Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 23, 2015, Pages 5634-5639

  Grienke, Ulrike ^a,b   Mair, Christina E ^a,b   Saxena, Priyanka ^b   Baburin, Igor ^b   Scheel, Olaf ^c   Ganzera, Markus ^a   Schuster, Daniela ^a   Hering, Steffen ^b   Rollinger, Judith M ^a,b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c Cytocentrics Bioscience GmbH   (Germany)

Author keywords

cardiotoxic risk; dietary supplement; hERG; lotus; Nelumbo nucifera; nuciferine; patch clamp assay; weight loss

Indexed keywords

ALKALOIDS; CHEMICAL COMPOUNDS; ELECTROPHYSIOLOGY; ETHERS; GENES; LIQUID CHROMATOGRAPHY; METABOLITES; MICROELECTRODES; NITROGEN COMPOUNDS; PLANTS (BOTANY);

HERG; LOTUS; NELUMBO NUCIFERA; NUCIFERINE; PATCH CLAMP; WEIGHT LOSS;

DIETARY SUPPLEMENTS;

NELUMBO NUCIFERA;

ALKALOID; ANTIOBESITY AGENT; APORPHINE; APORPHINE DERIVATIVE; PLANT EXTRACT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG;

ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DIETARY SUPPLEMENT; HUMAN; LOTUS; METABOLISM; PLANT LEAF; XENOPUS;

ALKALOIDS; ANIMALS; ANTI-OBESITY AGENTS; APORPHINES; CELL LINE; DIETARY SUPPLEMENTS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; LOTUS; PLANT EXTRACTS; PLANT LEAVES; POTASSIUM CHANNEL BLOCKERS; XENOPUS;

EID: 84935023894     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b01901     Document Type: Article

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