Biochemical and histopathological evaluations of ghrelin effects following cadmium toxicity in the rat testis

Andrologia

Volumn 47, Issue 6, 2015, Pages 634-643

  Kheradmand, A ^a,b   Alirezaei, M ^a   Dezfoulian, O ^a  

^a LORESTAN UNIVERSITY   (Iran)

^b LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidant enzymes; Cadmium; Ghrelin; Oxidative stress

Indexed keywords

CADMIUM; GHRELIN; GLUTATHIONE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; ANTIOXIDANT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GERM CELL; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SEMINIFEROUS TUBULE; SPERMATOGENESIS; TESTIS; TESTIS INJURY; ANIMAL; CADMIUM POISONING; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CADMIUM POISONING; GHRELIN; GLUTATHIONE; LIPID PEROXIDATION; MALE; RATS; RATS, WISTAR; SEMINIFEROUS TUBULES; SUPEROXIDE DISMUTASE; TESTIS;

EID: 84935093889     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/and.12311     Document Type: Article

References (64)

1. Acharya UR, Mishra M, Patro J, Pan MK (2008) Effect of vitamins C and E on spermatogenesis in mice exposed to cadmium. Reprod Toxicol 25:84-88.
2. Agarwal A, Ikemoto I, Loughlin KR (1997) Prevention of testicular damage by free-radical scavengers. Urology 50:759-763.
3. Aitken RJ, Roman SD (2008) Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev 1:15-24.
4. Amara S, Abdelmelek H, Garrel C, Guiaud P, Douki T, Ravanat JL, Favier A, Sakly M, Rhouma KB (2008) Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis. J Reprod Dev 54:129-134.
5. Aoki A, Hoffer AP (1978) Reexamination of the lesions in rat testis caused by cadmium. Biol Reprod 18:579-591.
6. Arthur JR (2000) The glutathione peroxidase. Cell Mol Life Sci 57:1825-1831.
7. Bagchi D, Bagchi M, Hassoun EA, Stohs SJ (1996) Cadmium-induced excretion of urinary lipid metabolites, DNA damage, glutathione depletion and hepatic lipid peroxidation in Sprague-Dawley rats. Biol Trace Elem Res 52:143-149.
8. Barreiro ML, Tena-Sempere M (2004) Ghrelin and reproduction: a novel signal linking energy status and fertility? Mol Cell Endocrinol 226:1-9.
9. Barreiro ML, Gaytan F, Castellano JM, Suominen JS, Roa J, Gaytan M, Aguilar E, Dieguez C, Toppari J, Tena-Sempere M (2004) Ghrelin inhibits the proliferative activity of immature Leydig cells in vitro and regulates stem cell factor messenger ribonucleic acid expression in rat testis. Endocrinology 145:4825-4834.
10. Bauche F, Fouchard MH, Jegou B (1993) Antioxidant system in rat testicular cells. FEBS Lett 349:392-396.
11. Bauer R, Demeter I, Hasemann V, Johansen JT (1980) Structural properties of the zinc site in Cu, Zn-superoxide dismutase: perturbed angular correlation of gamma ray spectroscopy on the Cu, 111Cd- superoxide dismutase derivative. Biochem Biophys Res Commun 94:1296-1302.
12. Budak E, Fernandez-Sanchez M, Bellver J, Cervero A, Simon C, Pellicer A (2006) Intractions of the hormones leptin, ghrelin, adiponectin, resistin and PYY3-36 with the reproductive system. Fertil Steril 85:1563-1581.
13. Casalino E, Cesare S, Clemente L (1997) Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 346:171-179.
14. Claiborne A (1986). Catalase activity. In: CRC Handbook of Methods For Oxygen Radical Research. Greenwald RA (ed). CRC Press, Boca Raton, FL, pp 283-284.
15. Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG (2004) Generally altered mice to evaluate glutathione homeostasis in health and disease. Free Radic Biol Med 37:1511-1518.
16. Doreswamy K, Shrilatha B, Rajeshkumar TM (2004) Nickel-induced oxidative stress in testis of mice: evidence of DNA damage and genotoxic effects. J Androl 25:996-1003.
17. Erkkila K, Pentikainen V, Wikstrom M, Parvinen M, Dunkel L (1999) Partial oxygen pressure and mitochondrial permeability transition affect germ cell apoptosis in the human testis. J Clin Endocrinol Metab 84:4253-4259.
18. Fernandez-Fernandez R, Navarro VM, Barreiro ML, Vigo EM, Tovar S, Sirotkin AV, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M (2005) Effect of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 146:3018-3025.
19. Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, Aguilar E, Pinilla L, Tene-Sempere M (2006) Novel signals for the interaction of energy balance and reproduction. Mol Cell Endocrinol 254-255:127-132.
20. Garcia YJ, Rodriguez-Malaver AJ, Penaloza N (2005) Lipid peroxidation measurement by thiobarbituric acid assay in rat cerebellar slices. J Neurosci Meth 144:127-135.
21. Garcia MC, Lopez M, Alvarez CV, Casanueva F, Tene-Sempere M, Dieguez C (2007) Role of ghrelin in reproduction. Reproduction 133:531-540.
22. Goyer RA, Liu J, Waalkes MP (2004) Cadmium and cancer of prostate and testis. Biometals 17:555-558.
23. Griffth OW (1999) Biological and pharmacological regulation of mammalian glutathione synthesis. Free Radic Biol Med 27:922-935.
24. Hakovitra H, Yan W, Kaleva M, Zhang F, Vanttinen K, Morris PL, Soder M, Parvinen M, Toppari J (1999) Function of stem cell factor as a survival factor of spermatogonia and localisation of messenger ribonucleic acid in the rat seminiferous epithelium. Endocrinology 140:1492-1498.
25. Ikeda M, Kodama H, Fukuda J, Shimizu Y, Murata M, Kumagai J, Tanaka T (1999) Role of radical oxygen species in rat testicular germ cell apoptosis induced by heat stress. Biol Reprod 61:393-399.
26. Ikemoto I, Machida T, Tanaka A, Kotera S, Mikuriya H, Takasi S (1990) Appearance of LDH-X activity in rat serum after acute and subacute testicular damage. Jpn. J Fertil Steril 35:247-252.
27. Iseri SO, Sener G, Yuksel M, Contuk G, Cetinel S, Gedik N, Yegen BC (2005) Ghrelin against alendronate-induced gastric damage in rats. J Endocrinol 187:399-406.
28. Johnsen SG (1970) Testicular biopsy score count-a method for registration of spermatogenesis in human testes: normal values and results in 352 hypogonadal males. Hormones 1:1-24.
29. Kara H, Cevik A, Konar V, Dayangae A, Yilmaz M (2007) Protective effects of antioxidants against cadmium-induced oxidative damage in rat testes. Biol Trace Elem Res 120:205-211.
30. Kawczynska-Drozdz A, Olszanecki R, Jawein J, Brzozowski T, Pawlik WW, Korbut R, Guzik TJ (2006) Ghrelin inhibits vascular superoxide production in spontaneously hypertensive rats. Am J Hypertens 19:764-767.
31. Kheradmand A, Alirezaei M, Asadian P, Rafiei Alavi E, Joorabi S (2009a) Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia 41:335-340.
32. Kheradmand A, Taati M, Babaei H (2009b) The effects of chronic administration of ghrelin on rat sperm quality and membrane integrity. Anim Biol 59:159-168.
33. Kheradmand A, Taati M, Babaei H (2009c) Ghrelin enhances viability of rat spermatozoa during incubation at 37°C. Iranian J Vet Res 10:103-109.
34. Kheradmand A, Roshangar L, Taati M (2009d) The role of ghrelin on the morphometry and intracellular changes in the rat testis. Tissue Cell 41:105-111.
35. Kheradmand A, Alirezaei M, Birjandi M (2010) Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary. Regul Pept 162:84-89.
36. Kheradmand A, Dezfoulian O, Tarrahi MJ (2011) Ghrelin attenuates heat-induced degenerative effects in the rat testis. Ragul Pept 167:97-104.
37. Kheradmand A, Dezfoulian O, Alirezaei M (2012) Ghrelin regulates Bax and PCNA but not Bcl-2 expressions following scrotal hyperthermia in the rat. Tissue Cell 44:308-315.
38. Kono Y, Fridovic I (1982) Superoxide radical inhibits catalase. J Biol Chem 257:5751-5754.
39. Koyuturk M, Yanardag R, Bolkent S, Tunali S (2006) Influence of combined antioxidants against cadmium induced testicular damage. Environ Toxicol Pharmacol 21:235-240.
40. Lowry O, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurements with the folin phenol reagent. J Biol Chem 193:265-275.
41. Martini AC, Fernandez-Fernandez R, Tovar S, Navarro VM, Vigo E, Vazquez MJ, Davies JS, Thompson NM, Aguilar E, Pinilla L, Wells T, Dieguez C, Tena-Sempere M (2006) Comparative analysis of the effect of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology 147:2374-2382.
42. Mathur PP, Huang L, Kashou A, Vaithinathan S, Agarwal A (2011) Environmental toxicants and testicular apoptosis. Open Reprod Sci J 3:114-124.
43. Messaoudi I, Banni M, Said L, Said K, Kerkeni A (2010) Evaluation of involvement of testicular metallothionein gene expression in the protective effect of zinc against cadmium-induced testicular pathology in rat. Reprod Toxicol 29:339-345.
44. Obay BD, Tasdemir E, Tumer C, Bilgin HM, Atmaca M (2008) Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model. Peptides 29:448-455.
45. 10 and Vitamin E. Reprod Toxicol 29:191-197.
46. Oldereid NB, Thomassen Y, Attramadal A, Olaisen B, Purvis K (1993) Concentrations of lead, cadmium and zinc in the tissues of reproductive organs of men. J Reprod Fertil 99:421-425.
47. Patra RC, Swarup D, Senapati SK (1999) Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic, renal and testicular tissue of rats. Vet Hum Toxicol 41:65-67.
48. Peltola V, Huhtaniemi I, Ahotupa M (1992) Antioxidant enzyme activity in the maturing rat testis. J Androl 13:450-455.
49. Petrie A, Watson P (1999) Statistics for Veterinary and Animal Science. Blackwell Science, London, pp 93-102.
50. Saradha B, Mathur PP (2006) Effect of environmental contaminants on male reproduction. Environ Toxicol Parmacol 21:34-41.
51. Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound and nonprotein sulfhydryl groups in tissues with Ellman's reagent. Anal Biochem 25:192-205.
52. Sen Gupta R, Sen Gupta E, Dhakal BK, Thakur Ahnn J (2004) Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species. Mol Cells 17:132-139.
53. Sewerynek E, Poeggeler B, Melchiorri D, Reiter RJ (1995) H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin. Neurosci Lett 195:203-205.
54. Singhal RK, Anderson ME, Meister A (1987) Glutathione, a first line of defence against Cd toxicity. FASEB J 1:220-223.
55. Siu ER, Mruk DD, Porto CS, Cheng CY (2009) Cadmium-induced testicular injury. Toxicol Appl Pharmacol 238:240-249.
56. Stohs SJ, Bagachi C (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18:321-336.
57. Subbarao KV, Richardson JS, Ang L (1990) Autopsy samples of Alzhaeimer s cortex show increase peroxidation in vitro. J Neurochem 55:342-345.
58. Taati M, Moghadasi M, Dezfoulian O, Asadian P, Kheradmand A, Abbasi M, Zendehdel M (2012) The effect of ghrelin pre-treatment on epididymal sperm quality and tissue antioxidant enzyme activities after testicular ischaemia/reperfusion in rats. J Physiol Biochem 68:91-97.
59. Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JE, Pinilla L, Casanueva FF, Dieguez C, Aguilar E (2002) Novel expression and functional role of ghrelin in rat testis. Endocrinology 143:717-725.
60. Thompson J, Bannigan J (2008) Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol 25:304-315.
61. Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis: a review. Toxicology 192:95-117.
62. Xu DX, Shen HM, Zhu QX, Chua L, Wang QN, Chia SE, Ong CN (2003) The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. Mutat Res 534:155-163.
63. Yang HS, Han DK, Kim JR, Sim JC (2006) Effects of α-tocopherol on cadmium-induced toxicity in rat testis and spermatogenesis. J Korean Med Sci 21:445-451.
64. Zwirska-Korczala K, Adamczyk-Sowa M, Sowa P, Pilc K, Suchanek R, Pierzchala K, Namyslowski G, Misiolek M, Sodowski K, Kato I, Kuwahara A, Zabielski R (2007) Role of leptin, ghrelin, angiotensin P{cyrillic} and orexins in 3T3 L1 preadipocyte cells proliferation and oxidative metabolism. J Physiol Pharmacol 58:53-64.