메뉴 건너뛰기




Volumn 6, Issue JUN, 2015, Pages

In vivo TCR signaling in CD4+ T cells imprints a cell-intrinsic, transient low-motility pattern independent of chemokine receptor expression levels, or microtubular network, integrin, and protein kinase C activity

Author keywords

CCR7; CD4+T cell migration; Lymph node; PKC; Stathmin; T cell activation

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; EZRIN; FREUND ADJUVANT; G PROTEIN COUPLED RECEPTOR KINASE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; L SELECTIN; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MOESIN; NOCODAZOLE; OVALBUMIN; PROTEIN KINASE C; RADIXIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; STATHMIN; T LYMPHOCYTE RECEPTOR; THROMBOXANE A2;

EID: 84935146520     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00297     Document Type: Article
Times cited : (6)

References (48)
  • 1
    • 0242551584 scopus 로고    scopus 로고
    • Homing and cellular traffic in lymph nodes
    • Andrian Von UH, Mempel TR. Homing and cellular traffic in lymph nodes. Nat Rev Immunol (2003) 3:867-78. doi: 10.1038/nri1222
    • (2003) Nat Rev Immunol , vol.3 , pp. 867-878
    • Andrian Von, U.H.1    Mempel, T.R.2
  • 2
    • 23944437624 scopus 로고    scopus 로고
    • Chemokine control of lymphocyte trafficking: a general overview
    • Stein JV, Nombela-Arrieta C. Chemokine control of lymphocyte trafficking: a general overview. Immunology (2005) 116:1-12. doi:10.1111/j.1365-2567.2005.02183.x
    • (2005) Immunology , vol.116 , pp. 1-12
    • Stein, J.V.1    Nombela-Arrieta, C.2
  • 3
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    • Cyster JG. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol (2005) 23:127-59. doi:10.1146/annurev.immunol.23.021704.115628
    • (2005) Annu Rev Immunol , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 4
    • 0037036142 scopus 로고    scopus 로고
    • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
    • Miller MJ, Wei SH, Parker I, Cahalan MD. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science (2002) 296:1869-73. doi:10.1126/science.1070051
    • (2002) Science , vol.296 , pp. 1869-1873
    • Miller, M.J.1    Wei, S.H.2    Parker, I.3    Cahalan, M.D.4
  • 5
    • 0037418183 scopus 로고    scopus 로고
    • Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy
    • Miller MJ, Wei SH, Cahalan MD, Parker I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A (2003) 100:2604-9. doi:10.1073/pnas.2628040100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2604-2609
    • Miller, M.J.1    Wei, S.H.2    Cahalan, M.D.3    Parker, I.4
  • 6
    • 5444229324 scopus 로고    scopus 로고
    • Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes
    • Miller MJ, Safrina O, Parker I, Cahalan MD. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med (2004) 200:847-56. doi:10.1084/jem.20041236
    • (2004) J Exp Med , vol.200 , pp. 847-856
    • Miller, M.J.1    Safrina, O.2    Parker, I.3    Cahalan, M.D.4
  • 7
    • 0037501371 scopus 로고    scopus 로고
    • Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes
    • Bousso P, Robey E. Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes. Nat Immunol (2003) 4:579-85. doi:10.1038/ni928
    • (2003) Nat Immunol , vol.4 , pp. 579-585
    • Bousso, P.1    Robey, E.2
  • 8
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel TR, Henrickson SE, Andrian Von UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature (2004) 427:154-9. doi:10.1038/nature02238
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Andrian Von, U.H.3
  • 9
    • 33845455093 scopus 로고    scopus 로고
    • Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
    • Bajénoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity (2006) 25:989-1001. doi:10.1016/j.immuni.2006.10.011
    • (2006) Immunity , vol.25 , pp. 989-1001
    • Bajénoff, M.1    Egen, J.G.2    Koo, L.Y.3    Laugier, J.P.4    Brau, F.5    Glaichenhaus, N.6
  • 10
    • 27744502556 scopus 로고    scopus 로고
    • CD4 T cells integrate signals delivered during successive D.C encounters in vivo.
    • Celli S, Garcia Z, Bousso P. CD4 T cells integrate signals delivered during successive DC encounters in vivo. J Exp Med (2005) 202:1271-8. doi:10.1084/jem.20051018
    • (2005) J Exp Med , vol.202 , pp. 1271-1278
    • Celli, S.1    Garcia, Z.2    Bousso, P.3
  • 11
    • 19344376093 scopus 로고    scopus 로고
    • Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
    • Obst R, van Santen H-M, Mathis D, Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med (2005) 201:1555-65. doi:10.1084/jem.20042521
    • (2005) J Exp Med , vol.201 , pp. 1555-1565
    • Obst, R.1    van Santen, H.-M.2    Mathis, D.3    Benoist, C.4
  • 12
    • 0041427767 scopus 로고    scopus 로고
    • Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking
    • Lehmann JCU, Jablonski-Westrich D, Haubold U, Gutierrez-Ramos J-C, Springer T, Hamann A. Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. J Immunol (2003) 171:2588-93. doi:10.4049/jimmunol.171.5.2588
    • (2003) J Immunol , vol.171 , pp. 2588-2593
    • Lehmann, J.C.U.1    Jablonski-Westrich, D.2    Haubold, U.3    Gutierrez-Ramos, J.-C.4    Springer, T.5    Hamann, A.6
  • 13
    • 77956525904 scopus 로고    scopus 로고
    • Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing
    • Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AIC, Martin AM, Soriano SF, et al. Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Blood (2010) 116:915-25. doi:10.1182/blood-2009-11-254334
    • (2010) Blood , vol.116 , pp. 915-925
    • Boscacci, R.T.1    Pfeiffer, F.2    Gollmer, K.3    Sevilla, A.I.C.4    Martin, A.M.5    Soriano, S.F.6
  • 14
    • 42649086026 scopus 로고    scopus 로고
    • CCR7 and its ligands: balancing immunity and tolerance
    • Förster R, Davalos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol (2008) 8:362-71. doi:10.1038/nri2297
    • (2008) Nat Rev Immunol , vol.8 , pp. 362-371
    • Förster, R.1    Davalos-Misslitz, A.C.2    Rot, A.3
  • 15
    • 33645289121 scopus 로고    scopus 로고
    • CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    • Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, et al. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature (2006) 440:540-4. doi:10.1038/nature04606
    • (2006) Nature , vol.440 , pp. 540-544
    • Shiow, L.R.1    Rosen, D.B.2    Brdicková, N.3    Xu, Y.4    An, J.5    Lanier, L.L.6
  • 16
    • 37849033437 scopus 로고    scopus 로고
    • S1P1 receptor signaling overrides retention mediated by G [alpha] i-coupled receptors to promote T cell egress
    • Pham T, Okada T, Matloubian M, Lo C, Cyster J. S1P1 receptor signaling overrides retention mediated by G [alpha] i-coupled receptors to promote T cell egress. Immunity (2008) 28:122-33. doi:10.1016/j.immuni.2007.11.017
    • (2008) Immunity , vol.28 , pp. 122-133
    • Pham, T.1    Okada, T.2    Matloubian, M.3    Lo, C.4    Cyster, J.5
  • 17
    • 0035554935 scopus 로고    scopus 로고
    • Separable effector T cell populations specialized for B cell help or tissue inflammation
    • Campbell DJ, Kim CH, Butcher EC. Separable effector T cell populations specialized for B cell help or tissue inflammation. Nat Immunol (2001) 2:876-81. doi:10.1038/ni0901-876
    • (2001) Nat Immunol , vol.2 , pp. 876-881
    • Campbell, D.J.1    Kim, C.H.2    Butcher, E.C.3
  • 18
    • 0032701695 scopus 로고    scopus 로고
    • In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
    • Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med (1999) 190:1123-34. doi:10.1084/jem.190.8.1123
    • (1999) J Exp Med , vol.190 , pp. 1123-1134
    • Ansel, K.M.1    McHeyzer-Williams, L.J.2    Ngo, V.N.3    McHeyzer-Williams, M.G.4    Cyster, J.G.5
  • 19
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot SM, Yaari G, Patel JR, Johnson KL, Gonzalez DG, Kleinstein SH, et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity (2011) 34(6):947-60. doi:10.1016/j.immuni.2011.03.024
    • (2011) Immunity , vol.34 , Issue.6 , pp. 947-960
    • Kerfoot, S.M.1    Yaari, G.2    Patel, J.R.3    Johnson, K.L.4    Gonzalez, D.G.5    Kleinstein, S.H.6
  • 20
    • 2442580827 scopus 로고    scopus 로고
    • CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes
    • Scimone ML, Felbinger TW, Mazo IB, Stein JV, Andrian Von UH, Weninger W. CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. J Exp Med (2004) 199:1113-20. doi:10.1084/jem.20031645
    • (2004) J Exp Med , vol.199 , pp. 1113-1120
    • Scimone, M.L.1    Felbinger, T.W.2    Mazo, I.B.3    Stein, J.V.4    Andrian Von, U.H.5    Weninger, W.6
  • 21
    • 33847376309 scopus 로고    scopus 로고
    • CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node
    • Okada T, Cyster J. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol (2007) 178:2973. doi:10.4049/jimmunol.178.5.2973
    • (2007) J Immunol , vol.178 , pp. 2973
    • Okada, T.1    Cyster, J.2
  • 22
    • 34249085248 scopus 로고    scopus 로고
    • CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner
    • Asperti-Boursin F, Real E, Bismuth G, Trautmann A, Donnadieu E. CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. J Exp Med (2007) 204:1167-79. doi:10.1084/jem.20062079
    • (2007) J Exp Med , vol.204 , pp. 1167-1179
    • Asperti-Boursin, F.1    Real, E.2    Bismuth, G.3    Trautmann, A.4    Donnadieu, E.5
  • 23
    • 0023934515 scopus 로고
    • Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production
    • Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, et al. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol (1988) 140:1401-7.
    • (1988) J Immunol , vol.140 , pp. 1401-1407
    • Sanders, M.E.1    Makgoba, M.W.2    Sharrow, S.O.3    Stephany, D.4    Springer, T.A.5    Young, H.A.6
  • 24
    • 82755192227 scopus 로고    scopus 로고
    • Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration
    • Schaeuble K, Hauser MA, Singer E, Groettrup M, Legler DF. Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration. J Immunol (2011) 187:5645-52. doi:10.4049/jimmunol.1101850
    • (2011) J Immunol , vol.187 , pp. 5645-5652
    • Schaeuble, K.1    Hauser, M.A.2    Singer, E.3    Groettrup, M.4    Legler, D.F.5
  • 26
    • 67649856866 scopus 로고    scopus 로고
    • Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
    • Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci U S A (2009) 106:9649-54. doi:10.1073/pnas.0904361106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9649-9654
    • Zidar, D.A.1    Violin, J.D.2    Whalen, E.J.3    Lefkowitz, R.J.4
  • 27
    • 2542423686 scopus 로고    scopus 로고
    • Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7
    • Kohout TA, Nicholas SL, Perry SJ, Reinhart G, Junger S, Struthers RS. Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7. J Biol Chem (2004) 279:23214-22. doi:10.1074/jbc.M402125200
    • (2004) J Biol Chem , vol.279 , pp. 23214-23222
    • Kohout, T.A.1    Nicholas, S.L.2    Perry, S.J.3    Reinhart, G.4    Junger, S.5    Struthers, R.S.6
  • 28
    • 84901286279 scopus 로고    scopus 로고
    • Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1
    • Bednar F, Song C, Bardi G, Cornwell W, Rogers TJ. Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1. J Immunol (2014) 192:5305-13. doi:10.4049/jimmunol.1302983
    • (2014) J Immunol , vol.192 , pp. 5305-5313
    • Bednar, F.1    Song, C.2    Bardi, G.3    Cornwell, W.4    Rogers, T.J.5
  • 29
  • 30
    • 20244375369 scopus 로고    scopus 로고
    • Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes
    • Manjunath N, Shankar P, Wan J, Weninger W, Crowley MA, Hieshima K, et al. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest (2001) 108:871-8. doi:10.1172/JCI13296
    • (2001) J Clin Invest , vol.108 , pp. 871-878
    • Manjunath, N.1    Shankar, P.2    Wan, J.3    Weninger, W.4    Crowley, M.A.5    Hieshima, K.6
  • 31
    • 0037034880 scopus 로고    scopus 로고
    • Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
    • Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature (2002) 416:94-9. doi:10.1038/416094a
    • (2002) Nature , vol.416 , pp. 94-99
    • Reif, K.1    Ekland, E.H.2    Ohl, L.3    Nakano, H.4    Lipp, M.5    Förster, R.6
  • 32
    • 0038824988 scopus 로고    scopus 로고
    • Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity
    • Kabashima K, Murata T, Tanaka H, Matsuoka T, Sakata D, Yoshida N, et al. Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nat Immunol (2003) 4:694-701. doi:10.1038/ni943
    • (2003) Nat Immunol , vol.4 , pp. 694-701
    • Kabashima, K.1    Murata, T.2    Tanaka, H.3    Matsuoka, T.4    Sakata, D.5    Yoshida, N.6
  • 33
    • 84923698167 scopus 로고    scopus 로고
    • Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions
    • Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, et al. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med (2014) 211(13):2507-17. doi:10.1084/jem.20140137
    • (2014) J Exp Med , vol.211 , Issue.13 , pp. 2507-2517
    • Moalli, F.1    Cupovic, J.2    Thelen, F.3    Halbherr, P.4    Fukui, Y.5    Narumiya, S.6
  • 34
    • 0033965785 scopus 로고    scopus 로고
    • Microtubule dynamics and tubulin interacting proteins
    • Walczak CE. Microtubule dynamics and tubulin interacting proteins. Curr Opin Cell Biol (2000) 12:52-6. doi:10.1016/S0955-0674(99)00056-3
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 52-56
    • Walczak, C.E.1
  • 35
    • 1242271991 scopus 로고    scopus 로고
    • Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1
    • Wittmann T, Bokoch GM, Waterman-Storer CM. Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem (2004) 279:6196-203. doi:10.1074/jbc.M307261200
    • (2004) J Biol Chem , vol.279 , pp. 6196-6203
    • Wittmann, T.1    Bokoch, G.M.2    Waterman-Storer, C.M.3
  • 36
    • 36248956701 scopus 로고    scopus 로고
    • Finding a way out: lymphocyte egress from lymphoid organs
    • Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol (2007) 8:1295-301. doi:10.1038/ni1545
    • (2007) Nat Immunol , vol.8 , pp. 1295-1301
    • Schwab, S.R.1    Cyster, J.G.2
  • 37
    • 0035344684 scopus 로고    scopus 로고
    • The CD8 response on autopilot
    • Bevan MJ, Fink PJ. The CD8 response on autopilot. Nat Immunol (2001) 2:381-2. doi:10.1038/87676
    • (2001) Nat Immunol , vol.2 , pp. 381-382
    • Bevan, M.J.1    Fink, P.J.2
  • 38
  • 39
    • 34848828559 scopus 로고    scopus 로고
    • Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation
    • Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D. Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation. Proc Natl Acad Sci U S A (2007) 104:15460-5. doi:10.1073/pnas.0707331104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15460-15465
    • Obst, R.1    van Santen, H.M.2    Melamed, R.3    Kamphorst, A.O.4    Benoist, C.5    Mathis, D.6
  • 40
    • 0037093850 scopus 로고    scopus 로고
    • Human B cells become highly responsive to macrophage-inflammatory protein-3/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding
    • Liao F, Shirakawa AK, Foley JF, Rabin RL, Farber JM. Human B cells become highly responsive to macrophage-inflammatory protein-3/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding. J Immunol (2002) 168:4871-80. doi:10.4049/jimmunol.168.10.4871
    • (2002) J Immunol , vol.168 , pp. 4871-4880
    • Liao, F.1    Shirakawa, A.K.2    Foley, J.F.3    Rabin, R.L.4    Farber, J.M.5
  • 42
    • 66449115901 scopus 로고    scopus 로고
    • STAT3-stathmin interactions control microtubule dynamics in migrating T-cells
    • Verma NK, Dourlat J, Davies AM, Long A, Liu WQ, Garbay C, et al. STAT3-stathmin interactions control microtubule dynamics in migrating T-cells. J Biol Chem (2009) 284:12349-62. doi:10.1074/jbc.M807761200
    • (2009) J Biol Chem , vol.284 , pp. 12349-12362
    • Verma, N.K.1    Dourlat, J.2    Davies, A.M.3    Long, A.4    Liu, W.Q.5    Garbay, C.6
  • 43
    • 77649292108 scopus 로고    scopus 로고
    • Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells
    • Takesono A, Heasman SJ, Wojciak-Stothard B, Garg R, Ridley AJ. Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells. PLoS One (2010) 5:e8774. doi:10.1371/journal.pone.0008774
    • (2010) PLoS One , vol.5
    • Takesono, A.1    Heasman, S.J.2    Wojciak-Stothard, B.3    Garg, R.4    Ridley, A.J.5
  • 44
    • 34548780292 scopus 로고    scopus 로고
    • Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces
    • Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, et al. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol (2007) 8:1076-85. doi:10.1038/ni1499
    • (2007) Nat Immunol , vol.8 , pp. 1076-1085
    • Woolf, E.1    Grigorova, I.2    Sagiv, A.3    Grabovsky, V.4    Feigelson, S.W.5    Shulman, Z.6
  • 45
    • 58149330180 scopus 로고    scopus 로고
    • Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility
    • Tooley AJ, Gilden J, Jacobelli J, Beemiller P, Trimble WS, Kinoshita M, et al. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol (2009) 11:17-26. doi:10.1038/ncb1808
    • (2009) Nat Cell Biol , vol.11 , pp. 17-26
    • Tooley, A.J.1    Gilden, J.2    Jacobelli, J.3    Beemiller, P.4    Trimble, W.S.5    Kinoshita, M.6
  • 46
    • 0031202175 scopus 로고    scopus 로고
    • Microtubule retraction into the uropod and its role in T cell polarization and motility
    • Ratner S, Sherrod WS, Lichlyter D. Microtubule retraction into the uropod and its role in T cell polarization and motility. J Immunol (1997) 159:1063-7.
    • (1997) J Immunol , vol.159 , pp. 1063-1067
    • Ratner, S.1    Sherrod, W.S.2    Lichlyter, D.3
  • 47
    • 79955727320 scopus 로고    scopus 로고
    • Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection
    • Kang SS, Herz J, Kim JV, Nayak D, Stewart-Hutchinson P, Dustin ML, et al. Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. J Exp Med (2011) 208:747-59. doi:10.1084/jem.20101295
    • (2011) J Exp Med , vol.208 , pp. 747-759
    • Kang, S.S.1    Herz, J.2    Kim, J.V.3    Nayak, D.4    Stewart-Hutchinson, P.5    Dustin, M.L.6
  • 48
    • 84905383006 scopus 로고    scopus 로고
    • Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g
    • Gérard A, Patiño-López G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, et al. Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g. Cell (2014) 158:492-505. doi:10.1016/j.cell.2014.05.044
    • (2014) Cell , vol.158 , pp. 492-505
    • Gérard, A.1    Patiño-López, G.2    Beemiller, P.3    Nambiar, R.4    Ben-Aissa, K.5    Liu, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.