Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography

Journal of Neurochemistry

Volumn 101, Issue 4, 2007, Pages 972-981

  Palomäki, Ville A B ^a   Lehtonen, Marko ^a   Savinainen, Juha R ^a   Laitinen, Jarmo T ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

2 arachidonoylglycerol; 35S GTP S autoradiography; Cannabinoid CB1 receptor; Endocannabinoid; Methyl arachidonoylfluorophosphonate; Tetrahydrolipstatin

Indexed keywords

1,6 HEXAMETHYLENEDICARBAMIC ACID BIS(CYCLOHEXANONE OXIME) ESTER; 2 ARACHIDONOYLGLYCEROL; CANNABINOID 1 RECEPTOR; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; FLUORIDE; HEXADECYLSULFONYL FLUORIDE; METHYL ARACHIDONYLFLUOROPHOSPHONATE; PHOSPHONIC ACID DERIVATIVE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HYDROLYSIS; LIPID STORAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; ARACHIDONIC ACIDS; AUTORADIOGRAPHY; BENZAMIDES; BINDING, COMPETITIVE; BRAIN; CARBAMATES; CRYOULTRAMICROTOMY; DRUG INTERACTIONS; ENZYME INHIBITORS; GLYCERIDES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; PHOSPHONIC ACIDS; PIPERIDINES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; SULFONES;

RATTUS;

EID: 34147148435     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04403.x     Document Type: Article

References (32)

1. Bisogno T., Cascio M. G., Saha B., et al. (2006) Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochim. Biophys. Acta 1761, 205 212.
2. Bisogno T., Howell F., Williams G., et al. (2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell Biol. 163, 463 468.
3. Dinh T. P., Carpenter D., Leslie F. M., Freund T. F., Katona I., Sensi S. L., Kathuria S. Piomelli D. (2002) Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc. Natl Acad. Sci. USA 99, 10.
4. Edwards D. A., Kim J. Alger B. E. (2005) Mechanisms of endocannabinoid response initiation in hippocampus. J. Neurophysiol. 95, 67 75.
5. Eljaschewitsch E., Witting A., Mawrin C., et al. (2006) The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron 49, 67 79.
6. 1 cannabinoid receptor-dependent modulation of feeding. J. Neurosci. 22, 9612 9617.
7. Goparaju S. K., Ueda N., Yamaguchi H. Yamamoto S. (1998) Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand. FEBS Lett. 422, 69 73.
8. Gulyas A. I., Cravatt B. F., Bracey M. H., Dinh T. P., Piomelli D., Boscia F. Freund T. F. (2004) Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Eur. J. Neurosci. 20, 441 458.
9. Herkenham M., Lynn A. B., Johnson M. R., Melvin L. S., de Costa B. R. Rice K. C. (1991) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. 11, 563 583.
10. Jaeger K. E., Dijkstra B. W. Reetz M. T. (1999) Bacterial biocatalysts: molecular biology, three-dimensional structures, and biotechnological applications of lipases. Annu. Rev. Microbiol. 53, 315 351.
11. Jung K. M., Mangieri R., Stapleton C., Kim J., Fegley D., Wallace M., Mackie K. Piomelli D. (2005) Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Mol. Pharmacol. 68, 1196 1202.
12. Katona I., Urban G. M., Wallace M., Ledent C., Jung K. M., Piomelli D., Mackie K. Freund T. F. (2006) Molecular composition of the endocannabinoid system at glutamatergic synapses. J. Neurosci. 26, 5628 5637.
13. Laitinen J. T. (1999) Selective detection of adenosine A1 receptor-dependent G-protein activity in basal and stimulated conditions of rat brain [35S]guanosine 5′-(gamma-thio)triphosphate autoradiography. Neuroscience 90, 1265 1279.
14. Laitinen J. T. (2004) [35S]GTPγS autoradiography: a powerful functional approach with expanding potential for neuropharmacological studies on receptors coupled to Gi family of G proteins. Curr. Neuropharmacol. 2, 191 206.
15. Massa F., Storr M. Lutz B. (2005) The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract. J. Mol. Med. 83, 944 954.
16. Palomäki V. A. Laitinen J. T. (2006) The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections. Br. J. Pharmacol. 147, 596 606.
17. Patricelli M. P. Cravatt B. F. (1999) Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism. Biochemistry 38, 14.
18. Piomelli D. (2003) The molecular logic of endocannabinoid signalling. Nat. Rev. Neurosci. 4, 873 884.
19. Saario S. M., Savinainen J. R., Laitinen J. T., Järvinen T. Niemi R. (2004) Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. Biochem. Pharmacol. 67, 1381 1387.
20. Saario S. M., Salo O. M., Nevalainen T., Poso A., Laitinen J. T., Järvinen T. Niemi R (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem. Biol. 12, 649 656.
21. Saario S. M., Palomäki V., Lehtonen M., Nevalainen T., Järvinen T. Laitinen J. T. (2006) URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. Chem. Biol. 13, 811 814.
22. 1 receptor-dependent G-protein activation in rat cerebellar membranes. Br. J. Pharmacol. 134, 664 672.
23. 1 receptors. Br. J. Pharmacol. 140, 1451 1459.
24. Sekar M. C., Dickinson K. E., Pruitt R. E., Hirschowitz B. I. Hokin L. E. (1990) Muscarinic receptor antagonist activity of diacylglycerol lipase and kinase inhibitors. Biochem. Pharmacol. 39, 2069 2073.
25. Sim L. J., Selley D. E. Childers S. R. (1995) In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5′-[gamma-[35S]thio]-triphosphate binding. Proc. Natl Acad. Sci. USA 92, 7242 7246.
26. Sovago J., Dupuis D. S., Gulyas B. Hall H. (2001) An overview on functional receptor autoradiography using [35S]GTPγS. Brain Res. Rev. 38, 149 164.
27. Stella N., Schweitzer P. Piomelli D. (1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature 388, 773 778.
28. 1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. J. Biol. Chem. 274, 2794 2801.
29. Sugiura T., Yoshinaga N. Waku K. (2001) Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation. Neurosci. Lett. 297, 175 178.
30. Sugiura T., Kishimoto S., Oka S. Gokoh M. (2006) Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog. Lipid. Res. 45, 405 446.
31. 1 receptor. J. Neurosci. 26, 4740 4751.
32. Zhi J., Melia A. T., Eggers H., Joly R. Patel I. H. (1995) Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J. Clin. Pharmacol. 35, 1103 1108.