Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase

Biochemical Pharmacology

Volumn 96, Issue 3, 2015, Pages 288-295

  Choughule, Kanika V ^a   Joswig Jones, Carolyn A ^a   Jones, Jeffrey P ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Aldehyde oxidase; Drug metabolism; Enzyme kinetics; Homology modelling; Methotrexate; Site directed mutagenesis

Indexed keywords

ALDEHYDE OXIDASE; ALDEHYDE OXIDASE 1; COMPLEMENTARY DNA; METHOTREXATE; NUCLEOTIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; AOX1 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; GUINEA PIG; HYDROXYLATION; LIVER CYTOSOL; MALE; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; KINETICS; LIVER; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; RHESUS MONKEY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SPRAGUE DAWLEY RAT; STRUCTURAL HOMOLOGY;

ALDEHYDE OXIDASE; AMINO ACID SEQUENCE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CATALYTIC DOMAIN; GUINEA PIGS; HUMANS; KINETICS; LIVER; MACACA MULATTA; METHOTREXATE; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

EID: 84934854500     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.05.010     Document Type: Article

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