TGFβ overrides HNF4α tumor suppressing activity through GSK3β inactivation: Implication for hepatocellular carcinoma gene therapy

Journal of Hepatology

Volumn 58, Issue 1, 2013, Pages 65-72

  Cozzolino, Angela Maria ^a   Alonzi, Tonino ^b   Santangelo, Laura ^a   Mancone, Carmine ^b   Conti, Beatrice ^b   Steindler, Corinna ^b   Musone, Mariateresa ^a   Cicchini, Carla ^a   Tripodi, Marco ^a,b   Marchetti, Alessandra ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

EMT; Gene therapy; GSK3 ; HCC; HNF4 ; TGF

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CANCER INVASION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; GEL MOBILITY SHIFT ASSAY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WOUND HEALING;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GENETIC THERAPY; GLYCOGEN SYNTHASE KINASE 3; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MICE; TRANSFORMING GROWTH FACTOR BETA; TUMOR MICROENVIRONMENT;

EID: 84871194102     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.08.023     Document Type: Article

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