Role of oxytocin/oxytocin receptor system in regulation of cell growth and neoplastic processes

Folia Biologica

Volumn 55, Issue 5, 2009, Pages 159-165

  Strunecka A ^a   Hynie, S ^a   Klenerová, Věra ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Carcinoma cells; Cell proliferation; G proteins; Kinases; Oxytocin; Oxytocin receptor; Phosphoinositides; Phospholipase C; Signalling pathways

Indexed keywords

CYSTYL AMINOPEPTIDASE; G PROTEIN COUPLED RECEPTOR; OXYTOCIN; OXYTOCIN RECEPTOR;

BINDING SITE; BRAIN REGION; BREAST CANCER; CANCER GROWTH; CANCER RESEARCH; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CHORIOCARCINOMA; ENDOMETRIUM CARCINOMA; ENDOTHELIUM CELL; HEART MUSCLE CELL; HUMAN; LUNG SMALL CELL CANCER; MYOMETRIUM; NEUROBLASTOMA; NONHUMAN; OSTEOBLAST; OVARY CARCINOMA; OXYTOCIN BLOOD LEVEL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TROPHOBLAST;

EID: 70449424394     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Acher, R., Chauvet, J., Chauvet, M. T. (1995) Man and the chimaera. Selective versus neutral oxytocin evolution. Adv. Exp. Med. Biol. 395, 615-627.
2. Al Sheikh Ali, A., Gunduz, M., Gunduz, E., Tamamura, R., Beder, L., Tominaga, S., Onoda, T., Yamanaka, N., Grenman, R., Shimizu, K., Nagai, N., Nagatsuka, H. (2008) Lack of B-RAF mutation in head and neck squamous cell carcinoma. Folia Biol. (Praha) 54, 157-161.
3. Bockaert, J., Pin, J. P. (1999) Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 18, 1723-1729.
4. Bussolati, G., Cassoni, P., Negro, F., Stella, A., Sapino, A. (1995) Effect of oxytocin on breast carcinoma cell growth. Adv. Exp. Med. Biol. 395, 553-554.
5. Cassoni, P., Sapino, A., Negro, F., Bussolati, G. (1994) Oxytocin inhibits proliferation of human breast cancer cell lines. Virchows Arch. 425, 467-472.
6. Cassoni, P., Sapino, A., Stella, A., Fortunati, N., Bussolati, G. (1998) Presence and significance of oxytocin receptors in human neuroblastomas and glial tumors. Int. J. Cancer 77, 695-700.
7. Cassoni, P., Fulcheri, E., Carcangiu, M. L., Stella, A., Deaglio, S., Bussolati, G. (2000) Oxytocin receptors in human adenocarcinomas of the endometrium: presence and biological significance. J. Pathol. 190, 470-477.
8. Cassoni, P., Marrocco, T., Deaglio, S., Sapino, A., Bussolati, G. (2001a) Biological relevance of oxytocin and oxytocin receptors in cancer cells and primary tumors. Ann. Oncol. 12 Suppl 2, S37-39.
9. Cassoni, P., Sapino, A., Munaron, L., Deaglio, S., Chini, B., Graziani, A., Ahmed, A., Bussolati, G. (2001b) Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. Endocrinology 142, 1130-1136.
10. Cassoni, P., Sapino, A., Deaglio, S., Bussolati, B., Volante, M., Munaron, L., Albini, A., Torrisi, A., Bussolati, G. (2002) Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk. Cancer Res. 62, 2406-2413.
11. Cassoni, P., Sapino, A., Marrocco, T., Chini, B., Bussolati, G. (2004) Oxytocin and oxytocin receptors in cancer cells and proliferation. J. Neuroendocrinol. 16, 362-364.
12. Cattaneo, M. G., Chini, B., Vicentini, L. M. (2008) Oxytocin stimulates migration and invasion in human endothelial cells. Br. J. Pharmacol. 153, 728-736.
13. Chini, B., Fanelli, F. (2000) Molecular basis of ligand binding and receptor activation in the oxytocin and vasopressin receptor family. Exp. Physiol. 85 (Spec No), 59S-66S.
14. Chini, B., Manning, M. (2007) Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges. Biochem. Soc. Trans. 35, 737-741.
15. Copland, J. A., Jeng, Y. J., Strakova, Z., Ives, K. L., Hellmich, M. R., Soloff, M. S. (1999) Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway. Endocrinology 140, 2258-2267.
16. Emmer, T., Volante, M., Pagani, A., Allia, E., Crafa, P., Bussolati, G. (2003) Potential applications of molecular biology in neuroendocrine tumors. Endocr. Pathol. 14, 319-328.
17. Faenza, I., Bregoli, L., Ramazzotti, G., Gaboardi, G., Follo, M. Y., Mongiorgi, S., Billi, A. M., Manzoli, L., Martelli, A. M., Cocco, L. (2008) Nuclear phospholipase C β1 and cellular differentiation. Front Biosci. 13, 2452-2463.
18. Fanelli, F., Barbier, P., Zanchetta, D., de Benedetti, P. G., Chini, B. (1999) Activation mechanism of human oxytocin receptor: a combined study of experimental and computer-simulated mutagenesis. Mol. Pharmacol. 56, 214-225.
19. Fu, L., Qin, Y. R., Xie, D., Hu, L., Kwong, D. L., Srivastava, G., Tsao, S. W., Guan, X. Y. (2007) Characterization of a novel tumor-suppressor gene PLC δ 1 at 3p22 in esophageal squamous cell carcinoma. Cancer Res. 67, 10720-10726.
20. Gimpl, G., Fahrenholz, F. (2001) The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 81, 629-683.
21. Gimpl, G., Postina, R., Fahrenholz, F., Reinheimer, T. (2005) Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur. J. Pharmacol. 510, 9-16.
22. Gimpl, G., Reitz, J., Brauer, S., Trossen, C. (2008) Oxytocin receptors: ligand binding, signalling and cholesterol dependence. Prog. Brain Res. 170, 193-204.
23. Hasbi, A., Devost, D., Laporte, S. A., Zingg, H. H. (2004) Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2. Mol. Endocrinol. 18, 1277-1286.
24. Herbert, Z., Botticher, G., Aschoff, A., Sendemir, E., Zermann, D. H., Arnold, R., Mall, G., Jirikowski, G. F. (2007) Changing caveolin-1 and oxytocin receptor distribution in the ageing human prostate. Anat. Histol. Embryol. 36, 361-365.
25. Hynie, S., Klenerová, V. (2008) Central regulating role of oxytocin. Psychiatrie 12 (Suppl. 2), 4-10. (in Czech)
26. Inoue, T., Kimura, T., Azuma, C., Inazawa, J., Takemura, M., Kikuchi, T., Kubota, Y., Ogita, K., Saji, F. (1994) Structural organization of the human oxytocin receptor gene. J. Biol. Chem. 269, 32451-32456.
27. Irino, Y., Cho, H., Nakamura, Y., Nakahara, M., Furutani, M., Suh, P. G., Takenawa, T., Fukami, K. (2004) Phospholipase C δ-type consists of three isozymes: bovine PLCδ2 is a homologue of human/mouse PLCδ4. Biochem. Biophys. Res. Commun. 320, 537-543.
28. Kimura, T., Tanizawa, O., Mori, K., Brownstein, M. J., Okayama, H. (1992) Structure and expression of a human oxytocin receptor. Nature 356, 526-529.
29. Kimura, T., Saji, F., Nishimori, K., Ogita, K., Nakamura, H., Koyama, M., Murata, Y. (2003) Molecular regulation of the oxytocin receptor in peripheral organs. J. Mol. Endocrinol. 30, 109-115.
30. Kinsey, C. G., Bussolati, G., Bosco, M., Kimura, T., Pizzorno, M. C., Chemin, M. I., Cassoni, P., Novak, J. F. (2007) Constitutive and ligand-induced nuclear localization of oxytocin receptor. J. Cell Mol. Med. 11, 96-110.
31. Klenerová, V., Hynie, S. (2008) Some newer findings concerning oxytocin receptor signaling. Českoslov. fyziol. 57, 10-16. (in Czech)
32. Luo, J., Manning, B. D., Cantley, L. C. (2003) Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4, 257-262.
33. Manning, B. D., Cantley, L. C. (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274.
34. Martelli, A. M., Fiume, R., Faenza, I., Tabellini, G., Evangelista, C., Bortul, R., Follo, M. Y., Fala, F., Cocco, L. (2005) Nuclear phosphoinositide specific phospholipase C (PI-PLC)-β 1: a central intermediary in nuclear lipid-dependent signal transduction. Histol. Histopathol. 20, 1251-1260.
35. Molnar, M., Hertelendy, F. (1990) Regulation of intracellular free calcium in human myometrial cells by prostaglandin F2 α: comparison with oxytocin. J. Clin. Endocrinol. Metab. 71, 1243-1250.
36. Morita, T., Shibata, K., Kikkawa, F., Kajiyama, H., Ino, K., Mizutani, S. (2004) Oxytocin inhibits the progression of human ovarian carcinoma cells in vitro and in vivo. Int. J. Cancer 109, 525-532.
37. Morris, A. J., Malbon, C. C. (1999) Physiological regulation of G protein-linked signaling. Physiol. Rev. 79, 1373-1430.
38. Novak, J. F., Judkins, M. B., Chemin, M. I., Cassoni, P., Bussolati, G., Nitche, J. A., Nishimoto, S. K. (2000) A plasmin-derived hexapeptide from the carboxyl end of osteocalcin counteracts oxytocin-mediated growth inhibition [corrected] of osteosarcoma cells. Cancer Res. 60, 3470-3476.
39. Park, E. S., Won, J. H., Han, K. J., Suh, P. G., Ryu, S. H., Lee, H. S., Yun, H. Y., Kwon, N. S., Baek, K. J. (1998) Phospholipase C-δ1 and oxytocin receptor signalling: evidence of its role as an effector. Biochem. J. 331 (Pt 1), 283-289.
40. Péqueux, C., Keegan, B. P., Hagelstein, M. T., Geenen, V., Legros, J. J., North, W. G. (2004) Oxytocin- and vasopressin-induced growth of human small-cell lung cancer is mediated by the mitogen-activated protein kinase pathway. Endocrinol. Relat. Cancer 11, 871-885.
41. Petersson, M. (2008) Opposite effects of oxytocin on proliferation of osteosarcoma cell lines. Regul. Pept. 150, 50-54.
42. Phaneuf, S., Carrasco, M. P., Europe-Finner, G. N., Hamilton, C. H., Lopez Bernal, A. (1996) Multiple G proteins and phospholipase C isoforms in human myometrial cells: implication for oxytocin action. J. Clin. Endocrinol. Metab. 81, 2098-2103.
43. Reversi, A., Cassoni, P., Chini, B. (2005) Oxytocin receptor signaling in myoepithelial and cancer cells. J. Mammary Gland Biol. Neoplasia 10, 221-229.
44. Reversi, A., Rimoldi, V., Brambillasca, S., Chini, B. (2006) Effects of cholesterol manipulation on the signaling of the human oxytocin receptor. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R861-869.
45. Rimoldi, V., Reversi, A., Taverna, E., Rosa, P., Francolini, M., Cassoni, P., Parenti, M., Chini, B. (2003) Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains. Oncogene 22, 6054-6060.
46. Sanborn, B. M., Qian, A., Ku, C. Y., Wen, Y., Anwer, K., Monga, M., Singh, S. P. (1995) Mechanisms regulating oxytocin receptor coupling to phospholipase C in rat and human myometrium. Adv. Exp. Med. Biol. 395, 469-479.
47. Sapino, A., Cassoni, P., Stella, A., Bussolati, G. (1998) Oxytocin receptor within the breast: biological function and distribution. Anticancer Res. 18, 2181-2186.
48. Spadaro, F., Ramoni, C., Mezzanzanica, D., Miotti, S., Alberti, P., Cecchetti, S., Iorio, E., Dolo, V., Canevari, S., Podo, F. (2008) Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells. Cancer Res. 68, 6541-6549.
49. Strakova, Z., Soloff, M. S. (1997) Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. Am. J. Physiol. 272, E870-876.
50. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306, 67-69.
51. Strunecká, A., Patočka, J. (2007) Guide to a walk through the phosphoinoisitide pathway. Psychiatrie 11, 8-12. (in Czech).
52. Suh, P. G., Park, J. I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S., Ryu, S. H. (2008) Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 41, 415-434.
53. Suzuki, Y., Shibata, K., Kikkawa, F., Kajiyama, H., Ino, K., Nomura, S., Tsujimoto, M., Mizutani, S. (2003) Possible role of placental leucine aminopeptidase in the antiproliferative effect of oxytocin in human endometrial adenocarcinoma. Clin. Cancer Res. 9, 1528-1534.
54. Takenawa, T., Nagai, Y. (1981) Purification of phosphatidylinositol- specific phospholipase C from rat liver. J. Biol. Chem. 256, 6769-6775.
55. Tasaka, K., Masumoto, N., Miyake, A., Tanizawa, O. (1991) Direct measurement of intracellular free calcium in cultured human myometrial cells stimulated by oxytocin: effects of extracellular calcium and calcium channel blockers. Obstet. Gynecol. 77, 101-106.
56. Verbeeck, M. A., Mummery, C. L., Feijen, A., Burbach, J. P. (1992) Survey of neuropeptide gene expression in tumor cell lines. Pathobiology 60, 127-135.
57. Wettschureck, N., Moers, A., Hamalainen, T., Lemberger, T., Schutz, G., Offermanns, S. (2004) Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice. Mol. Cell Biol. 24, 8048-8054.
58. Whittington, K., Connors, B., King, K., Assinder, S., Hogarth, K., Nicholson, H. (2007) The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate. Prostate 67, 1132-1142.
59. Yagisawa, H., Okada, M., Naito, Y., Sasaki, K., Yamaga, M., Fujii, M. (2006) Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-δ with the cell cycle. Biochim. Biophys. Acta 1761, 522-534.
60. Zhou, X. B., Lutz, S., Steffens, F., Korth, M., Wieland, T. (2007) Oxytocin receptors differentially signal via Gq and Gi proteins in pregnant and nonpregnant rat uterine myocytes: implications for myometrial contractility. Mol. Endocrinol. 21, 740-752.
61. Zingg, H. H., Laporte S. A. (2003) The oxytocin receptor. Trends Endocrinol. Metab. 14, 222-227.