Sesquiterpene lactones from Ambrosia spp. are active against a murine lymphoma cell line by inducing apoptosis and cell cycle arrest

Toxicology in Vitro

Volumn 29, Issue 7, 2015, Pages 1529-1536

  Martino, Renzo ^a   Beer, María Florencia ^a   Elso, Orlando ^a   Donadel, Osvaldo ^a   Sülsen, Valeria ^a   Anesini, Claudia ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Apoptosis; Cytotoxicity; Oxidative stress; Sesquiterpene lactones; T cell lymphoma

Indexed keywords

CATALASE; CUMANIN; PEROXIDASE; PERUVIN; PSILOSTACHYIN; PSILOSTACHYIN C; REACTIVE OXYGEN METABOLITE; SESQUITERPENE LACTONE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; FUSED HETEROCYCLIC RINGS; LACTONE; PYRONE DERIVATIVE; SESQUITERPENE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL DEATH; CELL MEDIATED CYTOTOXICITY; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; FLOW CYTOMETRY; LYMPHOMA CELL LINE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MTT ASSAY; NONHUMAN; RAGWEED; ANIMAL; CELL CYCLE CHECKPOINT; DRUG EFFECTS; LYMPHOMA; METABOLISM; TUMOR CELL LINE;

AMBROSIA; MURINAE;

AMBROSIA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; HETEROCYCLIC COMPOUNDS, 3-RING; LACTONES; LYMPHOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; PYRONES; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84934965668     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2015.06.011     Document Type: Article

References (33)

1. Alexander B., Browse D., Reading S., Benjamin I. A simple and accurate mathematicalmethodfor calculation of theEC50. J. Pharmacol. Toxicol.Methods 1999, 41:55-58.
2. Amslinger S. The unable functionality of alpha-beta unsaturated carbonyl compounds enables their differential application in biological systems. Chem. Med. Chem. 2010, 5:351-356.
3. Armitage J. The aggressive peripheral T-cell lymphomas: 2012 update on diagnosis, risk stratification, and management. Am. J. Hematol. 2012, 87:512-519.
4. Chaturvedi D. Sesquiterpene lactones: structural diversity and their biological activities. Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry 2011, 313-334. Research Signpost, Kerala, India.
5. Csupor-Löffler B., Hajdú Z., Zupkó I., Réthy B., Falkay G., Forgo P., Hohmann J. Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. Phytother. Res. 2009, 23:672-676.
6. Davicino R., Manuele M.G., Ferraro G., Micalizzi B., Anesini C. Modulatory effect of hydrogen peroxide on tumoral lymphocytes proliferation. Immunopharmacol. Immunotoxicol. 2009, 31:130-139.
7. Davicino R., Manuele M.G., Turner S., Ferraro G., Anesini C. Antiproliferative activity of Larrea divaricata Cav. on a lymphoma cell line: participation of hydrogen peroxide in its action. Cancer Invest. 2010, 28:13-22.
8. Davicino R., Genaro A., Cremaschi G., Anesini C. Leukotrienes antagonize the antiproliferative effect of Larrea divaricata Cav. on a lymphoma cell line interfering with cAMP intracellular level and PKC activity. Cancer Invest. 2011, 29:29-36.
9. Desoti V.C., Lazarin-Bidoia P., Sudatti D.B., Pereira R.C., Alonso A., Ueda-Nakamura T., Dias Filho B.P., Nakamura C.V., Oliveira Silva S. Trypanocidal action of (-) elatol involves an oxidative stress triggered by mitochondria dysfunction. Mar. Drugs 2012, 10:1631-1646.
10. Di Rosso M., Barreiro Arcos M.L., Elingold I., Sterle H., Baptista Ferreira S., Ferreira V., Galleano M., Cremaschi G., Dubin M. Novelo-naphthoquinones induce apoptosis of EL-4 T lymphoma cells through the increase of reactive oxygen species. Toxicol. In Vitro 2013, 27:2094-2104.
11. Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D.M., Forman D., Bray, F., 2012. Globocan 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. IARC Cancer. Base, p. 11.
12. Gach K., Janecka A. α-Methylene-γ-lactones as a novel class of anti-leukemic agents. Anticancer Agents Med. Chem. 2014, 14:688-694.
13. Ghantous A., Gali-Muhtasib H., Vuorela H., Saliba N.A., Darwiche N. What made sesquiterpene lactones reach cancer clinical trials?. Drug Discov. Today 2010, 15:668-678.
14. Hopfinger G., Griessl R., Sifft E., Taylor N., Kenner L., Greil R., Merkel O. Novel treatmentavenues for peripheralT-celllymphomas. Expert Opin. Drug Discov. 2012, 7:1149-1163.
15. Jaffe E. The 2008 WHO classification of lymphomas: implications for clinical practice and translational research. Hematol. Am. Soc. Hematol. Educ. Program. 2009, 1:523-531.
16. Khan M., Yi F., Rasul A., Li T., Wang N., Gao H., Gao R., Ma T. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life 2012, 64:783-794.
17. Kiguchi N., Maeda T., Kobayashi Y., Saika F., Kishioka S. Involvement of inflammatory mediators in neuropathic pain caused by vincristine. Int. Rev. Neurobiol. 2009, 85:179-190.
18. Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007, 87:99-163.
19. Lohberger B., Rinner B., Stuendl N., Kaltenegger H., Steinecker-Frohnwieser B., Bernhart E., Bonyadi Rad E., Weinberg A.M., Leithner A., Bauer R., Kretschmer N. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS One 2013, 8:1-9.
20. Manuele G., Barreiro Arcos M.L., Davicino R., Ferraro G., Cremaschi G., Anesini C. Mechanism of the antiproliferative action of limonene on a lymphoma cell line: participation of nitric oxide. Phytother. Res. 2009, 23:1011-1017.
21. Martino R., Sülsen V., Alonso R., Anesini C. A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line. Leukemia Res. 2013, 37:1137-1143.
22. Merfort I. Perspectives on sesquiterpene lactones in inflammation and cancer. Curr. Drug Targets 2011, 12:1560-1573.
23. Newman D., Cragg G. Natural products as sources of new drugs over the 30years from 1981 to 2010. J. Nat. Prod. 2012, 75:311-335.
24. Newman D., Cragg G. Natural products: a continuing source of novel drug leads. Biochim. Biophys. Acta 2013, 1830:3670-3695.
25. Porrata L.F., Rsitow K., Inwards D.J., Ansell S.M., Micallef I.N., Johnston P.B., Habermann T.M., Witzig T.E., Colgan J.P., Nowakowski G.S., Thompson C.A., Markovic S.N. Lymphopenia assessed during routine follow-up after immunochemotherapy (R-CHOP) is a risk factor for predicting relapse in patients with diffuse large B-cell lymphoma. Leukemia 2010, 24:1343-1349.
26. Saeidnia S. Anti-oxidative trypanocidal drugs myth or reality. Daru 2013, 21:21.
27. Scotti M.T., Fernandes M.B., Ferreira M.J., Emerenciano V.P. Quantitative structure-activity relationship of sesquiterpene lactones with cytotoxic activity. Bioorg. Med. Chem. 2007, 15:2927-2934.
28. Sturgeon C.M., Craig K., Brown C., Rundle N.T., Andersen R.J., Roberge M. Modulation of the G2 cell cycle checkpoint by sesquiterpene lactones psilostachyins A and C isolated from the common ragweed Ambrosia artemisiifolia. Planta Med. 2005, 71:938-943.
29. Sülsen V., Frank F., Cazorla S., Anesini C., Malchiodi E., Freixa B., Vila R., Muschietti L., Martino V. Trypanocidal and leishmanicidal activities of sesquiterpene lactones from Ambrosia tenuifolia Sprengel (Asteraceae). Antimicrob. Agents Chemother. 2008, 52:2415-2419.
30. Sülsen V., Frank F., Cazorla S., Barrera P., Freixa B., Vila R., Sosa M., Malchiodi E., Muschietti L., Martino V. Psilostachyin C: a natural compound with trypanocidal activity. Int. J. Antimicrob. Agents 2011, 37:536-543.
31. Sülsen V., Gutierrez Yappu D., Laurella L., Anesini C., Gimenez Turba A., Martino V., Muschietti L. In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia. Evid. Based Complement. Alternat. Med. 2011, 4. 352938.
32. Sülsen V., Cazorla S., Frank F., Laurella L., Muschietti L., Catalan C., Martino V., Malchiodi E. Natural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatids. PLoS Negl. Trop. Dis. 2013, 7(e2494):1-10.
33. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39:44-84.