Consumption of a whey protein-enriched diet may prevent hepatic steatosis associated with weight gain in elderly women

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 25, Issue 4, 2015, Pages 388-395

  Ooi, E M ^a   Adams, L A ^a,b   Zhu, K ^a,b   Lewis, J R ^a,b   Kerr, D A ^c   Meng, X ^e   Solah, V ^c   Devine, A ^d   Binns, C W ^c   Prince, R L ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^c CURTIN UNIVERSITY   (Australia)

^d EDITH COWAN UNIVERSITY   (Australia)

^e FLINDERS UNIVERSITY   (Australia)

Author keywords

Elderly; Fatty liver disease; Hepatic steatosis; Whey protein; Women

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MILK PROTEIN; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL; WHEY PROTEIN;

AGED; ARTICLE; ASSESSMENT OF HUMANS; BODY MASS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIGESTIVE TRACT PARAMETERS; DOUBLE BLIND PROCEDURE; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT SCORE; HUMAN; INSULIN RESISTANCE; LIVER TO SPLEEN RATIO; OBESITY; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; WAIST CIRCUMFERENCE; WEIGHT GAIN; BLOOD; CALORIC INTAKE; DIET; METABOLISM; MOTOR ACTIVITY; NEW ZEALAND; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIET; DOUBLE-BLIND METHOD; ENERGY INTAKE; FATTY LIVER; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; MOTOR ACTIVITY; NEW ZEALAND; TRIGLYCERIDES; WAIST CIRCUMFERENCE; WEIGHT GAIN; WHEY PROTEINS;

EID: 84933677903     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2014.11.005     Document Type: Article

References (29)

1. Chalasani N., Younossi Z., Lavine J.E., Diehl A.M., Brunt E.M., Cusi K., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012, 55:2005-2023.
2. Szczepaniak L.S., Nurenberg P., Leonard D., Browning J.D., Reingold J.S., Grundy S., et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005, 288:E462-E468.
3. Browning J.D., Szczepaniak L.S., Dobbins R., Nuremberg P., Horton J.D., Cohen J.C., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
4. Targher G., Bertolini L., Padovani R., Rodella S., Tessari R., Zenari L., et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 2007, 30:1212-1218.
5. Wong V.W., Chu W.C., Wong G.L., Chan R.S., Chim A.M., Ong A., et al. Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut 2012, 61:409-415.
6. Bhatia L.S., Curzen N.P., Calder P.C., Byrne C.D. Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?. Eur Heart J 2012, 33:1190-1200.
7. Yamada T., Fukatsu M., Suzuki S., Wada T., Yoshida T., Joh T. Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup. J Gastroenterol Hepatol 2010, 25:352-356.
8. Adams L.A., Lymp J.F., St Sauver J., Sanderson S.O., Lindor K.D., Feldstein A., et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005, 129:113-121.
9. Promrat K., Kleiner D.E., Niemeier H.M., Jackvony E., Kearns M., Wands J.R., et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010, 51:121-129.
10. Musso G., Gambino R., Cassader M., Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2010, 52:79-104.
11. Graf S., Egert S., Heer M. Effects of whey protein supplements on metabolism: evidence from human intervention studies. Curr Opin Clin Nutr Metab Care 2011, 14:569-580.
12. Bendtsen L.Q., Lorenzen J.K., Bendsen N.T., Rasmussen C., Astrup A. Effect of dairy proteins on appetite, energy expenditure, body weight, and composition: a review of the evidence from controlled clinical trials. Adv Nutr 2013, 4:418-438.
13. Baer D.J., Stote K.S., Paul D.R., Harris G.K., Rumpler W.V., Clevidence B.A. Whey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adults. J Nutr 2011, 141:1489-1494.
14. Wycherley T.P., Moran L.J., Clifton P.M., Noakes M., Brinkworth G.D. Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2012, 96:1281-1298.
15. Hamad E.M., Taha S.H., Abou Dawood A.G., Sitohy M.Z., Abdel-Hamid M. Protective effect of whey proteins against nonalcoholic fatty liver in rats. Lipids Health Dis 2011, 10:57.
16. Shertzer H.G., Woods S.E., Krishan M., Genter M.B., Pearson K.J. Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. J Nutr 2011, 141:582-587.
17. Morifuji M., Sakai K., Sanbongi C., Sugiura K. Dietary whey protein downregulates fatty acid synthesis in the liver, but upregulates it in skeletal muscle of exercise-trained rats. Nutrition 2005, 21:1052-1058.
18. McAllan L., Skuse P., Cotter P.D., O'Connor P., Cryan J.F., Ross R.P., et al. Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and the gut microbiota in C57BL/6J mice. PLoS One 2014, 9:e88904.
19. Zhu K., Meng X., Kerr D.A., Devine A., Solah V., Binns C.W., et al. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal women. J Bone Miner Res 2011, 26:2298-2306.
20. Bauer J., Biolo G., Cederholm T., Cesari M., Cruz-Jentoft A.J., Morley J.E., et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 2013, 14:542-559.
21. Schwenzer N.F., Springer F., Schraml C., Stefan N., Machann J., Schick F. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 2009, 51:433-445.
22. Barrera F., George J. The role of diet and nutritional intervention for the management of patients with NAFLD. Clin Liver Dis 2014, 18:91-112.
23. Kondo I., Ojima T., Nakamura M., Hayasaka S., Hozawa A., Saitoh S., et al. Consumption of dairy products and death from cardiovascular disease in the Japanese general population: the NIPPON DATA80. J Epidemiol 2013, 23:47-54.
24. Larsson S.C., Virtamo J., Wolk A. Dairy consumption and risk of stroke in Swedish women and men. Stroke 2012, 43:1775-1780.
25. Bortolotti M., Maiolo E., Corazza M., Van Dijke E., Schneiter P., Boss A., et al. Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients. Clin Nutr 2011, 30:494-498.
26. Chitapanarux T., Tienboon P., Pojchamarnwiputh S., Leelarungrayub D. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients. J Gastroenterol Hepatol 2009, 24:1045-1050.
27. Krieger J.W., Sitren H.S., Daniels M.J., Langkamp-Henken B. Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1. Am J Clin Nutr 2006, 83:260-274.
28. Mortensen L.S., Hartvigsen M.L., Brader L.J., Astrup A., Schrezenmeir J., Holst J.J., et al. Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein. Am J Clin Nutr 2009, 90:41-48.
29. Lambert J.E., Ramos-Roman M.A., Browning J.D., Parks E.J. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 2013, S0016-5085:01730-7.