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Volumn 30, Issue 4, 2015, Pages 327-332

The physiology of proinsulin c-peptide: Unanswered questions and a proposed model

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; G PROTEIN COUPLED RECEPTOR; INSULIN;

EID: 84936098144     PISSN: 15489213     EISSN: 15489221     Source Type: Journal    
DOI: 10.1152/physiol.00008.2015     Document Type: Article
Times cited : (24)

References (54)
  • 1
    • 84872019417 scopus 로고    scopus 로고
    • C-peptide prevents hyperglycemia-induced endothelial apoptosis through inhibition of reactive oxygen species-mediated transglutaminase 2 activation
    • Bhatt MP, Lim YC, Hwang J, Na S, Kim YM, Ha KS. C-peptide prevents hyperglycemia-induced endothelial apoptosis through inhibition of reactive oxygen species-mediated transglutaminase 2 activation. Diabetes62: 243–253, 2013.
    • (2013) Diabetes , vol.62 , pp. 243-253
    • Bhatt, M.P.1    Lim, Y.C.2    Hwang, J.3    Na, S.4    Kim, Y.M.5    Ha, K.S.6
  • 2
    • 84891350009 scopus 로고    scopus 로고
    • C-peptide activates AMPKalpha and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes
    • Bhatt MP, Lim YC, Kim YM, Ha KS. C-peptide activates AMPKalpha and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes. Diabetes62: 3851–3862, 2013.
    • (2013) Diabetes , vol.62 , pp. 3851-3862
    • Bhatt, M.P.1    Lim, Y.C.2    Kim, Y.M.3    Ha, K.S.4
  • 3
    • 84864345965 scopus 로고    scopus 로고
    • C-peptide and the risk for incident complications and mortality in type 2 diabetic patients: A retrospective cohort study after a 14-year follow-up
    • Bo S, Gentile L, Castiglione A, Prandi V, Canil S, Ghigo E, Ciccone G. C-peptide and the risk for incident complications and mortality in type 2 diabetic patients: a retrospective cohort study after a 14-year follow-up. Eur J Endocrinol167: 173–180, 2012.
    • (2012) Eur J Endocrinol , vol.167 , pp. 173-180
    • Bo, S.1    Gentile, L.2    Castiglione, A.3    Prandi, V.4    Canil, S.5    Ghigo, E.6    Ciccone, G.7
  • 5
    • 34548149533 scopus 로고    scopus 로고
    • Agonist selectivity in the oxytocin/ vasopressin receptor family: New insights and challenges
    • Chini B, Manning M. Agonist selectivity in the oxytocin/ vasopressin receptor family: new insights and challenges. Biochem Soc Trans35: 737–741, 2007.
    • (2007) Biochem Soc Trans , vol.35 , pp. 737-741
    • Chini, B.1    Manning, M.2
  • 6
    • 80054110857 scopus 로고    scopus 로고
    • C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells
    • Cifarelli V, Geng X, Styche A, Lakomy R, Trucco M, Luppi P. C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells. Diabetologia54: 2702–2712, 2011.
    • (2011) Diabetologia , vol.54 , pp. 2702-2712
    • Cifarelli, V.1    Geng, X.2    Styche, A.3    Lakomy, R.4    Trucco, M.5    Luppi, P.6
  • 7
    • 66049092244 scopus 로고    scopus 로고
    • (Pro)Insulin processing: A historical perspective
    • Davidson HW. (Pro)Insulin processing: a historical perspective. Cell Biochem Biophys 40: 143–158, 2004.
    • (2004) Cell Biochem Biophys , vol.40 , pp. 143-158
    • Davidson, H.W.1
  • 8
    • 0037321440 scopus 로고    scopus 로고
    • Amelioration of sensory nerve dysfunction by Cpeptide in patients with type 1 diabetes
    • Ekberg K, Brismar T, Johansson BL, Jonsson B, Lindstrom P, Wahren J. Amelioration of sensory nerve dysfunction by Cpeptide in patients with type 1 diabetes. Diabetes52: 536–541, 2003.
    • (2003) Diabetes , vol.52 , pp. 536-541
    • Ekberg, K.1    Brismar, T.2    Johansson, B.L.3    Jonsson, B.4    Lindstrom, P.5    Wahren, J.6
  • 9
    • 84863754429 scopus 로고    scopus 로고
    • Regulation of blood flow distribution in skeletal muscle: Role of erythrocyte-released ATP
    • Ellsworth ML, Sprague RS. Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP. J Physiol590: 4985–4991, 2012.
    • (2012) J Physiol , vol.590 , pp. 4985-4991
    • Ellsworth, M.L.1    Sprague, R.S.2
  • 11
    • 0022658946 scopus 로고
    • Specific binding of the C-peptide of proinsulin to cultured B-cells from a transplantable rat islet cell tumor
    • Flatt PR, Swanston-Flatt SK, Hampton SM, Bailey CJ, Marks V. Specific binding of the C-peptide of proinsulin to cultured B-cells from a transplantable rat islet cell tumor. Biosci Rep6: 193–199, 1986.
    • (1986) Biosci Rep , vol.6 , pp. 193-199
    • Flatt, P.R.1    Swanston-Flatt, S.K.2    Hampton, S.M.3    Bailey, C.J.4    Marks, V.5
  • 13
    • 84872224813 scopus 로고    scopus 로고
    • C-peptide-stimulated nitric oxide production in a cultured pulmonary artery endothelium is erythrocyte mediated and requires Zn2_
    • Giebink AW, Vogel PA, Medawala W, Spence DM. C-peptide-stimulated nitric oxide production in a cultured pulmonary artery endothelium is erythrocyte mediated and requires Zn2_. Diabetes Metab Res Rev29: 44–52, 2013.
    • (2013) Diabetes Metab Res Rev , vol.29 , pp. 44-52
    • Giebink, A.W.1    Vogel, P.A.2    Medawala, W.3    Spence, D.M.4
  • 15
    • 84857631025 scopus 로고    scopus 로고
    • C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia
    • Haidet J, Cifarelli V, Trucco M, Luppi P. C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia. Inflam Res61: 27–35, 2012.
    • (2012) Inflam Res , vol.61 , pp. 27-35
    • Haidet, J.1    Cifarelli, V.2    Trucco, M.3    Luppi, P.4
  • 17
    • 0038540318 scopus 로고    scopus 로고
    • Biochemical and pharmacological control of the multiplicity of coupling at G-protein- coupled receptors
    • Hermans E. Biochemical and pharmacological control of the multiplicity of coupling at G-protein- coupled receptors. Pharmacol Therap99: 25–44, 2003.
    • (2003) Pharmacol Therap , vol.99 , pp. 25-44
    • Hermans, E.1
  • 18
    • 65549115158 scopus 로고    scopus 로고
    • Cellular and physiological effects of C-peptide
    • Hills CE, Brunskill NJ. Cellular and physiological effects of C-peptide. Clin Sci116: 565–574, 2009.
    • (2009) Clin Sci , vol.116 , pp. 565-574
    • Hills, C.E.1    Brunskill, N.J.2
  • 20
    • 77950055170 scopus 로고    scopus 로고
    • C-peptide as a therapeutic tool in diabetic nephropathy
    • Hills CE, Brunskill NJ, Squires PE. C-peptide as a therapeutic tool in diabetic nephropathy. Am J Nephrol31: 389–397, 2010.
    • (2010) Am J Nephrol , vol.31 , pp. 389-397
    • Hills, C.E.1    Brunskill, N.J.2    Squires, P.E.3
  • 21
    • 0027941216 scopus 로고
    • Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases
    • Hutton JC. Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases. Diabetologia 37, Suppl 2: S48–S56, 1994.
    • (1994) Diabetologia , vol.37 , pp. S48-S56
    • Hutton, J.C.1
  • 24
    • 67651039308 scopus 로고    scopus 로고
    • Proinsulin C-peptide interaction with protein tyrosine phosphatase 1B demonstrated with a labeling reaction
    • Jagerbrink T, Lindahl E, Shafqat J, Jornvall H. Proinsulin C-peptide interaction with protein tyrosine phosphatase 1B demonstrated with a labeling reaction. Biochem Biophys Res Commun387: 31–35, 2009.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 31-35
    • Jagerbrink, T.1    Lindahl, E.2    Shafqat, J.3    Jornvall, H.4
  • 25
    • 0003453248 scopus 로고    scopus 로고
    • Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus
    • Johansson BL, Borg K, Fernqvist-Forbes E, Kernell A, Odergren T, Wahren J. Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus. Diabet Med17: 181–189, 2000.
    • (2000) Diabet Med , vol.17 , pp. 181-189
    • Johansson, B.L.1    Borg, K.2    Fernqvist-Forbes, E.3    Kernell, A.4    Odergren, T.5    Wahren, J.6
  • 26
    • 0035310362 scopus 로고    scopus 로고
    • Proinsulin C-peptide rapidly stimulates mitogen- activated protein kinases in Swiss 3T3 fibroblasts: Requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxinsensitive G-protein
    • Kitamura T, Kimura K, Jung BD, Makondo K, Okamoto S, Canas X, Sakane N, Yoshida T, Saito M. Proinsulin C-peptide rapidly stimulates mitogen- activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxinsensitive G-protein. Biochem J355: 123–129, 2001.
    • (2001) Biochem J , vol.355 , pp. 123-129
    • Kitamura, T.1    Kimura, K.2    Jung, B.D.3    Makondo, K.4    Okamoto, S.5    Canas, X.6    Sakane, N.7    Yoshida, T.8    Saito, M.9
  • 27
    • 84893119634 scopus 로고    scopus 로고
    • Impact of Cpeptide preservation on metabolic and clinical outcomes in the Diabetes Control and Complications Trial
    • Lachin JM, McGee P, Palmer JP. Impact of Cpeptide preservation on metabolic and clinical outcomes in the Diabetes Control and Complications Trial. Diabetes63: 739–748, 2014.
    • (2014) Diabetes , vol.63 , pp. 739-748
    • Lachin, J.M.1    McGee, P.2    Palmer, J.P.3
  • 28
    • 42449104397 scopus 로고    scopus 로고
    • Protein kinase C-zeta phosphorylates insulin receptor substrate- 1, -3, and -4 but not -2: Isoform specific determinants of specificity in insulin signaling
    • Lee S, Lynn EG, Kim JA, Quon MJ. Protein kinase C-zeta phosphorylates insulin receptor substrate- 1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling. Endocrinology149: 2451–2458, 2008.
    • (2008) Endocrinology , vol.149 , pp. 2451-2458
    • Lee, S.1    Lynn, E.G.2    Kim, J.A.3    Quon, M.J.4
  • 29
    • 84883810023 scopus 로고    scopus 로고
    • Dynamic localization and functional implications of C-peptide might for suppression of iNOS in high glucose-stimulated rat mesangial cells
    • Li Y, Zhao M, Li B, Qi J. Dynamic localization and functional implications of C-peptide might for suppression of iNOS in high glucose-stimulated rat mesangial cells. Mol Cell Endocrinol381: 255–260, 2013.
    • (2013) Mol Cell Endocrinol , vol.381 , pp. 255-260
    • Li, Y.1    Zhao, M.2    Li, B.3    Qi, J.4
  • 31
    • 84924028057 scopus 로고    scopus 로고
    • Proinsulin C-peptide prevents impaired wound healing by activating angiogenesis in diabetes
    • Lim YC, Bhatt MP, Kwon MH, Park D, Na S, Kim YM, Ha KS. Proinsulin C-peptide prevents impaired wound healing by activating angiogenesis in diabetes. J Invest Dermatol135: 269–278, 2015.
    • (2015) J Invest Dermatol , vol.135 , pp. 269-278
    • Lim, Y.C.1    Bhatt, M.P.2    Kwon, M.H.3    Park, D.4    Na, S.5    Kim, Y.M.6    Ha, K.S.7
  • 32
    • 48149103214 scopus 로고    scopus 로고
    • Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-kappaB pathway
    • Luppi P, Cifarelli V, Tse H, Piganelli J, Trucco M. Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-kappaB pathway. Diabetologia51: 1534–1543, 2008.
    • (2008) Diabetologia , vol.51 , pp. 1534-1543
    • Luppi, P.1    Cifarelli, V.2    Tse, H.3    Piganelli, J.4    Trucco, M.5
  • 33
    • 79955376981 scopus 로고    scopus 로고
    • C-peptide and long-term complications of diabetes
    • Luppi P, Cifarelli V, Wahren J. C-peptide and long-term complications of diabetes. Pediatr Diabetes12: 276–292, 2011.
    • (2011) Pediatr Diabetes , vol.12 , pp. 276-292
    • Luppi, P.1    Cifarelli, V.2    Wahren, J.3
  • 34
    • 69949182016 scopus 로고    scopus 로고
    • C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes
    • Luppi P, Geng X, Cifarelli V, Drain P, Trucco M. C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes. Diabetologia52: 2218–2228, 2009.
    • (2009) Diabetologia , vol.52 , pp. 2218-2228
    • Luppi, P.1    Geng, X.2    Cifarelli, V.3    Drain, P.4    Trucco, M.5
  • 38
    • 70349338611 scopus 로고    scopus 로고
    • Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways
    • Ragheb R, Shanab GM, Medhat AM, Seoudi DM, Adeli K, Fantus IG. Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. Biochem Biophys Res Commun389: 211–216, 2009.
    • (2009) Biochem Biophys Res Commun , vol.389 , pp. 211-216
    • Ragheb, R.1    Shanab, G.M.2    Medhat, A.M.3    Seoudi, D.M.4    Adeli, K.5    Fantus, I.G.6
  • 43
    • 0033746038 scopus 로고    scopus 로고
    • C-peptide inhibits leukocyte-endothelium interaction in the microcirculation during acute endothelial dysfunction
    • Scalia R, Coyle KM, Levine BJ, Booth G, Lefer AM. C-peptide inhibits leukocyte-endothelium interaction in the microcirculation during acute endothelial dysfunction. FASEB J14: 2357–2364, 2000.
    • (2000) FASEB J , vol.14 , pp. 2357-2364
    • Scalia, R.1    Coyle, K.M.2    Levine, B.J.3    Booth, G.4    Lefer, A.M.5
  • 44
    • 70449424394 scopus 로고    scopus 로고
    • Role of oxytocin/ oxytocin receptor system in regulation of cell growth and neoplastic processes
    • Strunecka A, Hynie S, Klenerova V. Role of oxytocin/ oxytocin receptor system in regulation of cell growth and neoplastic processes. Folia Biol (Krakow)55: 159–165, 2009.
    • (2009) Folia Biol (Krakow) , vol.55 , pp. 159-165
    • Strunecka, A.1    Hynie, S.2    Klenerova, V.3
  • 46
    • 84859520694 scopus 로고    scopus 로고
    • The clinical potential of C-peptide replacement in Type 1 diabetes
    • Wahren J, Kallas A, Sima AA. The clinical potential of C-peptide replacement in Type 1 diabetes. Diabetes61: 761–772, 2012.
    • (2012) Diabetes , vol.61 , pp. 761-772
    • Wahren, J.1    Kallas, A.2    Sima, A.A.3
  • 47
    • 84924144349 scopus 로고    scopus 로고
    • C-peptide: New findings and therapeutic possibilities
    • Wahren J, Larsson C. C-peptide: new findings and therapeutic possibilities. Diabetes Res Clin Pract107: 309–319, 2015.
    • (2015) Diabetes Res Clin Pract , vol.107 , pp. 309-319
    • Wahren, J.1    Larsson, C.2
  • 48
    • 3042786038 scopus 로고    scopus 로고
    • C-peptide induces chemotaxis of human CD4-positive cells: Involvement of pertussis toxin-sensitive G-proteins and phosphoinositide 3-kinase
    • Walcher D, Aleksic M, Jerg V, Hombach V, Zieske A, Homma S, Strong J, Marx N. C-peptide induces chemotaxis of human CD4-positive cells: involvement of pertussis toxin-sensitive G-proteins and phosphoinositide 3-kinase. Diabetes53: 1664–1670, 2004.
    • (2004) Diabetes , vol.53 , pp. 1664-1670
    • Walcher, D.1    Aleksic, M.2    Jerg, V.3    Hombach, V.4    Zieske, A.5    Homma, S.6    Strong, J.7    Marx, N.8
  • 50
    • 84855372404 scopus 로고    scopus 로고
    • Dissection of aberrant GPCR signaling in tumorigenesis– a systems biology approach
    • Wu J, Xie N, Zhao X, Nice EC, Huang C. Dissection of aberrant GPCR signaling in tumorigenesis– a systems biology approach. Cancer Genomics Proteomics9: 37–50, 2012.
    • (2012) Cancer Genomics Proteomics , vol.9 , pp. 37-50
    • Wu, J.1    Xie, N.2    Zhao, X.3    Nice, E.C.4    Huang, C.5
  • 51
    • 84880647133 scopus 로고    scopus 로고
    • Evidence for an interaction between proinsulin C-peptide and GPR146
    • Yosten GL, Kolar GR, Redlinger LJ, Samson WK. Evidence for an interaction between proinsulin C-peptide and GPR146. J Endocrinol218: B1–B8, 2013.
    • (2013) J Endocrinol , vol.218 , pp. B1-B8
    • Yosten, G.L.1    Kolar, G.R.2    Redlinger, L.J.3    Samson, W.K.4
  • 53
    • 84868383848 scopus 로고    scopus 로고
    • Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107
    • Yosten GL, Redlinger LJ, Samson WK. Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. Am J Physiol Regul Integr Comp Physiol303: R941–R949, 2012.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.303 , pp. R941-R949
    • Yosten, G.L.1    Redlinger, L.J.2    Samson, W.K.3
  • 54
    • 0036678101 scopus 로고    scopus 로고
    • Severe block in processing of proinsulin to insulin accompanied by elevation of des- 64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3
    • Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF. Severe block in processing of proinsulin to insulin accompanied by elevation of des- 64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci USA99: 10299–10304, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10299-10304
    • Zhu, X.1    Orci, L.2    Carroll, R.3    Norrbom, C.4    Ravazzola, M.5    Steiner, D.F.6


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