Central tolerance spares the private high-avidity CD4+ T-cell repertoire specific for an islet antigen in NOD mice

European Journal of Immunology

Volumn 45, Issue 7, 2015, Pages 1946-1956

  Serre, Laurent ^a,b,c,d   Fazilleau, Nicolas ^a,b,c,d   Guerder, Sylvie ^a,b,c,d  

^a University of Toulouse III   (France)

^b INSERM   (France)

^c CNRS   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

Autoimmunity; Avidity; CD4+ T cells; NOD; T cell tolerance; TCR repertoire

Indexed keywords

ANTIGEN; PANCREAS ISLET CELL ANTIGEN; PROTEIN S100B; SERINE PROTEINASE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; THYMUS SPECIFIC SERINE PROTEASE; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR; S100B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; HYBRIDOMA; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PRIORITY JOURNAL; STROMA CELL; THYMOCYTE; TISSUE SPECIFICITY; ANIMAL; DEFICIENCY; FLOW CYTOMETRY; IMMUNOLOGY; KNOCKOUT MOUSE; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CENTRAL TOLERANCE; DIABETES MELLITUS, TYPE 1; FLOW CYTOMETRY; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SERINE ENDOPEPTIDASES;

EID: 84935723454     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445290     Document Type: Article

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