Evaluation of involvement of testicular metallothionein gene expression in the protective effect of zinc against cadmium-induced testicular pathophysiology in rat

Reproductive Toxicology

Volumn 29, Issue 3, 2010, Pages 339-345

  Messaoudi, Imed ^a   Banni, Mohamed ^b   Saïd, Lamia ^a   Saïd, Khaled ^a   Kerkeni, Abdelhamid ^c  

^a Institut Superieur de Biotechnologie   (Tunisia)

^b ISA   (Tunisia)

^c UNIVERSITY OF MONASTIR   (Tunisia)

Author keywords

Cadmium; MT gene expression; Oxidative stress; Protection; Testicular pathophysiology; Zinc

Indexed keywords

CADMIUM; DRINKING WATER; METALLOTHIONEIN I; METALLOTHIONEIN II; SUPEROXIDE DISMUTASE; TESTOSTERONE; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; EXPOSURE; GENE EXPRESSION; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTECTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; TESTIS DISEASE; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL;

ANIMALS; CADMIUM; GENE EXPRESSION; LIPID PEROXIDATION; MALE; METALLOTHIONEIN; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TESTIS; WATER SUPPLY; ZINC;

RATTUS;

EID: 77951622003     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.01.004     Document Type: Article

References (57)

1. El-Demerdash F.M., Yousef M.I., Kedwany F.S., Baghdadi H.H. Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and beta-carotene. Food Chem Toxicol 2004, 42:1563-1571.
2. Goyer R.A., Liu J., Waalkes M.P. Cadmium and cancer of prostate and testis. Biometals 2004, 17:555-558.
3. Parizek J., Zahor Z. Effect of cadmium salts on testicular tissue. Nature 1956, 177:1036-1037.
4. Nolan C.V., Shaikh Z.A. An evaluation of tissue metallothionein and genetic resistance to cadmium toxicity in mice. Toxicol Appl Pharmacol 1986, 85(2):135-144.
5. Thompson J., Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol 2008, 25:304-315.
6. Yiin S.J., Cheru C.L., Sheu J.Y., Lin T.H. Cadmium-induced lipid peroxidation in rat testes and protection by selenium. Biometals 1999, 12:353-359.
7. Bonda E., Wlostowski T., Krasowska A. Testicular toxicity induced by dietary cadmium is associated with decreased testicular zinc and increased hepatic and renal metallothionein and zinc in the bank vole (Clethrionomys glareolus). Biometals 2004, 17:615-624.
8. Maitani T., Suzuki K.T. Essential metal contents and metallothionein-like protein in testes of mice after cadmium administration. Toxicology 1986, 40:1-12.
9. Koizumi T., Li Z.G. Role of oxidative stress in single-dose, cadmium-induced testicular cancer. J Toxicol Environ Health 1992, 37:25-36.
10. Oteiza P.I., Adonaylo V.N., Keen C.L. Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake. Toxicology 1999, 137:13-22.
11. Oteiza P.I., Olin K.L., Fraga C.G., Keen C.L. Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J Nutr 1995, 125:823-829.
12. Nodera M., Yanagisawa H., Wada O. Increased apoptosis in a variety of tissues of zinc-deficient rats. Life Sci 2001, 69:1639-1649.
13. Nordberg M., Nordberg G.F. Toxicological aspects of metallothionein. Cell Mol Biol 2000, 46:451-463.
14. Amara S., Abdelmelek H., Garrel C., Guiraud P., Douki T., Ravanat J.L., et al. Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis. J Reprod Dev 2008, 54:129-134.
15. Davis S.R., Cousins R.J. Metallothionein expression in animals: a physiological perspective on function. J Nutr 2000, 130:1085-1088.
16. Klaassen C.D., Liu J., Choudhuri S. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 1999, 39:267-294.
17. Waalkes M.P. Cadmium carcinogenesis. Mutat Res 2003, 533:107-120.
18. Jihen E.H., Messaoudi I., Fatima H., Kerkeni A. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food Chem Toxicol 2008, 46:3522-3527.
19. Messaoudi I, Hammouda F, El Heni J, Baati T, Saïd K, Kerkeni A. Reversal of cadmium induced oxidative stress in rat erythrocytes by selenium, zinc or their combination. Exp Toxicol Pathol; doi:10.1016/j.etp.2009.04.004.
20. Messaoudi I., El Heni J., Hammouda F., Saïd K., Kerkeni A. Protective effects of selenium, zinc, or their combination on cadmium-induced oxidative stress in rat kidney. Biol Trace Elem Res 2009, 130:152-161.
21. Brzóska M.M., Moniuszko-Jakoniuk J. Bone metabolism of male rats chronically exposed to cadmium. Toxicol Appl Pharmacol 2005, 207:195-211.
22. Wheeler M.J. The determination of bio-available testosterone. Ann Clin Biochem 1995, 32:345-357.
23. Marklund S., Marklund G. Involvement of the superoxyde anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974, 47:469-474.
24. Beers B., Sizer W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952, 195:133-139.
25. Buege JA, Aust SD. Microsomal lipid peroxidation, In: Packer, L. (editor), Meth Enzymol 1978; 52:302-310.
26. Bradford M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
27. Dondero F., Piacentini L., Banni M., Rebelo M., Burlando B., Viarengo A. Quantitative PCR analysis of two molluscan metallothionein genes unveils differential expression and regulation. Gene 2005, 345:259-270.
28. Pfaff M.W., Horgan G.W., Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002, 30:e36.
29. Kusakabe T., Nakajima K., Suzuki K., Nakazato K., Takada H., Satoh T., et al. The changes of heavy metal and metallothionein distribution in testis induced by cadmium exposure. BioMetals 2008, 21:71-81.
30. Yadav N., Khandelwal S. Effect of picroliv on cadmium induced testicular damage in rats. Food Chem Toxicol 2008, 46:494-501.
31. Aoki A., Hoffer A.P. Reexamination of the lesions in rat testis caused by cadmium. Biol Reprod 1978, 18:579-591.
32. Waalkes M.P., Rehm S., Devor D.E. The effects of continuous testosterone exposure on spontaneous and cadmium-induced tumors in the male Fischer (F344/NCr) rat: loss of testicular response. Toxicol Appl Pharmacol 1997, 142:40-46.
33. Yang J.M., Amush M., Chen Q.Y., Wu X.D., Pang B., Jiang X.Z. Cadmium-induced damage to primary cultures of rat Leydig cells. Reprod Toxicol 2003, 17:553-560.
34. Gunnarsson D., Nordberg G., Lundgren P., Selstam G. Cadmium-induced decrement of the LH receptor expression and cAMP levels in the testis of rats. Toxicology 2003, 183:57-63.
35. Stohs S.J., Bagachi C. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 1995, 18:321-336.
36. Casalino E., Cesare S., Clemente L. Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 1997, 346:171-179.
37. Sato M., Yamanobe K., Nagai Y. Sex-related differences in cadmium-induced lipid peroxidation in the rat. Life Sci 1983, 33:903-908.
38. Sugawara N., Sugawara C. Selenium protection against testicular lipid peroxidation from cadmium. J Appl Biochem 1984, 6:199-204.
39. Bauer R., Demeter I., Hasemann V., Johansen J.T. Structural properties of the zinc site in Cu, Zn-superoxide dismutase; perturbed angular correlation of gamma ray spectroscopy on the Cu, 111Cd-superoxide dismutase derivative. Biochem Biophys Res Commun 1980, 94:1296-1302.
40. Brzóska M.M., Moniuszko-Jakoniuk J. Interactions between cadmium and zinc in the organism. Food Chem Toxicol 2001, 39:967-980.
41. Dalton T.P., He L., Wang B., Miller M.L., Jin L., Stringer K.F., et al. Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proc Natl Acad Sci USA 2005, 102:3401-3406.
42. Wang B., Schneider S.N., Dragin N., Girijashanker K., Dalton T.P., He L., et al. Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. Am J Physiol Cell Physiol 2007, 292:1523-1535.
43. - dependent symporter: Kinetics, electrogenicity and trafficking. Biochem Biophys Res Commun 2008, 365:814-820.
44. Powell S.R. Antioxidant properties of zinc. J Nutr 2000, 130:1447-1454.
45. Souza V., Escobar Mdel C., Bucio L., Hernandez E., Gutierrez-Ruiz M.C. Zinc pretreatment prevents hepatic stellate cells from cadmium-produced oxidative damage. Cell Biol Toxicol 2004, 20:241-251.
46. Bray T.M., Bettger W.J. The physiological role of zinc as an antioxidant. Free Radic Biol Med 1990, 8:281-291.
47. Shiraishi N., Hochadel J.F., Coogan T.P., Koropatnick J., Waalkes M.P. Sensitivity to cadmium-induced genotoxicity in rat testicular cells is associated with minimal expression of the metallothionein gene. Toxicol Appl Pharmacol 1995, 130:229-236.
48. McKenna I.M., Bare R.M., Waalkes M.P. Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium. Toxicology 1996, 107:121-130.
49. De K.S., Enders G.C., Andrews G.K. High levels of metallothionein messenger RNAs in male germ cells of the adult mouse. Mol Endocrinol 1991, 5(5):628-636.
50. Waalkes M.P., Perantoni A.O., Rehm S. Tissue susceptibility factors in cadmium carcinogenesis. Biol Trace Elem Res 1989, 21:483-490.
51. Coogan T.P., Shiraishi N., Waalkes M.P. Metallothionein gene expression in the reproductive tissues of the Wistar rat: effects of treatment with metals and glucocorticoids. Toxic Subst Mech 1997, 16:357-370.
52. Kusakabe T., Nakajima K., Nakazato K., Suzuki K., Takada H., Satoh T., et al. Changes of heavy metal, metallothionein and heat shock proteins in sertoli cells induced by cadmium exposure. Toxicol In Vitro 2008, 22:1469-1475.
53. Searle P.F., Davison B.L., Stuart G.W., Wilkie T.M., Norstedt G., Palmiter R.D. Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol 1984, 4:1221-1230.
54. Ren X.Y., Zhou Y., Zhang J.P., Feng W.H., Jiao B.H. Metallothionein gene expression under different time in testicular sertoli and spermatogenic cells of rats treated with cadmium. Reprod Toxicol 2003, 17:219-227.
55. Waalkes M.P., Chernoff S.B., Klaassen C.D. Cadmium-binding proteins of rat testes. Characterization of a low-molecular mass protein that lacks identity with metallothionein. Biochem J 1984, 220(3):811-818.
56. Kaur G., Nath R., Gupta G.S. Purification and characterization of low molecular weight metal-binding protein from human testes. J Trace Elem Exp Med 1993, 6(1):1-13.
57. Shibnath G., Paulo O., Paula K., Shuk-mei H. Expression and regulation of metallothionein mRNA levels in the prostates of Noble rats: lack of expression in the ventral prostate and regulation by sex hormones in the dorsolateral prostate. Prostate 1996, 29:91-100.