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Volumn 15, Issue 1, 2015, Pages

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

Author keywords

c Crk; Cell adhesion; E cadherin; KRAS; Lung cancer; PAK1 kinase; Signal transduction

Indexed keywords

CATENIN; K RAS PROTEIN; ONCOPROTEIN; P21 ACTIVATED KINASE 1; PROTEIN P120; UVOMORULIN; CADHERIN; CRK PROTEIN, HUMAN; DELTA CATENIN; KRAS PROTEIN, HUMAN; P21 ACTIVATED KINASE; PAK1 PROTEIN, HUMAN; PROTEIN P21;

EID: 84935010215     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1360-4     Document Type: Article
Times cited : (26)

References (26)
  • 1
    • 84869225094 scopus 로고    scopus 로고
    • p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model
    • Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, et al. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012;72:5966-75.
    • (2012) Cancer Res , vol.72 , pp. 5966-5975
    • Chow, H.Y.1    Jubb, A.M.2    Koch, J.N.3    Jaffer, Z.M.4    Stepanova, D.5    Campbell, D.A.6
  • 2
    • 58149401317 scopus 로고    scopus 로고
    • Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells
    • McDaniel AS, Allen JD, Park SJ, Jaffer ZM, Michels EG, Burgin SJ, et al. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood. 2008;112:4646-54.
    • (2008) Blood , vol.112 , pp. 4646-4654
    • McDaniel, A.S.1    Allen, J.D.2    Park, S.J.3    Jaffer, Z.M.4    Michels, E.G.5    Burgin, S.J.6
  • 3
    • 84868626073 scopus 로고    scopus 로고
    • The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes
    • Singhal R, Kandel ES. The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes. Oncotarget. 2012;3:700-8.
    • (2012) Oncotarget , vol.3 , pp. 700-708
    • Singhal, R.1    Kandel, E.S.2
  • 4
    • 84874424655 scopus 로고    scopus 로고
    • Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling
    • Tabusa H, Brooks T, Massey AJ. Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling. Mol Cancer Res. 2013;11:109-21.
    • (2013) Mol Cancer Res , vol.11 , pp. 109-121
    • Tabusa, H.1    Brooks, T.2    Massey, A.J.3
  • 5
    • 84864405697 scopus 로고    scopus 로고
    • PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells
    • Rettig M, Trinidad K, Pezeshkpour G, Frost P, Sharma S, Moatamed F, et al. PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells. PLoS One. 2012;7:e42012.
    • (2012) PLoS One , vol.7 , pp. e42012
    • Rettig, M.1    Trinidad, K.2    Pezeshkpour, G.3    Frost, P.4    Sharma, S.5    Moatamed, F.6
  • 6
    • 0023864050 scopus 로고
    • A novel viral oncogene with structural similarity to phospholipase C
    • Mayer BJ, Hamaguchi M, Hanafusa H. A novel viral oncogene with structural similarity to phospholipase C. Nature. 1988;332:272-5.
    • (1988) Nature , vol.332 , pp. 272-275
    • Mayer, B.J.1    Hamaguchi, M.2    Hanafusa, H.3
  • 7
    • 0024153815 scopus 로고
    • Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C
    • Mayer BJ, Hamaguchi M, Hanafusa H. Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C. Cold Spring Harb Symp Quant Biol. 1988;53(Pt 2):907-14.
    • (1988) Cold Spring Harb Symp Quant Biol , vol.53 , pp. 907-914
    • Mayer, B.J.1    Hamaguchi, M.2    Hanafusa, H.3
  • 9
    • 79955523891 scopus 로고    scopus 로고
    • c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells
    • Mortazavi F, Dubinett S, Rettig M. c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells. Clin Exp Metastasis. 2011;28:391-404.
    • (2011) Clin Exp Metastasis , vol.28 , pp. 391-404
    • Mortazavi, F.1    Dubinett, S.2    Rettig, M.3
  • 10
    • 0242708621 scopus 로고    scopus 로고
    • A core function for p120-catenin in cadherin turnover
    • Davis MA, Ireton RC, Reynolds AB. A core function for p120-catenin in cadherin turnover. J Cell Biol. 2003;163:525-34.
    • (2003) J Cell Biol , vol.163 , pp. 525-534
    • Davis, M.A.1    Ireton, R.C.2    Reynolds, A.B.3
  • 12
    • 0242456021 scopus 로고    scopus 로고
    • Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells
    • Xiao K, Allison DF, Buckley KM, Kottke MD, Vincent PA, Faundez V, et al. Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J Cell Biol. 2003;163:535-45.
    • (2003) J Cell Biol , vol.163 , pp. 535-545
    • Xiao, K.1    Allison, D.F.2    Buckley, K.M.3    Kottke, M.D.4    Vincent, P.A.5    Faundez, V.6
  • 13
    • 54049134839 scopus 로고    scopus 로고
    • PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway
    • Chan PM, Lim L, Manser E. PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway. J Biol Chem. 2008;283:24949-61.
    • (2008) J Biol Chem , vol.283 , pp. 24949-24961
    • Chan, P.M.1    Lim, L.2    Manser, E.3
  • 16
    • 80054758429 scopus 로고    scopus 로고
    • Identification and characterization of mechanism of action of p 61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I
    • Chan LN, Fiji HD, Watanabe M, Kwon O, Tamanoi F. Identification and characterization of mechanism of action of p 61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I. PLoS One. 2011;6:e26135.
    • (2011) PLoS One , vol.6 , pp. e26135
    • Chan, L.N.1    Fiji, H.D.2    Watanabe, M.3    Kwon, O.4    Tamanoi, F.5
  • 17
    • 66849109067 scopus 로고    scopus 로고
    • In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I
    • Lu J, Chan L, Fiji HD, Dahl R, Kwon O, Tamanoi F. In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol Cancer Ther. 2009;8:1218-26.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1218-1226
    • Lu, J.1    Chan, L.2    Fiji, H.D.3    Dahl, R.4    Kwon, O.5    Tamanoi, F.6
  • 18
    • 44349178715 scopus 로고    scopus 로고
    • Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds
    • Watanabe M, Fiji HD, Guo L, Chan L, Kinderman SS, Slamon DJ, et al. Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds. J Biol Chem. 2008;283:9571-9.
    • (2008) J Biol Chem , vol.283 , pp. 9571-9579
    • Watanabe, M.1    Fiji, H.D.2    Guo, L.3    Chan, L.4    Kinderman, S.S.5    Slamon, D.J.6
  • 19
    • 84876741302 scopus 로고    scopus 로고
    • In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells
    • Zimonjic DB, Chan LN, Tripathi V, Lu J, Kwon O, Popescu NC, et al. In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells. BMC Cancer. 2013;13:198.
    • (2013) BMC Cancer , vol.13 , pp. 198
    • Zimonjic, D.B.1    Chan, L.N.2    Tripathi, V.3    Lu, J.4    Kwon, O.5    Popescu, N.C.6
  • 20
    • 30844467746 scopus 로고    scopus 로고
    • Lipid posttranslational modifications. Farnesyl transferase inhibitors
    • Basso AD, Kirschmeier P, Bishop WR. Lipid posttranslational modifications. Farnesyl transferase inhibitors. J Lipid Res. 2006;47:15-31.
    • (2006) J Lipid Res , vol.47 , pp. 15-31
    • Basso, A.D.1    Kirschmeier, P.2    Bishop, W.R.3
  • 21
    • 33746015955 scopus 로고    scopus 로고
    • Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors
    • Rowinsky EK. Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors. J Clin Oncol. 2006;24:2981-4.
    • (2006) J Clin Oncol , vol.24 , pp. 2981-2984
    • Rowinsky, E.K.1
  • 22
    • 18744363084 scopus 로고    scopus 로고
    • Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications
    • Caraglia M, Budillon A, Tagliaferri P, Marra M, Abbruzzese A, Caponigro F. Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications. Curr Drug Targets. 2005;6:301-23.
    • (2005) Curr Drug Targets , vol.6 , pp. 301-323
    • Caraglia, M.1    Budillon, A.2    Tagliaferri, P.3    Marra, M.4    Abbruzzese, A.5    Caponigro, F.6
  • 23
    • 4644228513 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate
    • Caraglia M, D'Alessandro AM, Marra M, Giuberti G, Vitale G, Viscomi C, et al. The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate. Oncogene. 2004;23:6900-13.
    • (2004) Oncogene , vol.23 , pp. 6900-6913
    • Caraglia, M.1    D'Alessandro, A.M.2    Marra, M.3    Giuberti, G.4    Vitale, G.5    Viscomi, C.6
  • 24
    • 35348852712 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways
    • Caraglia M, Marra M, Viscomi C, D'Alessandro AM, Budillon A, Meo G, et al. The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways. Int J Cancer. 2007;121:2317-30.
    • (2007) Int J Cancer , vol.121 , pp. 2317-2330
    • Caraglia, M.1    Marra, M.2    Viscomi, C.3    D'Alessandro, A.M.4    Budillon, A.5    Meo, G.6
  • 25
    • 80054936061 scopus 로고    scopus 로고
    • Inhibition of Ras for cancer treatment: the search continues
    • Baines AT, Xu D, Der CJ. Inhibition of Ras for cancer treatment: the search continues. Future Med Chem. 2011;3:1787-808.
    • (2011) Future Med Chem , vol.3 , pp. 1787-1808
    • Baines, A.T.1    Xu, D.2    Der, C.J.3
  • 26
    • 0035893740 scopus 로고    scopus 로고
    • Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models
    • Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, et al. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res. 2001;61:8758-68.
    • (2001) Cancer Res , vol.61 , pp. 8758-8768
    • Lobell, R.B.1    Omer, C.A.2    Abrams, M.T.3    Bhimnathwala, H.G.4    Brucker, M.J.5    Buser, C.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.