메뉴 건너뛰기




Volumn 12, Issue 1, 2015, Pages

Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes

Author keywords

Ectocervical explants; HIV 1 envelopes; Macrophages; T cells; Tropism

Indexed keywords

ARTICLE; CONTROLLED STUDY; ECTOCERVICAL EXPLANT; EXPLANT; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MONOCYTE; NONHUMAN; PSEUDOVIRION; REPORTER GENE; T LYMPHOCYTE; VIRAL TROPISM; VIRION; VIRUS ENVELOPE; VIRUS STRAIN; VIRUS TITRATION; CELL CULTURE; HUMAN; METABOLISM; PHYSIOLOGY; VIROLOGY;

EID: 84934907859     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/s12977-015-0176-2     Document Type: Article
Times cited : (6)

References (53)
  • 1
    • 0032837669 scopus 로고    scopus 로고
    • Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences
    • Carrington M, Dean M, Martin MP, O'Brien SJ (1999) Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum Mol Genet 8:1939-1945
    • (1999) Hum Mol Genet , vol.8 , pp. 1939-1945
    • Carrington, M.1    Dean, M.2    Martin, M.P.3    O'Brien, S.J.4
  • 2
    • 64049089430 scopus 로고    scopus 로고
    • Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants
    • Abrahams MR, Anderson JA, Giorgi EE, Seoighe C, Mlisana K, Ping LH et al (2009) Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants. J Virol 83:3556-3567
    • (2009) J Virol , vol.83 , pp. 3556-3567
    • Abrahams, M.R.1    Anderson, J.A.2    Giorgi, E.E.3    Seoighe, C.4    Mlisana, K.5    Ping, L.H.6
  • 4
    • 2942687021 scopus 로고    scopus 로고
    • Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages
    • Peters PJ, Bhattacharya J, Hibbitts S, Dittmar MT, Simmons G, Bell J et al (2004) Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages. J Virol 78:6915-6926
    • (2004) J Virol , vol.78 , pp. 6915-6926
    • Peters, P.J.1    Bhattacharya, J.2    Hibbitts, S.3    Dittmar, M.T.4    Simmons, G.5    Bell, J.6
  • 5
    • 33745234283 scopus 로고    scopus 로고
    • Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis
    • Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R et al (2006) Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis. J Virol 80:6324-6332
    • (2006) J Virol , vol.80 , pp. 6324-6332
    • Peters, P.J.1    Sullivan, W.M.2    Duenas-Decamp, M.J.3    Bhattacharya, J.4    Ankghuambom, C.5    Brown, R.6
  • 6
    • 0023214674 scopus 로고
    • Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms
    • Koyanagi Y, Miles S, Mitsuyasu RT, Merrill JE, Vinters HV, Chen IS (1987) Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236:819-822
    • (1987) Science , vol.236 , pp. 819-822
    • Koyanagi, Y.1    Miles, S.2    Mitsuyasu, R.T.3    Merrill, J.E.4    Vinters, H.V.5    Chen, I.S.6
  • 8
    • 33750485035 scopus 로고    scopus 로고
    • HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes
    • Goodenow MM, Collman RG (2006) HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes. J Leukoc Biol 80:965-972
    • (2006) J Leukoc Biol , vol.80 , pp. 965-972
    • Goodenow, M.M.1    Collman, R.G.2
  • 9
    • 0034796289 scopus 로고    scopus 로고
    • Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity
    • Gorry PR, Bristol G, Zack JA, Ritola K, Swanstrom R, Birch CJ et al (2001) Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol 75:10073-10089
    • (2001) J Virol , vol.75 , pp. 10073-10089
    • Gorry, P.R.1    Bristol, G.2    Zack, J.A.3    Ritola, K.4    Swanstrom, R.5    Birch, C.J.6
  • 10
    • 41149099165 scopus 로고    scopus 로고
    • Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors
    • Peters PJ, Duenas-Decamp MJ, Sullivan WM, Brown R, Ankghuambom C, Luzuriaga K et al (2008) Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors. Retrovirology 5:5
    • (2008) Retrovirology , vol.5 , pp. 5
    • Peters, P.J.1    Duenas-Decamp, M.J.2    Sullivan, W.M.3    Brown, R.4    Ankghuambom, C.5    Luzuriaga, K.6
  • 11
    • 80055096215 scopus 로고    scopus 로고
    • HIV-1 replication in the central nervous system occurs in two distinct cell types
    • Schnell G, Joseph S, Spudich S, Price RW, Swanstrom R (2011) HIV-1 replication in the central nervous system occurs in two distinct cell types. PLoS Pathog 7:e1002286
    • (2011) PLoS Pathog , vol.7 , pp. e1002286
    • Schnell, G.1    Joseph, S.2    Spudich, S.3    Price, R.W.4    Swanstrom, R.5
  • 12
    • 33847281316 scopus 로고    scopus 로고
    • Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion
    • Thomas ER, Dunfee RL, Stanton J, Bogdan D, Taylor J, Kunstman K et al (2007) Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion. Virology 360:105-119
    • (2007) Virology , vol.360 , pp. 105-119
    • Thomas, E.R.1    Dunfee, R.L.2    Stanton, J.3    Bogdan, D.4    Taylor, J.5    Kunstman, K.6
  • 13
    • 62749141506 scopus 로고    scopus 로고
    • Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes
    • Duenas-Decamp MJ, Peters PJ, Burton D, Clapham PR (2009) Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes. J Virol 83:2575-2583
    • (2009) J Virol , vol.83 , pp. 2575-2583
    • Duenas-Decamp, M.J.1    Peters, P.J.2    Burton, D.3    Clapham, P.R.4
  • 14
    • 33750036975 scopus 로고    scopus 로고
    • The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia
    • Dunfee RL, Thomas ER, Gorry PR, Wang J, Taylor J, Kunstman K et al (2006) The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia. Proc Natl Acad Sci USA 103:15160-15165
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15160-15165
    • Dunfee, R.L.1    Thomas, E.R.2    Gorry, P.R.3    Wang, J.4    Taylor, J.5    Kunstman, K.6
  • 15
    • 77956043460 scopus 로고    scopus 로고
    • HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12
    • Duenas-Decamp MJ, Clapham PR (2010) HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12. J Virol 84:9608-9612
    • (2010) J Virol , vol.84 , pp. 9608-9612
    • Duenas-Decamp, M.J.1    Clapham, P.R.2
  • 16
    • 79551700244 scopus 로고    scopus 로고
    • A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection
    • Musich T, Peters PJ, Duenas-Decamp MJ, Gonzalez-Perez MP, Robinson J, Zolla-Pazner S et al (2011) A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection. J Virol 85:2397-2405
    • (2011) J Virol , vol.85 , pp. 2397-2405
    • Musich, T.1    Peters, P.J.2    Duenas-Decamp, M.J.3    Gonzalez-Perez, M.P.4    Robinson, J.5    Zolla-Pazner, S.6
  • 17
    • 16244379228 scopus 로고    scopus 로고
    • Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages
    • Walter BL, Wehrly K, Swanstrom R, Platt E, Kabat D, Chesebro B (2005) Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages. J Virol 79:4828-4837
    • (2005) J Virol , vol.79 , pp. 4828-4837
    • Walter, B.L.1    Wehrly, K.2    Swanstrom, R.3    Platt, E.4    Kabat, D.5    Chesebro, B.6
  • 18
    • 84871993689 scopus 로고    scopus 로고
    • Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism
    • O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED et al (2013) Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism. J Virol 87:187-198
    • (2013) J Virol , vol.87 , pp. 187-198
    • O'Connell, O.1    Repik, A.2    Reeves, J.D.3    Gonzalez-Perez, M.P.4    Quitadamo, B.5    Anton, E.D.6
  • 19
    • 84858113500 scopus 로고    scopus 로고
    • Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue
    • Gonzalez-Perez MP, O'Connell O, Lin R, Sullivan WM, Bell J, Simmonds P (2012) Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue. Retrovirology 9:20
    • (2012) Retrovirology , vol.9 , pp. 20
    • Gonzalez-Perez, M.P.1    O'Connell, O.2    Lin, R.3    Sullivan, W.M.4    Bell, J.5    Simmonds, P.6
  • 21
    • 66049139947 scopus 로고    scopus 로고
    • Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection
    • Salazar-Gonzalez JF, Salazar MG, Keele BF, Learn GH, Giorgi EE, Li H et al (2009) Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. J Exp Med 206:1273-1289
    • (2009) J Exp Med , vol.206 , pp. 1273-1289
    • Salazar-Gonzalez, J.F.1    Salazar, M.G.2    Keele, B.F.3    Learn, G.H.4    Giorgi, E.E.5    Li, H.6
  • 23
    • 34249789875 scopus 로고    scopus 로고
    • Unique mutational patterns in the envelope alpha 2 amphipathic helix and acquisition of length in gp120 hypervariable domains are associated with resistance to autologous neutralization of subtype C human immunodeficiency virus type 1
    • Rong R, Gnanakaran S, Decker JM, Bibollet-Ruche F, Taylor J, Sfakianos JN et al (2007) Unique mutational patterns in the envelope alpha 2 amphipathic helix and acquisition of length in gp120 hypervariable domains are associated with resistance to autologous neutralization of subtype C human immunodeficiency virus type 1. J Virol 81:5658-5668
    • (2007) J Virol , vol.81 , pp. 5658-5668
    • Rong, R.1    Gnanakaran, S.2    Decker, J.M.3    Bibollet-Ruche, F.4    Taylor, J.5    Sfakianos, J.N.6
  • 24
    • 67749118313 scopus 로고    scopus 로고
    • Heterosexual transmission of human immunodeficiency virus type 1 subtype C: macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization
    • Isaacman-Beck J, Hermann EA, Yi Y, Ratcliffe SJ, Mulenga J, Allen S et al (2009) Heterosexual transmission of human immunodeficiency virus type 1 subtype C: macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization. J Virol 83:8208-8220
    • (2009) J Virol , vol.83 , pp. 8208-8220
    • Isaacman-Beck, J.1    Hermann, E.A.2    Yi, Y.3    Ratcliffe, S.J.4    Mulenga, J.5    Allen, S.6
  • 25
    • 77950493667 scopus 로고    scopus 로고
    • Donor and recipient envs from heterosexual human immunodeficiency virus subtype C transmission pairs require high receptor levels for entry
    • Alexander M, Lynch R, Mulenga J, Allen S, Derdeyn CA, Hunter E (2010) Donor and recipient envs from heterosexual human immunodeficiency virus subtype C transmission pairs require high receptor levels for entry. J Virol 84:4100-4104
    • (2010) J Virol , vol.84 , pp. 4100-4104
    • Alexander, M.1    Lynch, R.2    Mulenga, J.3    Allen, S.4    Derdeyn, C.A.5    Hunter, E.6
  • 26
    • 84872117539 scopus 로고    scopus 로고
    • Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants
    • Fouda GG, Mahlokozera T, Salazar-Gonzalez JF, Salazar MG, Learn G, Kumar SB et al (2013) Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. Retrovirology 10:3
    • (2013) Retrovirology , vol.10 , pp. 3
    • Fouda, G.G.1    Mahlokozera, T.2    Salazar-Gonzalez, J.F.3    Salazar, M.G.4    Learn, G.5    Kumar, S.B.6
  • 27
    • 84857830668 scopus 로고    scopus 로고
    • Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages
    • Ochsenbauer C, Edmonds TG, Ding H, Keele BF, Decker J, Salazar MG et al (2012) Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages. J Virol 86:2715-2728
    • (2012) J Virol , vol.86 , pp. 2715-2728
    • Ochsenbauer, C.1    Edmonds, T.G.2    Ding, H.3    Keele, B.F.4    Decker, J.5    Salazar, M.G.6
  • 28
    • 80052302577 scopus 로고    scopus 로고
    • Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins
    • Wilen CB, Parrish NF, Pfaff JM, Decker JM, Henning EA, Haim H et al (2011) Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins. J Virol 85:8514-8527
    • (2011) J Virol , vol.85 , pp. 8514-8527
    • Wilen, C.B.1    Parrish, N.F.2    Pfaff, J.M.3    Decker, J.M.4    Henning, E.A.5    Haim, H.6
  • 29
    • 84871985596 scopus 로고    scopus 로고
    • Mucosal tissue tropism and dissemination of HIV-1 subtype B acute envelope-expressing chimeric virus
    • King DF, Siddiqui AA, Buffa V, Fischetti L, Gao Y, Stieh D et al (2013) Mucosal tissue tropism and dissemination of HIV-1 subtype B acute envelope-expressing chimeric virus. J Virol 87:890-899
    • (2013) J Virol , vol.87 , pp. 890-899
    • King, D.F.1    Siddiqui, A.A.2    Buffa, V.3    Fischetti, L.4    Gao, Y.5    Stieh, D.6
  • 30
    • 0036776324 scopus 로고    scopus 로고
    • Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system
    • Gupta P, Collins KB, Ratner D, Watkins S, Naus GJ, Landers DV et al (2002) Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system. J Virol 76:9868-9876
    • (2002) J Virol , vol.76 , pp. 9868-9876
    • Gupta, P.1    Collins, K.B.2    Ratner, D.3    Watkins, S.4    Naus, G.J.5    Landers, D.V.6
  • 31
    • 84870829395 scopus 로고    scopus 로고
    • HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo
    • Merbah M, Arakelyan A, Edmonds T, Ochsenbauer C, Kappes JC, Shattock RJ et al (2012) HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo. PLoS One 7:e50839
    • (2012) PLoS One , vol.7 , pp. e50839
    • Merbah, M.1    Arakelyan, A.2    Edmonds, T.3    Ochsenbauer, C.4    Kappes, J.C.5    Shattock, R.J.6
  • 32
    • 17844376742 scopus 로고    scopus 로고
    • Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
    • Li Q, Duan L, Estes JD, Ma ZM, Rourke T, Wang Y et al (2005) Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434:1148-1152
    • (2005) Nature , vol.434 , pp. 1148-1152
    • Li, Q.1    Duan, L.2    Estes, J.D.3    Ma, Z.M.4    Rourke, T.5    Wang, Y.6
  • 33
    • 0032742547 scopus 로고    scopus 로고
    • Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells
    • Zhang Z, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, Reimann KA et al (1999) Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 286:1353-1357
    • (1999) Science , vol.286 , pp. 1353-1357
    • Zhang, Z.1    Schuler, T.2    Zupancic, M.3    Wietgrefe, S.4    Staskus, K.A.5    Reimann, K.A.6
  • 34
    • 77949409948 scopus 로고    scopus 로고
    • Targeting early infection to prevent HIV-1 mucosal transmission
    • Haase AT (2010) Targeting early infection to prevent HIV-1 mucosal transmission. Nature 464:217-223
    • (2010) Nature , vol.464 , pp. 217-223
    • Haase, A.T.1
  • 35
    • 84863263044 scopus 로고    scopus 로고
    • Evaluation of cervical mucosa in transmission bottleneck during acute HIV-1 infection using a cervical tissue-based organ culture
    • Shen C, Ding M, Ratner D, Montelaro RC, Chen Y, Gupta P (2012) Evaluation of cervical mucosa in transmission bottleneck during acute HIV-1 infection using a cervical tissue-based organ culture. PLoS One 7:e32539
    • (2012) PLoS One , vol.7 , pp. e32539
    • Shen, C.1    Ding, M.2    Ratner, D.3    Montelaro, R.C.4    Chen, Y.5    Gupta, P.6
  • 36
    • 77954908330 scopus 로고    scopus 로고
    • Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis
    • Duenas-Decamp MJ, Peters PJ, Repik A, Musich T, Gonzalez-Perez MP, Caron C et al (2010) Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis. Future Virol 5:417-433
    • (2010) Future Virol , vol.5 , pp. 417-433
    • Duenas-Decamp, M.J.1    Peters, P.J.2    Repik, A.3    Musich, T.4    Gonzalez-Perez, M.P.5    Caron, C.6
  • 37
    • 84925347191 scopus 로고    scopus 로고
    • HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages
    • Musich T, O'Connell O, Gonzalez-Perez MP, Derdeyn CA, Peters PJ, Clapham PR (2015) HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages. Retrovirology 12:25
    • (2015) Retrovirology , vol.12 , pp. 25
    • Musich, T.1    O'Connell, O.2    Gonzalez-Perez, M.P.3    Derdeyn, C.A.4    Peters, P.J.5    Clapham, P.R.6
  • 38
    • 28144449069 scopus 로고    scopus 로고
    • Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone
    • Pudney J, Quayle AJ, Anderson DJ (2005) Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol Reprod 73:1253-1263
    • (2005) Biol Reprod , vol.73 , pp. 1253-1263
    • Pudney, J.1    Quayle, A.J.2    Anderson, D.J.3
  • 39
    • 49349098903 scopus 로고    scopus 로고
    • Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysis
    • Powers KA, Poole C, Pettifor AE, Cohen MS (2008) Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysis. Lancet Infect Dis 8:553-563
    • (2008) Lancet Infect Dis , vol.8 , pp. 553-563
    • Powers, K.A.1    Poole, C.2    Pettifor, A.E.3    Cohen, M.S.4
  • 40
    • 79958104621 scopus 로고    scopus 로고
    • Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors
    • Brown RJ, Peters PJ, Caron C, Gonzalez-Perez MP, Stones L, Ankghuambom C et al (2011) Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors. J Virol 85:6024-6037
    • (2011) J Virol , vol.85 , pp. 6024-6037
    • Brown, R.J.1    Peters, P.J.2    Caron, C.3    Gonzalez-Perez, M.P.4    Stones, L.5    Ankghuambom, C.6
  • 41
    • 63149107945 scopus 로고    scopus 로고
    • Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection
    • Shen R, Richter HE, Clements RH, Novak L, Huff K, Bimczok D et al (2009) Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection. J Virol 83:3258-3267
    • (2009) J Virol , vol.83 , pp. 3258-3267
    • Shen, R.1    Richter, H.E.2    Clements, R.H.3    Novak, L.4    Huff, K.5    Bimczok, D.6
  • 42
    • 84899097258 scopus 로고    scopus 로고
    • Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages
    • Mlcochova P, Watters SA, Towers GJ, Noursadeghi M, Gupta RK (2014) Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages. Retrovirology 11:25
    • (2014) Retrovirology , vol.11 , pp. 25
    • Mlcochova, P.1    Watters, S.A.2    Towers, G.J.3    Noursadeghi, M.4    Gupta, R.K.5
  • 43
    • 70449370351 scopus 로고    scopus 로고
    • HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation
    • Tsang J, Chain BM, Miller RF, Webb BL, Barclay W, Towers GJ et al (2009) HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. AIDS 23:2255-2263
    • (2009) AIDS , vol.23 , pp. 2255-2263
    • Tsang, J.1    Chain, B.M.2    Miller, R.F.3    Webb, B.L.4    Barclay, W.5    Towers, G.J.6
  • 44
    • 79551618960 scopus 로고    scopus 로고
    • Early HIV-1 target cells in human vaginal and ectocervical mucosa
    • Shen R, Richter HE, Smith PD (2011) Early HIV-1 target cells in human vaginal and ectocervical mucosa. Am J Reprod Immunol 65:261-267
    • (2011) Am J Reprod Immunol , vol.65 , pp. 261-267
    • Shen, R.1    Richter, H.E.2    Smith, P.D.3
  • 45
    • 0032708384 scopus 로고    scopus 로고
    • Species-specific, postentry barriers to primate immunodeficiency virus infection
    • Hofmann W, Schubert D, LaBonte J, Munson L, Gibson S, Scammell J et al (1999) Species-specific, postentry barriers to primate immunodeficiency virus infection. J Virol 73:10020-10028
    • (1999) J Virol , vol.73 , pp. 10020-10028
    • Hofmann, W.1    Schubert, D.2    LaBonte, J.3    Munson, L.4    Gibson, S.5    Scammell, J.6
  • 46
    • 0036090585 scopus 로고    scopus 로고
    • Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
    • Wei X, Decker JM, Liu H, Zhang Z, Arani RB, Kilby JM et al (2002) Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother 46:1896-1905
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1896-1905
    • Wei, X.1    Decker, J.M.2    Liu, H.3    Zhang, Z.4    Arani, R.B.5    Kilby, J.M.6
  • 47
    • 0033780046 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding
    • O'Doherty U, Swiggard WJ, Malim MH (2000) Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding. J Virol 74:10074-10080
    • (2000) J Virol , vol.74 , pp. 10074-10080
    • O'Doherty, U.1    Swiggard, W.J.2    Malim, M.H.3
  • 48
    • 80053959566 scopus 로고    scopus 로고
    • Spinoculation triggers dynamic actin and cofilin activity that facilitates HIV-1 infection of transformed and resting CD4 T cells
    • Guo J, Wang W, Yu D, Wu Y (2011) Spinoculation triggers dynamic actin and cofilin activity that facilitates HIV-1 infection of transformed and resting CD4 T cells. J Virol 85:9824-9833
    • (2011) J Virol , vol.85 , pp. 9824-9833
    • Guo, J.1    Wang, W.2    Yu, D.3    Wu, Y.4
  • 49
    • 84923846505 scopus 로고    scopus 로고
    • Transmitted Virus Fitness and Host T Cell Responses Collectively Define Divergent Infection Outcomes in Two HIV-1 Recipients
    • Yue L, Pfafferott KJ, Baalwa J, Conrod K, Dong CC, Chui C et al (2015) Transmitted Virus Fitness and Host T Cell Responses Collectively Define Divergent Infection Outcomes in Two HIV-1 Recipients. PLoS Pathog 11:e1004565
    • (2015) PLoS Pathog , vol.11 , pp. e1004565
    • Yue, L.1    Pfafferott, K.J.2    Baalwa, J.3    Conrod, K.4    Dong, C.C.5    Chui, C.6
  • 50
    • 77953702265 scopus 로고    scopus 로고
    • Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection
    • Lynch RM, Rong R, Li B, Shen T, Honnen W, Mulenga J et al (2010) Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection. Virology 404:59-70
    • (2010) Virology , vol.404 , pp. 59-70
    • Lynch, R.M.1    Rong, R.2    Li, B.3    Shen, T.4    Honnen, W.5    Mulenga, J.6
  • 51
    • 70349695689 scopus 로고    scopus 로고
    • Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways
    • Rong R, Li B, Lynch RM, Haaland RE, Murphy MK, Mulenga J et al (2009) Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways. PLoS Pathog 5:e1000594
    • (2009) PLoS Pathog , vol.5 , pp. e1000594
    • Rong, R.1    Li, B.2    Lynch, R.M.3    Haaland, R.E.4    Murphy, M.K.5    Mulenga, J.6
  • 52
    • 78650633879 scopus 로고    scopus 로고
    • The B cell response is redundant and highly focused on V1V2 during early subtype C infection in a Zambian seroconverter
    • Lynch RM, Rong R, Boliar S, Sethi A, Li B, Mulenga J (2011) The B cell response is redundant and highly focused on V1V2 during early subtype C infection in a Zambian seroconverter. J Virol 85:905-915
    • (2011) J Virol , vol.85 , pp. 905-915
    • Lynch, R.M.1    Rong, R.2    Boliar, S.3    Sethi, A.4    Li, B.5    Mulenga, J.6
  • 53
    • 31144451337 scopus 로고    scopus 로고
    • Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants
    • Li Y, Svehla K, Mathy NL, Voss G, Mascola JR, Wyatt R (2006) Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants. J Virol 80:1414-1426
    • (2006) J Virol , vol.80 , pp. 1414-1426
    • Li, Y.1    Svehla, K.2    Mathy, N.L.3    Voss, G.4    Mascola, J.R.5    Wyatt, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.