Doxycycline inhibits leukemic cell migration via inhibition of matrix metalloproteinases and phosphorylation of focal adhesion kinase

Molecular Medicine Reports

Volumn 12, Issue 3, 2015, Pages 3374-3380

  Wang, Chunhuai ^a,b   Xiang, Ru ^b   Zhang, Xiangzhong ^a   Chen, Yunxian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Doxycycline; Focal adhesion kinase; Gelatinases; Leukemic cells; Migration

Indexed keywords

DOXYCYCLINE; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; ANTINEOPLASTIC ANTIBIOTIC; FOCAL ADHESION KINASE 1; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; PTK2 PROTEIN, HUMAN;

ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION; GENETICS; K-562 CELL LINE; LEUKEMIA; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING;

ANTIBIOTICS, ANTINEOPLASTIC; CELL MOVEMENT; DOXYCYCLINE; DRUG SCREENING ASSAYS, ANTITUMOR; FOCAL ADHESION KINASE 1; GENE EXPRESSION; HUMANS; K562 CELLS; LEUKEMIA; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84935496172     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3833     Document Type: Article

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