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Volumn 39, Issue 5, 2015, Pages 347-356

iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis

Author keywords

Childhood asthma; Genome wide association studies; Integrative genomics; Mediation analysis; Variance component tests

Indexed keywords

ALGORITHM; ASTHMA; BIOLOGICAL MODEL; CHILD; CHROMOSOME MAP; COMPUTER SIMULATION; FAMILY; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETICS; GENOMICS; HUMAN; HUMAN GENOME; PHENOTYPE; PROCEDURES; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84934441761     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.21905     Document Type: Article
Times cited : (33)

References (45)
  • 3
    • 84961945798 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 57:289-300.
    • (1995) J Roy Stat Soc B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 4
    • 84862751980 scopus 로고    scopus 로고
    • Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines
    • Berlivet S, Moussette S, Ouimet M, Verlaan DJ, Koka V, Al Tuwaijri A, Kwan T, Sinnett D, Pastinen T, Naumova AK. 2012. Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines. Hum Genet 131(7):1161-1171.
    • (2012) Hum Genet , vol.131 , Issue.7 , pp. 1161-1171
    • Berlivet, S.1    Moussette, S.2    Ouimet, M.3    Verlaan, D.J.4    Koka, V.5    Al Tuwaijri, A.6    Kwan, T.7    Sinnett, D.8    Pastinen, T.9    Naumova, A.K.10
  • 5
    • 0011241944 scopus 로고
    • Approximate inference in generalized linear mixed models
    • Breslow N, Clayton D. 1993. Approximate inference in generalized linear mixed models. J Am Stat Assoc 88:9-25.
    • (1993) J Am Stat Assoc , vol.88 , pp. 9-25
    • Breslow, N.1    Clayton, D.2
  • 6
    • 0000521192 scopus 로고    scopus 로고
    • Semiparametric regression analysis for clustered failure time data
    • Cai T, Wei L, Wilcox M. 2000. Semiparametric regression analysis for clustered failure time data. Biometrika 87:867-878.
    • (2000) Biometrika , vol.87 , pp. 867-878
    • Cai, T.1    Wei, L.2    Wilcox, M.3
  • 7
    • 84866356984 scopus 로고    scopus 로고
    • Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test
    • Cai T, Lin X, Carroll RJ. 2012. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics 13(4):776-790.
    • (2012) Biostatistics , vol.13 , Issue.4 , pp. 776-790
    • Cai, T.1    Lin, X.2    Carroll, R.J.3
  • 9
    • 84859260926 scopus 로고    scopus 로고
    • The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes
    • Cusanovich DA, Billstrand C, Zhou X, Chavarria C, DeLeon S, Michelini K, Pai AA, Ober C, Gilad Y. 2012. The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. Hum Mol Genet 21(9):2111-2123.
    • (2012) Hum Mol Genet , vol.21 , Issue.9 , pp. 2111-2123
    • Cusanovich, D.A.1    Billstrand, C.2    Zhou, X.3    Chavarria, C.4    De Leon, S.5    Michelini, K.6    Pai, A.A.7    Ober, C.8    Gilad, Y.9
  • 14
    • 77954157408 scopus 로고    scopus 로고
    • An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility loci for osteoporosis-related traits
    • Hsu YH, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB and others. 2010. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility loci for osteoporosis-related traits. PLoS Genet 6(6):e1000977.
    • (2010) PLoS Genet , vol.6 , Issue.6 , pp. e1000977
    • Hsu, Y.H.1    Zillikens, M.C.2    Wilson, S.G.3    Farber, C.R.4    Demissie, S.5    Soranzo, N.6    Bianchi, E.N.7    Grundberg, E.8    Liang, L.9    Richards, J.B.10
  • 15
    • 84961860903 scopus 로고    scopus 로고
    • Joint analysis of SNP and gene expression data in genetic association studies of complex diseases
    • Huang YT, VanderWeele TJ, Lin X. 2014. Joint analysis of SNP and gene expression data in genetic association studies of complex diseases. Ann Appl Stat 34(1):162-178.
    • (2014) Ann Appl Stat , vol.34 , Issue.1 , pp. 162-178
    • Huang, Y.T.1    VanderWeele, T.J.2    Lin, X.3
  • 17
    • 77953701161 scopus 로고    scopus 로고
    • Genome-wide association studies and "the art of the soluble"
    • Hunter DJ, Chanock SJ. 2010. Genome-wide association studies and "the art of the soluble". J Natl Cancer Inst 102(12):836-837.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.12 , pp. 836-837
    • Hunter, D.J.1    Chanock, S.J.2
  • 20
    • 40749104728 scopus 로고    scopus 로고
    • A powerful and flexible multilocus association test for quantitative traits
    • Kwee LC, Liu D, Lin X, Ghosh D, Epstein MP. 2008. A powerful and flexible multilocus association test for quantitative traits. Am J Hum Genet 82(2):386-397.
    • (2008) Am J Hum Genet , vol.82 , Issue.2 , pp. 386-397
    • Kwee, L.C.1    Liu, D.2    Lin, X.3    Ghosh, D.4    Epstein, M.P.5
  • 22
    • 84875990952 scopus 로고    scopus 로고
    • A cross-platform analysis of 14177 expression quantitative trait loci derived from lymphoblastoid cell lines
    • Liang L, Morar N, Dixon AL, Lathrop GM, Abecasis GR, Moffatt MF, Cookson WO. 2013. A cross-platform analysis of 14177 expression quantitative trait loci derived from lymphoblastoid cell lines. Genome Res 23(4):716-726.
    • (2013) Genome Res , vol.23 , Issue.4 , pp. 716-726
    • Liang, L.1    Morar, N.2    Dixon, A.L.3    Lathrop, G.M.4    Abecasis, G.R.5    Moffatt, M.F.6    Cookson, W.O.7
  • 23
    • 0000072057 scopus 로고    scopus 로고
    • Variance component testing in generalised linear models with random effects
    • Lin X. 1997. Variance component testing in generalised linear models with random effects. Biometrika 84:309-326.
    • (1997) Biometrika , vol.84 , pp. 309-326
    • Lin, X.1
  • 24
    • 48249142391 scopus 로고    scopus 로고
    • Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models
    • Liu D, Ghosh D, Lin X. 2008. Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models. BMC Bioinformatics 9:292.
    • (2008) BMC Bioinformatics , vol.9 , pp. 292
    • Liu, D.1    Ghosh, D.2    Lin, X.3
  • 27
    • 77951439152 scopus 로고    scopus 로고
    • Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS
    • Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ. 2010. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet 6(4):e1000888.
    • (2010) PLoS Genet , vol.6 , Issue.4 , pp. e1000888
    • Nicolae, D.L.1    Gamazon, E.2    Zhang, W.3    Duan, S.4    Dolan, M.E.5    Cox, N.J.6
  • 28
    • 0001781878 scopus 로고
    • Automatic smoothing of regression functions in generalized linear models
    • O'Sullivan F, Yandell BS, Raynor WJ, Jr. 1986. Automatic smoothing of regression functions in generalized linear models. J Am Stat Assoc 81:96-103.
    • (1986) J Am Stat Assoc , vol.81 , pp. 96-103
    • O'Sullivan, F.1    Yandell, B.S.2    Raynor, W.J.3
  • 30
    • 0001620867 scopus 로고
    • A resampling method based on pivotal functions
    • Parzen M, Wei L, Ying Z. 1994. A resampling method based on pivotal functions. Biometrika 81:341-350.
    • (1994) Biometrika , vol.81 , pp. 341-350
    • Parzen, M.1    Wei, L.2    Ying, Z.3
  • 32
    • 0026556155 scopus 로고
    • Identifiability and exchangeability for direct and indirect effects
    • Robins JM, Greenland S. 1992. Identifiability and exchangeability for direct and indirect effects. Epidemiology 3(2):143-155.
    • (1992) Epidemiology , vol.3 , Issue.2 , pp. 143-155
    • Robins, J.M.1    Greenland, S.2
  • 33
    • 0002531157 scopus 로고
    • Bayesian inference of causal effects
    • Rubin D. 1978. Bayesian inference of causal effects. Ann Stat 6:34-58.
    • (1978) Ann Stat , vol.6 , pp. 34-58
    • Rubin, D.1
  • 38
    • 77952685188 scopus 로고    scopus 로고
    • Expression of the Lycat gene in the mouse cardiovascular and female reproductive systems
    • Wang W, Ni L, Yu Q, Xiong J, Liu HC, Rosenwaks Z. 2010. Expression of the Lycat gene in the mouse cardiovascular and female reproductive systems. Dev Dyn 239(6):1827-1837.
    • (2010) Dev Dyn , vol.239 , Issue.6 , pp. 1827-1837
    • Wang, W.1    Ni, L.2    Yu, Q.3    Xiong, J.4    Liu, H.C.5    Rosenwaks, Z.6
  • 41
    • 84856557856 scopus 로고    scopus 로고
    • Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets
    • Xiong Q, Ancona N, Hauser ER, Mukherjee S, Furey TS. 2012. Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets. Genome Res 22(2):386-397.
    • (2012) Genome Res , vol.22 , Issue.2 , pp. 386-397
    • Xiong, Q.1    Ancona, N.2    Hauser, E.R.3    Mukherjee, S.4    Furey, T.S.5
  • 42
    • 44149127926 scopus 로고    scopus 로고
    • Substance dependence low-density whole genome association study in two distinct American populations
    • Yu Y, Kranzler HR, Panhuysen C, Weiss RD, Poling J, Farrer LA, Gelernter J. 2008. Substance dependence low-density whole genome association study in two distinct American populations. Hum Genet 123(5):495-506.
    • (2008) Hum Genet , vol.123 , Issue.5 , pp. 495-506
    • Yu, Y.1    Kranzler, H.R.2    Panhuysen, C.3    Weiss, R.D.4    Poling, J.5    Farrer, L.A.6    Gelernter, J.7
  • 43
    • 84857496912 scopus 로고    scopus 로고
    • Sequences prior to conserved catalytic motifs of polysialyltransferase ST8Sia IV are required for substrate recognition
    • Zapater JL, Colley KJ. 2012. Sequences prior to conserved catalytic motifs of polysialyltransferase ST8Sia IV are required for substrate recognition. J Biol Chem 287(9):6441-6453.
    • (2012) J Biol Chem , vol.287 , Issue.9 , pp. 6441-6453
    • Zapater, J.L.1    Colley, K.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.