Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats

Journal of Neurochemistry

Volumn 134, Issue 3, 2015, Pages 590-600

  Guan, Xuehai ^a,b   Fu, Qiaochu ^a   Xiong, Bingrui ^a   Song, Zhenpeng ^a   Shu, Bin ^a   Bu, Huilian ^a   Xu, Bing ^c   Manyande, Anne ^d   Cao, Fei ^a,e   Tian, Yuke ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

^c The Third Clinical Faculty of Guangxi University of Chinese Medicine   (China)

^d UNIVERSITY OF WEST LONDON   (United Kingdom)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Akt; bone cancer; pain; PI3K

Indexed keywords

5 [(2,2 DIFLUORO 1,3 BENZODIOXOL 5 YL)METHYLIDENE] 2,4 THIAZOLIDINEDIONE; EPHRIN RECEPTOR B1; EPHRIN RECEPTOR B2; MESSENGER RNA; NEURON SPECIFIC NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE B; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CG PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BONE CANCER; BONE CANCER PAIN; CANCER PAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; FEMALE; GENE EXPRESSION REGULATION; GLIA CELL; MICROGLIA; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL GANGLION; TUMOR CELL INOCULATION; UPREGULATION; ANIMAL; BONE TUMOR; CENTRAL NERVOUS SYSTEM SENSITIZATION; COMPLICATION; DISEASE MODEL; IMMUNOHISTOCHEMISTRY; METABOLISM; PAIN; PHYSIOLOGY; SPINAL CORD; WESTERN BLOTTING; WISTAR RAT;

RATTUS;

ANIMALS; BLOTTING, WESTERN; BONE NEOPLASMS; CENTRAL NERVOUS SYSTEM SENSITIZATION; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; DISEASE MODELS, ANIMAL; FEMALE; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; PAIN; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 84935499529     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13139     Document Type: Article

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