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Volumn 74, Issue 7, 2015, Pages 743-754

KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas

Author keywords

BRAF; Brain tumor; FGFR1; Glioma; Molecular diagnosis; Pilocytic astrocytoma; Prognosis

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 1; B RAF KINASE; BRAF PROTEIN, HUMAN; FGFR1 PROTEIN, HUMAN; ONCOPROTEIN;

EID: 84934285164     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0000000000000213     Document Type: Article
Times cited : (85)

References (58)
  • 2
    • 84899413788 scopus 로고    scopus 로고
    • Childhood and adolescent cancer statistics, 2014
    • Ward E, DeSantis C, Robbins A, et al. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 2014;64:83-103
    • (2014) CA Cancer J Clin , vol.64 , pp. 83-103
    • Ward, E.1    DeSantis, C.2    Robbins, A.3
  • 3
    • 84868023931 scopus 로고    scopus 로고
    • CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2005-2009
    • Dolecek TA, Propp JM, Stroup NE, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol 2012;14(Suppl 5):v1-49
    • (2012) Neuro Oncol , vol.14 , pp. v1-v49
    • Dolecek, T.A.1    Propp, J.M.2    Stroup, N.E.3
  • 5
    • 27744454314 scopus 로고    scopus 로고
    • Epidemiology of pediatric tumors of the nervous system according to the WHO 2000 classification: A report of 1,195 cases from a single institution
    • Rosemberg S, Fujiwara D. Epidemiology of pediatric tumors of the nervous system according to the WHO 2000 classification: a report of 1,195 cases from a single institution. Child Nerv Sys 2005;21:940-4
    • (2005) Child Nerv Sys , vol.21 , pp. 940-944
    • Rosemberg, S.1    Fujiwara, D.2
  • 6
    • 84901040227 scopus 로고    scopus 로고
    • Adult pilocytic astrocytomas: Clinical features and molecular analysis
    • Theeler BJ, Ellezam B, Sadighi ZS, et al. Adult pilocytic astrocytomas: clinical features and molecular analysis. Neuro Oncol 2014 2014;16:841-7. doi: 10.1093/neuonc/not246
    • (2014) Neuro Oncol 2014 , vol.16 , pp. 841-847
    • Theeler, B.J.1    Ellezam, B.2    Sadighi, Z.S.3
  • 7
    • 84862900240 scopus 로고    scopus 로고
    • MAPK pathway activation in pilocytic astrocytoma
    • Jones DT, Gronych J, Lichter P, et al. MAPK pathway activation in pilocytic astrocytoma. Cell Molec Life Sci 2012;69:1799-811
    • (2012) Cell Molec Life Sci , vol.69 , pp. 1799-1811
    • Jones, D.T.1    Gronych, J.2    Lichter, P.3
  • 8
    • 84862826608 scopus 로고    scopus 로고
    • Pilocytic astrocytoma survival in adults: Analysis of the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute
    • Johnson DR, Brown PD, Galanis E, et al. Pilocytic astrocytoma survival in adults: analysis of the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. J Neuro-oncol 2012;108:187-93
    • (2012) J Neuro-oncol , vol.108 , pp. 187-193
    • Johnson, D.R.1    Brown, P.D.2    Galanis, E.3
  • 9
    • 84874602325 scopus 로고    scopus 로고
    • Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma
    • Gutmann DH, McLellan MD, Hussain I, et al. Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma. Genome Res 2013;23:431-9
    • (2013) Genome Res , vol.23 , pp. 431-439
    • Gutmann, D.H.1    McLellan, M.D.2    Hussain, I.3
  • 10
    • 41649113333 scopus 로고    scopus 로고
    • Gliomas in neurofibromatosis type 1: A clinicopathologic study of 100 patients
    • Rodriguez FJ, Perry A, Gutmann DH, et al. Gliomas in neurofibromatosis type 1: a clinicopathologic study of 100 patients. J Neuropathol Exp Neurol 2008;67:240-9
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 240-249
    • Rodriguez, F.J.1    Perry, A.2    Gutmann, D.H.3
  • 11
    • 0033605481 scopus 로고    scopus 로고
    • Intracranial gliomas in neurofibromatosis type 1
    • Listernick R, Charrow J, Gutmann DH. Intracranial gliomas in neurofibromatosis type 1. Am J Med Gen 1999;89:38-44
    • (1999) Am J Med Gen , vol.89 , pp. 38-44
    • Listernick, R.1    Charrow, J.2    Gutmann, D.H.3
  • 12
    • 0142092642 scopus 로고    scopus 로고
    • Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1
    • Tada K, Kochi M, Saya H, et al. Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1. Neuro Oncol 2003;5:228-34
    • (2003) Neuro Oncol , vol.5 , pp. 228-234
    • Tada, K.1    Kochi, M.2    Saya, H.3
  • 13
    • 34248583922 scopus 로고    scopus 로고
    • MAPKs: Function, regulation, role in cancer and therapeutic targeting
    • Dhanasekaran DN, Johnson GL. MAPKs: function, regulation, role in cancer and therapeutic targeting. Oncogene 2007;26:3097-9
    • (2007) Oncogene , vol.26 , pp. 3097-3099
    • Dhanasekaran, D.N.1    Johnson, G.L.2
  • 14
    • 78049510048 scopus 로고    scopus 로고
    • Expression and functional role of negative signalling regulators in tumour development and progression
    • Murphy T, Hori S, Sewell J, et al. Expression and functional role of negative signalling regulators in tumour development and progression. Int J Cancer 2010;127:2491-9
    • (2010) Int J Cancer , vol.127 , pp. 2491-2499
    • Murphy, T.1    Hori, S.2    Sewell, J.3
  • 15
    • 84880983541 scopus 로고    scopus 로고
    • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    • Jones DT, Hutter B, Jager N, et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature Gen 2013;45:927-32
    • (2013) Nature Gen , vol.45 , pp. 927-932
    • Jones, D.T.1    Hutter, B.2    Jager, N.3
  • 16
    • 84878723078 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    • Zhang J, Wu G, Miller CP, et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nature Gen 2013;45:602-12
    • (2013) Nature Gen , vol.45 , pp. 602-612
    • Zhang, J.1    Wu, G.2    Miller, C.P.3
  • 17
    • 52649172327 scopus 로고    scopus 로고
    • Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma
    • Bar EE, Lin A, Tihan T, et al. Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma. J Neuropathol Exp Neurol 2008;67:878-87
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 878-887
    • Bar, E.E.1    Lin, A.2    Tihan, T.3
  • 18
    • 79959580390 scopus 로고    scopus 로고
    • Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
    • Capper D, Preusser M, Habel A, et al. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 2011;122:11-9
    • (2011) Acta Neuropathol , vol.122 , pp. 11-19
    • Capper, D.1    Preusser, M.2    Habel, A.3
  • 19
    • 66849099801 scopus 로고    scopus 로고
    • Activation of the ERK/MAPK pathway: A signature genetic defect in posterior fossa pilocytic astrocytomas
    • Forshew T, Tatevossian RG, Lawson AR, et al. Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol 2009;218:172-81
    • (2009) J Pathol , vol.218 , pp. 172-181
    • Forshew, T.1    Tatevossian, R.G.2    Lawson, A.R.3
  • 20
    • 80055084211 scopus 로고    scopus 로고
    • BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults
    • Hasselblatt M, Riesmeier B, Lechtape B, et al. BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults. Neuropathol Appl Neurobiol 2011;37:803-6
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 803-806
    • Hasselblatt, M.1    Riesmeier, B.2    Lechtape, B.3
  • 21
    • 79960388615 scopus 로고    scopus 로고
    • BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
    • Hawkins C, Walker E, Mohamed N, et al. BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma. Clin Cancer Res 2011;17:4790-8
    • (2011) Clin Cancer Res , vol.17 , pp. 4790-4798
    • Hawkins, C.1    Walker, E.2    Mohamed, N.3
  • 22
    • 79954441895 scopus 로고    scopus 로고
    • Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    • Schindler G, Capper D, Meyer J, et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 2011;121:397-405
    • (2011) Acta Neuropathol , vol.121 , pp. 397-405
    • Schindler, G.1    Capper, D.2    Meyer, J.3
  • 23
    • 82955249323 scopus 로고    scopus 로고
    • Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas
    • Tian Y, Rich BE, Vena N, et al. Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Molec Diag 2011;13:669-77
    • (2011) J Molec Diag , vol.13 , pp. 669-677
    • Tian, Y.1    Rich, B.E.2    Vena, N.3
  • 24
    • 67349219657 scopus 로고    scopus 로고
    • Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
    • Jones DT, Kocialkowski S, Liu L, et al. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene 2009;28:2119-23
    • (2009) Oncogene , vol.28 , pp. 2119-2123
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 25
    • 84922698954 scopus 로고    scopus 로고
    • Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131B-BRAF fusions in pediatric low-grade gliomas
    • Roth JJ, Santi M, Pollock AN, et al. Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131B-BRAF fusions in pediatric low-grade gliomas. Brain Pathol 2015;25:182-92
    • (2015) Brain Pathol , vol.25 , pp. 182-192
    • Roth, J.J.1    Santi, M.2    Pollock, A.N.3
  • 26
    • 79958087774 scopus 로고    scopus 로고
    • Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
    • Cin H, Meyer C, Herr R, et al. Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol 2011;121:763-74
    • (2011) Acta Neuropathol , vol.121 , pp. 763-774
    • Cin, H.1    Meyer, C.2    Herr, R.3
  • 27
    • 84899451831 scopus 로고    scopus 로고
    • The molecular and cell biology of pediatric low-grade gliomas
    • Chen YH, Gutmann DH. The molecular and cell biology of pediatric low-grade gliomas. Oncogene 2014;33:2019-26
    • (2014) Oncogene , vol.33 , pp. 2019-2026
    • Chen, Y.H.1    Gutmann, D.H.2
  • 28
    • 16344395995 scopus 로고    scopus 로고
    • Mutation analysis of B-RAF gene in human gliomas
    • Basto D, Trovisco V, Lopes JM, et al. Mutation analysis of B-RAF gene in human gliomas. Acta Neuropathol 2005;109:207-10
    • (2005) Acta Neuropathol , vol.109 , pp. 207-210
    • Basto, D.1    Trovisco, V.2    Lopes, J.M.3
  • 29
    • 84901324707 scopus 로고    scopus 로고
    • FGFR1 mutations in rosette-forming glioneuronal tumors of the fourth ventricle
    • Gessi M, Moneim YA, Hammes J, et al. FGFR1 mutations in rosette-forming glioneuronal tumors of the fourth ventricle. J Neuropathol Exp Neurol 2014;73:580-4
    • (2014) J Neuropathol Exp Neurol , vol.73 , pp. 580-584
    • Gessi, M.1    Moneim, Y.A.2    Hammes, J.3
  • 30
    • 79958112619 scopus 로고    scopus 로고
    • Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
    • Dutt A, Ramos AH, Hammerman PS, et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PloS One 2011;6:e20351
    • (2011) PloS One , vol.6
    • Dutt, A.1    Ramos, A.H.2    Hammerman, P.S.3
  • 31
    • 0027218571 scopus 로고
    • FGFRI and PLAT genes and DNA amplification at 8p12 in breast and ovarian cancers
    • Theillet C, Adelaide J, Louason G, et al. FGFRI and PLAT genes and DNA amplification at 8p12 in breast and ovarian cancers. Genes Chromosome Cancer 1993;7:219-26
    • (1993) Genes Chromosome Cancer , vol.7 , pp. 219-226
    • Theillet, C.1    Adelaide, J.2    Louason, G.3
  • 32
    • 84865805666 scopus 로고    scopus 로고
    • Transforming fusions of FGFR and TACC genes in human glioblastoma
    • Singh D, Chan JM, Zoppoli P, et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 2012;337:1231-5
    • (2012) Science , vol.337 , pp. 1231-1235
    • Singh, D.1    Chan, J.M.2    Zoppoli, P.3
  • 33
    • 84883647983 scopus 로고    scopus 로고
    • Outcome analysis of childhood pilocytic astrocytomas: A retrospective study of 148 cases at a single institution
    • Colin C, Padovani L, Chappe C, et al. Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution. Neuropathol Appl Neurobiol 2013;39:693-705
    • (2013) Neuropathol Appl Neurobiol , vol.39 , pp. 693-705
    • Colin, C.1    Padovani, L.2    Chappe, C.3
  • 34
    • 0041353859 scopus 로고    scopus 로고
    • Pilocytic astrocytomas in children: Prognostic factors - A retrospective study of 80 cases
    • discussion 54-5
    • Fernandez C, Figarella-Branger D, Girard N, et al. Pilocytic astrocytomas in children: prognostic factors - a retrospective study of 80 cases. Neurosurgery 2003;53:544-53; discussion 54-5
    • (2003) Neurosurgery , vol.53 , pp. 544-553
    • Fernandez, C.1    Figarella-Branger, D.2    Girard, N.3
  • 35
    • 71349083949 scopus 로고    scopus 로고
    • In pursuit of prognostic factors in children with pilocytic astrocytomas
    • Paixao Becker A, de Oliveira RS, Saggioro FP, et al. In pursuit of prognostic factors in children with pilocytic astrocytomas. Childs Nerv Syst 2010;26:19-28
    • (2010) Childs Nerv Syst , vol.26 , pp. 19-28
    • Paixao Becker, A.1    De Oliveira, R.S.2    Saggioro, F.P.3
  • 36
    • 0026580081 scopus 로고
    • Benign cerebellar astrocytomas of childhood
    • discussion 3
    • Schneider JH Jr, Raffel C, McComb JG. Benign cerebellar astrocytomas of childhood. Neurosurgery 1992;30:58-62; discussion 3
    • (1992) Neurosurgery , vol.30 , pp. 58-62
    • Schneider, J.H.1    Raffel, C.2    McComb, J.G.3
  • 37
    • 71549122009 scopus 로고    scopus 로고
    • Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors
    • Capper D, Weissert S, Balss J, et al. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol 2010;20:245-54
    • (2010) Brain Pathol , vol.20 , pp. 245-254
    • Capper, D.1    Weissert, S.2    Balss, J.3
  • 38
    • 82955165744 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors
    • Mellai M, Piazzi A, Caldera V, et al. IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors. J Neuro-oncol 2011;105:345-57
    • (2011) J Neuro-oncol , vol.105 , pp. 345-357
    • Mellai, M.1    Piazzi, A.2    Caldera, V.3
  • 39
    • 84907916641 scopus 로고    scopus 로고
    • T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness
    • Pinto F, Pertega-Gomes N, Pereira MS, et al. T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness. Clinical Cancer Res 2014;20:4949-61
    • (2014) Clinical Cancer Res , vol.20 , pp. 4949-4961
    • Pinto, F.1    Pertega-Gomes, N.2    Pereira, M.S.3
  • 40
    • 84899669381 scopus 로고    scopus 로고
    • Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease
    • Toschi L, Finocchiaro G, Nguyen TT, et al. Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease. PloS One 2014;9:e95303
    • (2014) PloS One , vol.9
    • Toschi, L.1    Finocchiaro, G.2    Nguyen, T.T.3
  • 41
    • 84893116875 scopus 로고    scopus 로고
    • ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers
    • Aisner DL, Nguyen TT, Paskulin DD, et al. ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers. Molec Cancer Res 2014;12:111-8
    • (2014) Molec Cancer Res , vol.12 , pp. 111-118
    • Aisner, D.L.1    Nguyen, T.T.2    Paskulin, D.D.3
  • 42
    • 84893717646 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer
    • Schultheis AM, Bos M, Schmitz K, et al. Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer. Mod Pathol 2014;27:214-21
    • (2014) Mod Pathol , vol.27 , pp. 214-221
    • Schultheis, A.M.1    Bos, M.2    Schmitz, K.3
  • 43
    • 84923068430 scopus 로고    scopus 로고
    • KRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopy
    • Yamane LS, Scapulatempo-Neto C, Alvarenga L, et al. KRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopy. Oncology Rep 2014;32:1419-26
    • (2014) Oncology Rep , vol.32 , pp. 1419-1426
    • Yamane, L.S.1    Scapulatempo-Neto, C.2    Alvarenga, L.3
  • 44
    • 0031213685 scopus 로고    scopus 로고
    • Cytogenetic analysis of 120 primary pediatric brain tumors and literature review
    • Bhattacharjee MB, Armstrong DD, Vogel H, et al. Cytogenetic analysis of 120 primary pediatric brain tumors and literature review. Cancer Gen Cytogen 1997;97:39-53
    • (1997) Cancer Gen Cytogen , vol.97 , pp. 39-53
    • Bhattacharjee, M.B.1    Armstrong, D.D.2    Vogel, H.3
  • 45
    • 0030818739 scopus 로고    scopus 로고
    • Chromosomal characteristics of childhood brain tumors
    • Bigner SH, McLendon RE, Fuchs H, et al. Chromosomal characteristics of childhood brain tumors. Cancer Gen Cytogen 1997;97:125-34
    • (1997) Cancer Gen Cytogen , vol.97 , pp. 125-134
    • Bigner, S.H.1    McLendon, R.E.2    Fuchs, H.3
  • 46
    • 43049124130 scopus 로고    scopus 로고
    • BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
    • Pfister S, Janzarik WG, Remke M, et al. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J Clin Invest 2008;118:1739-49
    • (2008) J Clin Invest , vol.118 , pp. 1739-1749
    • Pfister, S.1    Janzarik, W.G.2    Remke, M.3
  • 47
    • 66949147222 scopus 로고    scopus 로고
    • Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
    • Sievert AJ, Jackson EM, Gai X, et al. Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathol 2009;19:449-58
    • (2009) Brain Pathol , vol.19 , pp. 449-458
    • Sievert, A.J.1    Jackson, E.M.2    Gai, X.3
  • 48
    • 84930386971 scopus 로고    scopus 로고
    • V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior
    • Bannykh SI, Mirocha J, Nuno M, et al. V600E BRAF mutation in pilocytic astrocytoma is associated with a more diffuse growth pattern but does not confer a more aggressive clinical behavior. Cli Neuropathol 2014;33:388-98
    • (2014) Cli Neuropathol , vol.33 , pp. 388-398
    • Bannykh, S.I.1    Mirocha, J.2    Nuno, M.3
  • 49
    • 80054790555 scopus 로고    scopus 로고
    • BRAF mutations in advanced cancers: Clinical characteristics and outcomes
    • El-Osta H, Falchook G, Tsimberidou A, et al. BRAF mutations in advanced cancers: clinical characteristics and outcomes. PloS One 2011;6:e25806
    • (2011) PloS One , vol.6
    • El-Osta, H.1    Falchook, G.2    Tsimberidou, A.3
  • 50
    • 84862584008 scopus 로고    scopus 로고
    • Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma
    • Menzies AM, Haydu LE, Visintin L, et al. Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. Clinical Cancer Res 2012;18:3242-9
    • (2012) Clinical Cancer Res , vol.18 , pp. 3242-3249
    • Menzies, A.M.1    Haydu, L.E.2    Visintin, L.3
  • 51
    • 77955493250 scopus 로고    scopus 로고
    • Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032
    • Rubinstein JC, Sznol M, Pavlick AC, et al. Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032. J Transl Med 2010;8:67
    • (2010) J Transl Med , vol.8 , pp. 67
    • Rubinstein, J.C.1    Sznol, M.2    Pavlick, A.C.3
  • 52
    • 84876040346 scopus 로고    scopus 로고
    • Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas
    • Sievert AJ, Lang SS, Boucher KL, et al. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proc Natl Acad Sci USA 2013;110:5957-62
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 5957-5962
    • Sievert, A.J.1    Lang, S.S.2    Boucher, K.L.3
  • 53
    • 84899473817 scopus 로고    scopus 로고
    • Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas
    • Bautista F, Paci A, Minard-Colin V, et al. Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas. Ped Blood Cancer 2014;61:1101-3
    • (2014) Ped Blood Cancer , vol.61 , pp. 1101-1103
    • Bautista, F.1    Paci, A.2    Minard-Colin, V.3
  • 54
    • 84899485468 scopus 로고    scopus 로고
    • Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy
    • Robinson GW, Orr BA, Gajjar A. Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy. BMC Cancer 2014;14:258
    • (2014) BMC Cancer , vol.14 , pp. 258
    • Robinson, G.W.1    Orr, B.A.2    Gajjar, A.3
  • 55
    • 0028153931 scopus 로고
    • Expression of fibroblast growth factor receptor-1 in human glioma and meningioma tissues
    • discussion 5-6
    • Ueba T, Takahashi JA, Fukumoto M, et al. Expression of fibroblast growth factor receptor-1 in human glioma and meningioma tissues. Neurosurgery 1994;34:221-5; discussion 5-6
    • (1994) Neurosurgery , vol.34 , pp. 221-225
    • Ueba, T.1    Takahashi, J.A.2    Fukumoto, M.3
  • 56
    • 84902669919 scopus 로고    scopus 로고
    • FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI ensitivity across all lung cancer histologies
    • Wynes MW, Hinz TK, Gao D, et al. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI ensitivity across all lung cancer histologies. Clin Cancer Res 2014;20:3299-309
    • (2014) Clin Cancer Res , vol.20 , pp. 3299-3309
    • Wynes, M.W.1    Hinz, T.K.2    Gao, D.3
  • 57
    • 84925408760 scopus 로고    scopus 로고
    • Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors
    • Soria JC, DeBraud F, Bahleda R, et al. Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors. Ann Oncol 2014;25:2244-51
    • (2014) Ann Oncol , vol.25 , pp. 2244-2251
    • Soria, J.C.1    DeBraud, F.2    Bahleda, R.3
  • 58
    • 84918793590 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
    • Nakanishi Y, Akiyama N, Tsukaguchi T, et al. The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. Molec Cancer Ther 2014;13:2547-58
    • (2014) Molec Cancer Ther , vol.13 , pp. 2547-2558
    • Nakanishi, Y.1    Akiyama, N.2    Tsukaguchi, T.3


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