Adjudin targeting rabbit germ cell adhesion as a male contraceptive: A pharmacokinetics study

Journal of Andrology

Volumn 30, Issue 1, 2009, Pages 87-93

  Hu, Guo Xin ^a   Hu, Lu Feng ^a   Yang, Dai Zheng ^a   Li, Jun Wei ^a   Chen, Guo Rong ^b   Chen, Bing Bing ^a,c   Mruk, Dolores D ^c   Bonanomi, Michele ^d   Silvestrini, Bruno ^d   Cheng, C Yan ^c   Ge, Ren Shan ^a,c  

^a School of Pharmacy   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c ROCKEFELLER UNIVERSITY   (United States)

^d Bioprogress Pharmaceutical SpA   (Italy)

Author keywords

Male contraception; Sertoli germ cell adhesion; Testis

Indexed keywords

ADJUDIN; AF 2364; MALE CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL ADHESION; CONTRACEPTION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TARGETING; GERM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RABBIT; SEMINIFEROUS TUBULE EPITHELIUM; SPERMATID; SPERMATOGENESIS; TESTIS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; FERTILITY; HYDRAZINES; INDAZOLES; INJECTIONS, INTRAVENOUS; MALE; RABBITS; SPERMATOGENESIS; SPERMATOGENESIS-BLOCKING AGENTS;

EID: 58149291590     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.108.004994     Document Type: Article

References (11)

1. Altman DG, Machin D, Bryant TN, Gardner MJ. Confidence interval analysis [software included with book purchase]. Statistics with confidence. 2nd ed. London: BMB Books; 2000.
2. Chen YM, Lee NP, Mruk DD, Lee WM, Cheng CY. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Biol Reprod. 2003;69:656-672.
3. Cheng CY, Mruk D, Silvestrini B, Bonanomi M, Wong CH, Siu MK, Lee NP, Lui WY, Mo MY. AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3- carbohydrazide] is a potential male contraceptive: a review of recent data. Contraception. 2005;72:251-261.
4. Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, Saso L, Leone MG, Palmery M, Mruk D. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod. 2001;65:449-461.
5. Lee NP, Cheng CY. Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. J Cell Physiol. 2005;202:344-360.
6. Lee NP, Mruk DD, Wong CH, Cheng CY. Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Biol Reprod. 2005;73:458-471.
7. Mruk DD, Cheng CY. Cell-cell interactions at the ectoplasmic specialization in the testis. Trends Endocrinol Metab. 2004a;15:439-447.
8. Mruk DD, Cheng CY. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev. 2004b;25: 747-806.
9. Russell L. Movement of spermatocytes from the basal to the adluminal compartment of the rat testis. Am J Anat. 1977;148:313-328.
10. Xia W, Cheng CY. TGF-β3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: an in vivo study. Dev Biol. 2005;280:321-343.
11. Xia W, Mruk DD, Lee WM, Cheng CY. Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model. J Endocrinol. 2007;192:563-583.