Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential

Cell Reports

Volumn 11, Issue 5, 2015, Pages 808-820

  Kuntimaddi, Aravinda ^a   Achille, Nicholas J ^b   Thorpe, Jeremy ^a   Lokken, Alyson A ^b   Singh, Ritambhara ^a   Hemenway, Charles S ^c   Adli, Mazhar ^a   Zeleznik Le, Nancy J ^b   Bushweller, John H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; MIXED LINEAGE LEUKEMIA PROTEIN; MLL AF9 PROTEIN; PROTEIN AF9; PROTEIN DOT1L; UNCLASSIFIED DRUG; DOT1L PROTEIN, HUMAN; HISTONE; METHYLTRANSFERASE; MLL-AF9 FUSION PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN BINDING; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; GENE SEQUENCE; GENE TARGETING; GENETIC REGULATION; GENETIC TRANSFORMATION; HEMATOPOIETIC SYSTEM; HISTONE METHYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; BIOSYNTHESIS; CHEMISTRY; DNA SEQUENCE; GENETICS; METABOLISM; METHYLATION; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; CHROMATIN IMMUNOPRECIPITATION; HISTONES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA;

EID: 84933676245     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.04.004     Document Type: Article

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