Effects of darbepoetin-alpha in spinal cord ischemia-reperfusion injury in the rabbit

Acta Neurochirurgica

Volumn 154, Issue 6, 2012, Pages 1037-1044

  Yilmaz, Erdal Resit ^a   Kertmen, Hayri ^a   Dolgun, Habibullah ^a   Gürer, Bora ^a   Sanli, Ahmet Metin ^a   Kanat, Mehmet Ali ^b   Arikok, Ata Türker ^a   Bahsi, Seda Yilmaz ^c   Ergüder, Berrin Imge ^c   Sekerci, Zeki ^a  

^a DISKAPI YILDIRIM BEYAZIT TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b MINISTRY OF HEALTH   (Turkey)

^c ANKARA UNIVERSITY   (Turkey)

Author keywords

Darbepoetin alpha; Ischemia reperfusion; Neuroprotection; Spinal cord

Indexed keywords

CASPASE 3; MALONALDEHYDE; METHYLPREDNISOLONE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA OCCLUSION; APOPTOSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY ARTERY STENOSIS; LAPAROTOMY; LIPID PEROXIDATION; MALE; NERVE CELL DEGENERATION; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; SCORING SYSTEM; SHAM PROCEDURE; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; TARLOV SCORING SYSTEM; TISSUE LEVEL;

ANEMIA; ANIMALS; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; HEMATINICS; MALE; NEUROPROTECTIVE AGENTS; RABBITS; REPERFUSION INJURY; SPINAL CORD ISCHEMIA;

EID: 84862762177     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-012-1298-0     Document Type: Article

References (48)

1. E Ates AU Yalcin S Yilmaz T Koken C Tokyol 2005 Protective effect of erythropoietin on renal ischemia and reperfusion injury ANZ J Surg 75 1100 1105 16398819 10.1111/j.1445-2197.2005.03612.x (Pubitemid 43951373)
2. RD Azbill X Mu AJ Bruce-Keller MP Mattson JE Springer 1997 Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury Brain Res 765 283 290 9313901 10.1016/S0006-8993(97)00573-8 1:CAS:528:DyaK2sXks12nsLw%3D (Pubitemid 27397624)
3. WA Banks NL Jumbe CL Farrell ML Niehoff AC Heatherington 2004 Passage of erythropoietic agents across the blood-brain barrier: a comparison of human and murine erythropoietin and the analog darbepoetin alfa Eur J Pharmacol 505 93 101 15556141 10.1016/j.ejphar.2004.10.035 1:CAS:528:DC%2BD2cXhtVWjsLbL (Pubitemid 39535680)
4. L Belayev L Khoutorova W Zhao A Vigdorchik A Belayev R Busto E Magal MD Ginsberg 2005 Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats Stroke 36 1071 1076 15790949 10.1161/01.STR.0000163083.59201.34 (Pubitemid 40629305)
5. L Calvillo R Latini J Kajstura A Leri P Anversa P Ghezzi M Salio A Cerami M Brines 2005 Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling Proc Natl Acad Sci USA 100 4802 4806 10.1073/pnas.0630444100
6. M Celik N Gokmen S Erbayraktar M Akhisaroglu S Konakc C Ulukus S Genc K Genc E Sagiroglu A Cerami M Brines 2002 Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury Proc Natl Acad Sci USA 99 2258 2263 11854521 10.1073/pnas.042693799 1:CAS:528:DC%2BD38XitVSrtb8%3D (Pubitemid 34169048)
7. F Chronidou E Apostolakis I Papapostolou K Grintzalis CD Georgiou EN Koletsis M Karanikolas P Papathanasopoulos D Dougenis 2009 Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits J Cardiothorac Surg 4 50 19758462 10.1186/1749-8090-4-50
8. A Diaz-Ruiz C Rios I Duarte D Correa G Guizar-Sahagun I Grijalva I Madrazo A Ibarra 2000 Lipid peroxidation inhibition in spinal cord injury: cyclosporin-A vs methylprednisolone Neuroreport 11 1765 1767 10852240 10.1097/00001756-200006050-00033 1:CAS:528:DC%2BD3cXktlGitb0%3D (Pubitemid 30350349)
9. M Digicaylioglu SA Lipton 2001 Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades Nature 412 641 647 11493922 10.1038/35088074 1:CAS:528:DC%2BD3MXmtVCisbs%3D (Pubitemid 32772276)
10. H Dolgun Z Sekerci E Turkoglu H Kertmen ER Yilmaz M Anlar IB Erguder H Tuna 2010 Neuroprotective effect of mesna (2-mercaptoethane sulfonate) against spinal cord ischemia/reperfusion injury in rabbits J Clin Neurosci 17 486 489 20117935 10.1016/j.jocn.2009.07.108 1:CAS:528:DC%2BC3cXivFKgsbg%3D
11. RJ Dumont DO Okonkwo S Verma RJ Hurlbert PT Boulos DB Ellegala AS Dumont 2001 Acute spinal cord injury, part I: pathophysiologic mechanisms Clin Neuropharmacol 24 254 264 11586110 10.1097/00002826-200109000-00002 1:CAS:528:DC%2BD3MXnvVGjtrs%3D (Pubitemid 32906712)
12. JC Egrie JK Browne 2001 Development and characterization of novel erythropoiesis stimulating protein (NESP) Br J Cancer 84 3 10 11308268 10.1054/bjoc.2001.1746 1:CAS:528:DC%2BD3MXktF2gt7g%3D (Pubitemid 32453429)
13. H Ehrenreich M Hasselblatt C Dembowski L Cepek P Lewczuk M Stiefel HH Rustenbeck N Breiter S Jacob F Knerlich M Bohn W Poser E Rüther M Kochen O Gefeller C Gleiter TC Wessel M De Ryck L Itri H Prange A Cerami M Brines AL Sirén 2002 Erythropoietin therapy for acute stroke is both safe and beneficial Mol Med 8 495 505 12435860 1:CAS:528:DC%2BD38XovVWhsrg%3D (Pubitemid 36337492)
14. E Emery P Aldana MB Bunge W Puckett A Srinivasan RW Keane J Bethea AD Levi 1998 Apoptosis after traumatic human spinal cord injury J Neurosurg 89 911 920 9833815 10.3171/jns.1998.89.6.0911 1:STN:280:DyaK1M%2FkvFGlsw%3D%3D (Pubitemid 28544043)
15. E Gao M Boucher JK Chuprun RH Zhou AD Eckhart WJ Koch 2007 Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart Am J Physiol Heart Circ Physiol 293 H60 H68 17384131 10.1152/ajpheart.00227.2007 1:CAS:528:DC%2BD2sXovVyitLg%3D (Pubitemid 47105059)
16. T Genovese S Cuzzocrea 2008 Role of free radicals and poly (ADP-ribose)polymerase-1 in the development of spinal cord injury: new potential therapeutic targets Curr Med Chem 15 477 487 18289003 10.2174/ 092986708783503177 1:CAS:528:DC%2BD1cXnsVyisLc%3D (Pubitemid 351472414)
17. PG Gunasekar AG Kanthasamy JL Borowitz GE Isom 1995 NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death J Neurochem 65 2016 2021 7595485 10.1046/j.1471-4159.1995.65052016.x 1:CAS:528:DyaK2MXovFGmt7w%3D
18. C Hagl MA Ergin JD Galla SL Lansman JN McCullough D Spielvogel P Sfeir CA Bodian RB Griepp 2001 Neurologic outcome after ascending aorta-aortic arch operations: effect of brain protection technique in high-risk patients J Thorac Cardiovasc Surg 121 1107 1121 11385378 10.1067/mtc.2001.113179 1:STN:280:DC%2BD3Mzht1SqtA%3D%3D
19. T Hayashi M Sakuria K Abe M Sadahiro K Tabayashi Y Itoyama 1998 Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia Stroke 29 1007 1013 9596251 10.1161/01.STR.29.5.1007 1:STN:280: DyaK1c3lsFKqsg%3D%3D (Pubitemid 28228165)
20. DJ Hearse R Boli 1992 Reperfusion induced injury: manifestations, mechanisms, and clinical relevance Cardiovasc Res 26 101 108 1571929 10.1093/cvr/26.2.101 1:STN:280:DyaK383ktVKisg%3D%3D
21. AK Junk A Mammis SI Savitz M Singh S Roth S Malhotra PS Rosenbaum A Cerami M Brines DM Rosenbaum 2002 Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury Proc Natl Acad Sci USA 99 10659 10664 12130665 10.1073/pnas.152321399 1:CAS:528:DC%2BD38Xmt1ChsbY%3D
22. E Kaptanoglu I Solaroglu O Okutan HS Surucu F Akbiyik E Beskonakli 2004 Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: effect on lipid peroxidation and early ultrastructural findings Neurosurg Rev 27 113 120 12920606 10.1007/s10143-003-0300-y (Pubitemid 38374415)
23. SF Katircioglu AT Ulus P Gökçe S Sürücü 2000 Iloprost protects the spinal cord during aortic cross-clamping in a canine model J Cardiovasc Surg 41 89 93 1:STN:280:DC%2BD3c3psVaiuw%3D%3D (Pubitemid 30192904)
24. RW Keane S Kraydieh G Lotocki JR Bethea S Krajewski JC Reed WD Dietrich 2001 Apoptotic and anti-apoptotic mechanisms following spinal cord injury J Neuropathol Exp Neurol 60 422 429 11379817 1:CAS:528:DC%2BD3MXktleku7c%3D (Pubitemid 32467099)
25. U Klingmuller 1997 The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells signals emanating from the erythropoietin receptor Eur J Biochem 249 637 647 9395308 10.1111/j.1432-1033. 1997.t01-1-00637.x 1:CAS:528:DyaK2sXntl2hsro%3D (Pubitemid 27479032)
26. SB Krantz 1991 Erythropoietin Blood 77 419 434 1991159 1:CAS:528:DyaK3MXltVKisb0%3D
27. T Lappin 2003 The cellular biology of erythropoietin receptors Oncologist 8 15 18 12626783 10.1634/theoncologist.8-suppl-1-15 1:CAS:528: DC%2BD3sXis1Gmt7o%3D (Pubitemid 36331743)
28. M Li VO Ona M Chen L Tenneti X Zhang PE Stieg SA Lipton RM Friedlander 2000 Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury Neuroscience 99 333 342 10938439 10.1016/S0306-4522(00)00173-1 1:CAS:528:DC%2BD3cXlsVOrtLo%3D (Pubitemid 30628421)
29. Y Li M Chopp N Jiang F Yao C Zaloga 1995 Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat J Cereb Blood Flow Metab 15 389 397 7713996 10.1038/jcbfm.1995.49 1:CAS:528:DyaK2MXlslClt7s%3D
30. N Lukacova G Halat M Chavko J Marsala 1996 Ischemia-reperfusion injury in the spinal cord of rabbits strongly enhances lipid peroxidation and modifies phospholipid profiles Neurochem Res 21 869 873 8895838 10.1007/BF02532334 1:CAS:528:DyaK28XmsVejtbw%3D (Pubitemid 26343945)
31. A Markham HM Bryson 1995 Epoetin alfa. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in nonrenal applications Drugs 49 232 254 7729331 10.2165/00003495-199549020-00008 1:CAS:528: DyaK2MXkt1Citbo%3D
32. HH Marti M Bernaudin E Petit C Bauer 2000 Neuroprotection and angiogenesis: dual role of erythropoietin in brain ischemia News Physiol Sci 15 225 229 11390915 1:CAS:528:DC%2BD3cXnvV2rurg%3D
33. CJ Parsa A Matsumoto J Kim RU Riel LS Pascal GB Walton RB Thompson JA Petrofski BH Annex JS Stamler WJ Koch 2003 A novel protective effect of erythropoietin in the infarcted heart J Clin Invest 112 999 1007 14523037 1:CAS:528:DC%2BD3sXnvFGrsL0%3D (Pubitemid 38056315)
34. J Patton T Reeves J Wallace 2004 Effectiveness of darbepoetin alfa versus epoetin alfa in patients with chemotherapy-induced anemia treated in clinical practice Oncologist 9 451 458 15266098 10.1634/theoncologist.9-4-451 1:CAS:528:DC%2BD2cXntV2rsr4%3D (Pubitemid 39014556)
35. H Qian D Liu 1997 The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography Neurochem Res 22 1231 1236 9342727 10.1023/A: 1021980929422 1:CAS:528:DyaK2sXmslShurc%3D (Pubitemid 27440791)
36. Y Sadamoto K Igase M Sakanaka K Sato H Otsuka S Sakaki S Masuda R Sasaki 1998 Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery Biochem Biophys Res Commun 253 26 32 9875214 10.1006/bbrc.1998.9748 1:CAS:528:DyaK1cXotFSiu7s%3D (Pubitemid 29015594)
37. M Sakanaka TC Wen S Matsuda S Masuda E Morishita M Nagao R Sasaki 1995 In vivo evidence that erythropoietin protects neurons from ischemic damage Proc Natl Acad Sci USA 95 4635 4640 10.1073/pnas.95.8.4635 (Pubitemid 28207965)
38. M Sakurai T Nagata K Abe T Horinouchi Y Itoyama K Tabayashi 2003 Survival and death-promoting events after transient spinal cord ischemia in rabbits: induction of Akt and caspase3 in motor neurons J Thorac Cardiovasc Surg 125 370 377 12579107 10.1067/mtc.2003.112 1:CAS:528:DC%2BD3sXhvV2jtrc%3D (Pubitemid 36228315)
39. JW Schmidley 1990 Free radicals in central nervous system ischemia Stroke 21 1086 1090 2195717 10.1161/01.STR.21.7.1086 1:CAS:528:DyaK3MXktVGqtrk%3D (Pubitemid 20218176)
40. L Schwartzberg R Shiffman D Tomita B Stolshek G Rossi R Adamson 2003 A multicenter retrospective cohort study of practice patterns and clinical outcomes of the use of darbepoetin alfa and epoetin alfa for chemotherapy-induced anemia Clin Ther 25 2781 2796 14693304 10.1016/S0149- 2918(03)80333-8 1:CAS:528:DC%2BD2cXhtVynsg%3D%3D (Pubitemid 37510589)
41. B Sepodes R Maio R Pinto E Sharples P Oliveira M McDonald M Yaqoob C Thiemermann H Mota-Filipe 2006 Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat Transpl Int 19 919 926 17018128 10.1111/j.1432-2277.2006.00366.x 1:CAS:528:DC%2BD28Xht1ehsbjN (Pubitemid 44511117)
42. AL Siren M Fratelli M Brines C Goemans S Casagrande P Lewczuk S Keenan C Gleiter C Pasquali A Capobianco T Mennini R Heumann A Cerami H Ehrenreich P Ghezzi 2001 Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress Proc Natl Acad Sci USA 98 4044 4049 11259643 10.1073/pnas.051606598 1:CAS:528:DC%2BD3MXis1Khtrg%3D (Pubitemid 32249895)
43. F Squadrito D Altavilla G Squadrito GM Campo M Arlotta C Quartarone A Saitta AP Caputi 1999 Recombinant human erythropoietin inhibits iNOS activity and reverts vascular dysfunction in splanchnic artery occlusion shock Br J Pharmacol 127 482 428 10385249 10.1038/sj.bjp.0702521 1:CAS:528: DyaK1MXjs1yqsb0%3D (Pubitemid 29245687)
44. AF Tramontano R Muniyappa AD Black MC Blendea I Cohen L Deng JR Sowers MV Cutaia N El-Sherif 2003 Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway Biochem Biophys Res Commun 308 990 994 12927817 10.1016/S0006-291X(03)01503-1 1:CAS:528: DC%2BD3sXmsVGku7c%3D (Pubitemid 36976556)
45. Y Umeda Y Mori H Takagi H Iwata Y Matsuno H Hirose 2003 Surgical outcome of abdominal aortic aneurysm repair in patients undergoing chronic hemodialysis Heart Vessels 18 7 11 12644875 10.1007/s003800300001 (Pubitemid 36442900)
46. GL Wright P Hanlon K Amin C Steenberger E Murphy MO Arcasoy 2004 Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury FASEB J 18 1031 1033 15059965 1:CAS:528: DC%2BD2cXkslWiur8%3D (Pubitemid 39561515)
47. H Wu B Ren J Zhu G Dong B Xu C Wang X Zheng H Jing 2006 Pretreatment with recombined human erythropoietin attenuates ischemia-reperfusion-induced lung injury in rats Eur J Cardiothorac Surg 29 902 907 16675226 10.1016/j.ejcts.2006. 02.036
48. JA Zivin U DeGirolami 1980 Spinal cord infarction: a highly reproducible stroke model Stroke 11 200 202 7368250 10.1161/01.STR.11.2.200 1:STN:280:DyaL3c7mvF2jtA%3D%3D (Pubitemid 10133608)