Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography

European Journal of Nuclear Medicine

Volumn 23, Issue 4, 1996, Pages 390-394

  Cuocolo, Alberto ^a   Nicolai, Emanuele ^a   Colao, Annamaria ^a   Longobardi, Salvatore ^a   Cardei, Stefania ^a   Fazio, Serafino ^a   Merola, Bartolomeo ^a   Lombardi, Gaetano ^a   Saccà, Luigi ^a   Salvatore, Marco ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cardiac performance; Growth hormone deficiency; Radionuclide ventriculography

Indexed keywords

RECOMBINANT GROWTH HORMONE;

ADULT; ARTERIAL PRESSURE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GROWTH HORMONE DEFICIENCY; HEART INDEX; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HEART STROKE VOLUME; HUMAN; HYPOPITUITARISM; MALE; REST; SCINTIANGIOGRAPHY; TIME;

ADULT; FEMALE; GROWTH HORMONE; HUMANS; HYPOPITUITARISM; MALE; RADIONUCLIDE ANGIOGRAPHY; RECOMBINANT PROTEINS; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT;

EID: 9244241551     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01247366     Document Type: Article

References (17)

1. Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285-288.
2. Thuesen L, Christiansen JS, Sorensen KE, Jorgensen JOL, Orskov H, Henningsen P. Increased myocardial contractility following growth hormone administration in normal men. Dan Med Bull 1988; 35: 193-196.
3. Mayoux E, Ventura-Clapier R, Timsit J, Behar-Cohen F, Hoffmann C, Mercadier JJ. Mechanical properties of rat skinned fibers are altered by chronic growth hormone hypersecretion. Circ Res 1993; 72: 57-64.
4. Timsit J, Riou B, Bertherat J, et al. Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern and myosin adenosine triphosphate activity of rat left ventricle. J Clin Invest 1990; 86: 507-515.
5. Merola B, Cittadini A, Colao A, et al. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. J Clin Endocrinol Metab 1993; 77: 1658-1661.
6. Cittadini A, Cuocolo A, Merola B, et al. Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement. Am J Physiol 1994; 267: E219-E225.
7. Ghigo E, Mazza E, Imperiale E, et al. The enhancement of the cholinergic tone by pyridostigmine promotes both basal and growth hormone (GH)-releasing hormone induced GH secretion in children of short stature. J Clin Endocrinol Metab 1987; 65: 542-546.
8. Gil-Aid I, Topper E, Laron L. Opal clonidine as a growth hormone stimulation test [abstract]. Lancet 1977; II: 278.
9. Cuocolo A, Nicolai E, Fazio S, et al. Impaired left ventricular diastolic filling in patients with acromegaly: assessment with radionuclide angiography. J Nucl Med 1995; 36: 196-201.
10. Cuneo RC, Salomon F, Wilmshurst P, Byrne C, Wiles CM, Hesp P, Sonksen PH. Cardiovascular effects of growth-hormone-deficient adult: stimulation of the renin-aldosterone system. Clin Sci 1991; 81: 978-986.
11. Jorgensen JOL, Pedersen SA, Thuesen L, Jorgensen T, Ingemann-Hansen T, Skakkerbaek NE, Christiansen JS. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989; 1: 1221-1225.
12. Salomon F, Cuneo RC, Hesp P, Sonksen PH. The effects of treatment of recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 1989; 321: 1797-1803.
13. Starling MR, Dell'Italia LJ, Walsh RA, Little WC, Benedetto AR, Nusynowitz ML. Accurate estimates of absolute left ventricular volumes from equilibrium radionuclide angiographic count data using a single geometric attenuation correction. J Am Coll Cardiol 1984; 3: 789-798.
14. Feigenbaum H. Echocardiography, 2nd edn. Philadelphia: Lea and Febiger, 1979.
15. Bonow RO. Noninvasive evaluation of left ventricular diastolic function by radionuclide angiography: limitations and applications. Int J Cardiol 1984; 5: 659-663.
16. Ruthenford OM, Jones DA, Round JM, Buchanan CR, Preece MA. Changes in skelet al muscle and body composition after discontinuation of growth hormone treatment in growth hormone deficient young adults. Clin Endocrinol 1991; 34: 469-475.
17. Cuneo RC, Salomon F, McGauley GA, Sonksen PH. The growth hormone deficiency syndrome in adults. Clin Endocrinol 1992; 37: 387-397.