Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss

FASEB Journal

Volumn 29, Issue 6, 2015, Pages 2281-2291

  Jiang, Hongwei ^a,b   Wang, Yongqiang ^a   Viniegra, Ana ^a   Sima, Corneliu ^a   McCulloch, Christopher A ^a   Glogauer, Michael ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Actin; Bone resorption; Fusion; Osteoclastogenesis

Indexed keywords

ACTIN BINDING PROTEIN; ADSEVERIN; GELSOLIN; UNCLASSIFIED DRUG; SCINDERIN;

ACTIN FILAMENT; ALVEOLAR BONE; ALVEOLAR BONE LOSS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; GENE DELETION; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PERIODONTAL DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CYTOLOGY; DEFICIENCY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENETIC TRANSFECTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

MUS;

ACTIN CYTOSKELETON; ALVEOLAR BONE LOSS; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GELSOLIN; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; OSTEOCLASTS; PERIODONTAL DISEASES; TRANSFECTION;

EID: 84933557300     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-265744     Document Type: Article

References (36)

1. Boyle, W. J., Simonet, W. S., and Lacey, D. L. (2003) Osteoclast differentiation and activation. Nature 423, 337-342
2. Woo, J. T., Kasai, S., Stern, P. H., and Nagai, K. (2000) Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. J. Bone Miner. Res. 15, 650-662
3. Helming, L., and Gordon, S. (2009) Molecular mediators of macrophage fusion. Trends Cell Biol. 19, 514-522
4. Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., Oike, Y., Takeya, M., Toyama, Y., and Suda, T. (2005) DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202, 345-351
5. Jurdic, P., Saltel, F., Chabadel, A., and Destaing, O. (2006) Podosome and sealing zone: specificity of the osteoclast model. Eur. J. Cell Biol. 85, 195-202
6. Spinardi, L., and Marchisio, P. C. (2006) Podosomes as smart regulators of cellular adhesion. Eur. J. Cell Biol. 85, 191-194
7. Kanehisa, J., Yamanaka, T., Doi, S., Turksen, K., Heersche, J. N., Aubin, J. E., & Takeuchi, H. (1990) A band of F-actin containing podosomes is involved in bone resorption by osteoclasts, Bone. 11, 287-93
8. Silacci, P., Mazzolai, L., Gauci, C., Stergiopulos, N., Yin, H. L., and Hayoz, D. (2004) Gelsolin superfamily proteins: key regulators of cellular functions. Cell. Mol. Life Sci. 61, 2614-2623
9. Blangy, A., Touaitahuata, H., Cres, G., and Pawlak, G. (2012) Cofilin activation during podosome belt formation in osteoclasts. PLoS ONE 7, e45909
10. Hartwig, J. H., and Kwiatkowski, D. J. (1991) Actin-binding proteins. Curr. Opin. Cell Biol. 3, 87-97
11. Lueck, A., Brown, D., and Kwiatkowski, D. J. (1998) The actinbinding proteins adseverin and gelsolin are both highly expressed but differentially localized in kidney and intestine. J. Cell Sci. 111, 3633-3643
12. Chumnarnsilpa, S., Lee, W. L., Nag, S., Kannan, B., Larsson, M., Burtnick, L. D., and Robinson, R. C. (2009) The crystal structure of the C-terminus of adseverin reveals the actin-binding interface. Proc. Natl. Acad. Sci. USA 106, 13719-13724
13. Hassanpour, S., Jiang, H., Wang, Y., Kuiper, J. W., and Glogauer, M. (2014) The actin binding protein adseverin regulates osteoclastogenesis. PLoS ONE 9, e109078
14. Sakurai, T., Kurokawa, H., and Nonomura, Y. (1991) Comparison between the gelsolin and adseverin domain structure. J. Biol. Chem. 266, 15979-15983
15. Maekawa, S., and Sakai, H. (1990) Inhibition of actin regulatory activity of the 74-kDa protein from bovine adrenal medulla (adseverin) by some phospholipids. J. Biol. Chem. 265, 10940-10942
16. Yang, G., Zaidi, M., Zhang, W., Zhu, L. L., Li, J., Iqbal, J., Varbanov, A., Gross, G., Phipps, R., Troen, B. R., and Sun, L. (2008) Functional grouping of osteoclast genes revealed through microarray analysis. Biochem. Biophys. Res. Commun. 366, 352-359
17. Castro, C. H., Shin, C. S., Stains, J. P., Cheng, S. L., Sheikh, S., Mbalaviele, G., Szejnfeld, V. L., and Civitelli, R. (2004) Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J. Cell Sci. 117, 2853-2864
18. Wang, Y., Lebowitz, D., Sun, C., Thang, H., Grynpas, M. D., and Glogauer, M. (2008) Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis. J. Bone Miner. Res. 23, 260-270
19. Di Benedetto, G., Zoccarato, A., Lissandron, V., Terrin, A., Li, X., Houslay, M. D., Baillie, G. S., and Zaccolo, M. (2008) Protein kinase A type I and type II define distinct intracellular signaling compartments. Circ. Res. 103, 836-844
20. Götz, A., and Jessberger, R. (2013) Dendritic cell podosome dynamics does not depend on the F-actin regulator SWAP-70. PLoS ONE 8, e60642
21. Glogauer, M., Hartwig, J., and Stossel, T. (2000) Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils. J. Cell Biol. 150, 785-796
22. Sima, C., Gastfreund, S., Sun, C., and Glogauer, M. (2014) Racnull leukocytes are associated with increased inflammationmediated alveolar bone loss. Am. J. Pathol. 184, 472-482
23. Chiu, W. S., McManus, J. F., Notini, A. J., Cassady, A. I., Zajac, J. D., and Davey, R. A. (2004) Transgenic mice that express Cre recombinase in osteoclasts. Genesis 39, 178-185
24. Destaing, O., Saltel, F., Géminard, J. C., Jurdic, P., and Bard, F. (2003) Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein. Mol. Biol. Cell 14, 407-416
25. Janmey, P. A., and Stossel, T. P. (1987) Modulation of gelsolin function by phosphatidylinositol 4, 5-bisphosphate. Nature 325, 362-364
26. Lueck, A., Yin, H. L., Kwiatkowski, D. J., and Allen, P. G. (2000) Calcium regulation of gelsolin and adseverin: a natural test of the helix latch hypothesis. Biochemistry 39, 5274-5279
27. Dumitrescu Pene, T., Rosé, S. D., Lejen, T., Marcu, M. G., and Trifaró, J. M. (2005) Expression of various scinderin domains in chromaffin cells indicates that this protein acts as a molecular switch in the control of actin filament dynamics and exocytosis. J. Neurochem. 92, 780-789
28. Lee, C. Y., and Suzuki, J. B. (2009) CTX biochemical marker of bone metabolism. Is it a reliable predictor of bisphosphonateassociated osteonecrosis of the jaws after surgery? Part I: biological concepts with a review of the literature. Implant Dent. 18, 492-500
29. Henriksen, K., Tanko, L. B., Qvist, P., Delmas, P. D., Christiansen, C., and Karsdal, M. A. (2007) Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases. Osteoporos. Int. 18, 681-685
30. Nurminsky, D., Magee, C., Faverman, L., and Nurminskaya, M. (2007) Regulation of chondrocyte differentiation by actinsevering protein adseverin. Dev. Biol. 302, 427-437
31. Wilson, S. R., Peters, C., Saftig, P., and Brömme, D. (2009) Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J. Biol. Chem. 284, 2584-2592
32. Shilagardi, K., Li, S., Luo, F., Marikar, F., Duan, R., Jin, P., Kim, J. H., Murnen, K., and Chen, E. H. (2013) Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion. Science 340, 359-363
33. Abmayr, S. M., and Pavlath, G. K. (2012) Myoblast fusion: lessons from flies and mice. Development 139, 641-656
34. Rodriguez Del Castillo, A., Lemaire, S., Tchakarov, L., Jeyapragasan, M., Doucet, J. P., Vitale, M. L., and Trifaró, J. M. (1990) Chromaffin cell scinderin, a novel calcium-dependent actin filament-severing protein. EMBO J. 9, 43-52
35. Vitale, M. L., Rodríguez Del Castillo, A., Tchakarov, L., and Trifaró, J. M. (1991) Cortical filamentous actin disassembly and scinderin redistribution during chromaffin cell stimulation precede exocytosis, a phenomenon not exhibited by gelsolin. J. Cell Biol. 113, 1057-1067
36. Chellaiah, M., Kizer, N., Silva, M., Alvarez, U., Kwiatkowski, D., and Hruska, K. A. (2000) Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J. Cell Biol. 148, 665-678