Glucose-dependent insulin secretion in pancreatic β-cell islets from male rats requires Ca2+ release via ROS-stimulated ryanodine receptors

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Llanos, Paola ^a,b   Contreras Ferrat, Ariel ^a,b   Barrientos, Genaro ^b   Valencia, Marco ^b   Mears, David ^a,b,c   Hidalgo, Cecilia ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c Uniformed Services University of the Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CAFFEINE; CALCIUM ION; CALNEXIN; CARBACHOL; GLUCOSE; GLUCOSE TRANSPORTER 2; HYDROGEN PEROXIDE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INSULIN; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR; RYANODINE RECEPTOR 2; THAPSIGARGIN; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM; OXIDIZING AGENT; RYANODINE; SCAVENGER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; EXOCYTOSIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; RAT; S GLUTATHIONYLATION; ANIMAL; CELL CULTURE; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE; PANCREAS ISLET; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

RATTUS;

ACETYLCYSTEINE; ANIMALS; CAFFEINE; CALCIUM; CARBACHOL; CELL LINE, TUMOR; CELLS, CULTURED; FREE RADICAL SCAVENGERS; GENE EXPRESSION; GLUCOSE; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICROSCOPY, CONFOCAL; OXIDANTS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 84935006953     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129238     Document Type: Article

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