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Volumn 7, Issue 7, 2012, Pages

PAK1 Kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CATENIN; CRK II SERINE 41; P21 ACTIVATED KINASE 1; PROTEIN P120; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84864405697     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042012     Document Type: Article
Times cited : (40)

References (49)
  • 1
    • 0037093230 scopus 로고    scopus 로고
    • High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer
    • Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, et al. ((2002)) High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. JClinOncol 20:: 2417--2428.
    • (2002) JClinOncol , vol.20 , pp. 2417-2428
    • Bremnes, R.M.1    Veve, R.2    Gabrielson, E.3    Hirsch, F.R.4    Baron, A.5
  • 2
    • 35348863666 scopus 로고    scopus 로고
    • Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma
    • Chung Y, Lam AK, Luk JM, Law S, Chan KW, et al. ((2007)) Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma. AnnSurgOncol 14:: 3260--3267.
    • (2007) AnnSurgOncol , vol.14 , pp. 3260-3267
    • Chung, Y.1    Lam, A.K.2    Luk, J.M.3    Law, S.4    Chan, K.W.5
  • 3
    • 0242708621 scopus 로고    scopus 로고
    • A core function for p120-catenin in cadherin turnover
    • Davis MA, Ireton RC, Reynolds AB, ((2003)) A core function for p120-catenin in cadherin turnover. JCell Biol 163:: 525--534.
    • (2003) JCell Biol , vol.163 , pp. 525-534
    • Davis, M.A.1    Ireton, R.C.2    Reynolds, A.B.3
  • 5
    • 3242885068 scopus 로고    scopus 로고
    • NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression
    • Kelly KF, Spring CM, Otchere AA, Daniel JM, ((2004)) NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. JCell Sci 117:: 2675--2686.
    • (2004) JCell Sci , vol.117 , pp. 2675-2686
    • Kelly, K.F.1    Spring, C.M.2    Otchere, A.A.3    Daniel, J.M.4
  • 6
    • 4444317085 scopus 로고    scopus 로고
    • Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer
    • Reynolds AB, Carnahan RH, ((2004)) Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. SeminCell DevBiol 15:: 657--663.
    • (2004) SeminCell DevBiol , vol.15 , pp. 657-663
    • Reynolds, A.B.1    Carnahan, R.H.2
  • 7
    • 33845411513 scopus 로고    scopus 로고
    • p120-catenin: Past and present
    • Reynolds AB, ((2007)) p120-catenin: Past and present. BiochimBiophysActa 1773:: 2--7.
    • (2007) BiochimBiophysActa , vol.1773 , pp. 2-7
    • Reynolds, A.B.1
  • 8
    • 0242456021 scopus 로고    scopus 로고
    • Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells
    • Xiao K, Allison DF, Buckley KM, Kottke MD, Vincent PA, et al. ((2003)) Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. JCell Biol 163:: 535--545.
    • (2003) JCell Biol , vol.163 , pp. 535-545
    • Xiao, K.1    Allison, D.F.2    Buckley, K.M.3    Kottke, M.D.4    Vincent, P.A.5
  • 10
    • 54349083598 scopus 로고    scopus 로고
    • Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters
    • Zhai B, Yan HX, Liu SQ, Chen L, Wu MC, et al. ((2008)) Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters. World JGastroenterol 14:: 3739--3744.
    • (2008) World JGastroenterol , vol.14 , pp. 3739-3744
    • Zhai, B.1    Yan, H.X.2    Liu, S.Q.3    Chen, L.4    Wu, M.C.5
  • 11
    • 77952919218 scopus 로고    scopus 로고
    • p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells
    • Mortazavi F, An J, Dubinett S, Rettig M, ((2010)) p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells. MolCancer Res 8:: 762--774.
    • (2010) MolCancer Res , vol.8 , pp. 762-774
    • Mortazavi, F.1    An, J.2    Dubinett, S.3    Rettig, M.4
  • 12
    • 79955523891 scopus 로고    scopus 로고
    • c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells
    • Mortazavi F, Dubinett S, Rettig M, ((2011)) c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells. ClinExpMetastasis 28:: 391--404.
    • (2011) ClinExpMetastasis , vol.28 , pp. 391-404
    • Mortazavi, F.1    Dubinett, S.2    Rettig, M.3
  • 13
    • 0035475308 scopus 로고    scopus 로고
    • Crk family adaptors-signalling complex formation and biological roles
    • Feller SM, ((2001)) Crk family adaptors-signalling complex formation and biological roles. Oncogene 20:: 6348--6371.
    • (2001) Oncogene , vol.20 , pp. 6348-6371
    • Feller, S.M.1
  • 14
    • 77949828806 scopus 로고    scopus 로고
    • Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
    • Birge RB, Kalodimos C, Inagaki F, Tanaka S, ((2009)) Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell CommunSignal 7:: 13.
    • (2009) Cell CommunSignal , vol.7 , pp. 13
    • Birge, R.B.1    Kalodimos, C.2    Inagaki, F.3    Tanaka, S.4
  • 15
    • 0025332579 scopus 로고
    • Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity
    • Mayer BJ, Hanafusa H, ((1990)) Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. ProcNatlAcadSciUSA 87:: 2638--2642.
    • (1990) ProcNatlAcadSciUSA , vol.87 , pp. 2638-2642
    • Mayer, B.J.1    Hanafusa, H.2
  • 16
    • 0038505214 scopus 로고    scopus 로고
    • Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion
    • Kain KH, Gooch S, Klemke RL, ((2003)) Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene 22:: 6071--6080.
    • (2003) Oncogene , vol.22 , pp. 6071-6080
    • Kain, K.H.1    Gooch, S.2    Klemke, R.L.3
  • 17
    • 0034599542 scopus 로고    scopus 로고
    • Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
    • Cho SY, Klemke RL, ((2000)) Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. JCell Biol 149:: 223--236.
    • (2000) JCell Biol , vol.149 , pp. 223-236
    • Cho, S.Y.1    Klemke, R.L.2
  • 18
    • 36749011318 scopus 로고    scopus 로고
    • Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases
    • Zandy NL, Playford M, Pendergast AM, ((2007)) Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. ProcNatlAcadSciUSA 104:: 17686--17691.
    • (2007) ProcNatlAcadSciUSA , vol.104 , pp. 17686-17691
    • Zandy, N.L.1    Playford, M.2    Pendergast, A.M.3
  • 19
    • 40549133440 scopus 로고    scopus 로고
    • Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases
    • Zandy NL, Pendergast AM, ((2008)) Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases. Cell Cycle 7:: 444--448.
    • (2008) Cell Cycle , vol.7 , pp. 444-448
    • Zandy, N.L.1    Pendergast, A.M.2
  • 20
    • 0032532563 scopus 로고    scopus 로고
    • The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins
    • Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, et al. ((1998)) The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene 17:: 1893--1901.
    • (1998) Oncogene , vol.17 , pp. 1893-1901
    • Oehrl, W.1    Kardinal, C.2    Ruf, S.3    Adermann, K.4    Groffen, J.5
  • 21
    • 0034142337 scopus 로고    scopus 로고
    • Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation
    • Shi CS, Tuscano J, Kehrl JH, ((2000)) Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. Blood 95:: 776--782.
    • (2000) Blood , vol.95 , pp. 776-782
    • Shi, C.S.1    Tuscano, J.2    Kehrl, J.H.3
  • 23
    • 2542451854 scopus 로고    scopus 로고
    • Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions
    • Stofega MR, Sanders LC, Gardiner EM, Bokoch GM, ((2004)) Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. MolBiolCell 15:: 2965--2977.
    • (2004) MolBiolCell , vol.15 , pp. 2965-2977
    • Stofega, M.R.1    Sanders, L.C.2    Gardiner, E.M.3    Bokoch, G.M.4
  • 24
    • 0034680834 scopus 로고    scopus 로고
    • Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
    • Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, et al. ((2000)) Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. JBiolChem 275:: 36238--36244.
    • (2000) JBiolChem , vol.275 , pp. 36238-36244
    • Vadlamudi, R.K.1    Adam, L.2    Wang, R.A.3    Mandal, M.4    Nguyen, D.5
  • 25
    • 79955568142 scopus 로고    scopus 로고
    • Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells
    • Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, et al. ((2011)) Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. ProcNatlAcadSciUSA 108:: 7177--7182.
    • (2011) ProcNatlAcadSciUSA , vol.108 , pp. 7177-7182
    • Ong, C.C.1    Jubb, A.M.2    Haverty, P.M.3    Zhou, W.4    Tran, V.5
  • 26
    • 0034637444 scopus 로고    scopus 로고
    • Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis
    • Escalante M, Courtney J, Chin WG, Teng KK, Kim JI, et al. ((2000)) Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. JBiolChem 275:: 24787--24797.
    • (2000) JBiolChem , vol.275 , pp. 24787-24797
    • Escalante, M.1    Courtney, J.2    Chin, W.G.3    Teng, K.K.4    Kim, J.I.5
  • 27
    • 0028347526 scopus 로고
    • Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways
    • Hempstead BL, Birge RB, Fajardo JE, Glassman R, Mahadeo D, et al. ((1994)) Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways. MolCell Biol 14:: 1964--1971.
    • (1994) MolCell Biol , vol.14 , pp. 1964-1971
    • Hempstead, B.L.1    Birge, R.B.2    Fajardo, J.E.3    Glassman, R.4    Mahadeo, D.5
  • 28
    • 0344255674 scopus 로고    scopus 로고
    • Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    • Miller CT, Chen G, Gharib TG, Wang H, Thomas DG, et al. ((2003)) Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. Oncogene 22:: 7950--7957.
    • (2003) Oncogene , vol.22 , pp. 7950-7957
    • Miller, C.T.1    Chen, G.2    Gharib, T.G.3    Wang, H.4    Thomas, D.G.5
  • 29
    • 55249119108 scopus 로고    scopus 로고
    • Biochemical and structural characterization of the Pak1-LC8 interaction
    • Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T, et al. ((2008)) Biochemical and structural characterization of the Pak1-LC8 interaction. JBiolChem 283:: 27314--27324.
    • (2008) JBiolChem , vol.283 , pp. 27314-27324
    • Lightcap, C.M.1    Sun, S.2    Lear, J.D.3    Rodeck, U.4    Polenova, T.5
  • 32
    • 0033577902 scopus 로고    scopus 로고
    • p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
    • Sells MA, Boyd JT, Chernoff J, ((1999)) p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. JCell Biol 145:: 837--849.
    • (1999) JCell Biol , vol.145 , pp. 837-849
    • Sells, M.A.1    Boyd, J.T.2    Chernoff, J.3
  • 34
    • 0041423391 scopus 로고    scopus 로고
    • Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
    • Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, et al. ((2003)) Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. AmJPathol 163:: 985--992.
    • (2003) AmJPathol , vol.163 , pp. 985-992
    • Schraml, P.1    Schwerdtfeger, G.2    Burkhalter, F.3    Raggi, A.4    Schmidt, D.5
  • 35
    • 2542452838 scopus 로고    scopus 로고
    • Pak-1 expression increases with progression of colorectal carcinomas to metastasis
    • Carter JH, Douglass LE, Deddens JA, Colligan BM, Bhatt TR, et al. ((2004)) Pak-1 expression increases with progression of colorectal carcinomas to metastasis. ClinCancer Res 10:: 3448--3456.
    • (2004) ClinCancer Res , vol.10 , pp. 3448-3456
    • Carter, J.H.1    Douglass, L.E.2    Deddens, J.A.3    Colligan, B.M.4    Bhatt, T.R.5
  • 36
    • 0042466610 scopus 로고    scopus 로고
    • Pak1 and PIX regulate contact inhibition during epithelial wound healing
    • Zegers MM, Forget MA, Chernoff J, Mostov KE, Ter Beest MB, et al. ((2003)) Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J 22:: 4155--4165.
    • (2003) EMBO J , vol.22 , pp. 4155-4165
    • Zegers, M.M.1    Forget, M.A.2    Chernoff, J.3    Mostov, K.E.4    Ter Beest, M.B.5
  • 37
    • 0036711657 scopus 로고    scopus 로고
    • Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
    • Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, et al. ((2002)) Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. NatCell Biol 4:: 681--690.
    • (2002) NatCell Biol , vol.4 , pp. 681-690
    • Vadlamudi, R.K.1    Li, F.2    Adam, L.3    Nguyen, D.4    Ohta, Y.5
  • 38
    • 0033194037 scopus 로고    scopus 로고
    • Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
    • Edwards DC, Sanders LC, Bokoch GM, Gill GN, ((1999)) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. NatCell Biol 1:: 253--259.
    • (1999) NatCell Biol , vol.1 , pp. 253-259
    • Edwards, D.C.1    Sanders, L.C.2    Bokoch, G.M.3    Gill, G.N.4
  • 39
    • 0032511882 scopus 로고    scopus 로고
    • The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
    • King AJ, Sun H, Diaz B, Barnard D, Miao W, et al. ((1998)) The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396:: 180--183.
    • (1998) Nature , vol.396 , pp. 180-183
    • King, A.J.1    Sun, H.2    Diaz, B.3    Barnard, D.4    Miao, W.5
  • 40
    • 0030830220 scopus 로고    scopus 로고
    • Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
    • Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, et al. ((1997)) Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 16:: 6426--6438.
    • (1997) EMBO J , vol.16 , pp. 6426-6438
    • Frost, J.A.1    Steen, H.2    Shapiro, P.3    Lewis, T.4    Ahn, N.5
  • 41
    • 0029950672 scopus 로고    scopus 로고
    • Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members
    • Frost JA, Xu S, Hutchison MR, Marcus S, Cobb MH, ((1996)) Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. MolCell Biol 16:: 3707--3713.
    • (1996) MolCell Biol , vol.16 , pp. 3707-3713
    • Frost, J.A.1    Xu, S.2    Hutchison, M.R.3    Marcus, S.4    Cobb, M.H.5
  • 42
    • 0028820587 scopus 로고
    • Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
    • Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, et al. ((1995)) Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. JBiolChem 270:: 23934--23936.
    • (1995) JBiolChem , vol.270 , pp. 23934-23936
    • Zhang, S.1    Han, J.2    Sells, M.A.3    Chernoff, J.4    Knaus, U.G.5
  • 43
    • 0030134625 scopus 로고    scopus 로고
    • Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
    • Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, et al. ((1996)) Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. CurrBiol 6:: 598--605.
    • (1996) CurrBiol , vol.6 , pp. 598-605
    • Brown, J.L.1    Stowers, L.2    Baer, M.3    Trejo, J.4    Coughlin, S.5
  • 44
    • 0029911520 scopus 로고    scopus 로고
    • The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway
    • Teramoto H, Crespo P, Coso OA, Igishi T, Xu N, et al. ((1996)) The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway. JBiolChem 271:: 25731--25734.
    • (1996) JBiolChem , vol.271 , pp. 25731-25734
    • Teramoto, H.1    Crespo, P.2    Coso, O.A.3    Igishi, T.4    Xu, N.5
  • 45
    • 0031026132 scopus 로고    scopus 로고
    • Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
    • Westwick JK, Lambert QT, Clark GJ, Symons M, Van AL, et al. ((1997)) Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. MolCell Biol 17:: 1324--1335.
    • (1997) MolCell Biol , vol.17 , pp. 1324-1335
    • Westwick, J.K.1    Lambert, Q.T.2    Clark, G.J.3    Symons, M.4    van, A.L.5
  • 46
    • 0030584079 scopus 로고    scopus 로고
    • Apoptosis meets signal transduction: elimination of a BAD influence
    • Gajewski TF, Thompson CB, ((1996)) Apoptosis meets signal transduction: elimination of a BAD influence. Cell 87:: 589--592.
    • (1996) Cell , vol.87 , pp. 589-592
    • Gajewski, T.F.1    Thompson, C.B.2
  • 47
    • 33746383082 scopus 로고    scopus 로고
    • Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD
    • Sastry KS, Smith AJ, Karpova Y, Datta SR, Kulik G, ((2006)) Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD. JBiolChem 281:: 20891--20901.
    • (2006) JBiolChem , vol.281 , pp. 20891-20901
    • Sastry, K.S.1    Smith, A.J.2    Karpova, Y.3    Datta, S.R.4    Kulik, G.5
  • 48
    • 0040056864 scopus 로고    scopus 로고
    • p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
    • Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, et al. ((2000)) p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. MolCell Biol 20:: 453--461.
    • (2000) MolCell Biol , vol.20 , pp. 453-461
    • Schurmann, A.1    Mooney, A.F.2    Sanders, L.C.3    Sells, M.A.4    Wang, H.G.5
  • 49
    • 33750324597 scopus 로고    scopus 로고
    • HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta
    • Wang SE, Shin I, Wu FY, Friedman DB, Arteaga CL, ((2006)) HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res 66:: 9591--9600.
    • (2006) Cancer Res , vol.66 , pp. 9591-9600
    • Wang, S.E.1    Shin, I.2    Wu, F.Y.3    Friedman, D.B.4    Arteaga, C.L.5


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