The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid

Steroids

Volumn 99, Issue PB, 2015, Pages 172-177

  Crick, Peter J ^a,c   Beckers, Lien ^b   Baes, Myriam ^b   Van Veldhoven, Paul P ^b   Wang, Yuqin ^a   Griffiths, William J ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Bile acid; Brain; Derivatisation; LC MS

Indexed keywords

CHOLESTENOIC ACID; CHOLESTEROL DERIVATIVE; OXYSTEROL; UNCLASSIFIED DRUG; 7,25-DIHYDROXYCHOLESTEROL; CHOLESTANE DERIVATIVE; CHOLESTEROL; ENZYME; STEROL;

ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DERIVATIZATION; FEMALE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; METABOLISM; TANDEM MASS SPECTROMETRY;

ANIMALS; CHOLESTENES; CHOLESTEROL; ENZYMES; FEMALE; HYDROXYCHOLESTEROLS; MALE; MICE; STEROLS; TANDEM MASS SPECTROMETRY;

EID: 84936129830     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2015.02.021     Document Type: Article

References (22)

1. D.W. Russell The enzymes, regulation, and genetics of bile acid synthesis Annu Rev Biochem 72 2003 137 174
2. J.M. Lehmann, S.A. Kliewer, L.B. Moore, T.A. Smith-Oliver, B.B. Oliver, J.L. Su, and et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway J Biol Chem 272 1997 3137 3140
3. C. Liu, X.V. Yang, J. Wu, C. Kuei, N.S. Mani, L. Zhang, and et al. Oxysterols direct B-cell migration through EBI2 Nature 475 2011 519 523
4. S. Hannedouche, J. Zhang, T. Yi, W. Shen, D. Nguyen, J.P. Pereira, and et al. Oxysterols direct immune cell migration via EBI2 Nature 475 2011 524 527
5. E.R. Nelson, S.E. Wardell, J.S. Jasper, S. Park, S. Suchindran, M.K. Howe, and et al. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology Science 342 2013 1094 1098
6. Q. Wu, T. Ishikawa, R. Sirianni, H. Tang, J.G. McDonald, I.S. Yuhanna, and et al. 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth Cell Rep 5 2013 637 645
7. R.J. Fakheri, and N.B. Javitt 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols Steroids 77 2012 575 577
8. E. Fahy, S. Subramaniam, H.A. Brown, C.K. Glass, A.H. Merrill Jr., R.C. Murphy, and et al. A comprehensive classification system for lipids J Lipid Res 46 2005 839 861
9. I. Bjorkhem, A. Cedazo-Minguez, V. Leoni, and S. Meaney Oxysterols and neurodegenerative diseases Mol Aspects Med 30 2009 171 179
10. I. Bjorkhem, A. Lovgren-Sandblom, V. Leoni, S. Meaney, L. Brodin, L. Salveson, and et al. Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease Neurosci Lett 555 2013 102 105
11. A. Reboldi, E.V. Dang, J.G. McDonald, G. Liang, D.W. Russell, and J.G. Cyster 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon Science 345 2014 679 684
12. S. Theofilopoulos, Y. Wang, S.S. Kitambi, P. Sacchetti, K.M. Sousa, K. Bodin, and et al. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis Nat Chem Biol 9 2013 126 133
13. S. Theofilopoulos, W.J. Griffiths, P.J. Crick, S. Yang, A. Meljon, M. Ogundare, and et al. Cholestenoic acids regulate motor neuron survival via liver X receptors J Clin Invest 124 2014 4829 4842
14. A. Meljon, S. Theofilopoulos, C.H. Shackleton, G.L. Watson, N.B. Javitt, H.J. Knolker, and et al. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS J Lipid Res 53 2012 2469 2483
15. M. Ogundare, S. Theofilopoulos, A. Lockhart, L.J. Hall, E. Arenas, J. Sjovall, and et al. Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain? J Biol Chem 285 2010 4666 4679
16. L. Liu, and K. Duff A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse J Vis Exp 21 2008 960
17. W.J. Griffiths, P.J. Crick, Y. Wang, M. Ogundare, K. Tuschl, A.A. Morris, and et al. Analytical strategies for characterization of oxysterol lipidomes: liver X receptor ligands in plasma Free Radic Biol Med 59 2013 69 84
18. P.J. Crick, T. William Bentley, J. Abdel-Khalik, I. Matthews, P.T. Clayton, A.A. Morris, and et al. Quantitative charge-tags for sterol and oxysterol analysis Clin Chem 61 2014 400 411
19. S. Meaney, M. Heverin, U. Panzenboeck, L. Ekström, M. Axelsson, U. Andersson, and et al. Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid J Lipid Res 48 2007 944 951
20. L. Iuliano, P.J. Crick, C. Zerbinati, L. Tritapepe, J. Abdel-Khalik, M. Poirot, and et al. Cholesterol metabolites exported from human brain Steroids 99 2015 189 193
21. E. Lund, O. Andersson, J. Zhang, A. Babiker, G. Ahlborg, U. Diczfalusy, and et al. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans Arterioscler Thromb Vasc Biol 16 1996 208 212
22. H.J. ten Brink, C.M. van den Heuvel, B.T. Poll-The, R.J. Wanders, and C. Jakobs Peroxisomal disorders: concentrations of metabolites in cerebrospinal fluid compared with plasma J Inherit Metab Dis 16 1993 587 590