Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease

Cytotherapy

Volumn 17, Issue 5, 2015, Pages 665-679

  Han, Fabin ^a   Wang, Wei ^a   Chen, Baoxing ^a   Chen, Chao ^a   Li, Sen ^a   Lu, Xianjie ^a   Duan, Jing ^a   Zhang, Yang ^a   Zhang, Yu Alex ^b   Guo, Wennian ^a   Li, Guangyao ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Differentiation; Dopamine neuron; IPS cell; Neural stem cell; Parkinson's disease; Transplantation

Indexed keywords

DOPAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; OXIDOPAMINE; STAGE SPECIFIC EMBRYO ANTIGEN 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TYROSINE 3 MONOOXYGENASE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE MODEL; DOPAMINERGIC NERVE CELL; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOTOR PERFORMANCE; NERVE CELL; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKIN FIBROBLAST; TREATMENT OUTCOME; ANIMAL; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; IMMUNOHISTOCHEMISTRY; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MIDDLE AGED; MOTONEURON; MOUSE; PATHOLOGY; SKIN; SPRAGUE DAWLEY RAT; STEM CELL TRANSPLANTATION;

IPS; RATTUS;

AGED; ANIMALS; CELL DIFFERENTIATION; DOPAMINERGIC NEURONS; FEMALE; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE; MIDDLE AGED; MOTOR NEURONS; NEURAL STEM CELLS; OXIDOPAMINE; PARKINSON DISEASE; PLURIPOTENT STEM CELLS; RATS, SPRAGUE-DAWLEY; SKIN; STEM CELL TRANSPLANTATION; TYROSINE 3-MONOOXYGENASE;

EID: 84933671977     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2015.02.001     Document Type: Article

References (43)

1. Dawson T.M., Ko H.S., Dawson V.L. Genetic animal models of Parkinson's disease. Neuron 2010, 66:646-661.
2. Winkler C., Kirik D., Björklund A. Cell transplantation in Parkinson's disease: how can we make it work?. Trends Neurosci 2005, 28:86-92.
3. Parish C.L., Castelo-Branco G., Rawal N., Tonnesen J., Sorensen A.T., Salto C., et al. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. JClin Invest 2008, 118:149-160.
4. Mendez I., Viñuela A., Astradsson A., Mukhida K., Hallett P., Robertson H., et al. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med 2008, 14:507.
5. Lindvall O., Kokaia Z. Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Trends Pharmacol Sci 2009, 30:260-267.
6. Barker R.A., Barrett J., Mason S.L., Bjorklund A. Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease. Lancet Neurol 2013, 12:84-91.
7. Thomson J.A., Itskovitz-Eldor J., Shapiro S.S., Waknitz M.A., Swiergiel J.J., Marshall V.S., et al. Embryonic stem cell linesderived from human blastocysts. Science 1998, 282:1145-1147.
8. Bai H., Wang Z.Z. Directing human embryonic stem cells to generate vascular progenitor cells. Gene Ther 2008, 15:89-95.
9. Perrier A.L., Tabar V., Barberi T., Rubio M.E., Bruses J., Topf N., et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A 2004, 101:12543-12548.
10. Roy N.S., Cleren C., Singh S.K., Yang L., Beal M.F., Goldman S.A. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 2006, 12:1259-1268.
11. Yang D., Zhang Z.J., Oldenburg M., Ayala M., Zhang S.C. Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Stem Cells 2008, 26:55-63.
12. Sundberg M., Bogetofte H., Lawson T., Jansson J., Smith G., Astradsson A., et al. Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons. Stem Cells 2013, 31:1548-1562.
13. Jiang X., Gwye Y., McKeown S.J., Bronner-Fraser M., Lutzko C., Lawlor E.R. Isolation and characterization of neural crest stem cells derived from invitro-differentiated human embryonic stem cells. Stem Cells Dev 2009, 18:1059-1070.
14. Emborg M.E., Zhang Z., Joers V., Brunner K., Bondarenko V., Ohshima S., et al. Intracerebral transplantation of differentiated human embryonic stem cells to hemiparkinsonian monkeys. Cell Transplant 2013, 22:831-838.
15. Lindvall O., Barker R.A., Brüstle O., Isacson O., Svendsen C.N. Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell 2012, 10:151-155.
16. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
17. Yu J., Hu K., Smuga-Otto K., Tian S., Stewart R., Slukvin I.I., et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009, 324:797-801.
18. Han F. The Applications of the Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases. Chinese Journal of Cell Biology 2012, 34:403-414.
19. Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., et al. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science 2007, 318:1917-1920.
20. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
21. Ye Z., Zhan H., Mali P., Dowey S., Williams D.M., Jang Y.-Y., et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 2009, 114:5473-5480.
22. Park I.-H., Arora N., Huo H., Maherali N., Ahfeldt T., Shimamura A., et al. Disease-specific induced pluripotent stem cells. Cell 2008, 134:877-886.
23. Saha K., Jaenisch R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 2009, 5:584-595.
24. Wernig M., Zhao J.P., Pruszak J., Hedlund E., Fu D., Soldner F., et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A 2008, 105:5856-5861.
25. Yagi T., Ito D., Okada Y., Akamatsu W., Nihei Y., Yoshizaki T., et al. Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum Mol Genet 2011, 20:4530-4539.
26. Park I.H., Lerou P.H., Zhao R., Huo H., Daley G.Q. Generation of human-induced pluripotent stem cells. Nat Protoc 2008, 3:1180-1186.
27. Chambers S.M., Fasano C.A., Papapetrou E.P., Tomishima M., Sadelain M., Studer L. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 2009, 27:275-280.
28. Zeng H., Guo M., Martins-Taylor K., Wang X., Zhang Z., Park J.W., et al. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PloS One 2010, 5:e11853.
29. Suzuki M., McHugh J., Tork C., Shelley B., Klein S.M., Aebischer P., et al. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PloS One 2007, 2:e689.
30. Soldner F., Laganiere J., Cheng A.W., Hockemeyer D., Gao Q., Alagappan R., et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 2011, 146:318-331.
31. Ren Y., Jiang H., Hu Z., Fan K., Wang J., Janoschka S., et al. Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-Derived Human Neurons. Stem cells 2015, 33:68-78.
32. Astradsson A., Cooper O., Vinuela A., Isacson O. Recent advances in cell-based therapy for Parkinson disease. Neurosurgical Focus 2008, 24:E6.
33. Ebert A.D., Beres A.J., Barber A.E., Svendsen C.N. Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Exp Neurol 2008, 209:213-223.
34. Chen H.F., Yu C.Y., Chen M.J., Chou S.H., Chiang M.S., Chou W.H., et al. Characteristic expression of major histocompatibility complex and immune privilege genes in human pluripotent stem cells and the derivatives [published online ahead of print October 18, 2013]. Cell Transplant 2013.
35. Freed C.R., Greene P.E., Breeze R.E., Tsai W.Y., DuMouchel W., Kao R., et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. NEngl J Med 2001, 344:710-719.
36. Hargus G., Cooper O., Deleidi M., Levy A., Lee K., Marlow E., et al. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A 2010, 107:15921-15926.
37. Yamanaka S., Blau H.M. Nuclear reprogramming to a pluripotent state by three approaches. Nature 2010, 465:704-712.
38. Zhou T., Benda C., Dunzinger S., Huang Y., Ho J.C., Yang J., et al. Generation of human induced pluripotent stem cells from urine samples. Nat Protoc 2012, 7:2080-2089.
39. Geti I., Ormiston M.L., Rouhani F., Toshner M., Movassagh M., Nichols J., et al. Apractical and efficient cellular substrate for the generation of induced pluripotent stem cells from adults: blood-derived endothelial progenitor cells. Stem Cells Transl Med 2012, 1:855-865.
40. Lysy P.A., Smets F., Sibille C., Najimi M., Sokal E.M. Human skin fibroblasts: from mesodermal to hepatocyte-like differentiation. Hepatology 2007, 46:1574-1585.
41. Blurton-Jones M., Kitazawa M., Martinez-Coria H., Castello N.A., Muller F.J., Loring J.F., et al. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A 2009, 106:13594-13599.
42. Okita K., Matsumura Y., Sato Y., Okada A., Morizane A., Okamoto S., et al. Amore efficient method to generate integration-free human iPS cells. Nat Methods 2011, 8:409-412.
43. Okano H., Nakamura M., Yoshida K., Okada Y., Tsuji O., Nori S., et al. Steps toward safe cell therapy using induced pluripotent stem cells. Circ Res 2013, 112:523-533.