Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk

European Journal of Neurology

Volumn 22, Issue 8, 2015, Pages 1235-1241

  Harriott, A M ^a   Heckman, M G ^a   Rayaprolu, S ^a   Soto Ortolaza, A I ^a   Diehl, N N ^a   Kanekiyo, T ^a   Liu, C C ^a   Bu, G ^a   Malik, R ^b   Cole, J W ^c   Meschia, J F ^a   Ross, O A ^a   for the METASTROKE Consortium, ^d  

^a MAYO CLINIC   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

^d NONE

Author keywords

Genetics; Ischaemic stroke; Low density lipoprotein receptor related protein

Indexed keywords

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; BRAIN ISCHEMIA; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 1 GENE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6 GENE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE PATIENT; CEREBROVASCULAR ACCIDENT; GENETICS; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MALE; MIDDLE AGED; STROKE; YOUNG ADULT;

EID: 84935712325     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/ene.12735     Document Type: Article

References (23)

1. Go AS, Mozaffarian D, Roger VL, et al. Executive summary: heart disease and stroke statistics - 2014 update: a report from the American Heart Association. Circulation 2014; 129: 399-410.
2. Sharma P, Yadav S, Meschia JF. Genetics of ischaemic stroke. J Neurol Neurosurg Psychiatry 2013; 84: 1302-1308.
3. Traylor M, Farrall M, Holliday EG, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 2012; 11: 951-962.
4. Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem 2009; 284: 34045-34053.
5. Liu Q, Trotter J, Zhang J, et al. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J Neurosci 2010; 30: 17068-17078.
6. Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev 2008; 88: 887-918.
7. Muratoglu SC, Belgrave S, Hampton B, et al. LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1. Arterioscler Thromb Vasc Biol 2013; 33: 2137-2146.
8. Hopkins PN. Molecular biology of atherosclerosis. Physiol Rev 2013; 93: 1317-1542.
9. Gutierrez-Fernandez M, Rodriguez-Frutos B, Fuentes B, et al. CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke. Neurochem Int 2012; 60: 310-317.
10. Polavarapu R, Gongora MC, Yi H, et al. Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood 2007; 109: 3270-3278.
11. Abe T, Zhou P, Jackman K, et al. Lipoprotein receptor-related protein-6 protects the brain from ischemic injury. Stroke 2013; 44: 2284-2291.
12. Chasman DI, Schurks M, Anttila V, et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 2011; 43: 695-698.
13. Freilinger T, Anttila V, de Vries B, et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet 2012; 44: 777-782.
14. Peters BJ, Pett H, Klungel OH, et al. Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI. Atherosclerosis 2011; 217: 458-464.
15. Tomaszewski M, Charchar FJ, Barnes T, et al. A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler Thromb Vasc Biol 2009; 29: 1316-1321.
16. Bown MJ, Jones GT, Harrison SC, et al. Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. Am J Hum Genet 2011; 89: 619-627.
17. WHO MONICA Group. The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators. J Clin Epidemiol 1988; 41: 105-114.
18. Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41.
19. Mani A, Radhakrishnan J, Wang H, et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 2007; 315: 1278-1282.
20. Singh R, Smith E, Fathzadeh M, et al. Rare nonconservative LRP6 mutations are associated with metabolic syndrome. Hum Mutat 2013; 34: 1221-1225.
21. Willer CJ, Schmidt EM, Sengupta S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet 2013; 45: 1274-1283.
22. Waterworth DM, Ricketts SL, Song K, et al. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 2010; 30: 2264-2276.
23. Willer CJ, Sanna S, Jackson AU, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008; 40: 161-169.