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Volumn 19, Issue 2, 2014, Pages 237-239

Anti-addiction drug ibogaine inhibits hERG channels: A cardiac arrhythmia risk

Author keywords

Anti addiction drug; cardiac arrhythmias; hERG potassium channels; ibogaine; indole alkaloid; QT interval prolongation

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; IBOGAINE; KCNH1 PROTEIN, HUMAN; POTASSIUM CHANNEL HERG;

EID: 84894491360     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2012.00447.x     Document Type: Article
Times cited : (36)

References (9)
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  • 3
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    • Long-QT syndrome induced by the antiaddiction drug ibogaine
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    • Hoelen, D.W.1    Spiering, W.2    Valk, G.D.3
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    • Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
    • Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Strang I, Sullivan AT, Wallis R, Camm AJ, Hammond TG, (2003) Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res 58: 32-45.
    • (2003) Cardiovasc Res , vol.58 , pp. 32-45
    • Redfern, W.S.1    Carlsson, L.2    Davis, A.S.3    Lynch, W.G.4    MacKenzie, I.5    Palethorpe, S.6    Siegl, P.K.7    Strang, I.8    Sullivan, A.T.9    Wallis, R.10    Camm, A.J.11    Hammond, T.G.12
  • 7
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    • HERG potassium channels and cardiac arrhythmia
    • Sanguinetti MC, Tristani-Firouzi M, (2006) hERG potassium channels and cardiac arrhythmia. Nature 440: 463-469.
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    • Sanguinetti, M.C.1    Tristani-Firouzi, M.2
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    • Addiction research. Ibogaine therapy: A 'vast, uncontrolled experiment'
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    • Vastag, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.