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Volumn 494, Issue , 2008, Pages 1-8

Peptide-based drug design: Here and now

Author keywords

Backbone; Design; Nonnatural amino acids; Pharmacology; Recognition; Stability; Toxicity

Indexed keywords


EID: 84934444542     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-419-3_1     Document Type: Review
Times cited : (96)

References (31)
  • 1
    • 0036158878 scopus 로고    scopus 로고
    • Peptides as drugs: Is there a market?
    • Loffet, A. (2002) Peptides as drugs: Is there a market? J. Pept. Sci. 8, 1-7.
    • (2002) J. Pept. Sci , vol.8 , pp. 1-7
    • Loffet, A.1
  • 2
    • 24944540240 scopus 로고    scopus 로고
    • Progress in targeting HIV-1 entry
    • Ryser, H.J., and Fluckiger, R. (2005) Progress in targeting HIV-1 entry. Drug Discov. Today 10, 1085-1094.
    • (2005) Drug Discov. Today , vol.10 , pp. 1085-1094
    • Ryser, H.J.1    Fluckiger, R.2
  • 3
    • 33745092046 scopus 로고    scopus 로고
    • Peptide, peptidomimetic and small molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4
    • Kazmierski, W.M., Kenakin, T.P., and Gudmundsson, K.S. (2006) Peptide, peptidomimetic and small molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4. Chem. Biol. Drug Des. 67, 13-26.
    • (2006) Chem. Biol. Drug Des , vol.67 , pp. 13-26
    • Kazmierski, W.M.1    Kenakin, T.P.2    Gudmundsson, K.S.3
  • 4
    • 0032550337 scopus 로고    scopus 로고
    • Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: A novel inhibitory mechanism of HIV infectivity
    • Mack, M., Luckow, B., Nelson, P.J., et al. (1998) Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J. Exp. Med. 187, 1215-1224.
    • (1998) J. Exp. Med , vol.187 , pp. 1215-1224
    • Mack, M.1    Luckow, B.2    Nelson, P.J.3
  • 5
    • 9344239350 scopus 로고    scopus 로고
    • Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors
    • Hartley, O., Gaertner, H., Wilken, J., et al. (2004) Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors. Proc. Natl. Acad. Sci. USA 101, 16460-16465.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16460-16465
    • Hartley, O.1    Gaertner, H.2    Wilken, J.3
  • 6
    • 0027208560 scopus 로고
    • Peptide stability in drug development. II. Effect of single amino acid substitution and glycosylation on peptide reactivity in human serum
    • Powell, M.F., Stewart, T., Otvos, L., Jr., et al. (1993) Peptide stability in drug development. II. Effect of single amino acid substitution and glycosylation on peptide reactivity in human serum. Pharmacol. Res. 10, 1268-1273.
    • (1993) Pharmacol. Res , vol.10 , pp. 1268-1273
    • Powell, M.F.1    Stewart, T.2    Otvos Jr., L.3
  • 7
    • 0028233389 scopus 로고
    • Glycopeptide enkephalin analogues produce analgesia in mice; evidence for penetration of the blood-brain barrier
    • Polt, R., Porreca, F., Szabo, L Z., et al. (1994). Glycopeptide enkephalin analogues produce analgesia in mice; evidence for penetration of the blood-brain barrier. Proc. Natl. Acad. Sci. USA 91, 7114-7118.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7114-7118
    • Polt, R.1    Porreca, F.2    Szabo, L.Z.3
  • 8
    • 0034693398 scopus 로고    scopus 로고
    • Improved bioavailability to the brain of glycosylated Met-enkephalin analogs
    • Egleton, R.D., Mitchell, S.A., Huber, J.D., et al. (2000) Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Res. 881, 37-46.
    • (2000) Brain Res , vol.881 , pp. 37-46
    • Egleton, R.D.1    Mitchell, S.A.2    Huber, J.D.3
  • 10
    • 29244490903 scopus 로고    scopus 로고
    • Evaluation of drug penetration into the brain: A double study by in vivo imaging with positron emission tomography and using an in vitro model of the human blood-brain barrier
    • Josserand, V., Pelerin, H., de Bruin, B., et al. (2006) Evaluation of drug penetration into the brain: a double study by in vivo imaging with positron emission tomography and using an in vitro model of the human blood-brain barrier. J. Pharmacol. Exp. Ther. 316, 79-86.
    • (2006) J. Pharmacol. Exp. Ther , vol.316 , pp. 79-86
    • Josserand, V.1    Pelerin, H.2    de Bruin, B.3
  • 11
    • 85069255122 scopus 로고    scopus 로고
    • Innovations in oral peptide delivery
    • Werle, M. (2006) Innovations in oral peptide delivery. Future Drug Deliver. 39-40.
    • (2006) Future Drug Deliver , pp. 39-40
    • Werle, M.1
  • 12
    • 14544282377 scopus 로고    scopus 로고
    • Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?
    • Brogden, K.A. (2005) Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3, 238-250.
    • (2005) Nat. Rev. Microbiol , vol.3 , pp. 238-250
    • Brogden, K.A.1
  • 13
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff, M. (2002) Antimicrobial peptides of multicellular organisms. Nature 415, 389-395.
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 14
    • 0042430615 scopus 로고    scopus 로고
    • In vitro and in vivo activity of antibacterial peptide analogs against uropathogens
    • Cudic, M., Lockatell, C.V., Johnson, D.E., and Otvos, L., Jr. (2003) In vitro and in vivo activity of antibacterial peptide analogs against uropathogens. Peptides 24, 807-820.
    • (2003) Peptides , vol.24 , pp. 807-820
    • Cudic, M.1    Lockatell, C.V.2    Johnson, D.E.3    Otvos Jr., L.4
  • 15
    • 28044443162 scopus 로고    scopus 로고
    • Antibacterial peptides and proteins with multiple cellular targets
    • Otvos, L., Jr. (2005) Antibacterial peptides and proteins with multiple cellular targets. J. Pept. Sci. 11, 697-706.
    • (2005) J. Pept. Sci , vol.11 , pp. 697-706
    • Otvos Jr., L.1
  • 16
    • 0037667047 scopus 로고    scopus 로고
    • Large-scale manufacture of peptide therapeutics by chemical synthesis
    • Bray, B.L. (2003) Large-scale manufacture of peptide therapeutics by chemical synthesis. Nat. Rev. Drug Discovery 2, 587-593.
    • (2003) Nat. Rev. Drug Discovery , vol.2 , pp. 587-593
    • Bray, B.L.1
  • 17
    • 23644456345 scopus 로고    scopus 로고
    • Peptide leads new class of chronic pain drugs
    • Garber, K. (2005) Peptide leads new class of chronic pain drugs. Nat. Biotechnol. 23, 399.
    • (2005) Nat. Biotechnol , vol.23 , pp. 399
    • Garber, K.1
  • 18
    • 3543005927 scopus 로고    scopus 로고
    • Bioactive peptides based on diversity libraries, supramolecular chemistry and rational design; A class of peptide drugs. Introduction
    • Meloen, R., Timmerman, P., and Langedijk, H. (2004) Bioactive peptides based on diversity libraries, supramolecular chemistry and rational design; A class of peptide drugs. Introduction. Mol. Diversity 8, 57-59.
    • (2004) Mol. Diversity , vol.8 , pp. 57-59
    • Meloen, R.1    Timmerman, P.2    Langedijk, H.3
  • 19
    • 0033813525 scopus 로고    scopus 로고
    • A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive
    • Muderspach, L., Wilczynski, S., Roman, L., et al. (2000) A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin. Cancer Res. 6, 3406-3416.
    • (2000) Clin. Cancer Res , vol.6 , pp. 3406-3416
    • Muderspach, L.1    Wilczynski, S.2    Roman, L.3
  • 20
    • 61949392952 scopus 로고    scopus 로고
    • Rational design for peptide drugs
    • Agdeppa, E.D. (2004) Rational design for peptide drugs. J. Nucl. Med. 47, 22N-24N.
    • (2004) J. Nucl. Med , vol.47
    • Agdeppa, E.D.1
  • 21
    • 34147191481 scopus 로고    scopus 로고
    • Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes
    • Backer, M.V., Levashova, Z., Patel, V., et al. (2007) Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat. Med. 13, 504-509.
    • (2007) Nat. Med , vol.13 , pp. 504-509
    • Backer, M.V.1    Levashova, Z.2    Patel, V.3
  • 22
    • 0025238653 scopus 로고
    • Defined neurofilament, tau and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques
    • Arai, H., Lee, V.M.-Y., Otvos, L., Jr., et al. (1990) Defined neurofilament, tau and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques. Proc. Natl. Acad. Sci. USA 87, 2249-2253.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 2249-2253
    • Arai, H.1    Lee, V.M.-Y.2    Otvos Jr., L.3
  • 23
    • 0030750558 scopus 로고    scopus 로고
    • Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites
    • Hoffmann, R., Lee, V.M.Y., Leight, S., Varga, I., and Otvos, L., Jr. (1997) Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites. Biochemistry 36, 8114-8124.
    • (1997) Biochemistry , vol.36 , pp. 8114-8124
    • Hoffmann, R.1    Lee, V.M.Y.2    Leight, S.3    Varga, I.4    Otvos Jr., L.5
  • 24
    • 0038529679 scopus 로고    scopus 로고
    • Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease
    • Adessi, C., Frossard, M-J., Boissard, C., et al. (2003). Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease. J. Biol. Chem. 278, 13905-13991.
    • (2003) J. Biol. Chem , vol.278 , pp. 13905-13991
    • Adessi, C.1    Frossard, M.-J.2    Boissard, C.3
  • 25
    • 15444381244 scopus 로고    scopus 로고
    • Post-treatment assembly modifications by chemical methods
    • Kotha, S., and Lahiri, K. (2005) Post-treatment assembly modifications by chemical methods. Curr. Med. Chem. 12, 849-875.
    • (2005) Curr. Med. Chem , vol.12 , pp. 849-875
    • Kotha, S.1    Lahiri, K.2
  • 26
    • 0036489770 scopus 로고    scopus 로고
    • Recent development in peptide-based cancer therapeutics
    • Sehgal, A. (2002) Recent development in peptide-based cancer therapeutics. Curr. Opin. Drug Discov. Devel. 5, 245-250.
    • (2002) Curr. Opin. Drug Discov. Devel , vol.5 , pp. 245-250
    • Sehgal, A.1
  • 27
    • 28044454553 scopus 로고    scopus 로고
    • Current strategies for the development of peptide-based anti-cancer therapeutics
    • Borghouts, C., Kunz, C., and Groner, B. (2005) Current strategies for the development of peptide-based anti-cancer therapeutics. J. Pept. Sci. 11, 713-726.
    • (2005) J. Pept. Sci , vol.11 , pp. 713-726
    • Borghouts, C.1    Kunz, C.2    Groner, B.3
  • 28
    • 0036111856 scopus 로고    scopus 로고
    • SOM230: A novel somatostatin petidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile
    • Bruns, C., Lewis, I., Briner, U., Meno-Tetang, G., and Weckbecker, G. (2002) SOM230: a novel somatostatin petidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur. J. Endocrin. 146, 707-716.
    • (2002) Eur. J. Endocrin , vol.146 , pp. 707-716
    • Bruns, C.1    Lewis, I.2    Briner, U.3    Meno-Tetang, G.4    Weckbecker, G.5
  • 29
    • 34249111192 scopus 로고    scopus 로고
    • SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas
    • Fedele, M., DeMartino, I., Pivonello, R., et al. (2007) SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas. Clin. Cancer Res. 13, 2738-2744.
    • (2007) Clin. Cancer Res , vol.13 , pp. 2738-2744
    • Fedele, M.1    DeMartino, I.2    Pivonello, R.3
  • 30
    • 25144517155 scopus 로고    scopus 로고
    • Crsytal structures of a high-affinity macrocyclic peptide mimetic complex with the Grb2 SH2 domain
    • Phan, J., Shi, Z-D., Burke, T.R., Jr., and Waugh, D.S. (2005) Crsytal structures of a high-affinity macrocyclic peptide mimetic complex with the Grb2 SH2 domain. J. Mol. Biol. 353, 104-115.
    • (2005) J. Mol. Biol , vol.353 , pp. 104-115
    • Phan, J.1    Shi, Z.-D.2    Burke Jr., T.R.3    Waugh, D.S.4
  • 31
    • 0036086443 scopus 로고    scopus 로고
    • a and E-selectin in metastasis assessed with peptide antagonist. Peptides 23, 999-1010.
    • a and E-selectin in metastasis assessed with peptide antagonist. Peptides 23, 999-1010.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.