Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase

European Journal of Pharmaceutical Sciences

Volumn 77, Issue , 2015, Pages 180-188

  Navia Paldanius, Dina ^a   Aaltonen, Niina ^a   Lehtonen, Marko ^a   Savinainen, Juha R ^a   Taschler, Ulrike ^b   Radner, Franz P W ^b   Zimmermann, Robert ^b   Laitinen, Jarmo T ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

2 arachidonoylglycerol; Cannabinoid CB1 receptor; Desensitization; Endocannabinoid; Monoacylglycerol lipase knockout; 35S GTP S autoradiography

Indexed keywords

ACYLGLYCEROL LIPASE; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; HYDROLASE; SERINE HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; DESENSITIZATION; ENZYME ACTIVITY; IN VIVO STUDY; KNOCKOUT GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; WILD TYPE; ANIMAL; BRAIN; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; MICE; MICE, KNOCKOUT; MONOACYLGLYCEROL LIPASES; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION;

EID: 84934986052     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.06.005     Document Type: Article

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