메뉴 건너뛰기




Volumn 763, Issue , 2013, Pages 334-355

The apical ectoplasmic specialization-blood-testis barrier functional axis is A novel target for male contraception

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROBENZYL) 1H INDAZOLE 3 CARBOHYDRAZIDE; BETA1 INTEGRIN; CONNEXIN 43; FOCAL ADHESION KINASE; FOLLITROPIN; GELATINASE A; INDAZOLE DERIVATIVE; INTEGRIN; LUTEINIZING HORMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 6;

EID: 84934437789     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4711-5_17     Document Type: Article
Times cited : (18)

References (96)
  • 1
    • 0034011741 scopus 로고    scopus 로고
    • Potential impact of hormonal male contraception: Cross-cultural implications for development of novel preparations
    • Martin CW, Anderson RA, Cheng L, et al. Potential impact of hormonal male contraception: Cross-cultural implications for development of novel preparations. Hum Reprod 2000; 15:637-645
    • (2000) Hum Reprod , vol.15 , pp. 637-645
    • Martin, C.W.1    Anderson, R.A.2    Cheng, L.3
  • 2
    • 0034053261 scopus 로고    scopus 로고
    • Would women trust their partners to use a male pill?
    • Olasier AF, Anakwe R, Everington D, et al. Would women trust their partners to use a male pill? Hum Reprod 2000; 15:646-649
    • (2000) Hum Reprod , vol.15 , pp. 646-649
    • Olasier, A.F.1    Anakwe, R.2    Everington, D.3
  • 3
    • 33745166321 scopus 로고    scopus 로고
    • Abortion incidence and services in the United States. 1995-1996
    • Henshaw SK. Abortion incidence and services in the United States. 1995-1996. Fam Plann Perspect 1998; 30:263-270
    • (1998) Fam Plann Perspect , vol.30 , pp. 263-270
    • Henshaw, S.K.1
  • 4
    • 0000585726 scopus 로고
    • The cytology of the testis
    • eds. Knobil, E., et al. (Raven Press, New York
    • De Kretser D, Kerr J. The cytology of the testis. in The Physiology of Reproduction. Vol. I (eds. Knobil, E., et al. 837-932 (Raven Press, New York, 1988
    • (1988) The Physiology of Reproduction , vol.1 , pp. 837-932
    • De Kretser, D.1    Kerr, J.2
  • 5
    • 0020181783 scopus 로고
    • Regulation of the seminiferous epithelium
    • Parvinen M. Regulation of the seminiferous epithelium. EndocrRev 1982; 3:404-417
    • (1982) EndocrRev , vol.3 , pp. 404-417
    • Parvinen, M.1
  • 6
    • 0015255225 scopus 로고
    • Kinetics of spermatogenesis in mammals: Seminiferous epithelium cyele and spermatogonial renewal
    • Clermont Y. Kinetics of spermatogenesis in mammals: Seminiferous epithelium cyele and spermatogonial renewal. Physiol Rev 1972; 52: 198-235
    • (1972) Physiol Rev , vol.52 , pp. 198-235
    • Clermont, Y.1
  • 7
    • 59749102511 scopus 로고    scopus 로고
    • Spermatogenesis and cycle ofthe seminiferous epithelium
    • Ed. Cheng, CY, Austin. TX Landes Bioscience/Springer Science+Business Media. LLC; I-IS
    • Hess RA, De Franca LR. Spermatogenesis and cycle ofthe seminiferous epithelium. In: Molecular Mechanisms in Spermatogenesis. Ed. Cheng, CY, Austin. TX Landes Bioscience/Springer Science+Business Media. LLC 2008; I-IS
    • (2008) Molecular Mechanisms in Spermatogenesis
    • Hess, R.A.1    De Franca, L.R.2
  • 8
    • 3242879161 scopus 로고    scopus 로고
    • Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis
    • Mruk DD, Cheng CY. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 2004; 25:747-806
    • (2004) Endocr Rev , vol.25 , pp. 747-806
    • Mruk, D.D.1    Cheng, C.Y.2
  • 9
    • 84884099125 scopus 로고    scopus 로고
    • Endocrine regulation of spermatogenesis
    • Neill m Ed. 3rd Edition. Amsterdam Elsevier
    • O'Donnell L, Meachem SJ, Stanton PO, et al. Endocrine regulation of spermatogenesis. In: Neill m Ed. Physiology of Reproduction, 3rd Edition. Amsterdam, Elsevier. 2006; 1017-1069
    • (2006) Physiology of Reproduction , pp. 1017-1069
    • O'Donnell, L.1    Meachem, S.J.2    Stanton, P.O.3
  • 12
    • 0000212362 scopus 로고
    • Regulation of spermatogenesis
    • Knobil E, Neill JD, eds. New York: Raven Press
    • Sharpe RM. Regulation of spermatogenesis. In: The Physiology of Reproduction. Knobil E, Neill JD, eds. New York: Raven Press, 1994: 1363-1434
    • (1994) The Physiology of Reproduction , pp. 1363-1434
    • Sharpe, R.M.1
  • 13
    • 46949109724 scopus 로고    scopus 로고
    • Anchoringjunctions as drug targets: Role in contraceptive development
    • Mruk DD, Silvestrini B, Cheng CY. Anchoringjunctions as drug targets: Role in contraceptive development. Pharmacol Rev 2008; 60:146-180
    • (2008) Pharmacol Rev , vol.60 , pp. 146-180
    • Mruk, D.D.1    Silvestrini, B.2    Cheng, C.Y.3
  • 14
    • 0036788073 scopus 로고    scopus 로고
    • Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development
    • Cheng CY, Mruk DD. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol Rev 2002;82:825-874
    • (2002) Physiol Rev , vol.82 , pp. 825-874
    • Cheng, C.Y.1    Mruk, D.D.2
  • 16
    • 83455180883 scopus 로고    scopus 로고
    • Regulation of blood-Testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected tum of events
    • (doi: 11O.41611spmg.4161.4162.15745
    • Cheng CY, Wong EWP, Lie PPY, et al. Regulation of blood-Testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: An unexpected tum of events. Spermatogenesis 20 I I; I: 105-115 (doi: 11O.41611spmg.4161.4162.15745
    • (2011) Spermatogenesis , vol.1 , pp. 105-115
    • Cheng, C.Y.1    Wong, E.W.P.2    Lie, P.P.Y.3
  • 17
    • 84896930314 scopus 로고    scopus 로고
    • The blood-Testis barrier and its implication in male contraception
    • in press
    • Cheng CY, Mruk DD. The blood-Testis barrier and its implication in male contraception. Pharmacol Rev 2011; (in press
    • (2011) Pharmacol Rev
    • Cheng, C.Y.1    Mruk, D.D.2
  • 18
    • 66749093001 scopus 로고    scopus 로고
    • Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men
    • Ou Y, Liang X, Wu W, et al. Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men. J Clin Endocrinol Metab 2009; 94: 1910-1915
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1910-1915
    • Ou, Y.1    Liang, X.2    Wu, W.3
  • 19
    • 77949419079 scopus 로고    scopus 로고
    • Hormonal male contraception-A goal finally ralized?
    • Brannigan RE. Hormonal male contraception-A goal finally ralized? Nat Rev Urol 2009; 6:409-410
    • (2009) Nat Rev Urol , vol.6 , pp. 409-410
    • Brannigan, R.E.1
  • 20
    • 78650514394 scopus 로고    scopus 로고
    • Pharmacologic development of male hormonal contraceptive agents
    • Roth MY, Amory JK. Pharmacologic development of male hormonal contraceptive agents. Clin Pharmacol Ther 20 II; 89: 133-136
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 133-136
    • Roth, M.Y.1    Amory, J.K.2
  • 21
    • 32244436034 scopus 로고    scopus 로고
    • The androgen microenvironment of the human testis and hormonal control of spermatogenesis
    • Jarow JP, Zirkin BR. The androgen microenvironment of the human testis and hormonal control of spermatogenesis. Ann NY Acad Sci 2005; 1061 :208-220
    • (2005) Ann NY Acad Sci , vol.1061 , pp. 208-220
    • Jarow, J.P.1    Zirkin, B.R.2
  • 22
    • 0021705805 scopus 로고
    • On the androgen microenvironment of maturing spermatozoa
    • Turner TT, Jones CC, Howards SS, et al. On the androgen microenvironment of maturing spermatozoa. Endocrinology 1984; 115:1925-1932
    • (1984) Endocrinology , vol.115 , pp. 1925-1932
    • Turner, T.T.1    Jones, C.C.2    Howards, S.S.3
  • 23
    • 0031801509 scopus 로고    scopus 로고
    • Ethnic differences in testicular structure and spermatogenic potential may predispose testes of Asian men to heightened sensitivity to steroidal contraceptives
    • Johnson L, Bernard JJ, Rodriguez L, et al. Ethnic differences in testicular structure and spermatogenic potential may predispose testes of Asian men to heightened sensitivity to steroidal contraceptives. J Andro11998; 19:348-357
    • (1998) J Andro1 , vol.19 , pp. 348-357
    • Johnson, L.1    Bernard, J.J.2    Rodriguez, L.3
  • 24
    • 79960073500 scopus 로고    scopus 로고
    • Does ethnicity matter in male hormonal contraceptive efficacy?
    • Ilani N, Liu PY, SwerdloffRS, et al. Does ethnicity matter in male hormonal contraceptive efficacy? Asian J Andro12011; 13:579-584
    • (2011) Asian J Andro1 , vol.13 , pp. 579-584
    • Ilani, N.1    Liu, P.Y.2    Swerdloff, R.S.3
  • 25
    • 39849085977 scopus 로고    scopus 로고
    • New perspectives in nonhormonal male contraception
    • Mruk DD. New perspectives in nonhormonal male contraception. Trends Endocrinol Metab2008; 19:57-64
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 57-64
    • Mruk, D.D.1
  • 26
    • 38349148676 scopus 로고    scopus 로고
    • Delivering nonhormonal contraceptives to men: Advances and obstacles
    • Mruk DD, Chcng CY. Delivering nonhormonal contraceptives to men: Advances and obstacles. Trends Biotechnol2008; 26:90-99
    • (2008) Trends Biotechnol , vol.26 , pp. 90-99
    • Mruk, D.D.1    Chcng, C.Y.2
  • 28
    • 23844478817 scopus 로고    scopus 로고
    • AF-2364 [1-(2,4-dichlorobenzyl-IH-indazole-3-carbohydrazide 1 is a potential male contraceptive: A review of recent data
    • Cheng CY, Mruk DD, Silvestrini B, et al. AF-2364 [1-(2,4-dichlorobenzyl)- IH-indazole-3-carbohydrazide 1 is a potential male contraceptive: A review of recent data. Contraception 2005; 72:251-261
    • (2005) Contraception , vol.72 , pp. 251-261
    • Cheng, C.Y.1    Mruk, D.D.2    Silvestrini, B.3
  • 29
    • 77957752496 scopus 로고    scopus 로고
    • New frontiers in nonhormonal male contraception
    • Cheng CY, Mruk DD. New frontiers in nonhormonal male contraception. Contraception 20 10; 82:4 76-482
    • (2010) Contraception , vol.82 , Issue.4 , pp. 76-482
    • Cheng, C.Y.1    Mruk, D.D.2
  • 30
    • 33750735046 scopus 로고    scopus 로고
    • A male contraceptive targeting germ cell adhesion
    • Mruk DD, Wong CH, Silvestrini B, et al. A male contraceptive targeting germ cell adhesion. Nature Med 2006; 12: 1323-1328
    • (2006) Nature Med , vol.12 , pp. 1323-1328
    • Mruk, D.D.1    Wong, C.H.2    Silvestrini, B.3
  • 31
    • 77952756299 scopus 로고    scopus 로고
    • Regulating mitosis and meiosis in the male germ line: Critical functions for cyclins
    • Wolgemuth DJ, Roberts SS. Regulating mitosis and meiosis in the male germ line: Critical functions for cyclins. Philos Trans R Soc B BioI Sci 2010; 365:1653-1662
    • (2010) Philos Trans R Soc B BioI Sci , vol.365 , pp. 1653-1662
    • Wolgemuth, D.J.1    Roberts, S.S.2
  • 32
    • 77952749815 scopus 로고    scopus 로고
    • Transcription and posttranscriptional regulation of spermatogenesis
    • Bettegowda A, Wilkinson MF. Transcription and posttranscriptional regulation of spermatogenesis. Phil Trans R Soc Lond B BioI Sci 2010; 365:1637-1651
    • (2010) Phil Trans R Soc Lond B BioI Sci , vol.365 , pp. 1637-1651
    • Bettegowda, A.1    Wilkinson, M.F.2
  • 34
    • 77952752185 scopus 로고    scopus 로고
    • Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis
    • Pointis G, Gilleron J, Carette D, et al. Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis. Philos TransR SocLondBBiol Sci20 I 0; 365: 1607-1620
    • (2011) Philos TransR SocLondBBiol Sci , vol.365 , pp. 1607-1620
    • Pointis, G.1    Gilleron, J.2    Carette, D.3
  • 35
    • 77951187480 scopus 로고    scopus 로고
    • The key role of vitamin A in spermatogenesis
    • Hogarth CA, Griswold MD. The key role of vitamin A in spermatogenesis. J Clin Invest 201 0; 120:956-962
    • (2010) J Clin Invest , vol.120 , pp. 956-962
    • Hogarth, C.A.1    Griswold, M.D.2
  • 36
    • 47749101115 scopus 로고    scopus 로고
    • An autocrine axis in the testis that co-ordinates spermiation and blood-Testis barrierrestructuring during spermatogenesis
    • Yan HHN, Mruk DD, Wong EWP, et al. An autocrine axis in the testis that co-ordinates spermiation and blood-Testis barrierrestructuring during spermatogenesis. Proc Natl Acad Sci USA 2008; 105:8950-8955
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 8950-8955
    • Yan, H.H.N.1    Mruk, D.D.2    Wong, E.W.P.3
  • 37
    • 77954024451 scopus 로고    scopus 로고
    • A local autocrine axis in the testes that regulates spermatogenesis
    • Cheng CY, Mruk DD. A local autocrine axis in the testes that regulates spermatogenesis. Nature Rev Endocrinol2010; 6:380-395
    • (2010) Nature Rev Endocrinol , vol.6 , pp. 380-395
    • Cheng, C.Y.1    Mruk, D.D.2
  • 38
    • 0034915521 scopus 로고    scopus 로고
    • Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis
    • Cheng CY, Silvestrini B, Grima J, et al. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. BioI Reprod 2001; 65:449-461
    • (2001) BioI Reprod , vol.65 , pp. 449-461
    • Cheng, C.Y.1    Silvestrini, B.2    Grima, J.3
  • 39
    • 58149291590 scopus 로고    scopus 로고
    • Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study
    • Hu GX, Hu LF, Yang DZ, et al. Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study. J Androl 2009; 30:87-93
    • (2009) J Androl , vol.30 , pp. 87-93
    • Hu, G.X.1    Hu, L.F.2    Yang, D.Z.3
  • 40
    • 84896959573 scopus 로고    scopus 로고
    • Adj udin targeting dog germ cell adhesion as a male contraception
    • Abstract Albuquerque, NM 2008
    • Zhou HY, Hu GX, Hu LF, et al. Adj udin targeting dog germ cell adhesion as a male contraception. (Abstract American Society of Andrology Annual Meeting, Albuquerque, NM 2008 (2008
    • (2008) American Society of Andrology Annual Meeting
    • Zhou, H.Y.1    Hu, G.X.2    Hu, L.F.3
  • 43
    • 33846586935 scopus 로고    scopus 로고
    • Ectoplasmic specialization: A friend or a foe of spermatogenesis
    • Van HHN, Mruk DD, Lee WM, et al. Ectoplasmic specialization: A friend or a foe of spermatogenesis BioEssays 2007; 29:36-48
    • (2007) BioEssays , vol.29 , pp. 36-48
    • Van, H.H.N.1    Mruk, D.D.2    Lee, W.M.3
  • 44
    • 70349918230 scopus 로고    scopus 로고
    • An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective
    • Cheng CY, Mruk DD. An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective. Crit Rev Biochem Mol Bio12009; 44:245-263
    • (2009) Crit Rev Biochem Mol Bio1 , vol.44 , pp. 245-263
    • Cheng, C.Y.1    Mruk, D.D.2
  • 45
    • 39849110870 scopus 로고    scopus 로고
    • Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis
    • Wong EWP, Mruk DD, Cheng CY. Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis. Biochem Biophys Acta 2008; 1778:692-708
    • (2008) Biochem Biophys Acta , vol.1778 , pp. 692-708
    • Wong, E.W.P.1    Mruk, D.D.2    Cheng, C.Y.3
  • 46
    • 7444240899 scopus 로고    scopus 로고
    • Cell-cell interactions at the ectoplasmic specialization in the testis
    • Mruk DD, Cheng CY. Cell-cell interactions at the ectoplasmic specialization in the testis. Trends Endocrinol Metab 2004; 15:439-447
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 439-447
    • Mruk, D.D.1    Cheng, C.Y.2
  • 47
    • 4644328373 scopus 로고    scopus 로고
    • Dynamic cross-Talk between cells and the extracellular matrix in the testis
    • Siu MK Y, Cheng CY. Dynamic cross-Talk between cells and the extracellular matrix in the testis. BioEssays 2004; 26:978-992
    • (2004) BioEssays , vol.26 , pp. 978-992
    • Siu, M.K.Y.1    Cheng, C.Y.2
  • 48
    • 79958214687 scopus 로고    scopus 로고
    • The 13 I-integrin-p-FAK-p130Cas-DOCKI80-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes
    • Siu MKY, Wong CH, Xia W, et al. The 13 I-integrin-p-FAK-p130Cas-DOCKI80- RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes. Spermatogenesis 2011; 1:73-86
    • (2011) Spermatogenesis , vol.1 , pp. 73-86
    • Siu, M.K.Y.1    Wong, C.H.2    Xia, W.3
  • 49
    • 1242281830 scopus 로고    scopus 로고
    • Interactions of prot eases, protease inhibitors and the 131 integrinl1aminin y3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis
    • Siu MKY, Cheng CY. Interactions of prot eases, protease inhibitors and the 131 integrinl1aminin y3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis. BioI Reprod 2004; 70:945-964
    • (2004) BioI Reprod , vol.70 , pp. 945-964
    • Siu, M.K.Y.1    Cheng, C.Y.2
  • 50
    • 35348883542 scopus 로고    scopus 로고
    • Junction restructuring and spermatogenesis: The biology, regulation, and implication in male contraceptive development
    • Yan HHN, Mruk DD, Cheng CY. Junction restructuring and spermatogenesis: The biology, regulation, and implication in male contraceptive development. Curr Top Dev BioI 2008; 80:57-92
    • (2008) Curr Top Dev BioI , vol.80 , pp. 57-92
    • Yan, H.H.N.1    Mruk, D.D.2    Cheng, C.Y.3
  • 52
    • 0018759431 scopus 로고
    • 1-2,4-Dichlorobenzyl)-IH-indazole-3-carboxylic acid (DICA), an exfoliative antispermatogenic angent in the rat
    • LobI TJ. 1-(2,4-dichlorobenzyl)-IH-indazole-3-carboxylic acid (DICA), an exfoliative antispermatogenic angent in the rat. Arch Androl 1979; 2:353-363
    • (1979) Arch Androl , vol.2 , pp. 353-363
    • LobI, T.J.1
  • 53
    • 0019870061 scopus 로고
    • Effects oflonidamine (AF 1890 and its analogues on follicle-stimulating hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey
    • SuppI2
    • LobI T, Bardin C, Gunsalus G, et al. Effects oflonidamine (AF 1890) and its analogues on follicle-stimulating hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 1981; (SuppI2) 27:61-76
    • (1981) Chemotherapy , vol.27 , pp. 61-76
    • LobI, T.1    Bardin, C.2    Gunsalus, G.3
  • 55
    • 0035027440 scopus 로고    scopus 로고
    • Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide
    • Grima J, Silvestrini B, Cheng C. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3- carbohydrazide. BioI Reprod 2001; 64: 1500-1508
    • (2001) BioI Reprod , vol.64 , pp. 1500-1508
    • Grima, J.1    Silvestrini, B.2    Cheng, C.3
  • 56
    • 1242342879 scopus 로고    scopus 로고
    • Zyxin, axin and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis
    • Lee NPY, Mruk DD, Conway AM, et al. Zyxin, axin and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis. J Andro12004; 25:200-215
    • (2004) J Andro1 , vol.25 , pp. 200-215
    • Lee, N.P.Y.1    Mruk, D.D.2    Conway, A.M.3
  • 57
    • 47749130863 scopus 로고    scopus 로고
    • Par3/Par6 polarity complex co-ordinates apical ectoplasmic specialization and blood-Testis barrier restructuring during spermatogenesis
    • Wong EWP, Mruk DD, Lee WM, et al. Par3/Par6 polarity complex co-ordinates apical ectoplasmic specialization and blood-Testis barrier restructuring during spermatogenesis. Proc Natl Acad Sci USA 2008; 105:9657-9662
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9657-9662
    • Wong, E.W.P.1    Mruk, D.D.2    Lee, W.M.3
  • 58
    • 84855669276 scopus 로고    scopus 로고
    • Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility
    • in press; doi: 10.1 111/j.1365-2605.2010.01 I 83.x.
    • Mok KW, Mruk DD, Lee WM, et al. Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility. lnt J Androl2011 (in press; doi: 10.1 111/j.1365-2605.2010.01 I 83.x.
    • (2011) Int J Androl
    • Mok, K.W.1    Mruk, D.D.2    Lee, W.M.3
  • 59
    • 0038070531 scopus 로고    scopus 로고
    • Adheringjunction dynamics in the testis are regulated by an interplay of B I-integrin and focal adhesion complex (F AC)-Associated proteins
    • Siu MKY, Mrnk DD, Lee WM, et al. Adheringjunction dynamics in the testis are regulated by an interplay of B I-integrin and focal adhesion complex (F AC)-Associated proteins. Endocrinology 2003; 144:2141-2163
    • (2003) Endocrinology , vol.144 , pp. 2141-2163
    • Siu, M.K.Y.1    Mrnk, D.D.2    Lee, W.M.3
  • 60
    • 21644457437 scopus 로고    scopus 로고
    • Sertoli-germ cell anchoringjunction dynamics in the testis are regulated by an interplay of lipid and protein kinases
    • SiuMK Y, Wong CH, Lee WM, et al. Sertoli-germ cell anchoringjunction dynamics in the testis are regulated by an interplay of lipid and protein kinases. J BioI Chern 2005; 280:25029-25047
    • (2005) J BioI Chern , vol.280 , pp. 25029-25047
    • Siu, M.K.Y.1    Wong, C.H.2    Lee, W.M.3
  • 61
    • 0037306844 scopus 로고    scopus 로고
    • Ls the cadherin/catenincomplex a functional unit of cell-cell-Act in-based adherens junctions (AJ in the rat testis?
    • Lee NPY, Mrnk DD, Lee WM, et al.ls the cadherin/catenincomplex a functional unit of cell-cell-Act in-based adherens junctions (AJ) in the rat testis? BioI Reprod 2003; 68:489-508
    • (2003) BioI Reprod , vol.68 , pp. 489-508
    • Lee, N.P.Y.1    Mrnk, D.D.2    Lee, W.M.3
  • 62
    • 23844545574 scopus 로고    scopus 로고
    • Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)fB-catenin (CA TNB) signaling pathway: An in vitro and in vivo study
    • Lee NPY, Mruk DD, Wong CH, et al. Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)fB-catenin (CA TNB) signaling pathway: An in vitro and in vivo study. BioI Reprod 2005; 73:458-471
    • (2005) BioI Reprod , vol.73 , pp. 458-471
    • Lee, N.P.Y.1    Mruk, D.D.2    Wong, C.H.3
  • 63
    • 11144249434 scopus 로고    scopus 로고
    • Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis
    • Lee NPY, Cheng CY. Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. J Cell Physiol2005; 202:344-360
    • (2005) J Cell Physiol , vol.202 , pp. 344-360
    • Lee, N.P.Y.1    Cheng, C.Y.2
  • 64
    • 0038513420 scopus 로고    scopus 로고
    • Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCKlLlMK signaling pathway
    • Lui WY, Lee WM, Cheng CY. Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCKlLlMK signaling pathway. BioI Reprod 2003; 68:2189-2206
    • (2003) BioI Reprod , vol.68 , pp. 2189-2206
    • Lui, W.Y.1    Lee, W.M.2    Cheng, C.Y.3
  • 65
    • 77954920588 scopus 로고    scopus 로고
    • Restricted Arp3 expression in the testis prevents blood-Testis barrier disruption during junction restructuring at spermatogenesis
    • Lie PPY, Chan A YN, Mruk DD, et al. Restricted Arp3 expression in the testis prevents blood-Testis barrier disruption during junction restructuring at spermatogenesis. Proc Natl Acad Sci USA 2010; 107:11411-11416
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11411-11416
    • Lie, P.P.Y.1    Chan A, Y.N.2    Mruk, D.D.3
  • 66
    • 68849115313 scopus 로고    scopus 로고
    • Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-Testis barrier integrity in the seminiferous epithelium
    • Lie PPY, Mruk DD, Lee WM, et al. Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-Testis barrier integrity in the seminiferous epithelium. FASEB J 2009; 23:2555-2567
    • (2009) FASEB J , vol.23 , pp. 2555-2567
    • Lie, P.P.Y.1    Mruk, D.D.2    Lee, W.M.3
  • 67
    • 79955824328 scopus 로고    scopus 로고
    • Adjudin, a potential male contraceptive, exerts its effects locally in the seminifeorus epithelium of mammalian testes
    • Mok KW, Mruk DD, Lie PPY, et al. Adjudin, a potential male contraceptive, exerts its effects locally in the seminifeorus epithelium of mammalian testes. Reproduction 20 II; 141 :571-580
    • (2011) Reproduction , vol.141 , pp. 571-580
    • Mok, K.W.1    Mruk, D.D.2    Lie, P.P.Y.3
  • 68
    • 79954549857 scopus 로고    scopus 로고
    • Regulation of spermiogenesis, spermiation and blood-Testis barrier dynamics: Novel insights from studies on Eps8 and Arp3
    • Cheng CY, Mruk DD. Regulation of spermiogenesis, spermiation and blood-Testis barrier dynamics: Novel insights from studies on Eps8 and Arp3. Biochem J 2011; 435:553-562
    • (2011) Biochem J , vol.435 , pp. 553-562
    • Cheng, C.Y.1    Mruk, D.D.2
  • 69
    • 84896949669 scopus 로고    scopus 로고
    • Interactions oflaminin B3 fragment with B I-integrin receptor: A revisit ofthe apical ectoplasmic specialization-blood-Testis-barrier-hemidesmosome functional axis in the testis
    • in press
    • Cheng CY, Lie PPY, Mok KW, et al. Interactions oflaminin B3 fragment with B I-integrin receptor: A revisit ofthe apical ectoplasmic specialization-blood- Testis-barrier-hemidesmosome functional axis in the testis. Spermatogenesis (in press) 20 I.I.
    • (2011) Spermatogenesis
    • Cheng, C.Y.1    Lie, P.P.Y.2    Mok, K.W.3
  • 70
    • 72749106653 scopus 로고    scopus 로고
    • The complexities of antiretroviral drug-drug interactions: Role of ABC and SLC transporters
    • Kis 0, Robillard K, Chan GN, et al. The complexities of antiretroviral drug-drug interactions: Role of ABC and SLC transporters. Trends Pharmacol Sci 2010; 31 :22-35
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 22-35
    • Kis, O.1    Robillard, K.2    Chan, G.N.3
  • 71
    • 79651475092 scopus 로고    scopus 로고
    • Emerging role for drug transporters at the blood-Testis barrier
    • Mruk DD, Su L, Cheng CY. Emerging role for drug transporters at the blood-Testis barrier. Trends Pharmacol Sci 2011; 32:99-106
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 99-106
    • Mruk, D.D.1    Su, L.2    Cheng, C.Y.3
  • 72
    • 79951778173 scopus 로고    scopus 로고
    • Drug transporters, the blood-Testis barrier and spermatogenesis
    • Su L, Mruk DD, Cheng CY. Drug transporters, the blood-Testis barrier and spermatogenesis. J Endocrinol 2011; 208:207-223
    • (2011) J Endocrinol , vol.208 , pp. 207-223
    • Su, L.1    Mruk, D.D.2    Cheng, C.Y.3
  • 73
    • 79956267665 scopus 로고    scopus 로고
    • The blood-Testis and blood-epididymis barriers are more than just their tight junctions
    • Mital P, Hinton BT, Dufour JM. The blood-Testis and blood-epididymis barriers are more than just their tight junctions. BioI Reprod 2011; 84:851-858
    • (2011) BioI Reprod , vol.84 , pp. 851-858
    • Mital, P.1    Hinton, B.T.2    Dufour, J.M.3
  • 74
    • 71849115693 scopus 로고    scopus 로고
    • Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances
    • Cheng CY, Wong EWP, Van HHN, et al. Regulation of spermatogenesis in the microenvironment of the seminiferous epithelium: New insights and advances. Mol Cell Endocrinol 2010; 315:49-56
    • (2010) Mol Cell Endocrinol , vol.315 , pp. 49-56
    • Cheng, C.Y.1    Wong, E.W.P.2    Van, H.H.N.3
  • 75
    • 0038299227 scopus 로고    scopus 로고
    • Fer kinase/Fer T and adherens junction dynamics in the testis: An in vitro and in vivo study
    • Chen YM, Lee NPY, Mruk DD, et al. Fer kinase/Fer T and adherens junction dynamics in the testis: An in vitro and in vivo study. Bioi Reprod 2003; 69:656-672
    • (2003) Bioi Reprod , vol.69 , pp. 656-672
    • Chen, Y.M.1    Lee, N.P.Y.2    Mruk, D.D.3
  • 76
    • 33751560067 scopus 로고    scopus 로고
    • The Sertoli-spermatidjunctional complex adhesion strength is affec ted in vitro by adjudin
    • Wolski KM, Mruk DD, CameronDF. The Sertoli-spermatidjunctional complex adhesion strength is affec ted in vitro by adjudin. J Andro12006; 27:790-794
    • (2006) J Andro1 , vol.27 , pp. 790-794
    • Wolski, K.M.1    Mruk, D.D.2    Cameron, D.F.3
  • 77
    • 84896991439 scopus 로고    scopus 로고
    • P-glycoprotein regulates blood-Testis barrier dynamics via its effects on the occludin-ZO-I protein complex mediated by FAK
    • Su L, Mruk DD, Lui WY, et al. P-glycoprotein regulates blood-Testis barrier dynamics via its effects on the occludin-ZO-I protein complex mediated by FAK. Proc Natl Acad Sci USA (submitted) 2011
    • (2011) Proc Natl Acad Sci USA (submitted
    • Su, L.1    Mruk, D.D.2    Lui, W.Y.3
  • 78
    • 79958187254 scopus 로고    scopus 로고
    • Drug transporters and blood-Testis barrier function
    • Su L, Mruk DD, Lee WM, et al. Drug transporters and blood-Testis barrier function. J Endocrinol2011; 209:337-351
    • (2011) J Endocrinol , vol.209 , pp. 337-351
    • Su, L.1    Mruk, D.D.2    Lee, W.M.3
  • 79
    • 70350346593 scopus 로고    scopus 로고
    • Drug transporter, P-glycoprotein (MDRI), is an integrated component of the mammalian blood-Testis barrier
    • Su L, Cheng CY, Mruk DD. Drug transporter, P-glycoprotein (MDRI), is an integrated component of the mammalian blood-Testis barrier. Int J Biochem Cell BioI 2009; 41 :2578-2587
    • (2009) Int J Biochem Cell BioI , vol.41 , pp. 2578-2587
    • Su, L.1    Cheng, C.Y.2    Mruk, D.D.3
  • 80
    • 3242811705 scopus 로고    scopus 로고
    • Ectoplasmic specialization, a testis-specific cell-cell actin-based adherensj unction type: Is this a potential target for male contraceptive development
    • Lee NPY, Cheng CY. Ectoplasmic specialization, a testis-specific cell-cell actin-based adherensj unction type: Is this a potential target for male contraceptive development. Human Reprod Update 2004; 10:349-369
    • (2004) Human Reprod Update , vol.10 , pp. 349-369
    • Lee, N.P.Y.1    Cheng, C.Y.2
  • 81
    • 73949086560 scopus 로고    scopus 로고
    • Extracellular matrix and its role in spermatogenesis
    • Siu MKY, Cheng CY. Extracellular matrix and its role in spermatogenesis. Adv Exp Med Bioi 2008; 636:74-91
    • (2008) Adv Exp Med Bioi , vol.636 , pp. 74-91
    • Siu, M.K.Y.1    Cheng, C.Y.2
  • 82
    • 77954065271 scopus 로고    scopus 로고
    • 1-T ASSER: A unified platform for automated protein structure and function prediction
    • Roy A, Kueukural A, Zhang Y. 1-T ASSER: A unified platform for automated protein structure and function prediction. Nat Protoe 2010; 5:725-738
    • (2010) Nat Protoe , vol.5 , pp. 725-738
    • Roy, A.1    Kueukural, A.2    Zhang, Y.3
  • 84
    • 0035850669 scopus 로고    scopus 로고
    • Crystal structure of the extracellular segment of integrin alpha Vbeta3
    • Xiong JP, Stehle T, Diefenbach B, et al. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science 2001; 294:339-345
    • (2001) Science , vol.294 , pp. 339-345
    • Xiong, J.P.1    Stehle, T.2    Diefenbach, B.3
  • 85
    • 33748781976 scopus 로고    scopus 로고
    • Tools for integrated sequence-structure analysis with UCSF Chimera
    • Meng EC, Pettersen EF, Couch GS, et al. Tools for integrated sequence-structure analysis with UCSF Chimera. BMC Bioinformaties 2006; 7:339
    • (2006) BMC Bioinformaties , vol.7 , pp. 339
    • Meng, E.C.1    Pettersen, E.F.2    Couch, G.S.3
  • 86
    • 23844511497 scopus 로고    scopus 로고
    • Blood-Testis barrier dynamics are regulated by an engagement/ disengagement mechanism between tight and adherens junctions via peripheral adaptors
    • Van HHN, Cheng CY. Blood-Testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors. Proe Natl Aead Sci USA 2005; 102:11722-11727
    • (2005) Proe Natl Aead Sci USA , vol.102 , pp. 11722-11727
    • Van, H.H.N.1    Cheng, C.Y.2
  • 87
    • 77957264938 scopus 로고    scopus 로고
    • Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo
    • Su L, Cheng CY, Mruk DD. Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo. Int J Bioehem Cell Bioi 2010; 42: 1864-1875
    • (2010) Int J Bioehem Cell Bioi , vol.42 , pp. 1864-1875
    • Su, L.1    Cheng, C.Y.2    Mruk, D.D.3
  • 88
    • 18844436448 scopus 로고    scopus 로고
    • Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-Testis barrier integrity: An in vivo study using an androgen suppression model
    • Xia W, Wong CH, Lee NPY, et al. Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-Testis barrier integrity: An in vivo study using an androgen suppression model. J Cell Physiol2005; 205:141-157
    • (2005) J Cell Physiol , vol.205 , pp. 141-157
    • Xia, W.1    Wong, C.H.2    Lee, N.P.Y.3
  • 89
    • 73949155530 scopus 로고    scopus 로고
    • Cross-Talk between tight and anchoring junctions-lesson from the testis
    • Van HHN, Mruk DD, Lee WM, et al. Cross-Talk between tight and anchoring junctions-lesson from the testis. Adv Exp Med BioI 2008; 636:234-254
    • (2008) Adv Exp Med BioI , vol.636 , pp. 234-254
    • Van, H.H.N.1    Mruk, D.D.2    Lee, W.M.3
  • 90
    • 83455180875 scopus 로고    scopus 로고
    • Gap junctions and blood-Tissue barriers
    • Ed. Cheng c.y. Austin TX. Landes Bioscience and Springer Seienee+Business Media in press
    • Li MWM, Mruk DD, Cheng CY. Gap junctions and blood-Tissue barriers. In: Biology and Regulation of Blood-Tissue Barriers. Ed. Cheng c.y. Austin TX. Landes Bioscience and Springer Seienee+Business Media (in press, http://landesbioseienee.eom/eurie/ehapter4832/. 2011
    • (2011) Biology and Regulation of Blood-Tissue Barriers
    • Li, M.W.M.1    Mruk, D.D.2    Cheng, C.Y.3
  • 91
    • 34547678604 scopus 로고    scopus 로고
    • A Sertoli cell-specific knockout of eonnexin43 prevents initiation of spermatogenesis
    • Brehm R, Zeiler M, Ruttinger C, et al. A Sertoli cell-specific knockout of eonnexin43 prevents initiation of spermatogenesis. Am J Pathol 2007; 171: 19-31
    • (2007) Am J Pathol , vol.171 , pp. 19-31
    • Brehm, R.1    Zeiler, M.2    Ruttinger, C.3
  • 92
    • 77956396619 scopus 로고    scopus 로고
    • Major involvement of eonnexin 43 in seminiferous epithelial junction dynamics and male fertility
    • Carette D, Weider K, Gilleron J, et al. Major involvement of eonnexin 43 in seminiferous epithelial junction dynamics and male fertility. Dev Bioi 2010; 346:54-67
    • (2010) Dev Bioi , vol.346 , pp. 54-67
    • Carette, D.1    Weider, K.2    Gilleron, J.3
  • 93
    • 79958765541 scopus 로고    scopus 로고
    • Altered differentiation and clustering of Sertoli cells in transgenic mice showing a Sertoli cell specific knockout of the eonnexin 43 gene
    • Weider K, Bergmann M, Giese S, et al. Altered differentiation and clustering of Sertoli cells in transgenic mice showing a Sertoli cell specific knockout of the eonnexin 43 gene. Differentiation 2011; 82:38-49
    • (2011) Differentiation , vol.82 , pp. 38-49
    • Weider, K.1    Bergmann, M.2    Giese, S.3
  • 94
    • 34247482339 scopus 로고    scopus 로고
    • Proliferation of adult Sertoli cells following conditional knockout of the gap junctional protein GJA I (eonnexin 43) in mice
    • Sridharan S, Simon L, Meling DD, et al. Proliferation of adult Sertoli cells following conditional knockout of the gap junctional protein GJA I (eonnexin 43) in mice. Bioi Reprod 2007; 76:804-812
    • (2007) Bioi Reprod , vol.76 , pp. 804-812
    • Sridharan, S.1    Simon, L.2    Meling, D.D.3
  • 95
    • 67649635971 scopus 로고    scopus 로고
    • An oecludin-foeal adhesion kinase protein complex at the blood-Testis barrier: A study using the cadmium model
    • Siu ER, Wong EWP, Mruk DD, et al. An oecludin-foeal adhesion kinase protein complex at the blood-Testis barrier: A study using the cadmium model. Endocrinology 2009; 150:3336-3344
    • (2009) Endocrinology , vol.150 , pp. 3336-3344
    • Siu, E.R.1    Wong, E.W.P.2    Mruk, D.D.3
  • 96
    • 67249083120 scopus 로고    scopus 로고
    • Focal adhesion kinase is a blood-Testis barrier regulator
    • Siu ER, Wong EWP, Mruk DD, et al. Focal adhesion kinase is a blood-Testis barrier regulator. Proe Natl Aead Sci USA 2009; 106:9298-9303
    • (2009) Proe Natl Aead Sci USA , vol.106 , pp. 9298-9303
    • Siu, E.R.1    Wong, E.W.P.2    Mruk, D.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.