Down-Regulation of CDH1 Is Associated with Expression of SNAI1 in Colorectal Adenomas

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kroepil, Feride ^a   Fluegen, Georg ^a   Totikov, Zaurbek ^a   Baldus, Stephan E ^a   Vay, Christian ^a   Schauer, Matthias ^a   Topp, Stefan A ^a   Esch, Jan Schulte am ^a   Knoefel, Wolfram T ^a   Stoecklein, Nikolas H ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL 1; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST 1; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL ADENOMA; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VALIDATION STUDY;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; CADHERINS; COLORECTAL NEOPLASMS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR;

EID: 84867028114     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046665     Document Type: Article

References (38)

1. Polyak K, Weinberg RA, (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273.
2. Roussos ET, Keckesova Z, Haley JD, Epstein DM, Weinberg RA, et al. (2010) AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res 70: 7360-7364.
3. Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
4. Savagner P, Kusewitt DF, Carver EA, Magnino F, Choi C, et al. (2005) Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol 202: 858-866.
5. Hanahan D, Weinberg RA, (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.
6. Foubert E, De Craene B, Berx G, (2010) Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression. Breast Cancer Res 12: 206.
7. Franci C, Gallen M, Alameda F, Baro T, Iglesias M, et al. (2009) Snail1 protein in the stroma as a new putative prognosis marker for colon tumours. PLoS One 4: e5595.
8. Gomez I, Pena C, Herrera M, Munoz C, Larriba MJ, et al. (2011) TWIST1 is expressed in colorectal carcinomas and predicts patient survival. PLoS One 6: e18023.
9. Larriba MJ, Casado-Vela J, Pendas-Franco N, Pena R, Garcia de Herreros A, et al. (2010) Novel snail1 target proteins in human colon cancer identified by proteomic analysis. PLoS One 5: e10221.
10. Loboda A, Nebozhyn MV, Watters JW, Buser CA, Shaw PM, et al. (2011) EMT is the dominant program in human colon cancer. BMC Med Genomics 4: 9.
11. Okada T, Suehiro Y, Ueno K, Mitomori S, Kaneko S, et al. (2010) TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer. Genes Chromosomes Cancer 49: 452-462.
12. Roy HK, Smyrk TC, Koetsier J, Victor TA, Wali RK, (2005) The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig Dis Sci 50: 42-46.
13. Valdes-Mora F, Gomez del Pulgar T, Bandres E, Cejas P, Ramirez de Molina A, et al. (2009) TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer. Ann Surg Oncol 16: 78-87.
14. Oda H, Tsukita S, Takeichi M, (1998) Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation. Dev Biol 203: 435-450.
15. Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA, (2000) Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol 148: 779-790.
16. Hazan RB, Qiao R, Keren R, Badano I, Suyama K, (2004) Cadherin switch in tumor progression. Ann N Y Acad Sci 1014: 155-163.
17. Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ, (1999) N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 147: 631-644.
18. Rosivatz E, Becker I, Specht K, Fricke E, Luber B, et al. (2002) Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 161: 1881-1891.
19. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
20. Schmelzle M, Dizdar L, Matthaei H, Baldus SE, Wolters J, et al. (2011) Esophageal cancer proliferation is mediated by cytochrome P450 2C9 (CYP2C9). Prostaglandins Other Lipid Mediat 94: 25-33.
21. Raffel A, Eisenberger CF, Cupisti K, Schott M, Baldus SE, et al. (2010) Increased EpCAM expression in malignant insulinoma: potential clinical implications. Eur J Endocrinol 162: 391-398.
22. Blechschmidt K, Sassen S, Schmalfeldt B, Schuster T, Hofler H, et al. (2008) The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients. Br J Cancer 98: 489-495.
23. Rosivatz E, Becker I, Bamba M, Schott C, Diebold J, et al. (2004) Neoexpression of N-cadherin in E-cadherin positive colon cancers. Int J Cancer 111: 711-719.
24. Gagliardi G, Kandemir O, Liu D, Guida M, Benvestito S, et al. (1995) Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Arch 426: 149-154.
25. Hao X, Palazzo JP, Ilyas M, Tomlinson I, Talbot IC, (1997) Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. Anticancer Res 17: 2241-2247.
26. Jungck M, Grunhage F, Spengler U, Dernac A, Mathiak M, et al. (2004) E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression. Int J Colorectal Dis 19: 438-445.
27. Valizadeh A, Karayiannakis AJ, el-Hariry I, Kmiot W, Pignatelli M, (1997) Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps. Am J Pathol 150: 1977-1984.
28. Eyles J, Puaux AL, Wang X, Toh B, Prakash C, et al. (2010) Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J Clin Invest 120: 2030-2039.
29. Husemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, et al. (2008) Systemic spread is an early step in breast cancer. Cancer Cell 13: 58-68.
30. Sanger N, Effenberger KE, Riethdorf S, van Haasteren V, Gauwerky J, et al. (2011) Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ. Int J Cancer.
31. Steinert R, Vieth M, Hantschick M, Reymond MA, (2005) Epithelial cells disseminate into the bone marrow of colorectal adenoma patients. Gut 54: 1045-1046.
32. Marsman WA, Westerterp M, van Heek NJ, ten Kate FJ, Izbicki JR, et al. (2005) Epithelial cells in bone marrow: do they matter? Gut 54: 1821-1822.
33. Pantel K, Deneve E, Nocca D, Coffy A, Vendrell JP, et al. (2011) Circulating Epithelial Cells in Patients with Benign Colon Diseases. Clin Chem.
34. Brenner H, Hoffmeister M, Stegmaier C, Brenner G, Altenhofen L, et al. (2007) Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies. Gut 56: 1585-1589.
35. Risio M, (2010) Reprint of: the natural history of adenomas. Best Pract Res Clin Gastroenterol 24: 397-406.
36. Tannapfel A, Neid M, Aust D, Baretton G, (2010) The origins of colorectal carcinoma: specific nomenclature for different pathways and precursor lesions. Dtsch Arztebl Int 107: 760-766.
37. McDonald SA, Preston SL, Lovell MJ, Wright NA, Jankowski JA, (2006) Mechanisms of disease: from stem cells to colorectal cancer. Nat Clin Pract Gastroenterol Hepatol 3: 267-274.
38. Medema JP, Vermeulen L, (2011) Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 474: 318-326.