Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 309, Issue 1, 2015, Pages H114-H126

  Renga, Barbara ^a   Bucci, Mariarosaria ^b   Cipriani, Sabrina ^a   Carino, Adriana ^a   Monti, Maria Chiara ^c   Zampella, Angela ^b   Gargiulo, Antonella ^b   di Villa Bianca, Roberta D’Emmanuele ^b   Distrutti, Eleonora ^d   Fiorucci, Stefano ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d SANTA MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

Author keywords

Bile acids; GPBAR1; Hydrogen sulfide; Nitric oxide

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYSTATHIONINE GAMMA LYASE; HYDROGEN SULFIDE; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PHENYLEPHRINE; PROPARGYLGLYCINE; CHOLANIC ACID; CHOLIC ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, HUMAN; GPBAR1 PROTEIN, MOUSE; LITHOCHOLIC ACID; N(G)-IMINOETHYLORNITHINE; ORNITHINE; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VASCULAR RING; VASODILATATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; AORTA; BILE ACIDS AND SALTS; CHENODEOXYCHOLIC ACID; CHOLIC ACIDS; CYSTATHIONINE GAMMA-LYASE; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN SULFIDE; LITHOCHOLIC ACID; MICE, KNOCKOUT; ORNITHINE; PEPTIDES; RECEPTORS, G-PROTEIN-COUPLED; VASODILATION;

EID: 84935419690     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00087.2015     Document Type: Article

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