Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients

Journal of Gastroenterology and Hepatology (Australia)

Volumn 24, Issue 6, 2009, Pages 1045-1050

  Chitapanarux, Taned ^a,b   Tienboon, Prasong ^b   Pojchamarnwiputh, Suwalee ^a   Leelarungrayub, Donrawee ^b  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Glutathione; Nonalcoholic steatohepatitis; Whey protein isolate

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYSTEINE RICH WHEY PROTEIN; GASTROINTESTINAL AGENT; GLUTATHIONE; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DIET SUPPLEMENTATION; FATTY LIVER; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; KIDNEY FUNCTION; LIVER; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OPEN STUDY; OXIDATIVE STRESS; PILOT STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DIET; PROTEIN ISOLATION; SIDE EFFECT; WHEY;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CYSTEINE; DIETARY SUPPLEMENTS; FATTY LIVER; FEMALE; GLUTATHIONE; HUMANS; MALE; MIDDLE AGED; MILK PROTEINS; OXIDATIVE STRESS; PILOT PROJECTS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 66549084530     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2009.05865.x     Document Type: Article

References (20)

1. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116: 1413-19. PMID: 10348825 [PubMed-indexed for MEDLINE]
2. Bugianesi E, Leone N, Vanni E et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123: 134-40. PMID: 12105842 [PubMed-indexed for MEDLINE]
3. James O, Day C. Non-alcoholic steatohepatitis: another disease of affluence. Lancet 1999; 353b: 1634-6. PMID: 10335777 [PubMed-indexed for MEDLINE]
4. Day CP. Non-alcoholic steatohepatitis (NASH): where are we now and where are we going? Gut 2002; 50: 585-8. PMID: 11950797 [PubMed-indexed for MEDLINE]
5. Wieckowska A, McCullough AJ, Feldstein AE. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 2007; 46: 582-9. PMID: 17661414 [PubMed-indexed for MEDLINE]
6. Altomare E, Vendemiale G, Albano O. Hepatic glutathione content in patients with alcoholic and non alcoholic liver diseases. Life Sci. 1988; 43: 991-8. PMID: 3172971 [PubMed-indexed for MEDLINE]
7. Shigesawa T, Sato C, Marumo F. Significance of plasma glutathione determination in patients with alcoholic and non-alcoholic liver disease. J. Gastroenterol. Hepatol. 1992; 7: 7-11. PMID: 1543872 [PubMed-indexed for MEDLINE]
8. Seifert CF, Anderson DC, Bui B et al. Correlation of acetaminophen and ethanol use, plasma glutathione concentrations and diet with hepatotoxicity. Pharmacotherapy 1994; 14: 376-7.
9. Meister A, Anderson ME, Glutathione Annu. Rev. Biochem. 1983 52 711-760
10. Micke P, Beeh KM, Schlaak JF, Buhl R. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Eur. J. Clin. Invest. 2001; 31: 171-8. PMID: 11168457 [PubMed-indexed for MEDLINE]
11. Limanond P, Raman SS, Lassman C et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings. Radiology 2004; 230: 276-80. PMID: 14695401 [PubMed-indexed for MEDLINE]
12. Leelarungrayub N, Sutabhaha T, Pothongsunun P, Chanarat N. Exhaustive exercise test and oxidative stress response in athletic and sedentary subjects. CMU J 2005; 4: 183-90.
13. McAuley KA, Williams SM, Mann JI et al. Diagnosing insulin resistance in the general population. Diabetes Care 2001; 24: 460-4. PMID: 11289468 [PubMed-indexed for MEDLINE]
14. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22: 1462-70. PMID: 10480510 [PubMed-indexed for MEDLINE]
15. Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome-a new worldwide definition. Lancet 2005; 366: 1059-62. PMID: 16182882 [PubMed-indexed for MEDLINE]
16. Angulo P. Nonalcoholic fatty liver disease. N. Engl. J. Med. 2002; 346: 1221-31. PMID: 11961152 [PubMed-indexed for MEDLINE]
17. Hamaguchi M, Kojima T, Takeda N et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann. Intern. Med. 2005; 143: 722-8. PMID: 16287793 [PubMed-indexed for MEDLINE]
18. Bonnefont-Rousselot D, Ratziu V, Giral P et al. Blood oxidative stress markers are unreliable markers of hepatic steatosis. Aliment. Pharmacol. Ther. 2006; 23: 91-8. PMID: 16393285 [PubMed-indexed for MEDLINE]
19. Scheen AJ, Luyckx FH. Nonalcoholic steatohepatitis and insulin resistance: interface between gastroenterologists and endocrinologists. Acta Clin. Belg. 2003; 58: 81-91. PMID: 12836490 [PubMed-indexed for MEDLINE]
20. Saglam K, Kili R, Yilmaz MI, Gulec M, Baykal Y, Kutlu M. Insulin resistance in patients with steatohepatitis. Hepatogastroenterology 2003; 50: 456-9. PMID: 12749246 [PubMed-indexed for MEDLINE]