Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specifc antigens and DAMPs

OncoImmunology

Volumn 1, Issue 6, 2012, Pages 976-978

  Yi, Yongxiang ^a   Zhou, Zhenxian ^a   Shu, Su ^a   Fang, Yuan ^a   Twitty, Chris ^b   Hilton, Traci L ^c   Aung, Sandra ^c   Urba, Walter J ^b   Fox, Bernard A ^b   Hu, Hong Ming ^a,b   Li, Yuhuan ^b  

^a Nanjing Second Hospital   (China)

^b PROVIDENCE PORTLAND MEDICAL CENTER   (United States)

^c Ubivac   (United States)

Author keywords

Autophagosome; C type lectin; Cross presentation; DAMP; Dendritic cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL PROTEIN; DAMP PROTEIN; GAMMA INTERFERON; HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE FRAGMENT; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CD8+ T LYMPHOCYTE; CELL DEATH; COMPLEX FORMATION; CROSS PRESENTATION; DENDRITIC CELL; EFFECTOR CELL; EXOSOME; HUMAN; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; SECRETORY VESICLE; T LYMPHOCYTE ACTIVATION;

EID: 84878253490     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.20059     Document Type: Article

References (10)

1. Morselli E, Galluzzi L, Kepp O, Vicencio JM, Criollo A, Maiuri MC, et al. Anti- and pro-tumor functions of autophagy. Biochim Biophys Acta 2009; 1793:1524-32; PMID:19371598; http://dx.doi.org/10.1016/j. bbamcr.2009.01.006.
2. Li Y, Wang LX, Yang G, Hao F, Urba WJ, Hu HM. Efficient cross-presentation depends on autoph-agy in tumor cells. Cancer Res 2008; 68:6889-95; PMID:18757401; http://dx.doi.org/10.1158/0008-5472.CAN-08-0161.
3. Li Y, Wang LX, Pang P, Cui Z, Aung S, Haley D, et al. Tumor-derived autophagosome vaccine: mechanism of cross-presentation and therapeutic efficacy. Clin Cancer Res 2011; 17:7047-57; PMID:22068657; http://dx.doi.org/10.1158/1078-0432.CCR-11-0951.
4. Kurts C, Robinson BW, Knolle PA. Cross-priming in health and disease. Nat Rev Immunol 2010; 10:403-14; PMID:20498667; http://dx.doi.org/10.1038/ nri2780.
5. Twitty CG, Jensen SM, Hu HM, Fox BA. Tumor-derived autophagosome vaccine: induction of cross-protective immune responses against short-lived proteins through a p62-dependent mechanism. Clin Cancer Res 2011; 17:6467-81; PMID:21810919; http://dx.doi.org/10.1158/1078-0432.CCR-11-0812.
6. Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med 2009; 206:1983-94; PMID:19703986; http://dx.doi.org/10.1084/ jem.20090480.
7. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007; 449:564-9; PMID:17873860; http://dx.doi.org/10.1038/nature06116.
8. Oppenheim JJ, Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol 2005; 17:359-65; PMID:15955682; http://dx.doi. org/10.1016/j.coi.2005.06.002.
9. Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P, et al. Autophagy-dependent anticancer immune responses induced by chemo-therapeutic agents in mice. Science 2011; 334:1573-7; PMID:22174255; http://dx.doi.org/10.1126/sci-ence.1208347.
10. Galluzzi L, Senovilla L, Zitvogel L, Kroemer G. The secretally: immunostimulation by anticancer drugs. Nat Rev Drug Discov 2012; 11:215-33; PMID:22301798; http://dx.doi.org/10.1038/nrd3626.