Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro

Human Molecular Genetics

Volumn 24, Issue 13, 2015, Pages 3689-3698

  Senfter, Daniel ^a   Holzner, Silvio ^a   Kalipciyan, Maria ^a   Staribacher, Anna ^a   Walzl, Angelika ^a   Huttary, Nicole ^a   Krieger, Sigurd ^a   Brenner, Stefan ^b   Jäger, Walter ^b   Krupitza, Georg ^a   Dolznig, Helmut ^a   Mader, Robert M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; METHYLCELLULOSE; MICRORNA 141; MICRORNA 200; MICRORNA 200A; MICRORNA 200B; MICRORNA 200C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG; UVOMORULIN; VASCULAR ENDOTHELIAL CADHERIN; HOMEODOMAIN PROTEIN; MICRORNA; MIRN141 MICRORNA, HUMAN; MIRN200 MICRORNA, HUMAN; SNAIL FAMILY TRANSCRIPTION FACTORS; ZEB1 PROTEIN, HUMAN;

ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CELL CONTACT; CELL MIGRATION; COCULTURE; COLON CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME REGULATION; ENZYME REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMIT OF DETECTION; METASTASIS POTENTIAL; MOLECULAR SIZE; PHENOTYPE; PLASTICITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SURFACE PROPERTY; TUMOR INVASION; TUMOR SPHEROID; TUMOR VASCULARIZATION; COLONIC NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; ENDOTHELIUM CELL; GENETICS; LYMPH NODE METASTASIS; METABOLISM; MULTICELLULAR SPHEROID; MULTIGENE FAMILY; PATHOLOGY; TUMOR CELL CULTURE; TUMOR CELL LINE;

CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; ENDOTHELIAL CELLS; FLUOROURACIL; HOMEODOMAIN PROTEINS; HUMANS; LYMPHATIC METASTASIS; MICRORNAS; MULTIGENE FAMILY; NEOPLASM INVASIVENESS; SPHEROIDS, CELLULAR; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 84936748784     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv113     Document Type: Article

References (32)

1. Edwards, B.K., Ward, E., Kohler, B.A., Eheman, C., Zauber, A. G., Anderson, R.N., Jemal, A., Schymura, M.J., Lansdorp-Vogelaar, I., Seeff, L.C. et al. (2010) Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer, 116, 544-573.
2. Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C. and Parkin, D.M. (2008) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 127, 2893-2917.
3. Goldberg, R.M., Sargent, D.J., Morton, R.F., Fuchs, C.S., Ramanathan, R.K., Williamson, S.K., Findlay, B.P., Pitot, H.C. and Alberts, S.R. (2004) A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol., 22, 23-30.
4. McKeown, E., Nelson, D.W., Johnson, E.K., Maykel, J.A., Stojadinovic, A., Nissan, A., Avital, I., Brucher, B.L. and Steele, S.R. (2014) Current approaches and challenges for monitoring treatment response in colon and rectal cancer. J. Cancer, 5, 31-43.
5. Sanchez-Tillo, E., Siles, L., de Barrios, O., Cuatrecasas, M., Vaquero, E.C., Castells, A. and Postigo, A. (2012) Expanding roles of ZEB factors in tumorigenesis and tumor progression. Am. J. Cancer Res., 1, 897-912.
6. Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E. and Kutay, U. (2004) Nuclear export of microRNA precursors. Science, 303, 95-98.
7. Stoorvogel, W. (2012) Functional transfer of microRNA by exosomes. Blood, 119, 646-648.
8. Azmi, A.S., Bao, B. and Sarkar, F.H. (2013) Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Rev., 32, 623-642.
9. van den Boorn, J.G., Dassler, J., Coch, C., Schlee, M. and Hartmann, G. (2013) Exosomes as nucleic acid nanocarriers. Adv. Drug Deliv. Rev., 65, 331-335.
10. Moshammer, M.I., Kalipciyan, M., Bartsch, R., Steger, G.G., Sedivy, R. and Mader, R.M. (2014) Exosomal microRNA transfer varies with specific microRNAs functional in colorectal cancer and cellular differentiation. Int. J. Clin. Pharmacol. Ther., 52, 87-88.
11. Yang, M., Chen, J., Su, F., Yu, B., Su, F., Lin, L., Liu, Y., Huang, J. D. and Song, E. (2011) Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol. Cancer, 10, 117.
12. Kerjaschki, D., Bago-Horvath, Z., Rudas, M., Sexl, V., Schneckenleithner, C., Wolbank, S., Bartel, G., Krieger, S., Kalt, R., Hantusch, B. et al. (2011) Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J. Clin. Invest., 121, 2000-2012.
13. Vonach, C., Viola, K., Giessrigl, B., Huttary, N., Raab, I., Kalt, R., Krieger, S., Vo, T.P., Madlener, S., Bauer, S. et al. (2011) NF-kappaB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells. Br. J. Cancer, 105, 263-271.
14. Langheinrich, M.C., Schellerer, V., Perrakis, A., Lohmuller, C., Schildberg, C., Naschberger, E., Sturzl, M., Hohenberger, W. and Croner, R.S. (2012) Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract. Int. J. Clin. Exp. Pathol., 5, 614-623.
15. Giessrigl, B., Yazici, G., Teichmann, M., Kopf, S., Ghassemi, S., Atanasov, A.G., Dirsch, V.M., Grusch, M., Jager, W., Ozmen, A. et al. (2012) Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers. Int. J. Oncol., 40, 2063-2074.
16. Viola, K., Kopf, S., Huttary, N., Vonach, C., Kretschy, N., Teichmann, M., Giessrigl, B., Raab, I., Stary, S., Krieger, S. et al. (2013) Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion. Br. J. Cancer, 108, 564-569.
17. Viola, K., Kopf, S., Rarova, L., Jarukamjorn, K., Kretschy, N., Teichmann, M., Vonach, C., Atanasov, A.G., Giessrigl, B., Huttary, N. et al. (2013) Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis. Arch. Toxicol., 87, 1301-1312.
18. Chen, X., Wang, Y., Xia, H., Wang, Q., Jiang, X., Lin, Z., Ma, Y., Yang, Y. and Hu, M. (2012) Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis. Mol. Biol. Rep., 39, 6707-6714.
19. Schmidt, W.M., Kalipciyan, M., Dornstauder, E., Rizovski, B., Steger, G.G., Sedivy, R., Mueller, M.W. and Mader, R.M. (2004) Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int. J. Cancer, 112, 200-212.
20. Uchide, K., Sakon, M., Ariyoshi, H., Nakamori, S., Tokunaga, M. and Monden, M. (2007) Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle. Ann. Surg. Oncol., 14, 862-868.
21. Mader, R.M., Wieser, M., Berger, W., Kalipciyan, M., Hackl, M., Steger, G.G. and Grillari, J. (2011) Relevance of microRNA modulation in chemoresistant colon cancer in vitro. Int. J. Clin. Pharmacol. Ther., 49, 67-68.
22. Gregory, P.A., Bracken, C.P., Bert, A.G. and Goodall, G.J. (2008) MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle, 7, 3112-3118.
23. Paterson, E.L., Kazenwadel, J., Bert, A.G., Khew-Goodall, Y., Ruszkiewicz, A. and Goodall, G.J. (2013) Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia, 15, 180-191.
24. Madlener, S., Saiko, P., Vonach, C., Viola, K., Huttary, N., Stark, N., Popescu, R., Gridling, M., Vo, N.T., Herbacek, I. et al. (2010) Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro. Br. J. Cancer, 102, 1361-1370.
25. Tentes, I.K., Schmidt, W.M., Krupitza, G., Steger, G.G., Mikulits, W., Kortsaris, A. and Mader, R.M. (2010) Long-term persistence of acquired resistance to 5-fluorouracil in the colon cancer cell line SW620. Exp. Cell Res., 316, 3172-3181.
26. Kroepil, F., Fluegen, G., Totikov, Z., Baldus, S.E., Vay, C., Schauer, M., Topp, S.A., Esch, J.S., Knoefel, W.T. and Stoecklein, N.H. (2012) Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas. PLoS One, 7, e46665.
27. Gregory, P.A., Bert, A.G., Paterson, E.L., Barry, S.C., Tsykin, A., Farshid, G., Vadas, M.A., Khew-Goodall, Y. and Goodall, G.J. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol., 10, 593-601.
28. Park, S.M., Gaur, A.B., Lengyel, E. and Peter, M.E. (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev., 22, 894-907.
29. Diaz-Martin, J., Diaz-Lopez, A., Moreno-Bueno, G., Castilla, M. A., Rosa-Rosa, J.M., Cano, A. and Palacios, J. (2014) A core microRNA signature associated with inducers of the epithelialto-mesenchymal transition. J. Pathol., 232, 319-329.
30. Kretschy, N., Teichmann, M., Kopf, S., Atanasov, A.G., Saiko, P., Vonach, C., Viola, K., Giessrigl, B., Huttary, N., Raab, I. et al. (2013) In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br. J. Cancer, 108, 570-578.
31. Teichmann, M., Kretschy, N., Kopf, S., Jarukamjorn, K., Atanasov, A.G., Viola, K., Giessrigl, B., Saiko, P., Szekeres, T., Mikulits, W. et al. (2014) Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model. Arch. Toxicol., 88, 691-699.
32. Pfaffl, M.W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res., 29, e45.