Of LAP, CUPS, and DRibbles - Unconventional use of autophagy proteins for MHC restricted antigen presentation

Frontiers in Immunology

Volumn 6, Issue APR, 2015, Pages

  Münz, Christian ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Atg; Endocytosis; Exocytosis; TLRs; Unconventional secretion

Indexed keywords

ANTIGEN; AUTOPHAGY PROTEIN 5; BECLIN 1; DIAZEPAM BINDING INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN SERINE THREONINE KINASE;

ANTIGEN PRESENTATION; AUTOPHAGOSOME; CD4+ T LYMPHOCYTE; CELL MIGRATION; CROSS PRESENTATION; EXOCYTOSIS; HUMAN; LC3 ASSOCIATED PHAGOCYTOSIS; MACROAUTOPHAGY; MULTIVESICULAR BODY; PHAGOCYTOSIS; PROTEIN SECRETION; SHORT SURVEY;

EID: 84934275822     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00200     Document Type: Short Survey

References (35)

1. Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol (2011) 27:107-32. doi: 10.1146/annurev-cellbio-092910-154005
2. Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Overvatn A, et al. FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol (2010) 188:253-69. doi:10.1083/jcb.200907015
3. McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, et al. PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol Cell (2015) 57:39-54. doi:10.1016/j.molcel.2014.11.006
4. Blum JS, Wearsch PA, Cresswell P. Pathways of antigen processing. Annu Rev Immunol (2013) 31:443-73. doi:10.1146/annurev-immunol-032712-095910
5. Sanjuan MA, Dillon CP, Tait SW, Moshiach S, Dorsey F, Connell S, et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature (2007) 450:1253-7. doi:10.1038/nature06421
6. Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, et al. Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A (2009) 106:6226-31. doi:10.1073/pnas.0811045106
7. Romao S, Gasser N, Becker AC, Guhl B, Bagajic M, Vanoaica LD, et al. Essential autophagy proteins stabilize pathogen containing phagosomes for prolonged MHC class II antigen processing. J Cell Biol (2013) 203:757-66. doi:10.1083/jcb.201308173
8. Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M. Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol (2011) 13:1335-43. doi:10.1038/ncb2363
9. Ma J, Becker C, Lowell CA, Underhill DM. Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem (2012) 287:34149-56. doi:10.1074/jbc. M112.382812
10. Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, et al. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A (2011) 108:17396-401. doi:10.1073/pnas.1113421108
11. Ma J, Becker C, Reyes C, Underhill DM. Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production. J Immunol (2014) 192:1356-60. doi:10.4049/jimmunol.1302835
12. Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity (2012) 37:986-97. doi:10.1016/j.immuni.2012.09.014
13. Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 32:227-39. doi:10.1016/j.immuni.2009.12.006
14. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science (2005) 307:1630-4. doi:10.1126/science.1108003
15. Malhotra V. Unconventional protein secretion: an evolving mechanism. EMBO J (2013) 32:1660-4. doi:10.1038/emboj.2013.104
16. Dupont N, Jiang S, Pilli M, Ornatowski W, Bhattacharya D, Deretic V. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J (2011) 30:4701-11. doi:10.1038/emboj.2011.398
17. Duran JM, Anjard C, Stefan C, Loomis WF, Malhotra V. Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol (2010) 188:527-36. doi:10.1083/jcb.200911154
18. Manjithaya R, Anjard C, Loomis WF, Subramani S. Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation. J Cell Biol (2010) 188:537-46. doi:10.1083/jcb.200911149
19. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 456(7219):259-63. doi:10.1038/nature07416
20. Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell (2010) 141:1135-45. doi:10.1016/j.cell.2010.05.009
21. DeSelm CJ, Miller BC, Zou W, Beatty WL, van Meel E, Takahata Y, et al. Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell (2011) 21:966-74. doi:10.1016/j.devcel.2011.08.016
22. Bruns C, McCaffery JM, Curwin AJ, Duran JM, Malhotra V. Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. J Cell Biol (2011) 195:979-92. doi:10.1083/jcb.201106098
23. Cruz-Garcia D, Curwin AJ, Popoff JF, Bruns C, Duran JM, Malhotra V. Remodeling of secretory compartments creates CUPS during nutrient starvation. J Cell Biol (2014) 207:695-703. doi:10.1083/jcb.201407119
24. Rubartelli A, Cozzolino F, Talio M, Sitia R. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J (1990) 9:1503-10.
25. Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol (2014) 30:255-89. doi:10.1146/annurev-cellbio-101512-122326
26. Li Y, Wang LX, Yang G, Hao F, Urba WJ, Hu HM. Efficient cross-presentation depends on autophagy in tumor cells. Cancer Res (2008) 68:6889-95. doi:10.1158/0008-5472.CAN-08-0161
27. Uhl M, Kepp O, Jusforgues-Saklani H, Vicencio JM, Kroemer G, Albert ML. Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells. Cell Death Differ (2009) 16:991-1005. doi:10.1038/cdd.2009.8
28. Yi Y, Zhou Z, Shu S, Fang Y, Twitty C, Hilton TL, et al. Autophagy-assisted antigen cross-presentation: autophagosome as the argo of shared tumor-specific antigens and DAMPs. Oncoimmunology (2012) 1:976-8. doi:10.4161/onci.20059
29. Twitty CG, Jensen SM, Hu HM, Fox BA. Tumor-derived autophagosome vaccine: induction of cross-protective immune responses against short-lived proteins through a p62-dependent mechanism. Clin Cancer Res (2011) 17:6467-81. doi:10.1158/1078-0432.CCR-11-0812
30. Jackson WT, Giddings TH Jr, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, et al. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol (2005) 3:e156. doi:10.1371/journal.pbio.0030156
31. Kyei GB, Dinkins C, Davis AS, Roberts E, Singh SB, Dong C, et al. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 186:255-68. doi:10.1083/jcb.200903070
32. Nowag H, Guhl B, Thriene K, Romao S, Ziegler U, Dengjel J, et al. Macroautopphagy proteins assist Epstein Barr virus production and get incorporated into the virus particles. EBio Medicine (2014) 1:116-25. doi:10.1016/j.ebiom.2014.11.007
33. Nowag H, Münz C. Diverting autophagic membranes for exocytosis. Autophagy (2015) 11:425-7. doi:10.1080/15548627.2015.1009793
34. Ye W, Xing Y, Paustian C, van de Ven R, Moudgil T, Hilton TL, et al. Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory T cells. J Transl Med (2014) 12:100. doi:10.1186/1479-5876-12-100
35. Li Y, Wang LX, Pang P, Cui Z, Aung S, Haley D, et al. Tumor-derived autophagosome vaccine: mechanism of cross-presentation and therapeutic efficacy. Clin Cancer Res (2011) 17:7047-57. doi:10.1158/1078-0432.CCR-11-0951