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Volumn 31, Issue 5, 2010, Pages 389-397

C-peptide as a therapeutic tool in diabetic nephropathy

Author keywords

C peptide; Diabetic nephropathy

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ALBUMIN; C PEPTIDE; CALCIUM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROINSULIN; PROTEIN KINASE C; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 77950055170     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000289864     Document Type: Review
Times cited : (68)

References (56)
  • 1
    • 0014540571 scopus 로고
    • Proinsulin, Secretion, metabolism, immunological and biological properties
    • Rubenstein AH, Melani F, Pilkis S, Steiner DF: Proinsulin. Secretion, metabolism, immunological and biological properties. Postgrad Med J 1969; 45: 476-481.
    • (1969) Postgrad Med J , vol.45 , pp. 476-481
    • Rubenstein, A.H.1    Melani, F.2    Pilkis, S.3    Steiner, D.F.4
  • 3
  • 4
    • 0031702795 scopus 로고    scopus 로고
    • Effects of C-peptide on renal function at the early stage of experimental diabetes
    • Sjoquist M, Huang W, Johansson B-L: Effects of C-peptide on renal function at the early stage of experimental diabetes. Kidney Int 1998; 54: 758-764.
    • (1998) Kidney Int , vol.54 , pp. 758-764
    • Sjoquist, M.1    Huang, W.2    Johansson, B.-L.3
  • 7
    • 10744230562 scopus 로고    scopus 로고
    • Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide
    • Wallerath T, Kunt T, Forst T: Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide. Nitric Oxide 2003; 9: 95-102.
    • (2003) Nitric Oxide , vol.9 , pp. 95-102
    • Wallerath, T.1    Kunt, T.2    Forst, T.3
  • 8
    • 33645469061 scopus 로고    scopus 로고
    • C-peptide signals via Gα i to protect against TNF-α-mediated apoptosis of opossum kidney proximal tubular cells
    • Al-Rasheed NM, Willars GB, Brunskill NJ: C-peptide signals via Gα i to protect against TNF-α-mediated apoptosis of opossum kidney proximal tubular cells. J Am Soc Nephrol 2006; 17: 986-995.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 986-995
    • Al-Rasheed, N.M.1    Willars, G.B.2    Brunskill, N.J.3
  • 9
    • 66049134863 scopus 로고    scopus 로고
    • C-peptide reverses TGF-β 1 -induced changes in renal proximal tubular cells: Implications for treatment of diabetic nephropathy
    • Hills CE, Al-Rasheed N, Al-Rasheed N, Willars GB, Brunskill NJ: C-peptide reverses TGF-β 1 -induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy. Am J Physiol Renal Physiol 2009; 296:F614-F621.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Hills, C.E.1    Al-Rasheed, N.2    Al-Rasheed, N.3    Willars, G.B.4    Brunskill, N.J.5
  • 10
    • 1442346948 scopus 로고    scopus 로고
    • United States Renal Data System (USRDS) . Bethesda, National Institute of Health/National Institute of Diabetes and Digestive and Kidney Disease
    • United States Renal Data System (USRDS): Annual data report: atlas of end-stage renal disease in the United States. Bethesda, National Institute of Health/National Institute of Diabetes and Digestive and Kidney Disease, 2003.
    • (2003) Annual Data Report: Atlas of End-stage Renal Disease in the United States
  • 11
    • 55249114365 scopus 로고    scopus 로고
    • DN: Important pathophysiologic mechanisms
    • Soldatos G, Cooper ME: DN: Important pathophysiologic mechanisms. Diabetes Res Clin Pract 2008; 82(suppl 1):S75-S79.
    • (2008) Diabetes Res Clin Pract , vol.82 , Issue.SUPPL.1
    • Soldatos, G.1    Cooper, M.E.2
  • 12
  • 13
    • 0019460233 scopus 로고
    • Glomerular hemodynamics in experimental diabetes mellitus
    • Hostetter TH, Troy JL, Brenner BM: Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 1981; 19: 410-415.
    • (1981) Kidney Int , vol.19 , pp. 410-415
    • Hostetter, T.H.1    Troy, J.L.2    Brenner, B.M.3
  • 14
    • 0024422014 scopus 로고
    • Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients
    • Steffes MW, Osterby R, Chavers B, Mauer SM: Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes 1989; 38: 1077-1081.
    • (1989) Diabetes , vol.38 , pp. 1077-1081
    • Steffes, M.W.1    Osterby, R.2    Chavers, B.3    Mauer, S.M.4
  • 15
    • 0029043874 scopus 로고
    • Glycosylated hemoglobin and the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus
    • Krolewski AS, Laffel LM, Krolewski M, Quinn M, Warram JH: Glycosylated hemoglobin and the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus. N Engl J Med 1995; 332: 1251-1255.
    • (1995) N Engl J Med , vol.332 , pp. 1251-1255
    • Krolewski, A.S.1    Laffel, L.M.2    Krolewski, M.3    Quinn, M.4    Warram, J.H.5
  • 16
    • 9144245074 scopus 로고    scopus 로고
    • Pathogenesis of diabetic nephropathy
    • Pickup JC, Williams G (eds) ed 3 Oxford, Blackwell Science
    • Gnudi L, Gruden G, Viberti G: Pathogenesis of diabetic nephropathy; in Pickup JC, Williams G (eds): Textbook of Diabetes, ed 3. Oxford, Blackwell Science, 2003, pp 52.1- 53.21.
    • (2003) Textbook of Diabetes , pp. 521-5321
    • Gnudi, L.1    Gruden, G.2    Viberti, G.3
  • 19
    • 0026558822 scopus 로고
    • The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin- dependent) diabetic patients
    • Johansson BL, Sjöberg S, Wahren J: The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin- dependent) diabetic patients. Diabetologia 1992; 35: 121-128.
    • (1992) Diabetologia , vol.35 , pp. 121-128
    • Johansson, B.L.1    Sjöberg, S.2    Wahren, J.3
  • 20
    • 0027527613 scopus 로고
    • Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1
    • Johansson BL, Kernell A, Sjöberg S, Wahren J: Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. J Clin Endocrinol Metab 1993; 77: 976-981.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 976-981
    • Johansson, B.L.1    Kernell, A.2    Sjöberg, S.3    Wahren, J.4
  • 21
    • 0003453248 scopus 로고    scopus 로고
    • Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type 1 diabetes mellitus
    • Johansson BL, Borg K, Fernqvist-Forbes E, Kernell A, Odergren T, Wahren J: Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type 1 diabetes mellitus. Diabet Med 2000; 17: 181-189.
    • (2000) Diabet Med , vol.17 , pp. 181-189
    • Johansson, B.L.1    Borg, K.2    Fernqvist-Forbes, E.3    Kernell, A.4    Odergren, T.5    Wahren, J.6
  • 22
    • 70350705959 scopus 로고    scopus 로고
    • Proinsulin C-peptide reduces diabetes- induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption
    • Nordquist L, Brown R, Fasching A, Persson P, Palm F: Proinsulin C-peptide reduces diabetes- induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption. Am J Physiol Renal Physiol 2009; 297:F1265-F1272.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Nordquist, L.1    Brown, R.2    Fasching, A.3    Persson, P.4    Palm, F.5
  • 23
    • 34447624323 scopus 로고    scopus 로고
    • The C-peptide fragment EVARQ reduces glomerular hyperfiltration in streptozotocin-induced diabetic rats
    • Nordquist L, Moe E, Sjöquist M: The C-peptide fragment EVARQ reduces glomerular hyperfiltration in streptozotocin-induced diabetic rats. Diabetes Metab Res Rev 2007; 23: 400-405.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 400-405
    • Nordquist, L.1    Moe, E.2    Sjöquist, M.3
  • 24
    • 65549115158 scopus 로고    scopus 로고
    • Cellular and physiological effects of C-peptide
    • Hills CE, Brunskill NJ: Cellular and physiological effects of C-peptide. Clin Sci 2009; 116: 565-574.
    • (2009) Clin Sci , vol.116 , pp. 565-574
    • Hills, C.E.1    Brunskill, N.J.2
  • 25
    • 76149123913 scopus 로고    scopus 로고
    • C-peptide and its intracellular signalling
    • Hills CE, Brunskill NJ: C-peptide and its intracellular signalling. Rev Diabet Stud 2009; 6: 138-147.
    • (2009) Rev Diabet Stud , vol.6 , pp. 138-147
    • Hills, C.E.1    Brunskill, N.J.2
  • 26
    • 0022658946 scopus 로고
    • Specific binding of the C-peptide of proinsulin to cultured B cells from a transplantable rat islet cell tumor
    • Flatt PR, Swanston-Flatt SK, Hampton SM, Bailey CJ, Marks V: Specific binding of the C-peptide of proinsulin to cultured B cells from a transplantable rat islet cell tumor. Biosci Rep 1986; 6: 193-199.
    • (1986) Biosci Rep , vol.6 , pp. 193-199
    • Flatt, P.R.1    Swanston-Flatt, S.K.2    Hampton, S.M.3    Bailey, C.J.4    Marks, V.5
  • 28
    • 0022602308 scopus 로고
    • Infusion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagon in healthy subjects
    • Hoogwerf BJ, Bantle JP, Gaenslen HE, Greenberg BZ, Senske BJ, Francis R, Goetz FC: Infusion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagon in healthy subjects. Metabolism 1986; 35: 122-125.
    • (1986) Metabolism , vol.35 , pp. 122-125
    • Hoogwerf, B.J.1    Bantle, J.P.2    Gaenslen, H.E.3    Greenberg, B.Z.4    Senske, B.J.5    Francis, R.6    Goetz, F.C.7
  • 29
    • 0031781527 scopus 로고    scopus 로고
    • Differential effects of proinsulin C-peptide fragments on Na + ,K + - ATPase activity of renal tubule segments
    • Ohtomo Y, Bergman T, Johansson BL, Jörnvall H, Wahren J: Differential effects of proinsulin C-peptide fragments on Na + ,K + - ATPase activity of renal tubule segments. Diabetologia 1998; 41: 287-291.
    • (1998) Diabetologia , vol.41 , pp. 287-291
    • Ohtomo, Y.1    Bergman, T.2    Johansson, B.L.3    Jörnvall, H.4    Wahren, J.5
  • 33
    • 12944323190 scopus 로고    scopus 로고
    • C peptide stimulates ERK-1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells
    • Zhong Z, Davidescu A, Ehrén I, Ekberg K, Jörnvall H, Wahren J, Chibalin AV: C peptide stimulates ERK-1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells. Diabetologia 2005; 48: 187-197.
    • (2005) Diabetologia , vol.48 , pp. 187-197
    • Zhong, Z.1    Davidescu, A.2    Ehrén, I.3    Ekberg, K.4    Jörnvall, H.5    Wahren, J.6    Chibalin, A.V.7
  • 34
    • 0013336206 scopus 로고    scopus 로고
    • Effects of proinsulin C-peptide on nitric oxide, microvascular blood flow and erythrocyte Na + ,K + -ATPase activity in diabetes mellitus type 1
    • Forst T, Dufayet De La Tour D, Kunt T: Effects of proinsulin C-peptide on nitric oxide, microvascular blood flow and erythrocyte Na + ,K + -ATPase activity in diabetes mellitus type 1. Clin Sci 2000; 98: 283-290.
    • (2000) Clin Sci , vol.98 , pp. 283-290
    • Forst, T.1    Dufayet De La Tour, D.2    Kunt, T.3
  • 35
    • 0030031555 scopus 로고    scopus 로고
    • C peptide stimulates rat renal tubular Na + /K + -ATPase activity in synergism with neuropeptide y
    • Ohtomo Y, Aperia A, Sahlgren B, Johansson BL, Wahren J: C peptide stimulates rat renal tubular Na + /K + -ATPase activity in synergism with neuropeptide Y. Diabetologia 1996; 39: 199-205.
    • (1996) Diabetologia , vol.39 , pp. 199-205
    • Ohtomo, Y.1    Aperia, A.2    Sahlgren, B.3    Johansson, B.L.4    Wahren, J.5
  • 36
    • 0026523129 scopus 로고
    • Differentiation of renal Na + -K + - ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters
    • Chen CC: Differentiation of renal Na + -K + - ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters. Eur J Pharmacol 1992; 225: 275-279.
    • (1992) Eur J Pharmacol , vol.225 , pp. 275-279
    • Chen, C.C.1
  • 37
    • 0032977914 scopus 로고    scopus 로고
    • The effect of human proinsulin C peptide on erythrocyte deformability in patients with type 1 diabetes mellitus
    • Kunt T, Schneider S, Pfutzner A: The effect of human proinsulin C peptide on erythrocyte deformability in patients with type 1 diabetes mellitus. Diabetologia 1999; 42: 465-471.
    • (1999) Diabetologia , vol.42 , pp. 465-471
    • Kunt, T.1    Schneider, S.2    Pfutzner, A.3
  • 38
    • 44649163269 scopus 로고    scopus 로고
    • C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients
    • Hach T, Forst T, Kunt T, Ekberg K, Pfützner A, Wahren J: C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients. Exp Diabetes Res 2008; 2008: 730594.
    • (2008) Exp Diabetes Res , vol.2008 , pp. 730594
    • Hach, T.1    Forst, T.2    Kunt, T.3    Ekberg, K.4    Pfützner, A.5    Wahren, J.6
  • 39
    • 36649008678 scopus 로고    scopus 로고
    • Metal-activated Cpeptide facilitates glucose clearance and the release of a nitric oxide stimulus via the GLUT-1 transporter
    • Meyer JA, Froelich JM, Reid GE, Karunarathne WK, Spence DM: Metal-activated Cpeptide facilitates glucose clearance and the release of a nitric oxide stimulus via the GLUT-1 transporter. Diabetologia 2008; 51: 175-182.
    • (2008) Diabetologia , vol.51 , pp. 175-182
    • Meyer, J.A.1    Froelich, J.M.2    Reid, G.E.3    Karunarathne, W.K.4    Spence, D.M.5
  • 40
    • 0030853312 scopus 로고    scopus 로고
    • Nitric oxide released from activated platelets inhibits platelet recruitment
    • Freedman JE, Loscalzo J, Barnard MR: Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest 1997; 100: 350-356.
    • (1997) J Clin Invest , vol.100 , pp. 350-356
    • Freedman, J.E.1    Loscalzo, J.2    Barnard, M.R.3
  • 41
    • 0037235849 scopus 로고    scopus 로고
    • Detection of ATPinduced nitric oxide in a biomimetic circulatory vessel containing an immobilized endothelium
    • Kotsis DH, Spence DM: Detection of ATPinduced nitric oxide in a biomimetic circulatory vessel containing an immobilized endothelium. Anal Chem 2003; 75: 145-151.
    • (2003) Anal Chem , vol.75 , pp. 145-151
    • Kotsis, D.H.1    Spence, D.M.2
  • 42
    • 0348107405 scopus 로고    scopus 로고
    • Proinsulin C peptide increases nitric oxide production by enhancing mitogen-activated protein kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats
    • Kitamura T, Kimura K, Makondo K, Furuya DT, Suzuki M, Yoshida T, Saito M: Proinsulin C peptide increases nitric oxide production by enhancing mitogen-activated protein kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats. Diabetologia 2003; 46: 1698-1705.
    • (2003) Diabetologia , vol.46 , pp. 1698-1705
    • Kitamura, T.1    Kimura, K.2    Makondo, K.3    Furuya, D.T.4    Suzuki, M.5    Yoshida, T.6    Saito, M.7
  • 44
    • 44149124018 scopus 로고    scopus 로고
    • Simultaneous determination of cell aging and ATP release from erythrocytes and its implications in type 2 diabetes
    • Subasinghe W, Spence DM: Simultaneous determination of cell aging and ATP release from erythrocytes and its implications in type 2 diabetes. Anal Chim Acta 2008; 618: 227-233.
    • (2008) Anal Chim Acta , vol.618 , pp. 227-233
    • Subasinghe, W.1    Spence, D.M.2
  • 45
    • 70349333078 scopus 로고    scopus 로고
    • Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia- induced phosphatidylserine externalization and reversed by metformin
    • Meyer JA, Subasinghe W, Sima AA: Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia- induced phosphatidylserine externalization and reversed by metformin. Mol Biosyst 2009; 5: 1157-1162.
    • (2009) Mol Biosyst , vol.5 , pp. 1157-1162
    • Meyer, J.A.1    Subasinghe, W.2    Sima, A.A.3
  • 46
    • 0024367014 scopus 로고
    • Phospholipid and fatty acid composition of erythrocytes in type 1 and type 2 diabetes
    • Freyburger G, Gin A, Heape A: Phospholipid and fatty acid composition of erythrocytes in type 1 and type 2 diabetes. Metab Clin Exp 1989; 38: 673-678.
    • (1989) Metab Clin Exp , vol.38 , pp. 673-678
    • Freyburger, G.1    Gin, A.2    Heape, A.3
  • 48
    • 33748585929 scopus 로고    scopus 로고
    • Metformin increases blood flow and forearm glucose uptake in a group of non-obese type 2 diabetes patients
    • Magalhães FO, Gouveia LM, Torquato MT: Metformin increases blood flow and forearm glucose uptake in a group of non-obese type 2 diabetes patients. Horm Metab Res 2006; 38: 513-517.
    • (2006) Horm Metab Res , vol.38 , pp. 513-517
    • Magalhães, F.O.1    Gouveia, L.M.2    Torquato, M.T.3
  • 53
    • 0036098930 scopus 로고    scopus 로고
    • An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients
    • Katz A, Caramori ML, Sisson-Ross S, Groppoli T, Basgen JM, Mauer M: An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients. Kidney Int 2002; 61: 2058-2066.
    • (2002) Kidney Int , vol.61 , pp. 2058-2066
    • Katz, A.1    Caramori, M.L.2    Sisson-Ross, S.3    Groppoli, T.4    Basgen, J.M.5    Mauer, M.6
  • 54
    • 70350545853 scopus 로고    scopus 로고
    • TGF-β1 - Induced epithelial- to-mesenchymal transition and therapeutic intervention in diabetic nephropathy
    • Hills CE, Squires PE: TGF-β1 - induced epithelial- to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. Am J Nephrol 2010; 31: 68-74.
    • Am J Nephrol , vol.2010 , Issue.31 , pp. 68-74
    • Hills, C.E.1    Squires, P.E.2
  • 55
    • 0027452124 scopus 로고
    • The extracellular matrix in DN
    • Ziyadeh FN: The extracellular matrix in DN. Am J Kidney Dis 1993; 22: 736-744.
    • (1993) Am J Kidney Dis , vol.22 , pp. 736-744
    • Ziyadeh, F.N.1
  • 56
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad 3 and Smad 4 to critical TGF-β inducible elements in the promoter of the human plasminogen activator inhibitor-type 1 gene
    • Dennler S, Itoh S, Vivien D, Dijke P, Huet S, Gauthier J: Direct binding of Smad 3 and Smad 4 to critical TGF-β inducible elements in the promoter of the human plasminogen activator inhibitor-type 1 gene. EMBO J 1998; 17: 3091-3100.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    Dijke, P.4    Huet, S.5    Gauthier, J.6


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