In vitro studies of phenethyl isothiocyanate against the growth of LN229 human glioma cells

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 4, 2015, Pages 4269-4276

  Su, Ji Chun ^a,b   Lin, Kai ^c   Wang, Yan ^d   Sui, Shao Hua ^c   Gao, Zhi Yu ^c   Wang, Zhi Gang ^a  

^a SHANDONG UNIVERSITY   (China)

^b TAIAN CENTRAL HOSPITAL   (China)

^c LIAOCHENG PEOPLE'S HOSPITAL   (China)

^d Taishan Coal Sanatorium of Shandong Province ^*  (China)

Author keywords

Glioma; LN229 cells; Phenethyl isothiocyanate

Indexed keywords

ANTINEOPLASTIC AGENT; CASP3 PROTEIN, HUMAN; CASPASE 3; GLUTATHIONE; ISOTHIOCYANIC ACID DERIVATIVE; PHENETHYL ISOTHIOCYANATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

APOPTOSIS; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; G2 PHASE CELL CYCLE CHECKPOINT; GLIOMA; HUMAN; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; G2 PHASE CELL CYCLE CHECKPOINTS; GLIOMA; GLUTATHIONE; HUMANS; ISOTHIOCYANATES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 84935099583     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Laws ER, Thapar K. Brain tumors. CA Cancer J Clin 1993; 43: 263-271.
2. Wang WX, Ji YH. Scorpion venom induces glioma cell apoptosis in vitro and inhibits glioma tumor growth in vivo. J Euro Oncol 2005; 73: 1-7.
3. Chung FL. Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse. Exp Lung Res 2001; 27: 319-330.
4. Conaway CC, Wang CX, Pittman B, Yang YM, Schwartz JE, Tian D, Mclntee EJ, Hecht SS, Chung FL. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res 2005; 65: 8548-8557.
5. Sticha KR, Kenney PM, Boysen G, Liang H, Su X, Wang M, Upadhyaya P, Hecht SS. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo (a) pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis 2002; 23: 1433-1439.
6. Zhang Y, Talalay P. Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res 1994; 54: 1976s-1981s.
7. Verhoeven DT, Verhagen H, Goldbohm RA, Van Poppel G. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact 1997; 103: 79-126.
8. Kassie F, Knasmuller S. Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC). Chem Biol Interact 2000; 127: 163-180.
9. Satyan KS, Swamy N, Dizon DS, Singh R, Granai CO, Brard L. Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: Role of caspase and MAPK activation. Gynecol Oncol 2006; 103: 261-279.
10. Conaway CC, Yang YM, Chung FL. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 2002; 3: 233-255.
11. Fahey JW, Zalcmann AT, Talalay P. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 2001; 56: 5-51.
12. Hecht SS. Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev 2000; 32: 395-411.
13. Hwang ES, Lee HJ. Effects of Phenethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. Int J Food Sci Nutr 2010; 61: 324-336.
14. Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008; 359: 492507.
15. Louis DN. Molecular pathology of malignant gliomas. Annu Rev Pathol 2006; 1: 97117.
16. Claus EB, Black PM. Survival rates and patterns of care for patients diagnosed with supratentorial lowgrade gliomas: data from the SEER program, 19732001. Cancer 2006; 106: 13581363.
17. Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013; 13: 1126.
18. Cerchia L, Martinez Montero JC, Monfared P. Signal transduction alterations in glioma: implications for diagnosis and therapy. J Signal Transduct 2012; 2012: 704247.
19. Mellinghoff IK, Lassman AB, Wen PY. Signal transduction inhibitors and antiangiogenic therapies for malignant glioma. Glia 2011; 59: 12051212.
20. Kim R, Emi M, Tanabe K, Uchida Y, Arihiro K. The role of apoptotic or nonapoptotic cell death in determining cellular response to anticancer treatment. Eur J Surg Oncol 2006; 32: 269-277.
21. Yu R, Mandlekar S, Harvey KJ, Ucker DS, Kong AN. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like activity. Cancer Res 1998; 58: 402-408.
22. Zhang Y, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther 2003; 2: 1045-1052.
23. Wu SJ, Ng LT, Lin CC. Effects of antioxidants and caspase-3 inhibitor on the Phenethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells. Eur J Pharmacol 2005; 518: 96-106.
24. Lee DH, Rhee JG, Lee YJ. Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. Br J Pharmacol 2009; 157: 1189-1202.
25. Hori YS, Kuno A, Hosoda R, Horio Y. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PLoS One 2013; 8: e73875.
26. Zhong YJ, Liu SP, Firestone RA, Hong YP, Li Y. Anticancer effects of AcPhe Lys PABC doxorubicin via mitochondria centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC803 cells. Oncol Rep 2013; 30: 1681-1686.