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Volumn 26, Issue 2, 2008, Pages 90-99

Delivering non-hormonal contraceptives to men: advances and obstacles

Author keywords

[No Author keywords available]

Indexed keywords

CONTRACEPTIVES; THERAPEUTIC COMPOUNDS;

EID: 38349148676     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2007.10.009     Document Type: Review
Times cited : (29)

References (75)
  • 2
    • 0346655112 scopus 로고    scopus 로고
    • Progress towards hormonal male contraception
    • Kamischke A., and Nieschlag E. Progress towards hormonal male contraception. Trends Pharmacol. Sci. 25 (2004) 49-57
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 49-57
    • Kamischke, A.1    Nieschlag, E.2
  • 3
    • 0036098726 scopus 로고    scopus 로고
    • Gossypol: a contraceptive for men
    • Coutinho E.M. Gossypol: a contraceptive for men. Contraception 65 (2002) 259-263
    • (2002) Contraception , vol.65 , pp. 259-263
    • Coutinho, E.M.1
  • 4
    • 0031745078 scopus 로고    scopus 로고
    • Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug
    • Waites G.M., et al. Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. Int. J. Androl. 21 (1998) 8-12
    • (1998) Int. J. Androl. , vol.21 , pp. 8-12
    • Waites, G.M.1
  • 5
    • 0023231271 scopus 로고
    • Tripterygium wilfordii, a Chinese herb effective in male fertility regulation
    • Qian S.Z. Tripterygium wilfordii, a Chinese herb effective in male fertility regulation. Contraception 36 (1987) 335-345
    • (1987) Contraception , vol.36 , pp. 335-345
    • Qian, S.Z.1
  • 6
    • 27544465448 scopus 로고    scopus 로고
    • Nonhormonal drugs for contraception in men: a systematic review
    • Lopez L.M., et al. Nonhormonal drugs for contraception in men: a systematic review. Obstet. Gynecol. Surv. 60 (2005) 746-752
    • (2005) Obstet. Gynecol. Surv. , vol.60 , pp. 746-752
    • Lopez, L.M.1
  • 7
    • 0036788073 scopus 로고    scopus 로고
    • Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development
    • Cheng C.Y., and Mruk D.D. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol. Rev. 82 (2002) 825-874
    • (2002) Physiol. Rev. , vol.82 , pp. 825-874
    • Cheng, C.Y.1    Mruk, D.D.2
  • 8
    • 0037168595 scopus 로고    scopus 로고
    • Reversible infertility in male mice after oral administration of alkylated imino sugars: a hormonal approach to male contraception
    • van der Spoel A.C., et al. Reversible infertility in male mice after oral administration of alkylated imino sugars: a hormonal approach to male contraception. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 17173-17178
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 17173-17178
    • van der Spoel, A.C.1
  • 9
    • 34247860866 scopus 로고    scopus 로고
    • Miglustat has no apparent effect on spermatogenesis in normal men
    • Amory J.K., et al. Miglustat has no apparent effect on spermatogenesis in normal men. Hum. Reprod. 22 (2007) 702-707
    • (2007) Hum. Reprod. , vol.22 , pp. 702-707
    • Amory, J.K.1
  • 10
    • 33644529456 scopus 로고    scopus 로고
    • Antisperm immunity for contraception
    • Naz R.K. Antisperm immunity for contraception. J. Androl. 27 (2006) 153-159
    • (2006) J. Androl. , vol.27 , pp. 153-159
    • Naz, R.K.1
  • 11
    • 17144382068 scopus 로고    scopus 로고
    • Contraceptive vaccines targeting sperm
    • Suri A. Contraceptive vaccines targeting sperm. Expert Opin. Biol. Ther. 5 (2005) 381-392
    • (2005) Expert Opin. Biol. Ther. , vol.5 , pp. 381-392
    • Suri, A.1
  • 12
    • 23844478817 scopus 로고    scopus 로고
    • AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data
    • Cheng C.Y., et al. AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data. Contraception 72 (2005) 251-261
    • (2005) Contraception , vol.72 , pp. 251-261
    • Cheng, C.Y.1
  • 13
    • 3242879161 scopus 로고    scopus 로고
    • Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis
    • Mruk D.D., and Cheng C.Y. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr. Rev. 25 (2004) 747-806
    • (2004) Endocr. Rev. , vol.25 , pp. 747-806
    • Mruk, D.D.1    Cheng, C.Y.2
  • 14
    • 0027771127 scopus 로고
    • The Sertoli-germ cell communication network in mammals
    • Jegou B. The Sertoli-germ cell communication network in mammals. Int. Rev. Cytol. 147 (1993) 25-96
    • (1993) Int. Rev. Cytol. , vol.147 , pp. 25-96
    • Jegou, B.1
  • 15
    • 0026641564 scopus 로고
    • The Sertoli cell in vivo and in vitro
    • Jegou B. The Sertoli cell in vivo and in vitro. Cell Biol. Toxicol. 8 (1992) 49-54
    • (1992) Cell Biol. Toxicol. , vol.8 , pp. 49-54
    • Jegou, B.1
  • 16
    • 0002702079 scopus 로고
    • Sertoli cell toxicants
    • Russell L., and Griswold M. (Eds), Cache River Press, Clearwater
    • Boekelheide K. Sertoli cell toxicants. In: Russell L., and Griswold M. (Eds). The Sertoli Cell (1993), Cache River Press, Clearwater 551-575
    • (1993) The Sertoli Cell , pp. 551-575
    • Boekelheide, K.1
  • 17
    • 0021654914 scopus 로고
    • Lonidamine and related compounds
    • Silvestrini B., et al. Lonidamine and related compounds. Prog. Med. Chem. 21 (1984) 110-135
    • (1984) Prog. Med. Chem. , vol.21 , pp. 110-135
    • Silvestrini, B.1
  • 18
    • 0034915521 scopus 로고    scopus 로고
    • Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis
    • Cheng C.Y., et al. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol. Reprod. 65 (2001) 449-461
    • (2001) Biol. Reprod. , vol.65 , pp. 449-461
    • Cheng, C.Y.1
  • 19
    • 0038299227 scopus 로고    scopus 로고
    • Fer kinase/Fer T and adherens junction dynamics in the testis: an in vitro and in vivo study
    • Chen Y.M., et al. Fer kinase/Fer T and adherens junction dynamics in the testis: an in vitro and in vivo study. Biol. Reprod. 69 (2003) 656-672
    • (2003) Biol. Reprod. , vol.69 , pp. 656-672
    • Chen, Y.M.1
  • 20
    • 0035027440 scopus 로고    scopus 로고
    • Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide
    • Grima J., et al. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide. Biol. Reprod. 64 (2001) 1500-1508
    • (2001) Biol. Reprod. , vol.64 , pp. 1500-1508
    • Grima, J.1
  • 21
    • 33750735046 scopus 로고    scopus 로고
    • A male contraceptive targeting germ cell adhesion
    • Mruk D.D., et al. A male contraceptive targeting germ cell adhesion. Nat. Med. 12 (2006) 1323-1328
    • (2006) Nat. Med. , vol.12 , pp. 1323-1328
    • Mruk, D.D.1
  • 22
    • 0035178312 scopus 로고    scopus 로고
    • Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats
    • Hild S.A., et al. Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats. Biol. Reprod. 65 (2001) 1771-1779
    • (2001) Biol. Reprod. , vol.65 , pp. 1771-1779
    • Hild, S.A.1
  • 23
    • 34447313392 scopus 로고    scopus 로고
    • Acute adverse effects of the indenopyridine CDB-4022 on the ultrastructure of Sertoli cells, spermatocytes, and spermatids in rat testes: Comparison to the known Sertoli cell toxicant di-n-pentylphthalate (DPP)
    • Hild S.A., et al. Acute adverse effects of the indenopyridine CDB-4022 on the ultrastructure of Sertoli cells, spermatocytes, and spermatids in rat testes: Comparison to the known Sertoli cell toxicant di-n-pentylphthalate (DPP). J. Androl. 28 (2007) 621-629
    • (2007) J. Androl. , vol.28 , pp. 621-629
    • Hild, S.A.1
  • 24
    • 33947415685 scopus 로고    scopus 로고
    • Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: Induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis)
    • Hild S.A., et al. Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: Induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). Endocrinology 148 (2007) 1784-1796
    • (2007) Endocrinology , vol.148 , pp. 1784-1796
    • Hild, S.A.1
  • 25
    • 0034973368 scopus 로고    scopus 로고
    • Lupron Depot prevention of antispermatogenic/antifertility activity of the indenopyridine, CDB-4022, in the rat
    • Hild S.A., et al. Lupron Depot prevention of antispermatogenic/antifertility activity of the indenopyridine, CDB-4022, in the rat. Biol. Reprod. 65 (2001) 165-172
    • (2001) Biol. Reprod. , vol.65 , pp. 165-172
    • Hild, S.A.1
  • 26
    • 0034115882 scopus 로고    scopus 로고
    • Unique and multifunctional adhesion junctions in the testis: ectoplasmic specializations
    • Vogl A.W., et al. Unique and multifunctional adhesion junctions in the testis: ectoplasmic specializations. Arch. Histol. Cytol. 63 (2000) 1-15
    • (2000) Arch. Histol. Cytol. , vol.63 , pp. 1-15
    • Vogl, A.W.1
  • 27
    • 33846586935 scopus 로고    scopus 로고
    • Ectoplasmic specialization: a friend or a foe of spermatogenesis?
    • Yan H.H.N., et al. Ectoplasmic specialization: a friend or a foe of spermatogenesis?. Bioessays 29 (2007) 36-48
    • (2007) Bioessays , vol.29 , pp. 36-48
    • Yan, H.H.N.1
  • 28
    • 4644328373 scopus 로고    scopus 로고
    • Dynamic cross-talk between cells and the extracellular matrix in the testis
    • Siu M.K.Y., and Cheng C.Y. Dynamic cross-talk between cells and the extracellular matrix in the testis. Bioessays 26 (2004) 978-992
    • (2004) Bioessays , vol.26 , pp. 978-992
    • Siu, M.K.Y.1    Cheng, C.Y.2
  • 29
    • 18244400414 scopus 로고    scopus 로고
    • Strength measurement of the Sertoli-spermatid junctional complex
    • Wolski K.M., et al. Strength measurement of the Sertoli-spermatid junctional complex. J. Androl. 26 (2005) 354-359
    • (2005) J. Androl. , vol.26 , pp. 354-359
    • Wolski, K.M.1
  • 30
    • 33751560067 scopus 로고    scopus 로고
    • The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin
    • Wolski K.M., et al. The Sertoli-spermatid junctional complex adhesion strength is affected in vitro by adjudin. J. Androl. 27 (2006) 790-794
    • (2006) J. Androl. , vol.27 , pp. 790-794
    • Wolski, K.M.1
  • 31
    • 0017578731 scopus 로고
    • Movement of spermatocytes from the basal to the adluminal compartment of the rat testis
    • Russell L. Movement of spermatocytes from the basal to the adluminal compartment of the rat testis. Am. J. Anat. 148 (1977) 313-328
    • (1977) Am. J. Anat. , vol.148 , pp. 313-328
    • Russell, L.1
  • 32
    • 0037374822 scopus 로고    scopus 로고
    • TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study
    • Lui W.Y., et al. TGF-β3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study. Endocrinology 144 (2003) 1139-1142
    • (2003) Endocrinology , vol.144 , pp. 1139-1142
    • Lui, W.Y.1
  • 33
    • 33745220527 scopus 로고    scopus 로고
    • Differential interactions between transforming growth factor-β3/TßR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion
    • Xia W., et al. Differential interactions between transforming growth factor-β3/TßR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. J. Biol. Chem. 281 (2006) 16799-16813
    • (2006) J. Biol. Chem. , vol.281 , pp. 16799-16813
    • Xia, W.1
  • 34
    • 0037230154 scopus 로고    scopus 로고
    • The interplay of collagen IV, tumor necrosis factor-α, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloprotease-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis
    • Siu M.K.Y., et al. The interplay of collagen IV, tumor necrosis factor-α, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloprotease-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis. Endocrinology 144 (2003) 371-387
    • (2003) Endocrinology , vol.144 , pp. 371-387
    • Siu, M.K.Y.1
  • 35
    • 33747881517 scopus 로고    scopus 로고
    • Tumor necrosis factor α reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes
    • Li M.W.M., et al. Tumor necrosis factor α reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes. J. Endocrinol. 190 (2006) 313-329
    • (2006) J. Endocrinol. , vol.190 , pp. 313-329
    • Li, M.W.M.1
  • 36
    • 34247225991 scopus 로고    scopus 로고
    • C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes
    • Xia W., et al. C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 3841-3846
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 3841-3846
    • Xia, W.1
  • 37
    • 19044391626 scopus 로고    scopus 로고
    • TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: an in vivo study
    • Xia W., and Cheng C.Y. TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: an in vivo study. Dev. Biol. 280 (2005) 321-343
    • (2005) Dev. Biol. , vol.280 , pp. 321-343
    • Xia, W.1    Cheng, C.Y.2
  • 38
    • 1342283974 scopus 로고    scopus 로고
    • Regulation of blood-testis barrier dynamics: an in vivo study
    • Wong C.H., et al. Regulation of blood-testis barrier dynamics: an in vivo study. J. Cell Sci. 117 (2004) 783-798
    • (2004) J. Cell Sci. , vol.117 , pp. 783-798
    • Wong, C.H.1
  • 39
    • 0026544420 scopus 로고
    • Effect of cadmium chloride on transepithelial electrical resistance of Sertoli cell monolayers in two-compartment cultures - a new model for toxicological investigations of the 'blood-testis' barrier in vitro
    • Janecki A., et al. Effect of cadmium chloride on transepithelial electrical resistance of Sertoli cell monolayers in two-compartment cultures - a new model for toxicological investigations of the 'blood-testis' barrier in vitro. Toxicol. Appl. Pharmacol. 112 (1992) 51-57
    • (1992) Toxicol. Appl. Pharmacol. , vol.112 , pp. 51-57
    • Janecki, A.1
  • 40
    • 0035047037 scopus 로고    scopus 로고
    • Is cadmium chloride-induced inter-Sertoli tight junction permeability barrier disruption a suitable in vitro model to study the events of junction disassembly during spermatogenesis in the rat testis?
    • Chung N.P.Y., and Cheng C.Y. Is cadmium chloride-induced inter-Sertoli tight junction permeability barrier disruption a suitable in vitro model to study the events of junction disassembly during spermatogenesis in the rat testis?. Endocrinology 142 (2001) 1878-1888
    • (2001) Endocrinology , vol.142 , pp. 1878-1888
    • Chung, N.P.Y.1    Cheng, C.Y.2
  • 41
    • 28044449945 scopus 로고    scopus 로고
    • Androgen regulates the permeability of the blood-testis barrier
    • Meng J., et al. Androgen regulates the permeability of the blood-testis barrier. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16696-16700
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 16696-16700
    • Meng, J.1
  • 42
    • 33751507373 scopus 로고    scopus 로고
    • Androgen receptor in Sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes
    • Wang R.S., et al. Androgen receptor in Sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes. Endocrinology 147 (2006) 5624-5633
    • (2006) Endocrinology , vol.147 , pp. 5624-5633
    • Wang, R.S.1
  • 43
    • 38349138523 scopus 로고    scopus 로고
    • Yan, H.H.N. et al. Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells. FASEB J. (in press)
  • 44
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2 and BRCP (ABCG2) in tissue defense
    • Leslie E.M., et al. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2 and BRCP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204 (2005) 216-237
    • (2005) Toxicol. Appl. Pharmacol. , vol.204 , pp. 216-237
    • Leslie, E.M.1
  • 45
    • 3242785620 scopus 로고    scopus 로고
    • Importance of P-glycoprotein at blood-tissue barriers
    • Fromm M.F. Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol. Sci. 25 (2004) 423-429
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 423-429
    • Fromm, M.F.1
  • 46
    • 0036892223 scopus 로고    scopus 로고
    • Multidrug resistance genes and p-glycoprotein in the testis of the rat, mouse, guinea pig, and human
    • Melaine N., et al. Multidrug resistance genes and p-glycoprotein in the testis of the rat, mouse, guinea pig, and human. Biol. Reprod. 67 (2002) 1699-1707
    • (2002) Biol. Reprod. , vol.67 , pp. 1699-1707
    • Melaine, N.1
  • 47
    • 4444310389 scopus 로고    scopus 로고
    • The distribution of drug-efflux pumps, Pgp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours
    • Bart J., et al. The distribution of drug-efflux pumps, Pgp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours. Eur. J. Cancer 40 (2004) 2064-2070
    • (2004) Eur. J. Cancer , vol.40 , pp. 2064-2070
    • Bart, J.1
  • 48
    • 0029952418 scopus 로고    scopus 로고
    • Altered pharmacokinetics of vinblastine in mdr 1a P-glycoprotein deficient mice
    • Van Asperen J., et al. Altered pharmacokinetics of vinblastine in mdr 1a P-glycoprotein deficient mice. J. Natl. Cancer Inst. 88 (1996) 994-999
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 994-999
    • Van Asperen, J.1
  • 49
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • Schinkel A.H., et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77 (1994) 491-502
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1
  • 50
    • 0028825399 scopus 로고
    • Absence of the mdrl1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin and cyclosporin A
    • Schinkel A.H., et al. Absence of the mdrl1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin and cyclosporin A. J. Clin. Invest. 96 (1995) 1698-1705
    • (1995) J. Clin. Invest. , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1
  • 51
    • 0034121122 scopus 로고    scopus 로고
    • Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testis
    • Choo E.F., et al. Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testis. Drug Metab. Dispos. 28 (2000) 655-660
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 655-660
    • Choo, E.F.1
  • 52
    • 38349132240 scopus 로고    scopus 로고
    • Setchell, B.P. Blood-testis barrier, junctional and transport proteins and spermatogenesis. In Molecular Mechanisms in Spermatogenesis (Cheng, C.Y., ed.), Landes Bioscience (in press)
  • 53
    • 0029098102 scopus 로고
    • The molecular biology of the FSH receptor
    • Griswold M.D., et al. The molecular biology of the FSH receptor. J. Steroid Biochem. Mol. Biol. 53 (1995) 215-218
    • (1995) J. Steroid Biochem. Mol. Biol. , vol.53 , pp. 215-218
    • Griswold, M.D.1
  • 54
    • 0034463924 scopus 로고    scopus 로고
    • Definition and measurement of follicle stimulating hormone
    • Rose M.P., et al. Definition and measurement of follicle stimulating hormone. Endocr. Rev. 21 (2000) 5-21
    • (2000) Endocr. Rev. , vol.21 , pp. 5-21
    • Rose, M.P.1
  • 55
    • 0028978687 scopus 로고
    • Both of the β-subunit carbohydrate residues of follicle-stimulating hormone determine the metabolic clearance rate and in vivo potency
    • Bishop L.A., et al. Both of the β-subunit carbohydrate residues of follicle-stimulating hormone determine the metabolic clearance rate and in vivo potency. Endocrinology 136 (1995) 2635-2640
    • (1995) Endocrinology , vol.136 , pp. 2635-2640
    • Bishop, L.A.1
  • 56
    • 0028289785 scopus 로고
    • Specific roles for the asparagine-linked carbohydrate residues of recombinant human follicle stimulating hormone in receptor binding and signal transduction
    • Bishop L.A., et al. Specific roles for the asparagine-linked carbohydrate residues of recombinant human follicle stimulating hormone in receptor binding and signal transduction. Mol. Endocrinol. 8 (1994) 722-731
    • (1994) Mol. Endocrinol. , vol.8 , pp. 722-731
    • Bishop, L.A.1
  • 57
    • 0028358162 scopus 로고
    • Site-directed mutagenesis defines the individual roles of the glycosylation sites on follicle-stimulating hormone
    • Flack M.R., et al. Site-directed mutagenesis defines the individual roles of the glycosylation sites on follicle-stimulating hormone. J. Biol. Chem. 269 (1994) 14015-14020
    • (1994) J. Biol. Chem. , vol.269 , pp. 14015-14020
    • Flack, M.R.1
  • 58
    • 0028006709 scopus 로고
    • Receptor binding and signal transduction are dissociable functions requiring different sites on follicle-stimulating hormone
    • Valove F.M., et al. Receptor binding and signal transduction are dissociable functions requiring different sites on follicle-stimulating hormone. Endocrinology 135 (1994) 2657-2661
    • (1994) Endocrinology , vol.135 , pp. 2657-2661
    • Valove, F.M.1
  • 59
    • 0028855750 scopus 로고
    • The role of glycosylation in regulating the glycoprotein hormone free α-subunit and free β-subunit combination in the extraembryonic coelomic fluid of early pregnancy
    • Blithe D.L., and Iles R.K. The role of glycosylation in regulating the glycoprotein hormone free α-subunit and free β-subunit combination in the extraembryonic coelomic fluid of early pregnancy. Endocrinology 136 (1995) 903-910
    • (1995) Endocrinology , vol.136 , pp. 903-910
    • Blithe, D.L.1    Iles, R.K.2
  • 60
    • 0028890259 scopus 로고
    • Glycoprotein hormones: glycobiology of gonadotrophins, thyrotrophin and free α subunit
    • Thotakura N.R., and Blithe D.L. Glycoprotein hormones: glycobiology of gonadotrophins, thyrotrophin and free α subunit. Glycobiology 5 (1995) 3-10
    • (1995) Glycobiology , vol.5 , pp. 3-10
    • Thotakura, N.R.1    Blithe, D.L.2
  • 62
    • 13844298046 scopus 로고    scopus 로고
    • Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides
    • Gupta B., et al. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv. Drug Deliv. Rev. 57 (2005) 637-651
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 637-651
    • Gupta, B.1
  • 63
    • 0025029073 scopus 로고    scopus 로고
    • Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption
    • Donovan M.D., et al. Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption. Pharm. Res. 7 (2000) 863-868
    • (2000) Pharm. Res. , vol.7 , pp. 863-868
    • Donovan, M.D.1
  • 64
    • 0026586445 scopus 로고
    • Drug metabolism in the nasal mucosa
    • Sarkar M.A. Drug metabolism in the nasal mucosa. Pharm. Res. 9 (1992) 1-9
    • (1992) Pharm. Res. , vol.9 , pp. 1-9
    • Sarkar, M.A.1
  • 65
    • 0035130249 scopus 로고    scopus 로고
    • The biopharmaceutical aspects of nasal mucoadhesive drug delivery
    • Ugwoke M.I., et al. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J. Pharm. Pharmacol. 53 (2001) 3-21
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 3-21
    • Ugwoke, M.I.1
  • 66
    • 0025851808 scopus 로고
    • The nasal mucociliary clearance: relevance to nasal drug delivery
    • Schipper N.G.M., et al. The nasal mucociliary clearance: relevance to nasal drug delivery. Pharm. Res. 8 (1991) 807-814
    • (1991) Pharm. Res. , vol.8 , pp. 807-814
    • Schipper, N.G.M.1
  • 67
    • 26644434124 scopus 로고    scopus 로고
    • Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives
    • Ugwoke M.I., et al. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv. Drug Deliv. Rev. 57 (2005) 1640-1665
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1640-1665
    • Ugwoke, M.I.1
  • 68
    • 0037433789 scopus 로고    scopus 로고
    • Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: Comparison with hydroxypropyl- and dimethyl-β-cyclodextrins
    • Sinswat P., and Tengamnuay P. Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: Comparison with hydroxypropyl- and dimethyl-β-cyclodextrins. Int. J. Pharm. 257 (2003) 15-22
    • (2003) Int. J. Pharm. , vol.257 , pp. 15-22
    • Sinswat, P.1    Tengamnuay, P.2
  • 69
    • 0032971987 scopus 로고    scopus 로고
    • Evaluation of the clearance characteristics of bioadhesive systems in humans
    • Soane R.J., et al. Evaluation of the clearance characteristics of bioadhesive systems in humans. Int. J. Pharm. 178 (1999) 55-65
    • (1999) Int. J. Pharm. , vol.178 , pp. 55-65
    • Soane, R.J.1
  • 70
    • 10744233376 scopus 로고    scopus 로고
    • A clinical trial of 7α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men
    • von Eckardstein S., et al. A clinical trial of 7α-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men. J. Clin. Endocrinol. Metab. 88 (2003) 5232-5239
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 5232-5239
    • von Eckardstein, S.1
  • 71
    • 0035927197 scopus 로고    scopus 로고
    • Formulation of a reservoir-type testosterone transdermal delivery system
    • Kim M.K., et al. Formulation of a reservoir-type testosterone transdermal delivery system. Int. J. Pharm. 219 (2001) 51-59
    • (2001) Int. J. Pharm. , vol.219 , pp. 51-59
    • Kim, M.K.1
  • 72
    • 30344481679 scopus 로고    scopus 로고
    • Pharmacokinetics of a testosterone gel in healthy postmenopausal women
    • Singh A.B., et al. Pharmacokinetics of a testosterone gel in healthy postmenopausal women. J. Clin. Endocrinol. Metab. 91 (2006) 136-144
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 136-144
    • Singh, A.B.1
  • 73
    • 0029954703 scopus 로고    scopus 로고
    • Testicular microvascular blood flow: alteration after Leydig cell eradication and ischemia but not experimental varicocele
    • Turner T.T., et al. Testicular microvascular blood flow: alteration after Leydig cell eradication and ischemia but not experimental varicocele. J. Androl. 17 (1996) 239-248
    • (1996) J. Androl. , vol.17 , pp. 239-248
    • Turner, T.T.1
  • 74
    • 0021336791 scopus 로고
    • Microvascular architecture of the pampiniform plexus-testicular artery system in the rat: a scanning electron microscope study of corrosion casts
    • Ohtsuka A. Microvascular architecture of the pampiniform plexus-testicular artery system in the rat: a scanning electron microscope study of corrosion casts. Am. J. Anat. 169 (1984) 285-293
    • (1984) Am. J. Anat. , vol.169 , pp. 285-293
    • Ohtsuka, A.1
  • 75
    • 36048951795 scopus 로고    scopus 로고
    • Piezoelectric control of needle-free transdermal drug delivery
    • Stachowiak J.C., et al. Piezoelectric control of needle-free transdermal drug delivery. J. Control Release 124 (2007) 88-97
    • (2007) J. Control Release , vol.124 , pp. 88-97
    • Stachowiak, J.C.1


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