Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 2, 2009, Pages 143-151

  Gu, Dong Fang ^a   Li, Xue Lian ^a   Qi, Zhi Ping ^a   Shi, Sha Shan ^a   Hu, Mei Qin ^a   Liu, Dong Min ^a   She, Cheng Bai ^a   Lv, Yan Jie ^a   Li, Bao Xin ^b   Yang, Bao Feng ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Key Laboratory   (China)

Author keywords

HEK293 cells; HERG channel; Immunofluorescence; Neferine; Patch clamp; Western blot

Indexed keywords

ISOQUINOLINE ALKALOID; NEFERINE; NELUMBO NUCIFERA EXTRACT; POTASSIUM CHANNEL HERG;

AMPLITUDE MODULATION; ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; ELECTRIC POTENTIAL; GENETIC TRANSFECTION; HEART ARRHYTHMIA; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; PATCH CLAMP; POTASSIUM CURRENT; WESTERN BLOTTING;

BENZYLISOQUINOLINES; BLOTTING, WESTERN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INHIBITORY CONCENTRATION 50; NELUMBO; PATCH-CLAMP TECHNIQUES; SEEDS; TRANSFECTION;

EID: 67449110714     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0419-7     Document Type: Article

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