETA ELEMENE; BIOLOGICAL MARKER; DIHYDROSYRINDINE; ETHYL 3 (4 HYDROXYPHENYL) ACRYLATE; EUDESM 4(15),7 DIENE 9ALPHA,11 DIOL; HINESOL; ICARISIDE D1; LUTEOLIN; PALMIC ACID; SELINA 4(14),7(11) DIEN 8 ONE; SITOSTEROL; STIGMASTEROL; UMBELLIFERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 7-HYDROXYCOUMARIN; ATRACTYLENOLIDE I; ATRACTYLENOLIDE II; ATRACTYLENOLIDE III; HERBACEOUS AGENT; LACTONE; SESQUITERPENE; UMBELLIFERONE DERIVATIVE;

ARTICLE; ATRACTYLODES; ATRACTYLODES MACROCEPHALA KOIDZ; CELL ACTIVITY; CHEMICAL COMPOSITION; CHEMOTAXONOMY; CONTROLLED STUDY; DRUG STRUCTURE; GASTROINTESTINAL TRACT FUNCTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; PARTIAL LEAST SQUARES REGRESSION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WHEAT BRAN; CHEMISTRY; CHINESE MEDICINE; DISCRIMINANT ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; RHIZOME;

ATRACTYLODES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISCRIMINANT ANALYSIS; DRUGS, CHINESE HERBAL; LACTONES; MASS SPECTROMETRY; MEDICINE, CHINESE TRADITIONAL; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; RHIZOME; SESQUITERPENES; UMBELLIFERONES;

EID: 84901617697     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.05.010     Document Type: Article

References (25)

1. Zhao Z.Z., Liang Z.T., Chan K., Lu G.H., Lai E., Lee M., Chen H.B., Li L. A unique issue in the standardization of Chinese Materia Medica: processing. Planta Med. 2010, 76:1975-1986.
2. Jin S.Y., Wang Q. Studies on Processing of Chinese Medicinal Yinpian and Its Clinical Application 2004, Press of Chemistry Industry, Beijing. first ed.
3. Ye D.J., Yuan S.T. Dictionary of Chinese Herbal Processing Science 2005, Shanghai Science and Technology Press, Shanghai. first ed.
4. Cai B.C., Wu H., Kadota S., Hattori M., Namba T. Processing of Nux vomica. III. Effects of seven different processing of Nux vomica on chemical constituents and acute toxicity. J. Trad. Med. 1994, 11:134-141.
5. Cai B.C., Nagasawa T., Kadota S., Hattori M., Namba T., Kuraishi Y. Processing of Nux vomica. VII. Antinociceptive effects of crude alkaloids from the processed and unprocessed seeds of Strychnos Nux-vomica in mice. Biol. Pharm. Bull. 1996, 19:127-131.
6. State Pharmacopoeia Committee Pharmacopoeia of the People's Republic of China (Part I) 2010, 95-96. Chinese Medicine Science and Technology Press, Beijing. first ed.
7. Wang K.T., Chen L.G., Yang L.L., Ke W.M., Chang H.C., Wang C.C. Analysis of the sesquiterpenoids in processed Atractylodis rhizoma. Chem. Pharm. Bull. 2007, 55:50-56.
8. Nicholson J.K., Wilson I.D. Understanding global systems biology: metabonomics and the continuum of metabolism. Nat. Rev. Drug Discov. 2003, 2:668-677.
9. Murch S.J., Vasantha Rupasinghe H.P., Goodenowe D., Saxena P.K. A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds. Plant Cell Rep. 2004, 23:419-425.
10. Dai H., Xiao C.N., Liu H.B., Tang H.R. Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion. J. Proteome Res. 2010, 9:1460-1475.
11. Yang S.O., Shin Y.S., Hyun S.H., Choa S., Bang K.H., Lee D., Choi S.P., Choi H.K. NMR-based metabolic profiling and differentiation of ginseng roots according to cultivation ages. J. Pharm. Biomed. Anal. 2012, 58:19-26.
12. Zhang H.M., Li S.L., Zhang H., Wang Y., Zhao Z.L., Chen S.L., Xu H.X. Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach. J. Pharm. Biomed. Anal. 2012, 62:258-273.
13. Toh D.F., New L.S., Koh H.L., Chan E.C.Y. Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginseng. J. Pharm. Biomed. Anal. 2010, 52:43-50.
14. Li S.L., Song J.Z., Qiao C.F., Zhou Y., Qian K.D., Lee K.H., Xu H.X. A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis. J. Pharm. Biomed. Anal. 2010, 51:812-823.
15. Geng L.L., Sun H.Y., Yuan Y., Liu Z.Z., Cui Y., Bi K.S., Chen X.H. Discrimination of raw and vinegar-processed Genkwa Flos using metabolomics coupled with multivariate data analysis: a discrimination study with metabolomics coupled with PCA. Fitoterapia 2013, 84:286-294.
16. Quaroni A., Wands J., Trelstad R.L., Isselbacher K.J. Epithelioid cell cultures from rat small intestine, characterization by morphologic and immunologic criteria. J. Cell Biol. 1979, 80:248-265.
17. Xian C.J. Roles of growth factors in chemotherapy-induced intestinal mucosal damage repair. Curr. Pharm. Biotechnol. 2003, 4:260-269.
18. Smith C.A., Want E.J., O'Maille G., Abagyan R., Siuzdak G. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal. Chem. 2006, 78:779-787.
19. Xia J., Mandal R., Sinelnikov I., Broadhurst D., Wishart D.S. MetaboAnalyst 2.0 - a comprehensive server for metabolomic data analysis. Nucleic Acids Res. 2012, 40:127-133.
20. Xia J., Psychogios N., Young N., Wishart D.S. MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucl. Acids Res. 2009, 37:652-660.
21. Yu H.F., Xu G.X., Fan X.M. The effect of ghrelin on cell proliferation in small intestinal IEC-6 cells. Biomed. Pharmacother. 2013, 67:235-239.
22. Hikino H., Hikino Y., Yosioka I. Studies on the constituents of Atractylodes. IX. Structure and autoxidation of atractylon. Chem. Pharm. Bull. 1964, 12:755-760.
23. +-ATPase activity by atractylon, a major component of Byaku-jutsu, by interaction with enzyme in the E2 state. Biochem. Pharmacol. 1996, 51:339-343.
24. Wang K.T., Chen L.G., Wu C.H., Chang C.C., Wang C.C. Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol induced gastric ulcer in vitro and in vivo. J. Pharm. Pharmacol. 2010, 62:381-388.
25. Dong H.Y., He L.C., Huang M., Dong Y.L. Anti-inflammatory components isolated from Atractylodes macrocephala Koidz. Nat. Prod. Res. 2008, 22:1418-1427.